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Technical Note: Automatic segmentation of CT images for ventral body composition analysis.

Abstract：

PURPOSE:Body composition is known to be associated with many diseases including diabetes, cancers, and cardiovascular diseases. In this paper, we developed a fully automatic body tissue decomposition procedure to segment three major compartments that are related to body composition analysis - subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and muscle. Three additional compartments - the ventral cavity, lung, and bones - were also segmented during the segmentation process to assist segmentation of the major compartments. METHODS:A convolutional neural network (CNN) model with densely connected layers was developed to perform ventral cavity segmentation. An image processing workflow was developed to segment the ventral cavity in any patient's computed tomography (CT) using the CNN model, then further segment the body tissue into multiple compartments using hysteresis thresholding followed by morphological operations. It is important to segment ventral cavity firstly to allow accurate separation of compartments with similar Hounsfield unit (HU) inside and outside the ventral cavity. RESULTS:The ventral cavity segmentation CNN model was trained and tested with manually labeled ventral cavities in 60 CTs. Dice scores (mean ± standard deviation) for ventral cavity segmentation were 0.966 ± 0.012. Tested on CT datasets with intravenous (IV) and oral contrast, the Dice scores were 0.96 ± 0.02, 0.94 ± 0.06, 0.96 ± 0.04, 0.95 ± 0.04, and 0.99 ± 0.01 for bone, VAT, SAT, muscle, and lung, respectively. The respective Dice scores were 0.97 ± 0.02, 0.94 ± 0.07, 0.93 ± 0.06, 0.91 ± 0.04, and 0.99 ± 0.01 for non-contrast CT datasets. CONCLUSION:A body tissue decomposition procedure was developed to automatically segment multiple compartments of the ventral body. The proposed method enables fully automated quantification of three-dimensional (3D) ventral body composition metrics from CT images.

journal_name

Med Phys

journal_title

Medical physics

authors

Fu Y,Ippolito JE,Ludwig DR,Nizamuddin R,Li HH,Yang D

doi

10.1002/mp.14465

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

5723-5730

issue

eissn

0094-2405

issn

2473-4209

journal_volume

pub_type

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Technical Note: Automatic segmentation of CT images for ventral body composition analysis.