Adipose Tissue in Metabolic Syndrome: Onset and Progression of Atherosclerosis.

Abstract:

:Metabolic syndrome (MetS) should be considered a clinical entity when its different symptoms share a common etiology: obesity/insulin resistance as a result of a multi-organ dysfunction. The main interest in treating MetS as a clinical entity is that the addition of its components drastically increases the risk of atherosclerosis. In MetS, the adipose tissue plays a central role along with an unbalanced gut microbiome, which has become relevant in recent years. Once visceral adipose tissue (VAT) increases, dyslipidemia and endothelial dysfunction follow as additive risk factors. However, when the nonalcoholic fatty liver is present, risk of a cardiovascular event is highly augmented. Epicardial adipose tissue (EAT) seems to increase simultaneously with the VAT. In this context, the former may play a more important role in the development of the atherosclerotic plaque than the latter. Hence, EAT may act as a paracrine tissue vis-à-vis the coronary arteries favoring the local inflammation and the atheroma calcification.

journal_name

Arch Med Res

authors

Luna-Luna M,Medina-Urrutia A,Vargas-Alarcón G,Coss-Rovirosa F,Vargas-Barrón J,Pérez-Méndez Ó

doi

10.1016/j.arcmed.2015.05.007

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

392-407

issue

5

eissn

0188-4409

issn

1873-5487

pii

S0188-4409(15)00125-3

journal_volume

46

pub_type

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