Abstract:
:Metabolic syndrome (MetS) should be considered a clinical entity when its different symptoms share a common etiology: obesity/insulin resistance as a result of a multi-organ dysfunction. The main interest in treating MetS as a clinical entity is that the addition of its components drastically increases the risk of atherosclerosis. In MetS, the adipose tissue plays a central role along with an unbalanced gut microbiome, which has become relevant in recent years. Once visceral adipose tissue (VAT) increases, dyslipidemia and endothelial dysfunction follow as additive risk factors. However, when the nonalcoholic fatty liver is present, risk of a cardiovascular event is highly augmented. Epicardial adipose tissue (EAT) seems to increase simultaneously with the VAT. In this context, the former may play a more important role in the development of the atherosclerotic plaque than the latter. Hence, EAT may act as a paracrine tissue vis-à-vis the coronary arteries favoring the local inflammation and the atheroma calcification.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Luna-Luna M,Medina-Urrutia A,Vargas-Alarcón G,Coss-Rovirosa F,Vargas-Barrón J,Pérez-Méndez Ódoi
10.1016/j.arcmed.2015.05.007subject
Has Abstractpub_date
2015-07-01 00:00:00pages
392-407issue
5eissn
0188-4409issn
1873-5487pii
S0188-4409(15)00125-3journal_volume
46pub_type
杂志文章,评审abstract:BACKGROUND:Pyruvate kinase isozymes in human breast tumor tissue were compared in this study with normal human breast tissue. Two forms of pyruvate kinase present in normal and tumor human breast were purified by ammonium sulfate precipitation, dialysis, gel filtration, ion exchange, and affinity chromatography. Molecu...
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journal_title:Archives of medical research
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journal_title:Archives of medical research
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doi:10.1016/S0188-4409(03)00076-6
更新日期:2003-09-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2016.12.003
更新日期:2016-11-01 00:00:00
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journal_title:Archives of medical research
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更新日期:2002-11-01 00:00:00
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journal_title:Archives of medical research
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journal_title:Archives of medical research
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
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doi:
更新日期:1996-10-01 00:00:00
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journal_title:Archives of medical research
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doi:
更新日期:1996-01-01 00:00:00
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journal_title:Archives of medical research
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journal_title:Archives of medical research
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更新日期:2008-08-01 00:00:00
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journal_title:Archives of medical research
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更新日期:1997-01-01 00:00:00
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journal_title:Archives of medical research
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journal_title:Archives of medical research
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更新日期:2018-11-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00