Abstract：
OBJECTIVE:The aim of the study was to evaluate the effect of systemically administrated curcumin on the prevention of peridural fibrotic tissue and adhesion formation in a rat laminectomy model. METHODS:Thirty-two Wistar albino rats were randomly selected and equally divided into 4 groups as follows: negative control group (group I) did not undergo operation; positive control group (group II) underwent laminectomy without treatment; group III (low-dose curcumin; 100 mg/kg); and group IV (high-dose curcumin; 200 mg/kg). Curcumin was administered intraperitoneally per day for 7 days after surgery starting from day 0. Twenty-eight days after surgery, T12 and L4 vertebral columns, paraspinal tissues, and epidural scar tissue were dissected en bloc and prepared for histopathologic examinations. All specimens were examined for inflammation, epidural fibrosis (EF), foreign body reaction, medulla spinalis retraction, granulation tissue, and arachnoid involvement. A Kruskal-Wallis test followed by a Dunn multiple comparison test were used for statistical analysis, and a P value <0.05 was considered as statistically significant. RESULTS:Curcumin treatment significantly reduced inflammation, foreign body reaction, granulation tissue formation, medulla spinalis retraction, and EF formation compared with positive control group (P < 0.05); however, no significant differences were found between the 2 groups that received different doses of curcumin. CONCLUSIONS:The results of the present study showed that systemic administration of curcumin was effective in reducing EF formation, inflammation, granulation tissue formation, medulla spinalis retraction, and foreign body reaction in the laminectomy area. Our results suggest that antiinflammatory activities of curcumin are beneficial for attenuation of EF formation.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Demirel C,Turkoz D,Yazicioglu IM,Cokluk Cdoi
10.1016/j.wneu.2020.09.140subject
Has Abstractpub_date
2021-01-01 00:00:00pages
e141-e148eissn
1878-8750issn
1878-8769pii
S1878-8750(20)32159-8journal_volume
145pub_type
杂志文章abstract：BACKGROUND:During the current global crisis unleashed by the severe acute respiratory syndrome coronavirus 2 outbreak, surgical departments have considerably reduced the amount of elective surgeries. This decrease leads to less time in the surgical room to develop and improve the surgical skills of residents. In this s...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.07.114
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:To present the clinical characteristics and prognostic factors of neurologic recovery in patients with cervical spinal tuberculosis (CST). METHODS:General description and multivariate analysis were used to detect possible predictors of the outcome of patients with neurologic deficit. Follow-up data were used...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.01.015
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:The pathophysiology of spinal cord injury (SCI) with the information obtained to date has not been elucidated fully. A safe drug or treatment protocol that results in cell regeneration for SCI remains unknown. Neuroprotective and neuroregenerative effects of riluzole, administered after a SCI, have been shown...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.02.171
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:In this series, we present 3 cases that show the use of a skull-mounted tracker for image-guided navigation for anterior skull base surgery and ventricular catheter placement procedures. This system obviates fiducials or face masks during the surgical procedure itself and allows for the performance of facial ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.03.007
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:The prognosis in cervical spinal cord injury is poor, and surgical and neurointensive care management need further improvement. Monitoring of the intraspinal pressure (ISP) at an early stage after traumatic spinal cord injury (tSCI) is useful clinically. MATERIALS AND METHODS:Obtaining continuous spinal cord...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.05.138
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:The Timed Up and Go (TUG) test, as a measure of objective functional impairment in lumbar degenerative disk disease (DDD), complements patient-reported outcome measures (PROMs) of subjective functional impairment. METHODS:Prospective 2-center study on consecutive patients scheduled for surgical treatment fo...
journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2016.11.039
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:To identify whether age, sex, and lesion location are associated with initial presentation in patients with brain arteriovenous malformations (AVMs). METHODS:Collected data of 3299 consecutive patients with AVM treated at Beijing Tiantan Hosptial from January 1980 to January 2015 were analyzed. The variables...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.10.060
更新日期：2016-03-01 00:00:00
abstract：:Extent of resection and tumor grade are considered the most important predictors of progression-free survival (PFS) in meningiomas. However, adjuvant therapy for atypical meningiomas remains controversial, with variable PFS rates of up to 40%. The current mitotic index (MI) range for atypical meningiomas is broad, com...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2020.06.189
更新日期：2020-10-01 00:00:00
abstract：:Vertigo is one of the most common presentations in adult patients. Among the various causes of vertigo, so-called cervical vertigo is still a controversial entity. Cervical vertigo was first thought to be due to abnormal input from cervical sympathetic nerves based on the work of Barré and Liéou in 1928. Later studies...
journal_title：World neurosurgery
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.wneu.2017.10.063
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:Meningeal hemangiopericytoma (HPC) is a rare, aggressive central nervous system tumor that tends to invade locally and to metastasize, and has a high rate of recurrence. METHODS:This study presents a retrospective review of patients managed for intracranial HPC at Rome University Hospital. RESULTS:A total o...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2013.11.009
更新日期：2014-03-01 00:00:00
abstract：:An elderly woman was transferred for biopsy of a pontine lesion. Her condition, including gait disturbances, truncal ataxia, and dysarthria-presumed to be due to severe alcohol abuse-had deteriorated during treatment of ambulatory-acquired pneumonia. No electrolyte abnormalities were noted during hospitalization. Howe...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.05.061
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVE:To explore the effect and safety of transforaminal percutaneous endoscopic decompression for lower thoracic spinal stenosis. METHODS:We reviewed 6 patients receiving transforaminal percutaneous endoscopic thoracic decompression for sympathetic symptoms in the lower extremities. Pre- and postoperative Frankel...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.186
更新日期：2019-08-01 00:00:00
abstract：INTRODUCTION:While surgical resection remains a primary treatment for accessible arteriovenous malformations (AVMs), stereotactic radiosurgery (SRS) has become thoroughly integrated into the AVM armamentarium; however, delayed sequelae of this treatment have become evident with increased long-term follow-up. To our kno...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.12.109
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Reports of cerebral aneurysm and aneurysm rupture during pregnancy are rare in the literature. Aneurysms might rupture and cause intracranial hemorrhage during or after pregnancy. Aneurysmal subarachnoid hemorrhage during pregnancy presents a challenge regarding treatment and management. No institution has r...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.04.238
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Aortic pseudoaneurysms are a rare cause of chronic back pain, usually resulting from compression of the adjacent neurovasculature. It is uncommon for patients with pseudoaneurysms of the abdominal aorta to present in a delayed fashion after initial traumatic injury. CASE DESCRIPTION:We describe an unusual c...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.11.035
更新日期：2018-02-01 00:00:00
abstract：:Arachnoiditis ossificans of the spine is a very rare entity defined as an ossification of the leptomeninges resulting in neurologic declines. We describe the case of a 42-year-old woman, without any obvious predisposing factor, who presented with a very progressive cauda equina syndrome. The imaging findings on magnet...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2021.01.057
更新日期：2021-01-25 00:00:00
abstract：OBJECTIVE:This report describes 2 techniques for controlling otherwise difficult-to-control hemorrhage from choanoid bony foramina. METHODS:Medical records of 3 patients in whom vigorous and difficult-to-control bleeding from choanoid cranial foramina was successfully halted are reviewed. RESULTS:In 2 patients, vigor...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.01.128
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:The cervical spine may be used as a harvesting site of local autograft material during anterior cervical discectomy and fusion procedures. We analyzed the quality and composition of bone grafts obtained from different parts of the cervical vertebrae in a cadaveric model. METHODS:Five fresh adult human cadav...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.12.175
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:Shunt overdrainage is a potential complication in pediatric hydrocephalus. The addition of adjustable gravitational units to previous shunt systems has been proposed as effective management for this problem. These devices have been traditionally implanted over the occipital bone. We propose chest implantation...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.11.001
更新日期：2020-11-07 00:00:00
abstract：BACKGROUND:We report the efficacy and safety of surgical treatment with the orbitozygomatic transsylvian approach and the rarity of accompanying subarachnoid hemorrhage, Terson syndrome, and ruptured giant basilar tip aneurysm in a patient affected by moyamoya disease with a good outcome. METHODS:A 40-year-old man wit...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.03.059
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE:Venous thromboembolism (VTE), which includes deep venous thrombosis and pulmonary embolism, is a serious and potentially fatal surgical complication. The goal of our study was to examine preoperative characteristics, incidence, and outcomes of patients with VTE after elective thoracic/thoracolumbar level spin...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2011.12.089
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:The foramen of Luschka is a natural aperture between the fourth ventricle and the subarachnoid space at the cerebellopontine angle. Membranous closure of this foramen is referred to as primary obstruction. Available information about this variant and its role in the development of the cysts of the posterior ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.01.037
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Vagus nerve stimulation (VNS) has become an increasingly popular procedure for the treatment of epilepsy and depression. Significant complications or side effects associated with VNS surgery may result from either the inadvertent direct injury to the vagus nerve as part of the surgical approach, placement of...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.08.014
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:Racial disparities have been shown to affect surgical outcomes. However, the effect of race on complex spinal fusion outcomes remains understudied. The aim of this study is to determine if patient race affects 30-day complication rates after elective complex spinal fusion (≥5 levels). METHODS:The medical rec...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.12.029
更新日期：2017-03-01 00:00:00
abstract：:There are only three fully trained neurosurgeons to care for Tanzania's population of more than 41 million people. Madaktari was founded in 2006 to serve as a physician training partnership to establish more self-sufficient health care through education and training. Medical students play a valuable role in Madaktari ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2010.05.039
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVES:Non-small-cell lung cancer (NSCLC) is one of the most common primary tumor sites among patients with metastatic spinal cord compression (MSCC). This disorder is related to neurologic dysfunction and can reduce the quality of life, but the association between MSCC and death is unclear. The aim of this study w...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.09.079
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of important trials on the practice of neurosurgery. METHODS:We hypothesized that evidence from trials addressing the management of intracranial aneurysms (International Subarachnoid Aneurysm Trial [ISAT]) and nontraumatic intracerebral hemorrhages (Surgical Trial in Intracerebral Hemo...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.01.011
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Recently, novel mobile intraoperative fan-beam computed tomography (CT) was introduced, allowing for real-time navigation and immediate intraoperative evaluation of neural decompression in spine surgery. This study sought to investigate whether intraoperatively assessed neural decompression during minimally ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.07.167
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:The decision between conservative management and invasive treatment of juxtaorbital intracranial vascular anomalies can be challenging. Whereas arteriovenous malformations (AVMs) can lead to vision loss and are potentially life-threatening if they rupture, invasive endovascular and surgical procedures also c...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2013.01.093
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Pediatric cerebral ganglioneuroblastoma is an exceedingly rare tumor. CASE DESCRIPTION:We describe the case of a 4-year-old boy with sudden mental status decline who was found to have a large intracranial lesion with intraventricular extension. CONCLUSION:Management of the case and pathologic findings are ...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2018.02.115
更新日期：2018-05-01 00:00:00
