Abstract：
:Healthy brain tissue pulsates with the cardiac cycle, but whether brain tissue pulsations (BTPs) are impaired by tissue ischemia due to ischemic stroke is currently unclear. This study is the first to explore the clinical potential of measuring BTPs using ultrasound in acute ischemic stroke patients. BTPs were measured in 24 healthy volunteers (aged 52-82 years) and 14 acute ischemic stroke patients (aged 51-86 years) using a novel Transcranial Tissue Doppler (TCTD) method. Measurements were quick to perform and were well tolerated by all subjects. A mixed-methods approach was used for blinded analysis of recordings. This identified qualitative disruption of BTPs in acute stroke patients, which were used to create an analysis checklist. Blinded BTP analysis by novices using the checklist resulted in high sensitivity but low specificity for stroke detection. Quantitative analysis also identified differences between stroke and healthy participants, including weaker BTPs in stroke patients. This first study reporting BTP characteristics in acute ischemic stroke revealed weaker brain tissue pulsations and waveform disruption in acute stroke patients. However, further clinical evaluation using a larger sample size is required to confirm these findings and to explore whether TCTD monitoring might be beneficial for clinical neuromonitoring.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Ince J,Banahan C,Venturini S,Alharbi M,Turner P,Oura M,Beach KW,Robinson TG,Mistri AK,Lecchini-Visintini A,Minhas JS,Chung EMLdoi
10.1016/j.jns.2020.117164subject
Has Abstractpub_date
2020-12-15 00:00:00pages
117164eissn
0022-510Xissn
1878-5883pii
S0022-510X(20)30500-1journal_volume
419pub_type
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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更新日期：2016-06-15 00:00:00
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更新日期：1976-08-01 00:00:00
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更新日期：2014-10-15 00:00:00
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更新日期：2011-11-15 00:00:00
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journal_title：Journal of the neurological sciences
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更新日期：2020-01-15 00:00:00
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abstract：:We have previously reported reduced ability of ALS fibroblasts to repair genomic DNA damage produced by alkylating agents. This report presents our experience of studying DNA repair in lymphocytes from ALS patients. The repair of N-methylpurines produced by treatment with the alkylating agent, methyl methanesulfonate,...
journal_title：Journal of the neurological sciences
pub_type： 杂志文章
doi：10.1016/0022-510x(93)90225-n
更新日期：1993-04-01 00:00:00
