Exogenous lung surfactant: effect on radiographic appearance in premature infants.

Abstract:

:At birth, premature infants of 25-29 weeks gestation, at high risk for development of neonatal respiratory distress syndrome (RDS), were given a single dose (90 mg) of calf lung surfactant extract (CLSE) by intratracheal instillation. The frequency and severity of RDS were assessed with use of a simple radiographic scoring system in which pulmonary parenchymal densities and the prominence of the air-bronchogram effect were used as indicators of widespread atelectasis. Radiographs were obtained in surfactant-treated and control infants within the first 90 minutes of life as part of an initial evaluation of their pulmonary status. Subsequent examinations were performed at less than 24 hours and less than 48 hours of age. Radiographic assessment of lung disease compared consistently with coordinated data on oxygen and mean airway pressure requirements of the infants. Both indicated a significantly decreased frequency and severity of RDS in the infants treated with surfactant. The results provide supporting evidence of the effectiveness of exogenous lung surfactant replacement in mitigating RDS in very premature infants.

journal_name

Radiology

journal_title

Radiology

authors

Wood BP,Sinkin RA,Kendig JW,Notter RH,Shapiro DL

doi

10.1148/radiology.165.1.3306780

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

11-3

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

165

pub_type

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