Abstract:
BACKGROUND:Individuals with cerebral palsy (CP) experience bone loss due to impaired weight bearing. Despite serious complications, there is no standard medication. OBJECTIVE:To develop a new pharmacological agent, we performed a series of studies. The primary aim was to develop an animal model of CP to use our target medication based on transcriptome analysis of individuals with CP. The secondary aim was to show the therapeutic capability of collagen-binding peptide (CBP) in reversing bone loss in the CP mouse model. METHODS:A total of 119 people with CP and 13 healthy adults participated in the study and 140 mice were used for the behavioral analysis and discovery of therapeutic effects in the preclinical study. The mouse model of CP was induced by hypoxic-ischemic brain injury. Inclusion and exclusion criteria were established for CBP medication in the CP mouse model with bone loss. RESULTS:On the basis of clinical outcomes showing insufficient mechanical loading from non-ambulatory function and that underweight mainly affects bone loss in adults with CP, we developed a mouse model of CP with bone loss. Injury severity and body weight mainly affected bone loss in the CP mouse model. Transcriptome analysis showed SPP1 expression downregulated in adults with CP who showed lower bone density than healthy controls. Therefore, a synthesized CBP was administered to the mouse model. Trabecular thickness, total collagen and bone turnover activity increased with CBP treatment as compared with the saline control. Immunohistochemistry showed increased immunoreactivity of runt-related transcription factor 2 and osteocalcin, so the CBP participated in osteoblast differentiation. CONCLUSIONS:This study can provide a scientific basis for a promising translational approach for developing new anabolic CBP medication to treat bone loss in individuals with CP.
journal_name
Ann Phys Rehabil Medjournal_title
Annals of physical and rehabilitation medicineauthors
Shin YK,Heo JH,Lee JY,Park YJ,Cho SRdoi
10.1016/j.rehab.2020.09.009subject
Has Abstractpub_date
2020-12-01 00:00:00eissn
1877-0657issn
1877-0665pii
S1877-0657(20)30190-1pub_type
杂志文章abstract:OBJECTIVES:For hospitalizations in rehabilitation centers (RCs) in France, the quantification of healthcare givers' activity is based on the dependency of the patients, defined as a total or partial inability to perform activities required for daily living without help. The tools currently used to quantify dependency a...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2018.04.006
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:The Pediatric Stroke Outcome Measure-Summary of Impressions (PSOM-SOI) measures neurological function across right and left sensorimotor domains (Item A), language production (Item B), language comprehension (Item C), and cognition/behaviour (Item D). OBJECTIVE:This study was a cross-cultural adaptation int...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2019.10.010
更新日期:2019-12-06 00:00:00
abstract:OBJECTIVE:The Osteoarthritis Quality of Life scale (OAQoL) is an osteoarthritis-specific measure developed in the United Kingdom by a needs-based approach. This study describes the adaptation and validation of this English scale into French. METHODS:The OAQoL was translated into French by a dual-panel technique follow...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2015.09.003
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:In a survey of 100 transtibial amputees (TTA) in the study place, it was noticed that nearly 30% of total activities performed by crutches. It was recorded nearly 52% of the amputees were totally independent, 39% had to use a crutch or cane and only 9% need not used any devices simply because they are unawar...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2012.02.006
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Recent studies reported that wearable sensor devices show low validity for assessing the amount of energy expenditure in individuals after stroke. OBJECTIVE:We aimed to evaluate the validity of energy expenditure calculation based on the product of energy cost and walked distance estimated by wearable devic...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2019.07.002
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To assess with an isokinetic dynamometer the force and endurance of the spinal flexor and extensor muscles in pre-teens or teens aged 11 to 13 and 14 to 16 years with and without low back pain (LBP). METHOD:The control group and the LBP group were homogeneous in terms of age, weight, height and Body Mass Ind...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2013.10.004
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:Focus on the different therapeutic patient education (TPE) programs for stroke survivors found in the literature. Verify their content and efficacy. METHOD:A literature review was conducted by searching for entries from 1966 to 2011 in the Medline and Cochrane Library databases. The references for the accep...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rehab.2012.08.011
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:People who survive severe brain damage may eventually develop a prolonged consciousness disorder. Others can regain full consciousness but remain unable to speak or move because of the severity of the lesions, as for those with locked-in syndrome (LIS). Brain-computer interface techniques can be useful to di...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2019.02.005
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze the prevalence of claw toes and its correlation to other lower limb disorders as well as the global functional recovery in a population of hemiplegic patients 1year post-stroke. PATIENTS AND METHODS:This prospective study included 39 stroke patients hospitalized in the Ph...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2009.12.005
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:With Nordic walking, or walking with poles, one can travel a greater distance and at a higher rate than with walking without poles, but whether the activity is beneficial for patients with cardiovascular disease is unknown. OBJECTIVE:This randomized controlled trial was undertaken to determine whether Nordi...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rehab.2016.12.004
更新日期:2017-07-01 00:00:00
abstract::This document is part of the "Care Pathways in Physical and Rehabilitation Medicine" series developed by the French Physical and Rehabilitation Medicine Society (Sofmer) and the French Physical and Rehabilitation Medicine Federation (Fedmer). For a given patient profile, each concise document describes the patient's n...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2012.08.010
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:About two-thirds of stroke patients present long-term upper-limb impairment and limitations of activity, which constitutes a challenge in rehabilitation. This situation is particularly true in developing countries, where there is a need for inexpensive rehabilitation solutions. OBJECTIVE:This study assessed...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2020.03.017
更新日期:2020-10-15 00:00:00
abstract:OBJECTIVE:Compare the clinical outcomes of different knee braces in the early phase of rehabilitation after anterior cruciate ligament reconstruction (ACLR) in athletes. MATERIALS AND METHODS:We conducted a retrospective database study of athletes during early rehabilitation in a tertiary referral hospital between 1 F...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2017.02.001
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVES:To specify outcomes and identify prognostic factors of neurologic and functional recovery in patients with an acute traumatic spinal cord injury (SCI) associated with cervical spinal canal stenosis (SCS), without spinal instability. METHODS:A retrospective study was conducted using data from a Regional Depa...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2017.09.003
更新日期:2018-01-01 00:00:00
abstract::Walk tests, principally the six-minute walk test (6mWT), constitute a safe, useful submaximal tool for exercise tolerance testing in cardiac rehabilitation (CR). The 6mWT result reflects functional status, walking autonomy and efficacy of CR on walking endurance, which is more pronounced in patients with low functiona...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rehab.2013.09.003
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:There are no handbook or recommendations for the use of pharmacological agents to treat neurobehavioral disorders after traumatic brain injury (TBI). This work proposes a systematic review of the literature and a user guide on neuroleptics, antidepressants, beta-blockers, mood stabilizers and other medication...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,实务指引,评审
doi:10.1016/j.rehab.2015.10.003
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Cervical radiculopathy is most often related to foraminal stenosis due to osteoarthritic changes of the uncovertebral joints anteriorly or zygapophyseal joints posteriorly, rather than disc herniation. OBJECTIVES:To describe anatomical specificities of the degenerated cervical spine. METHODS:A critical nar...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rehab.2015.12.006
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Amyotrophic lateral sclerosis (ALS) has long been considered a pure motor neurodegenerative disease. However, now, extra-motor manifestations such as cognitive-behavioral disorders are considered not rare and are even a severity factor of the disease. Experiencing anosognosia (i.e., the inability to recogniz...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2020.08.004
更新日期:2020-10-13 00:00:00
abstract:OBJECTIVES:Visuospatial neglect (VSN) is a common cognitive disorder after stroke. The primary aim of this systematic review was to provide an overview of the impact of VSN in 3 aspects: (1) activities of daily living (ADL), (2) participation, and (3) caregiver burden. The second aim was to investigate the differences ...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rehab.2019.05.006
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:Evaluation of the effects of 6 weeks of wheelchair endurance training on arterial stiffness in an individual with paraplegia. METHODS:A 22-year-old male patient with complete (ASIA A) paraplegia (T11) was tested before and after training (30 minutes three times per week). Physical performance and cardiorespi...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2008.11.002
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To present an up-to-date literature review of osteoporosis in spinal cord injury (SCI) patients, in view of the seriousness of this complication (with a high risk of fractures) and the complexity of its diagnosis, evaluation and treatment. METHODS:A Medline search with the following keywords: immobilization ...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rehab.2010.10.001
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:The main objective of this study was to describe the distribution of referrals offered to patients assessed in the "Post-Acute Stroke program" of Bordeaux University Hospital (France). This program was developed in 2008 to organize the dispensation of care in rehabilitation units specialized in neurological d...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2016.02.003
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:The pre-return-to-work medical consultation during sick leave for low back pain (LBP) aims at assessing the worker's ability to resume working without risk for his/her health, and anticipating any difficulties inherent to returning to work and job retention. This article summarizes the good practices guideli...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rehab.2015.08.001
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:The Leisure Time Physical Activity Questionnaire (LTPAQ) measures the duration of physical activities performed during the past 7 days, and results are expressed in minutes. This study aimed to translate this questionnaire into Canadian-French and to evaluate the content validity and its test-retest reliabil...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2018.12.002
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Physical exercise is widely prescribed in rehabilitation programmes for low back pain (LBP). The LBP patient often asks whether this physical activity should be maintained and, in some cases, whether he/she should resume or take up a sport. PURPOSE:To answer these two questions by performing a review of lit...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rehab.2013.08.007
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:To describe the frequency with which members of the French general population in the 30-to-69 age class sought care for lower back pain (LBP) from various healthcare professionals and to identify associated parameters. MATERIAL AND METHODS:Data were collected in the 2002-2003 Décennale Santé survey, which i...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2010.03.006
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:The non pharmacological approach is an important issue in the treatment of psychological and behavioural disorders in traumatic brain injury (TBI) patients. It remains nevertheless insufficiently known and defined. The objective of this work was to develop precise recommendations for caregivers and relativ...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rehab.2015.12.001
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Botuloscope is a cohort study supported by a French public grant and aiming to evaluate a 1-year treatment of the post-stroke spastic upper limb with botulinum toxin type A (BoNT-A) in terms of individual satisfaction with respect to personalized goals and quality of life. METHODS:This was an open-label pro...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.rehab.2019.06.003
更新日期:2019-07-01 00:00:00
abstract:AIM:Evaluate the need for integrated teaching on normal and pathological gait at medical school. METHOD:A questionnaire filled out by 91 French general practitioners (GPs, 130 of whom were contacted) with an average of 19 years of practice and 56 sixth-year medical students. Assessment of the students' knowledge of no...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2010.11.005
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Some patients with postoperative adhesive capsulitis reach a plateau in their recovery with a standard protocol of physical therapy (PT), which puts them at risk for further surgical intervention. OBJECTIVES:We aimed to evaluate therapy for postoperative adhesive capsulitis of the shoulder in 2 groups of pa...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2016.04.010
更新日期:2016-09-01 00:00:00