Segmentation and classification of thyroid follicular neoplasm using cascaded convolutional neural network.

Abstract:

:In this paper, we present a segmentation and classification method for thyroid follicular neoplasms based on a combination of the prior-based level set method and deep convolutional neural network. The proposed method aims to discriminate thyroid follicular adenoma (TFA) and follicular thyroid carcinoma (FTC) in ultrasound images. In their appearance, these two kinds of tumours have similar shapes, sizes and contrasts. Therefore, it is difficult for even ultrasound specialists to distinguish them. Because of the complex background in thyroid ultrasound images, before distinguishing TFA and FTC, we need to segment the lesions from the whole image for each patient. The main challenge of segmentation is that the images often have weak edges and heterogeneous regions. The main issue of classification is that the accuracy depends on the features extracted from the segmentation results. To solve these problems, we conduct the two tasks, i.e. segmentation and classification, by a cascaded learning architecture. For segmentation, to obtain more accurate results, we exploit the Res-U-net framework and the prior-based level set method to enhance their respective abilities. Then, the classification network is trained by sharing shallow layers of the segmentation network. Testing the proposed method on real patient data shows that it is able to segment the lesion areas in thyroid ultrasound images with a Dice score of 92.65% and to distinguish TFA and FTC with a classification accuracy of 96.00%.

journal_name

Phys Med Biol

authors

Yang B,Yan M,Yan Z,Zhu C,Xu D,Dong F

doi

10.1088/1361-6560/abc6f2

subject

Has Abstract

pub_date

2020-11-02 00:00:00

eissn

0031-9155

issn

1361-6560

pub_type

杂志文章
  • SNR and noise measurements for medical imaging: I. A practical approach based on statistical decision theory.

    abstract::A method of measuring the image quality of medical imaging equipment is considered within the framework of statistical decision theory. In this approach, images are regarded as random vectors and image quality is defined in the context of the image information available for performing a specified detection or discrimi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/38/1/006

    authors: Tapiovaara MJ,Wagner RF

    更新日期:1993-01-01 00:00:00

  • In-bore setup and software for 3T MRI-guided transperineal prostate biopsy.

    abstract::MRI-guided prostate biopsy in conventional closed-bore scanners requires transferring the patient outside the bore during needle insertion due to the constrained in-bore space, causing a safety hazard and limiting image feedback. To address this issue, we present our custom-made in-bore setup and software to support M...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/18/5823

    authors: Tokuda J,Tuncali K,Iordachita I,Song SE,Fedorov A,Oguro S,Lasso A,Fennessy FM,Tempany CM,Hata N

    更新日期:2012-09-21 00:00:00

  • A monoscopic method for real-time tumour tracking using combined occasional x-ray imaging and continuous respiratory monitoring.

    abstract::Three major linear accelerator vendors offer gantry-mounted single (monoscopic) x-ray imagers. The use of monoscopic imaging to estimate three-dimensional (3D) target positions has not been fully explored. The purpose of this work is to develop and investigate a robust monoscopic method for real-time tumour tracking, ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/11/006

    authors: Cho B,Suh Y,Dieterich S,Keall PJ

    更新日期:2008-06-07 00:00:00

  • The induction of hyperthermia by ultrasound; its value and associated problems: II. Scanned-plane transducer.

    abstract::A system is described in which large superficial areas of tissue may be heated using a single plane ultrasonic transducer scanned in a raster fashion. The shape of the heated area is determined by the movement of a microswitch which is activated when it strikes the rigid edge of a hole of the required shape cut in a p...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/30/12/006

    authors: ter Haar G,Hopewell JW

    更新日期:1985-12-01 00:00:00

  • Automatic classification of dental artifact status for efficient image veracity checks: effects of image resolution and convolutional neural network depth.

    abstract::Enabling automated pipelines, image analysis and big data methodology in cancer clinics requires thorough understanding of the data. Automated quality assurance steps could improve the efficiency and robustness of these methods by verifying possible data biases. In particular, in head and neck (H&N) computed-tomograph...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab5427

    authors: Welch ML,McIntosh C,Purdie TG,Wee L,Traverso A,Dekker A,Haibe-Kains B,Jaffray DA

    更新日期:2020-01-10 00:00:00

  • Measurement of patient entrance surface dose rates for fluoroscopic x-ray units.

    abstract::Measurements of patient entrance surface dose rate provide valuable data for interpreting results from dose-area product studies on fluoroscopic x-ray equipment. Methods for measurement of entrance surface dose rate with backscatter and incident dose rate without backscatter have been investigated. Entrance surface do...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/40/5/008

    authors: Martin CJ

    更新日期:1995-05-01 00:00:00

  • A robust state-space kinetics-guided framework for dynamic PET image reconstruction.

    abstract::Dynamic PET image reconstruction is a challenging issue due to the low SNR and the large quantity of spatio-temporal data. We propose a robust state-space image reconstruction (SSIR) framework for activity reconstruction in dynamic PET. Unlike statistically-based frame-by-frame methods, tracer kinetic modeling is inco...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/8/010

    authors: Tong S,Alessio AM,Kinahan PE,Liu H,Shi P

    更新日期:2011-04-21 00:00:00

  • Modeling late rectal toxicities based on a parameterized representation of the 3D dose distribution.

    abstract::Many models exist for predicting toxicities based on dose-volume histograms (DVHs) or dose-surface histograms (DSHs). This approach has several drawbacks as firstly the reduction of the dose distribution to a histogram results in the loss of spatial information and secondly the bins of the histograms are highly correl...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/7/013

    authors: Buettner F,Gulliford SL,Webb S,Partridge M

    更新日期:2011-04-07 00:00:00

  • Monte Carlo verification of IMRT dose distributions from a commercial treatment planning optimization system.

    abstract::The purpose of this work was to use Monte Carlo simulations to verify the accuracy of the dose distributions from a commercial treatment planning optimization system (Corvus, Nomos Corp., Sewickley, PA) for intensity-modulated radiotherapy (IMRT). A Monte Carlo treatment planning system has been implemented clinically...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/9/303

    authors: Ma CM,Pawlicki T,Jiang SB,Li JS,Deng J,Mok E,Kapur A,Xing L,Ma L,Boyer AL

    更新日期:2000-09-01 00:00:00

  • Medical applications of synchrotron radiation.

    abstract::The medical imaging and therapeutic technologies that are based on the use of radiation are reviewed briefly, with special emphasis on the recent developments of synchrotron radiation (SR) methods. New results have been achieved in all of these areas since the last comprehensive reviews were written in this field. Thi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1088/0031-9155/48/13/201

    authors: Suortti P,Thomlinson W

    更新日期:2003-07-07 00:00:00

  • Enhancement of subharmonic emission from encapsulated microbubbles by using a chirp excitation technique.

    abstract::Subharmonic contrast imaging promises to improve ultrasound-imaging quality by taking advantage of an increased contrast to tissue signal. However, acoustic pressures beyond the subharmonic generation threshold using common ultrasound pulses may induce significant contrast microbubble destruction. In this work, a chir...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/18/005

    authors: Zhang D,Gong Y,Gong X,Liu Z,Tan K,Zheng H

    更新日期:2007-09-21 00:00:00

  • A comparison between track-structure, condensed-history Monte Carlo simulations and MIRD cellular S-values.

    abstract::The S-value is a standard measure in cellular dosimetry. S-values are calculated by applying analytical methods or by Monte Carlo simulation. In Monte Carlo simulation, particles are either tracked individually event-by-event or close events are condensed and processed collectively in different steps. Both of these me...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/62/5/N90

    authors: Tajik-Mansoury MA,Rajabi H,Mozdarani H

    更新日期:2017-03-07 00:00:00

  • Slice NEQ and system DQE to assess CT imaging performance.

    abstract::The standard Fourier metrics used for assessing image quality in computed tomography (CT) use a planar (2D) formulation of the noise equivalent quanta (NEQ) without a specific concept to manage the influence of longitudinal resolution variations, thus create a bias in the comparison of image quality for different reco...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab807a

    authors: Monnin P,Viry A,Verdun FR,Racine D

    更新日期:2020-06-09 00:00:00

  • Multi-layer imager design for mega-voltage spectral imaging.

    abstract::The architecture of multi-layer imagers (MLIs) can be exploited to provide megavoltage spectral imaging (MVSPI) for specific imaging tasks. In the current work, we investigated bone suppression and gold fiducial contrast enhancement as two clinical tasks which could be improved with spectral imaging. A method based on...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aabe21

    authors: Myronakis M,Hu YH,Fueglistaller R,Wang A,Baturin P,Huber P,Morf D,Star-Lack J,Berbeco R

    更新日期:2018-05-10 00:00:00

  • Simultaneous minimization of leaf travel distance and tongue-and-groove effect for segmental intensity-modulated radiation therapy.

    abstract::This paper introduces a method to simultaneously minimize the leaf travel distance and the tongue-and-groove effect for IMRT leaf sequences to be delivered in segmental mode. The basic idea is to add a large enough number of openings through cutting or splitting existing openings for those leaf pairs with openings few...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/23/009

    authors: Dai J,Que W

    更新日期:2004-12-07 00:00:00

  • An automated, fast and accurate registration method to link stranded seeds in permanent prostate implants.

    abstract::The geometry of a permanent prostate implant varies over time. Seeds can migrate and edema of the prostate affects the position of seeds. Seed movements directly influence dosimetry which relates to treatment quality. We present a method that tracks all individual seeds over time allowing quantification of seed moveme...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/20/N391

    authors: Westendorp H,Nuver TT,Moerland MA,Minken AW

    更新日期:2015-10-21 00:00:00

  • Monte Carlo dosimetric study of the BEBIG Co-60 HDR source.

    abstract::Although not as widespread as Ir-192, Co-60 is also available on afterloading equipment devoted to high dose rate brachytherapy, mainly addressed to the treatment of gynaecological lesions. The purpose of this study is to obtain the dosimetric parameters of the Co-60 source used by the BEBIG MultiSource remote afterlo...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/21/N03

    authors: Ballester F,Granero D,Pérez-Calatayud J,Casal E,Agramunt S,Cases R

    更新日期:2005-11-07 00:00:00

  • Rotational IMRT delivery using a digital linear accelerator in very high dose rate 'burst mode'.

    abstract::Recently, there has been a resurgence of interest in arc-based IMRT, through the use of 'conventional' multileaf collimator (MLC) systems that can treat large tumor volumes in a single, or very few pass(es) of the gantry. Here we present a novel 'burst mode' modulated arc delivery approach, wherein 2000 monitor units ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/7/002

    authors: Salter BJ,Sarkar V,Wang B,Shukla H,Szegedi M,Rassiah-Szegedi P

    更新日期:2011-04-07 00:00:00

  • Refraction-angle resolution of diffraction enhanced imaging.

    abstract::As a new method, x-ray diffraction enhanced imaging (DEI) has extremely high sensitivity for weakly absorbing low-Z samples in medical and biological fields. Conventional performance parameters, such as spatial resolution and low-contrast resolution, are not enough to describe the characteristics of a DEI system. This...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/12/002

    authors: Huang ZF,Kang KJ,Li Z

    更新日期:2006-06-21 00:00:00

  • Optical studies of vaporization and stability of fluorescently labelled perfluorocarbon droplets.

    abstract::Droplets of liquid perfluorocarbon (PFC) are under study as the next generation of contrast agents for ultrasound (US). These droplets can be selectively vaporized into echogenic gas bubbles in situ by externally applied US, with numerous applications to diagnosis and therapy. However, little is known about the mechan...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/21/7205

    authors: Reznik N,Seo M,Williams R,Bolewska-Pedyczak E,Lee M,Matsuura N,Gariepy J,Foster FS,Burns PN

    更新日期:2012-11-07 00:00:00

  • Implementation of biologically conformal radiation therapy (BCRT) in an algorithmic segmentation-based inverse planning approach.

    abstract::The development of new biological imaging technologies offers the opportunity to further individualize radiotherapy. Biologically conformal radiation therapy (BCRT) implies the use of the spatial distribution of one or more radiobiological parameters to guide the IMRT dose prescription. Our aim was to implement BCRT i...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/16/N02

    authors: Vanderstraeten B,De Gersem W,Duthoy W,De Neve W,Thierens H

    更新日期:2006-08-21 00:00:00

  • Plane wave versus focused transmissions for contrast enhanced ultrasound imaging: the role of parameter settings and the effects of flow rate on contrast measurements.

    abstract::Contrast enhanced ultrasound (CEUS) and dynamic contrast enhanced ultrasound (DCE-US) can be used to provide information about the vasculature aiding diagnosis and monitoring of a number of pathologies including cancer. In the development of a CEUS imaging system, there are many choices to be made, such as whether to ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab13f2

    authors: Moghimirad E,Bamber J,Harris E

    更新日期:2019-04-23 00:00:00

  • Measurement of flow velocity fields in small vessel-mimic phantoms and vessels of small animals using micro ultrasonic particle image velocimetry (micro-EPIV).

    abstract::Determining a multidimensional velocity field within microscale opaque fluid flows is needed in areas such as microfluidic devices, biofluid mechanics and hemodynamics research in animal studies. The ultrasonic particle image velocimetry (EchoPIV) technique is appropriate for measuring opaque flows by taking advantage...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/20/003

    authors: Qian M,Niu L,Wang Y,Jiang B,Jin Q,Jiang C,Zheng H

    更新日期:2010-10-21 00:00:00

  • An analysis of beam parameters on proton-acoustic waves through an analytic approach.

    abstract::It has been reported that acoustic waves are generated when a high-energy pulsed proton beam is deposited in a small volume within tissue. One possible application of proton-induced acoustics is to get real-time feedback for intra-treatment adjustments by monitoring such acoustic waves. A high spatial resolution in ul...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa642c

    authors: Kipergil EA,Erkol H,Kaya S,Gulsen G,Unlu MB

    更新日期:2017-06-21 00:00:00

  • A method to reconstruct intra-fractional liver motion in rotational radiotherapy using linear fiducial markers.

    abstract::Complex intra-fractional motion and deformation of the liver significantly impacts the accuracy of delivered dose in radiotherapy. It limits margin reduction, dose escalation and normal tissue sparing. A critical component of motion management is to accurately reconstruct tumor motion. In this study, we developed a si...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab4c0d

    authors: Chi Y,Shen C,Li B,Zhang Y,Yang M,Folkert M,Jia X

    更新日期:2019-11-21 00:00:00

  • Characterization of optical parameters with a human forearm at the region from 1.15 to 1.52 microm using diffuse reflectance measurements.

    abstract::Time- and space-resolved diffuse reflectance measurements were used to identify the optical parameters, the reduced scattering and absorption coefficients, of bulk living tissue in the region from 1.15 to 1.52 microm. Although in this region the detector was limited in its temporal resolution, we applied a peak-time s...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/11/021

    authors: Nishimura G,Kida I,Tamura M

    更新日期:2006-06-07 00:00:00

  • Analyses of multi-irradiation film for system alignments in stereotactic radiotherapy (SRT) and radiosurgery (SRS).

    abstract::In stereotactic radiosurgery, a seven-irradiation film was used to define any discrepancy between the beam and target centres. A mathematical model based on the linac alignment and target set-up was developed to diagnose the discrepancies of the seven-irradiation film between the beam and simulation target centres. Fr...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/9/003

    authors: Tsai JS

    更新日期:1996-09-01 00:00:00

  • High resolution propagation-based imaging system for in vivo dynamic computed tomography of lungs in small animals.

    abstract::We have developed an x-ray imaging system for in vivo four-dimensional computed tomography (4DCT) of small animals for pre-clinical lung investigations. Our customized laboratory facility is capable of high resolution in vivo imaging at high frame rates. Characterization using phantoms demonstrate a spatial resolution...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aab8d2

    authors: Preissner M,Murrie RP,Pinar I,Werdiger F,Carnibella RP,Zosky GR,Fouras A,Dubsky S

    更新日期:2018-04-20 00:00:00

  • High-resolution fluence verification for treatment plan specific QA in ion beam radiotherapy.

    abstract::Ion beam radiotherapy exploits the finite range of ion beams and the increased dose deposition of ions toward the end of their range in material. This results in high dose conformation to the target region, which can be further increased using scanning ion beams. The standard method for patient-plan verification in io...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/6/1725

    authors: Martišíková M,Brons S,Hesse BM,Jäkel O

    更新日期:2013-03-21 00:00:00

  • Dose measurements in inhomogeneous bone/tissue and lung/tissue phantoms for angiography using synchrotron radiation.

    abstract::For angiography using synchrotron radiation we measured the absorbed dose distribution in inhomogeneous phantoms with thin LiF:Mg, Cu, P, LiF:Mg, Ti thermoluminescent dosimeters (TLDs) in tissue and lung substitutes, and with Mg2SiO4:Tb TLDs in bone substitute for 33.32 keV monoenergetic photons from synchrotron radia...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/3/308

    authors: Nariyama N,Namito Y,Ban S,Hirayama H

    更新日期:2001-03-01 00:00:00