Abstract:
:A series of polycyclic skeleton of truxene and triazatruxene analogs has been synthesized and evaluated for antitumor and DNA binding activities. The synthesized structures were confirmed by different spectroscopic techniques such as IR, 1HNMR, 13CNMR, and mass spectroscopy. The antitumor screening was performed adopting the NCI protocol against 60 different cell lines. Compounds 2 and 8 proved to be the most active ones among the other target compounds. In a trial to investigate the mechanism of action of the target compounds, DNA binding activity was also investigated. Compounds 3f, 4-8 exhibited good binding activity explaining their mechanism. In addition, molecular modeling studies were also performed for more clearance of the data obtained from the biological screening.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
El Sayed MT,Shabaan SN,Sarhan AE,El-Messery SM,El-Sayed SM,Hassan GSdoi
10.1016/j.bioorg.2020.104323subject
Has Abstractpub_date
2020-11-01 00:00:00pages
104323eissn
0045-2068issn
1090-2120pii
S0045-2068(20)31621-7journal_volume
104pub_type
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