Lack of the nucleoside transporter ENT1 results in the Augustine-null blood type and ectopic mineralization.

abstract：:In an international collaborative study, a central histologic review identified 891 patients with essential thrombocythemia, strictly defined by World Health Organization criteria. After a median follow-up of 6.2 years, 109 (12%) patients experienced arterial (n = 79) or venous (n = 37) thrombosis. In multivariable an...

journal_title：Blood

authors： Carobbio A,Thiele J,Passamonti F,Rumi E,Ruggeri M,Rodeghiero F,Randi ML,Bertozzi I,Vannucchi AM,Antonioli E,Gisslinger H,Buxhofer-Ausch V,Finazzi G,Gangat N,Tefferi A,Barbui T

更新日期：2011-06-02 00:00:00

abstract：:Although imatinib, a BCR-ABL tyrosine kinase inhibitor, is used to treat acute Philadelphia chromosome-positive (Ph(+)) leukemia, it does not prevent central nervous system (CNS) relapses resulting from poor drug penetration through the blood-brain barrier. Imatinib and dasa-tinib (a dual-specific SRC/BCR-ABL kinase i...

journal_title：Blood

authors： Porkka K,Koskenvesa P,Lundán T,Rimpiläinen J,Mustjoki S,Smykla R,Wild R,Luo R,Arnan M,Brethon B,Eccersley L,Hjorth-Hansen H,Höglund M,Klamova H,Knutsen H,Parikh S,Raffoux E,Gruber F,Brito-Babapulle F,Dombret H,Dua

更新日期：2008-08-15 00:00:00

abstract：:Immunohistochemistry (IHC) was performed on archived bone marrow (BM) with a phosphospecific anti-AKT antibody. IHC on 26 BM biopsies from patients with multiple myeloma (MM) demonstrated phospho-AKT staining of malignant plasma cells in a cell membrane-specific pattern, whereas nonmalignant hematopoietic cells did no...

journal_title：Blood

authors： Hsu J,Shi Y,Krajewski S,Renner S,Fisher M,Reed JC,Franke TF,Lichtenstein A

更新日期：2001-11-01 00:00:00

abstract：:Alas2 encodes the erythroid-specific delta-aminolevulinate synthase (ALAS2 or ALAS-E), the first enzyme in heme biosynthesis in erythroid cells. Mice with the Alas2-null phenotype showed massive cytoplasmic, but not mitochondrial, iron accumulation in their primitive erythroblasts. Because these animals died by day 11...

journal_title：Blood

authors： Harigae H,Nakajima O,Suwabe N,Yokoyama H,Furuyama K,Sasaki T,Kaku M,Yamamoto M,Sassa S

更新日期：2003-02-01 00:00:00

abstract：:Macrophage mannose receptor (MR) participates in pathogen recognition, clearance of endogenous serum glycoproteins, and antigen presentation. MR is also present on lymphatic vessels, where its function is unknown. Here we show that migration of lymphocytes from the skin into the draining lymph nodes through the affere...

journal_title：Blood

authors： Marttila-Ichihara F,Turja R,Miiluniemi M,Karikoski M,Maksimow M,Niemelä J,Martinez-Pomares L,Salmi M,Jalkanen S

更新日期：2008-07-01 00:00:00

abstract：:To address the mechanism by which the human globin genes are activated during erythropoiesis, we have used a tiled microarray to analyze the pattern of transcription factor binding and associated histone modifications across the telomeric region of human chromosome 16 in primary erythroid and nonerythroid cells. This ...

journal_title：Blood

authors： De Gobbi M,Anguita E,Hughes J,Sloane-Stanley JA,Sharpe JA,Koch CM,Dunham I,Gibbons RJ,Wood WG,Higgs DR

更新日期：2007-12-15 00:00:00

abstract：:At inflammatory sites, proteoglycans are both secreted by activated mononuclear leukocytes and released as a consequence of extracellular matrix degradation. Chondroitin 4-sulfate proteoglycans constitute the predominant ones produced by activated human monocytes/macrophages. In this study, we show that two chondroiti...

journal_title：Blood

authors： Rachmilewitz J,Tykocinski ML

更新日期：1998-07-01 00:00:00

abstract：:Tumor cells from six patients with immunoglobulin G (IgG) multiple myeloma were analyzed for surface antigens, cytoplasmic paraprotein, morphology, and response to various culture conditions. The tumor marker was the paraprotein idiotype. Low numbers of tumor cells were found in the blood of most of the patients. In s...

journal_title：Blood

authors： King MA,Nelson DS

更新日期：1989-05-15 00:00:00

abstract：:Vaccination with antigen-presenting cells (APCs) engineered to mimic mechanisms of immune stimulation represents a promising approach for cancer immunotherapy. Dendritic cell vaccines have entered phase 3 testing in adult malignancies, but such vaccines in children have been limited. We demonstrate that CD40-activated...

journal_title：Blood

authors： Coughlin CM,Vance BA,Grupp SA,Vonderheide RH

更新日期：2004-03-15 00:00:00

abstract：:Thymosin beta 4 (T beta 4) was originally isolated as a thymic hormone. Its functional properties remain obscure; however, the N-terminal peptidic sequence could have a regulatory function on hematopoietic stem cell proliferation. To investigate the mechanism of T beta 4 expression, we studied T beta 4 gene expression...

journal_title：Blood

authors： Shimamura R,Kudo J,Kondo H,Dohmen K,Gondo H,Okamura S,Ishibashi H,Niho Y

更新日期：1990-09-01 00:00:00

abstract：:Outcome in multiple myeloma is highly variable and a better understanding of the factors that influence disease biology is essential to understand and predict behavior in individual patients. In the present study, we analyzed combined genomewide DNA methylation and gene expression data of patients treated in the Medic...

journal_title：Blood

authors： Kaiser MF,Johnson DC,Wu P,Walker BA,Brioli A,Mirabella F,Wardell CP,Melchor L,Davies FE,Morgan GJ

更新日期：2013-07-11 00:00:00

abstract：:Genetic risk factors contribute to adverse outcome of hematopoietic stem cell transplantation (HSCT). Mismatching of the HLA complex most strongly determines outcomes, whereas non-HLA genetic polymorphisms are also having an impact. Although the majority of HSCTs are mismatched, only few studies have investigated the ...

journal_title：Blood

authors： Harkensee C,Oka A,Onizuka M,Middleton PG,Inoko H,Hirayasu K,Kashiwase K,Yabe T,Nakaoka H,Gennery AR,Ando K,Morishima Y,Japan Marrow Donor Program.

更新日期：2012-06-28 00:00:00

abstract：:B19 parvovirus is the etiologic agent of fifth disease and transient aplastic crisis. In natural infections, B19 antigen and DNA have been detected in sera early in the course of aplastic crisis and only rarely in fifth disease. We have found B19 DNA in circulating cells of infected patients by DNA dot blot with a vir...

journal_title：Blood

authors： Kurtzman GJ,Gascon P,Caras M,Cohen B,Young NS

更新日期：1988-05-01 00:00:00

abstract：:In lymphatic tissues, chronic lymphocytic leukemia (CLL) cells are interspersed with CD68(+) nurselike cells (NLCs), T cells, and other stromal cells that constitute the leukemia microenvironment. However, the mechanism regulating colocalization of CLL and these accessory cells are largely unknown. To dissect the mole...

journal_title：Blood

authors： Burger JA,Quiroga MP,Hartmann E,Bürkle A,Wierda WG,Keating MJ,Rosenwald A

更新日期：2009-03-26 00:00:00

abstract：:Exposed subendothelial collagen acts as a substrate for platelet adhesion and thrombus formation after vascular injury. Synthetic collagen-derived triple-helical peptides, designated collagen-related peptide (CRP), GFOGER, and VWF-III, can specifically engage the platelet collagen receptors, glycoprotein VI and integr...

journal_title：Blood

authors： Pugh N,Simpson AM,Smethurst PA,de Groot PG,Raynal N,Farndale RW

更新日期：2010-06-17 00:00:00

abstract：:The transcription factor KLF4 may act both as an oncogene and a tumor suppressor in a tissue-depending manner. In T- and pre-B-cell lymphoma, KLF4 was found to act as tumor suppressor. We found the KLF4 promoter methylated in B-cell lymphoma cell lines and in primary cases of B-cell lymphomas, namely, follicular lymph...

journal_title：Blood

authors： Guan H,Xie L,Leithäuser F,Flossbach L,Möller P,Wirth T,Ushmorov A

更新日期：2010-09-02 00:00:00

abstract：:Human umbilical vein endothelial cells in culture (HUVEC) express receptors for urokinase-type plasminogen activators (u-PA). The immunochemical nature of this receptor and its relationship to u-PA receptors expressed by other cell types is unknown. Cross-linking active site-blocked u-PA to HUVEC lead to an increase i...

journal_title：Blood

authors： Barnathan ES,Kuo A,Karikó K,Rosenfeld L,Murray SC,Behrendt N,Rønne E,Weiner D,Henkin J,Cines DB

更新日期：1990-11-01 00:00:00

abstract：:AALL07P2 evaluated whether substitution of Erwinia asparaginase 25000 IU/m(2) for 6 doses given intramuscularly Monday/Wednesday/Friday (M/W/F) to children and young adults with acute lymphoblastic leukemia and clinical allergy to pegaspargase would provide a 48-hour nadir serum asparaginase activity (NSAA) ≥ 0.10 IU/...

journal_title：Blood

authors： Salzer WL,Asselin B,Supko JG,Devidas M,Kaiser NA,Plourde P,Winick NJ,Reaman GH,Raetz E,Carroll WL,Hunger SP

更新日期：2013-07-25 00:00:00

abstract：:The inv(11)(p15q22) is a recurrent chromosomal abnormality associated with de novo and therapy-related myeloid malignancies. Here we report the molecular definition of this chromosomal aberration in four patients. Positional cloning showed the consistent rearrangement of the DDX10 gene on chromosome 11q22, which encod...

journal_title：Blood

authors： Arai Y,Hosoda F,Kobayashi H,Arai K,Hayashi Y,Kamada N,Kaneko Y,Ohki M

更新日期：1997-06-01 00:00:00

abstract：:T-cell progenitors in the embryonic bone marrow express the tyrosine kinase receptor c-kit. RR5, an anti-MHC class II beta chain monoclonal antibody, subdivides this c-kit positive population. Intrathymic transfer experiments showed that most of the T-cell progenitors belong to the MHC class II(+)/c-kit(+) bone marrow...

journal_title：Blood

authors： Ody C,Corbel C,Dunon D,Vainio O,Imhof BA

更新日期：2000-12-01 00:00:00

abstract：:Oncogenic RAS alleles encode proteins that accumulate in the guanosine triphosphate (GTP)-bound state. Because post-translational processing of Ras by farnesyltransferase is essential for biologic function, inhibitors of this enzyme have been developed as rational cancer therapeutics. We have investigated farnesyltran...

journal_title：Blood

authors： Mahgoub N,Taylor BR,Gratiot M,Kohl NE,Gibbs JB,Jacks T,Shannon KM

更新日期：1999-10-01 00:00:00

abstract：:The switch from fetal to adult hemoglobin is incomplete; the residual fetal hemoglobin in adults is restricted to a subset of erythrocytes called F cells. F-cell levels are influenced by a sequence variant (C-->T) at position -158 upstream of the gamma-globin gene, termed the XmnI-Ggamma polymorphism. How the Ggamma-1...

journal_title：Blood

authors： Garner C,Silver N,Best S,Menzel S,Martin C,Spector TD,Thein SL

更新日期：2004-10-01 00:00:00

abstract：:Hypomethylating agents (HMAs) improve survival in patients with higher-risk myelodysplastic syndromes (MDS) but are less well-studied in lower-risk disease. We compared the safety and efficacy of low-dose decitabine vs low-dose azacitidine in this group of patients. Adults with low- or intermediate 1-risk MDS or MDS/m...

journal_title：Blood

authors： Jabbour E,Short NJ,Montalban-Bravo G,Huang X,Bueso-Ramos C,Qiao W,Yang H,Zhao C,Kadia T,Borthakur G,Pemmaraju N,Sasaki K,Estrov Z,Cortes J,Ravandi F,Alvarado Y,Komrokji R,Sekeres MA,Steensma DP,DeZern A,Roboz G,

更新日期：2017-09-28 00:00:00

abstract：:After DNA replication, sister chromatids must be untangled, or decatenated, before mitosis so that chromatids do not tear during anaphase. Topoisomerase IIalpha (Topo IIalpha) is the major decatenating enzyme. Topo IIalpha inhibitors prevent decatenation, causing cells to arrest during mitosis. Here we report that acu...

journal_title：Blood

authors： Wray J,Williamson EA,Sheema S,Lee SH,Libby E,Willman CL,Nickoloff JA,Hromas R

更新日期：2009-08-27 00:00:00

abstract：:We evaluated a treatment strategy targeting both lymphoma cells (by rituximab) and the microenvironment (by thalidomide) in 16 patients with relapsed/refractory mantle cell lymphoma (MCL). Rituximab was administered at 375 mg/m(2) for 4 weekly doses concomitantly with thalidomide (200 mg daily, with a dose increment t...

journal_title：Blood

authors： Kaufmann H,Raderer M,Wöhrer S,Püspök A,Bankier A,Zielinski C,Chott A,Drach J

更新日期：2004-10-15 00:00:00

abstract：:In 1981 the BFM group introduced a new treatment strategy for B-cell acute lymphoblastic leukemia (B-ALL). A cytoreductive prephase (prednisone/cyclophosphamide) was followed by eight 5-day courses of chemotherapy. Fractionated cyclophosphamide, methotrexate (MTX) 0.5 g/m2 (24-hour infusion), and MTX intrathecally wer...

journal_title：Blood

authors： Reiter A,Schrappe M,Ludwig WD,Lampert F,Harbott J,Henze G,Niemeyer CM,Gadner H,Müller-Weihrich S,Ritter J

更新日期：1992-11-15 00:00:00

abstract：:Human bone marrow (BM) cells contain low levels of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, which may explain their susceptibility to nitrosourea-induced cytotoxicity and the development of secondary leukemia after nitrosourea treatment. Isolated CD34+ myeloid progenitors were also found to have l...

journal_title：Blood

authors： Gerson SL,Phillips W,Kastan M,Dumenco LL,Donovan C

更新日期：1996-09-01 00:00:00

abstract：:For many years, human hemoglobin (Hb) isolated from erythrocytes has been investigated as a potential oxygen delivery therapeutic. Advantages with respect to the need for blood typing were balanced with various undesirable properties of cell-free Hb, including cost, overall oxygen affinity, alterations in cooperativit...

journal_title：Blood

authors： Sanders KE,Lo J,Sligar SG

更新日期：2002-07-01 00:00:00

abstract：:Factor VIII procoagulant protein (VIII:C) purified from commercial factor VIII concentrate contained multiple polypeptides ranging in mol wt from 79,000 to 188,000, all of which were removed from solution by a monoclonal anti-VIII:C antibody specific for a thrombin-sensitive epitope. In a time-course digest of the pur...

journal_title：Blood

authors： Fulcher CA,Roberts JR,Zimmerman TS

更新日期：1983-04-01 00:00:00

abstract：:Minimal residual disease (MRD) negativity, defined as <1 chronic lymphocytic leukemia (CLL) cell detectable per 10 000 leukocytes, has been shown to independently predict for clinical outcome in patients receiving combination chemoimmunotherapy in the frontline setting. However, the long-term prognostic value of MRD s...

journal_title：Blood

authors： Kwok M,Rawstron AC,Varghese A,Evans PA,O'Connor SJ,Doughty C,Newton DJ,Moreton P,Hillmen P

更新日期：2016-12-15 00:00:00