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Does Type 2 Diabetes Genetic Testing and Counseling Reduce Modifiable Risk Factors? A Randomized Controlled Trial of Veterans.

Abstract：

OBJECTIVE:We examined the clinical utility of supplementing type 2 diabetes mellitus (DM) risk counseling with DM genetic test results and counseling. RESEARCH DESIGN AND METHODS:In this randomized controlled trial, non-diabetic overweight/obese veteran outpatients aged 21 to 65 years received DM risk estimates for lifetime risk, family history, and fasting plasma glucose, followed by either genetic test results (CR+G; N = 303) or control eye disease counseling (CR+EYE; N = 298). All participants received brief lifestyle counseling encouraging weight loss to reduce the risk of DM. RESULTS:The mean age was 54 years, 53% of participants were black, and 80% were men. There was no difference between arms in weight (estimated mean difference between CR+G vs. CR+EYE at 3 months = 0.2 kg, 95% CI: -0.3 to 0.7; at 6 months = 0.4 kg, 95 % CI: -0.3 to 1.1), insulin resistance, perceived risk, or physical activity at 3 or 6 months. Calorie and fat intake were lower in the CR+G arm at 3 months (p's ≤ 0.05) but not at 6 months (p's > 0.20). CONCLUSIONS:Providing patients with genetic test results was not more effective in changing patient behavior to reduce the risk of DM compared to conventional risk counseling. TRIAL REGISTRATION:ClinicalTrials.gov NCT01060540 http://clinicaltrials.gov/show/NCT01060540.

journal_name

J Gen Intern Med

journal_title

Journal of general internal medicine

authors

Voils CI,Coffman CJ,Grubber JM,Edelman D,Sadeghpour A,Maciejewski ML,Bolton J,Cho A,Ginsburg GS,Yancy WS Jr

doi

10.1007/s11606-015-3315-5

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1591-8

issue

11

eissn

0884-8734

issn

1525-1497

pii

10.1007/s11606-015-3315-5

journal_volume

30

pub_type

杂志文章,随机对照试验

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