Ultrastructure of Developing Feline Nonciliated Bronchiolar Epithelial Cells.

Abstract:

:The ultrastructure of the developing bronchiolar cell was studied in six age groups: prenatal (60 d post-conception); postnatal (1-, 7-, 14- and 21-day-old); and adult. Following intratracheal fixation, the lung tissue was processed for scanning and transmission electron microscopy. The lining of terminal bronchioles consists of cuboidal to columnar nonciliated bronchiolar cells (NBCs) and ciliated with or without microvilli. NBCs were recognized by indented centrally located nucleus. The apical surface extended beyond the surface of neighboring cells and was covered by minute microvilli, except in prenatal kittens. The NBCs of the adult were characterized by abundant mitochondria and glycogen inclusions. In prenatal kittens, the cytoplasm was filled with patches of alpha and beta form of glycogen. Postnatally, glycogen was reduced in quantity, became scattered throughout the cytoplasm and was predominantly of the beta form. Islands of cytoplasm, separated from the apical cytoplasm were observed in the lumen of adult bronchioles. This suggests an apocrine mode of secretion. The NBCs attain maturity by three weeks of age.

journal_name

Ultrastruct Pathol

authors

Al-Tikriti MS,Henry RW

doi

10.3109/01913123.2015.1013654

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

245-54

issue

4

eissn

0191-3123

issn

1521-0758

journal_volume

39

pub_type

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