Short-term low-protein diet during pregnancy alters islet area and protein content of phosphatidylinositol 3-kinase pathway in rats.

Abstract:

:The phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways mediate β cell growth, proliferation, survival and death. We investigated whether protein restriction during pregnancy alters islet morphometry or the expression and phosphorylation of several proteins involved in the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. As controls, adult pregnant and non-pregnant rats were fed a normal-protein diet (17%). Pregnant and non-pregnant rats in the experimental groups were fed a low-protein diet (6%) for 15 days. Low protein diet during pregnancy increased serum prolactin level, reduced serum corticosterone concentration and the expression of both protein kinase B/AKT1 (AKT1) and p70 ribosomal protein S6 kinase (p70S6K), as well as the islets area, but did not alter the insulin content of pancreatic islets. Pregnancy increased the expression of the Src homology/collagen (SHC) protein and the extracellular signal-regulated kinases 1/2 (ERK1/2) independent of diet. ERK1/2 phosphorylation (pERK1/2) was similar in islets from pregnant and non-pregnant rats fed a low-protein diet, and was higher in islets from pregnant rats than in islets from non-pregnant rats fed a normal-protein diet. Thus, a short-term, low-protein diet during pregnancy was sufficient to reduce the levels of proteins in the phosphatidylinositol 3-kinase pathway and affect islet morphometry.

journal_name

An Acad Bras Cienc

authors

Salvatierra CS,Reis SR,Pessoa AF,De Souza LM,Stoppiglia LF,Veloso RV,Reis MA,Carneiro EM,Boschero AC,Colodel EM,Arantes VC,Latorraca MQ

doi

10.1590/0001-3765201520140251

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

1007-18

issue

2

eissn

0001-3765

issn

1678-2690

pii

S0001-37652015005040251

journal_volume

87

pub_type

杂志文章
  • S-(+)- and R-(-)-linalool: a comparison of the in vitro anti-Aeromonas hydrophila activity and anesthetic properties in fish.

    abstract::Linalool is the main compound of many essential oils and occurs in two isomeric forms: S-(+)- and R-(-)-linalool. This study aimed to determine if linalool isomers have different antimicrobial and anesthetic properties in fish. For this purpose, these compounds were previously isolated from Lippia alba (Mill.)N. E. Br...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720150643

    authors: Silva LL,Balconi LS,Gressler LT,Garlet QI,Sutili FJ,Vargas APC,Baldisserotto B,Morel AF,Heinzmann BM

    更新日期:2017-01-01 00:00:00

  • Litter Size Reduction Induces Metabolic and Histological Adjustments in Dams throughout Lactation with Early Effects on Offspring.

    abstract::In the present study we analyzed morphological and metabolic alterations in dams nursing small litters and their consequences to offspring throughout lactation. Offspring sizes were adjusted to Small Litter (SL, 3 pups/ dam) and Normal Litter (NL, 9 pups/ dam). Body weight, food intake, white adipose tissue (WAT) cont...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920170971

    authors: Xavier JLP,Scomparin DX,Pontes CC,Ribeiro PR,Cordeiro MM,Marcondes JA,Mendonça FO,Silva MTD,Oliveira FB,Franco GCN,Grassiolli S

    更新日期:2019-03-21 00:00:00

  • Production of crispy bread snacks containing chicken meat and chicken meat powder.

    abstract::Chicken meat in two different forms (chicken meat and chicken meat powder) were added into white flour and whole wheat blend baguette bread formulations for protein enrichment and finally developing new and healthy snacks. The chicken meat and powder levels were 10% for white flour baguette, and 15% for whole wheat bl...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150059

    authors: Cakmak H,Altinel B,Kumcuoglu S,Kisla D,Tavman S

    更新日期:2016-10-01 00:00:00

  • A link between the hippocampal and the striatal memory systems of the brain.

    abstract::Two major memory systems have been recognized over the years (Squire 1987): the declarative memory system, which is under the control of the hippocampus and related temporal lobe structures, and the procedural or habit memory system, which is under the control of the striatum and its connections. Most if not all learn...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/s0001-37652006000300011

    authors: Rossato JI,Zinn CG,Furini C,Bevilaqua LR,Medina JH,Cammarota M,Izquierdo I

    更新日期:2006-09-01 00:00:00

  • Drought monitoring in the Brazilian Semiarid region.

    abstract::Drought is a natural and recurrent phenomenon. It is considered 'a natural disaster' whenever it occurs in an intensive manner in highly populated regions, resulting in significant damage (material and human) and loss (socioeconomic). This paper presents the efforts developed to monitor the impact of drought in the se...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720170209

    authors: Alvalá RCS,Cunha APMA,Brito SSB,Seluchi ME,Marengo JA,Moraes OLL,Carvalho MA

    更新日期:2019-01-01 00:00:00

  • Comparative morpho-anatomical studies of the lesions caused by citrus leprosis virus on sweet orange.

    abstract::The leprosis disease shows a viral etiology and the citrus leprosis virus is considered its etiologic agent. The disease may show two types of cytopatologic symptom caused by two virus: nuclear (CiLV-N) and cytoplasmic (CiLV-C) types. The aim of this study was to compare the morpho-anatomical differences in the lesion...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652010000200025

    authors: Marques JP,Kitajima EW,Freitas-Astúa J,Appezzato-da-Glória B

    更新日期:2010-06-01 00:00:00

  • Comparative pollen preferences by africanized honeybees Apis mellifera L. of two colonies in Pará de Minas, Minas Gerais, Brazil.

    abstract::The aim of this study was to investigate the polliniferous floral sources used by Apis mellifera (L.) (africanized) in an apiary situated in Pará de Minas, Minas Gerais state, and evaluate the pollen prefences among the beehives. Two beehives of Langstroth type with frontal pollen trap collectors were used. The harves...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652010000200005

    authors: da Luz CF,Bacha Junior GL,Fonseca RL,Sousa PR

    更新日期:2010-06-01 00:00:00

  • Modeling the reflection of Photosynthetically active radiation in a monodominant floodable forest in the Pantanal of Mato Grosso State using multivariate statistics and neural networks.

    abstract::The study of radiation entrance and exit dynamics and energy consumption in a system is important for understanding the environmental processes that rule the biosphere-atmosphere interactions of all ecosystems. This study provides an analysis of the interaction of energy in the form of photosynthetically active radiat...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150176

    authors: Curado LF,Musis CR,Cunha CR,Rodrigues TR,Pereira VM,Nogueira JS,Sanches L

    更新日期:2016-09-01 00:00:00

  • Bits and q-bits as versatility measures.

    abstract::Using Shannon information theory is a common strategy to measure any kind of variability in a signal or phenomenon. Some methods were developed to adapt information entropy measures to bird song data trying to emphasize its versatility aspect. This classical approach, using the concept of bit, produces interesting res...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652004000200035

    authors: Piqueira JR

    更新日期:2004-06-01 00:00:00

  • Microhabitat of small mammals at ground and understorey levels in a deciduous, southern Atlantic forest.

    abstract::Each animal species selects specific microhabitats for protection, foraging, or micro-climate. To understand the distribution patterns of small mammals on the ground and in the understorey, we investigated the use of microhabitats by small mammals in a deciduous forest of southern Brazil. Ten trap stations with seven ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/S0001-37652013000200017

    authors: Melo GL,Miotto B,Peres B,Cáceres NC

    更新日期:2013-04-01 00:00:00

  • Acritarchs of the Ediacaran Frecheirinha Formation, Ubajara Group, Northeastern Brazil.

    abstract::We report for the first time the occurrence of organic-walled microfossils in Ediacaran limestones and marls of the Frecheirinha Formation, Ubajara Group, and the first Precambrian acritarchs so far reported for northeastern Brazil. The assemblage of the Frecheirinha Formation represents a low-diversity microflora com...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520140430

    authors: Chiglino L,Gaucher C,Sial AN,Ferreira VP

    更新日期:2015-04-01 00:00:00

  • Contrasting life-histories in two syntopic amphibians of the Leptodactylus fuscus group (Heyer 1978).

    abstract::We used skeletochronology to compare age, size, reproductive parameters and growth patterns of two related, anuran amphibians from Northern Argentina: Leptodactylus bufonius (n=69) and L. latinasus (n=56), in order to better understand their coexistence in syntopy. Previous studies showed that the two species overlap ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3675201920180507

    authors: Marangoni F,Courtis A,Piñeiro JM,Ingaramo MDR,Cajade R,Stănescu F

    更新日期:2019-07-29 00:00:00

  • Developmental anatomy of Cyperus laxus (non-Nranz) and Fimbristylis dichotoma (Kranz) (Cyperaceae, Poales) and tissue continuity.

    abstract::The Cyperaceae species are present in different ecosystems and constitute the herbaceous extract. Of the approximately 5,500 species of the family; a third has Kranz anatomy, representing an important characteristic of the taxonomy and phylogeny of the group. In Cyperus laxus L. (non-Kranz) and Fimbristylis dichotoma ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/S0001-37652013005000032

    authors: Martins S,Scatena VL

    更新日期:2013-04-01 00:00:00

  • Osteoderm microstructure of Riostegotherium yanei, the oldest Xenarthra.

    abstract::Abstract: Riostegotherium yanei from the Itaboraí Basin, Brazil, is the oldest known Xenarthra. This paper aims to describe the internal morphology of the osteoderms of Riostegotherium yanei from the perspective of histology and micro-CT approaches, expanding the available data on cingulate osteoderm microstructure. ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920181290

    authors: Bergqvist LP,Pereira PVLGC,Machado AS,Castro MC,Melki LB,Lopes RT

    更新日期:2019-09-02 00:00:00

  • The synergetic modulation of the excitability of central gray matter by a neuropeptide: two protocols using excitation waves in chick retina.

    abstract::The isolated chick retina provides an in vitro tissue model, in which two protocols were developed to verify the efficacy of a peptide in the excitability control of the central gray matter. In the first, extra-cellular potassium homeostasis is challenged at long intervals and in the second, a wave is trapped in a rin...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652009000100006

    authors: Lima VM,Piqueira JR,Hanke W

    更新日期:2009-03-01 00:00:00

  • Physicochemical quality profiles of commercial oral tablets and capsules containing lutein - impact of insufficient specific sanitary regulations.

    abstract::Dietary supplements in many countries such as the USA do not require registration prior to commercialization. The Agência Nacional de Vigilância Sanitária (ANVISA) registers substances with functional properties as foods. Lutein is a carotenoid with antioxidant activity available on the market. However, no regulatory ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170972

    authors: Anselmo CS,Mendes TC,Cabral LM,Sousa VP

    更新日期:2018-07-01 00:00:00

  • Cohort study of cardiovascular risk in asymptomatic young adults: subclinical atherosclerosis and coronary calcium score.

    abstract::Coronary artery calcification is an early marker of subclinical atherosclerosis, but little research has been done in asymptomatic individuals under 45 years. In this cohort study with 17 years of follow-up, 155 participants were assessed in 2016 with a coronary calcium score for the association with cardiovascular ri...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820180052

    authors: Poletto S,Schvartzman PR,Bruscato NM,Moriguchi E

    更新日期:2018-09-01 00:00:00

  • Influence of the nycthemeral cycle on the roosting behaviour of the Orange-winged Amazon.

    abstract::Environmental stimuli exert important effects on the expression of the endogenous rhythms. Daily movements of groups of parrots in response to the light/dark cycle have been studied by several researchers. However, the factors modifying the intrinsic rhythmicity of this behaviour remain little known. This study descri...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012005000029

    authors: Moura LN,Silva ML,Vielliard JM

    更新日期:2012-06-01 00:00:00

  • The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks.

    abstract::Long-term potentiation (LTP) is the enhancement of postsynaptic responses for hours, days or weeks following the brief repetitive afferent stimulation of presynaptic afferents. It has been proposed many times over the last 30 years to be the basis of long-term memory. Several recent findings finally supported this hyp...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652008000100007

    authors: Izquierdo I,Cammarota M,Da Silva WC,Bevilaqua LR,Rossato JI,Bonini JS,Mello P,Benetti F,Costa JC,Medina JH

    更新日期:2008-03-01 00:00:00

  • Trichomes and hydrocarbons associated with the tomato plant antixenosis to the leafminer.

    abstract::The objective of this work was to study the density of trichomes and hydrocarbons associated with the resistance by antixenosis of 42 subsamples of tomato plants from the Horticultural Germplasm Bank of the Universidade Federal de Viçosa (HGB-UFV) to Liriomyza trifolii. These subsamples were studied in addition to 'Sa...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012000100021

    authors: Fernandes ME,Fernandes FL,Silva DJ,Picanço MC,Jhamc GN,Carneiro PC,Queiroz RB

    更新日期:2012-03-01 00:00:00

  • New approaches to the treatment of orphan genetic disorders: Mitigating molecular pathologies using chemicals.

    abstract::With the advance and popularization of molecular techniques, the identification of genetic mutations that cause diseases has increased dramatically. Thus, the number of laboratories available to investigate a given disorder and the number of subsequent diagnosis have increased over time. Although it is necessary to id...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/0001-3765201520140711

    authors: Velho RV,Sperb-Ludwig F,Schwartz IV

    更新日期:2015-08-01 00:00:00

  • Taxonomic notes on Lyroglossa and Pteroglossa (Orchidaceae: Spiranthinae): two new generic records for the flora of Rio Grande do Sul.

    abstract::Lyroglossa and Pteroglossa (Orchidaceae: Spiranthinae) are first recorded for Rio Grande do Sul. Descriptions, illustrations, taxonomic notes and distribution are presented. We also provide an artificial key to distinguish the genera of the "Stenorrhynchos Clade" reported so far in Rio Grande do Sul. ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Buzatto CR,Singer RB,Bordignon SAL

    更新日期:2014-06-01 00:00:00

  • Alcoholic extract of propolis in Nile tilapia post-larvae and fingerlings' diets: effects on production performance, body composition and intestinal histology.

    abstract::The aim of this study was to evaluate the production performance of Nile tilapia post-larvae and fingerlings fed with increasing levels of alcoholic extract of propolis into diets. In Experiment 1, 1800 post-larvae were distributed in 30 tanks, in a completely randomized design with five treatments composed by the inc...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920180297

    authors: Santos LDD,Zadinelo IV,Silva LCRD,Zilli RL,Barreiros MAB,Mauerwerk MT,Meurer F

    更新日期:2019-05-23 00:00:00

  • In vivo biocompatibility of silicon dioxide nanofilm used as antimicrobial agent on acrylic surface.

    abstract::the focus ofthis study was to testthe hypothesisthatthere would be no difference betweenthe biocompatibility of silicon dioxide nanofilms used as antimicrobial agents. Sixty male Wistar rats were divided into 4 groups (n=15): Group C (Control,Polyethylene), Group AR (Acrylic Resin), Group NP (Acrylic Resin coated with...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020181120

    authors: Lacerda-Santos R,Lima ABL,Penha ESD,Santos AD,Carvalho FG,Pithon MM,Dantas AFM

    更新日期:2020-04-17 00:00:00

  • A weighted negative binomial Lindley distribution with applications to dispersed data.

    abstract::A new discrete distribution is introduced. The distribution involves the negative binomial and size biased negative binomial distributions as sub-models among others and it is a weighted version of the two parameter discrete Lindley distribution. The distribution has various interesting properties, such as bathtub sha...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170733

    authors: Bakouch HS

    更新日期:2018-07-01 00:00:00

  • Description of the immature stages of Stenocrates agricola Dechambre & Hardy (Coleoptera: Scarabaeidae: Dynastinae: Cyclocephalini) with redescription of the adult and discussion of its tribal position.

    abstract::The enigmatic genus Stenocrates Burmeister has 52 species that are widely distributed from Mexico to Argentina, but mainly in South America. In the present study, the larva of the third instar and pupa of Stenocrates agricola Dechambre & Hardy, 2004 are described and illustrated based on specimens from Argentina, this...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020190967

    authors: Ibarra-Polesel MG,Neita-Moreno JC,Ratcliffe BC

    更新日期:2020-10-23 00:00:00

  • Thin molecular films of supramolecular porphyrins.

    abstract::A relevant series of symmetric supramolecular porphyrins has been obtained by attaching four [RuII(bipy)2Cl] groups to the pyridyl substituents of meso-tetra(4-pyridyl)porphyrin and its metallated derivatives. These compounds display a rich electrochemistry and versatile catalytic, electrocatalytic and photochemical p...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652000000100003

    authors: Araki K,Lima Sde S,Winnischofer H

    更新日期:2000-01-01 00:00:00

  • Optimization of RT-PCR reactions in studies with genes of lignin biosynthetic route in Saccharum spontaneum.

    abstract::Saccharum spontaneum has been used for the development of energy cane a crop aimed to be used for the production of second-generation ethanol, or lignocellulosic ethanol. Lignin is a main challenge in the conversion of cell wall sugars into ethanol. In our studies to isolate the genes the lignin biosynthesis in S. spo...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170250

    authors: Llerena JPP,Araújo P,Mazzafera P

    更新日期:2018-01-01 00:00:00

  • Consumption of Euterpe edulis fruit by wildlife: implications for conservation and management of the Southern Brazilian Atlantic Forest.

    abstract::This study aimed to measure the wildlife consumption of Euterpe edulis fruit and use this data to discuss management possibilities. To estimate infructescence fruit volume consumed, collectors were installed in fruit-bearing palms. To characterize consumption from the ground, samples were placed next to fruiting palms...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920180537

    authors: Silva JZD,Reis MSD

    更新日期:2019-01-01 00:00:00

  • Chemical composition and antimicrobial activity of essential oils of Ocimum canum Sims. and Ocimum selloi Benth.

    abstract::This work describes the chemical composition and antimicrobial activity of the volatile oils of Ocimum canum and Ocimum selloi, both occurring in Jequié/BA, northeastern Brazil. The plants were collected in the winter/2005 and summer/2006, the oils extracted by steam distillation and further analyzed by GC-MS. A total...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652011005000019

    authors: Nascimento JC,Barbosa LC,Paula VF,David JM,Fontana R,Silva LA,França RS

    更新日期:2011-09-01 00:00:00