Improving CAR T-cells: The next generation.

Abstract:

:The introduction of chimeric antigen receptor (CAR) T-cell therapy in acute lymphoblastic leukemia (ALL) has dramatically altered the landscape of treatment options available to children and adults with ALL. With complete remission induction rates exceeding 70% in most trials and FDA approval of one CD19 CAR T-cell construct in ALL, CAR T-cell therapy has become a mainstay in the ALL treatment algorithm for those with relapsed/refractory disease. Despite the high remission induction rate, with growing experience using CAR T-cell therapy in ALL, a host of barriers to maintaining long-term durable remissions have been identified. Specifically, relapse after, resistance to, or loss of long-term CAR T-cell persistence may all hinder CAR T-cell efficacy. In this review, we provide an overview of the current limitations which inform the design of the next generation of CAR T-cells and discuss advances in CAR T-cell engineering aimed to improve upon outcomes with CAR T-cell-based therapy in ALL.

journal_name

Semin Hematol

journal_title

Seminars in hematology

authors

Marple AH,Bonifant CL,Shah NN

doi

10.1053/j.seminhematol.2020.07.002

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

115-121

issue

3

eissn

0037-1963

issn

1532-8686

pii

S0037-1963(20)30020-2

journal_volume

57

pub_type

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