Coated nanodiamonds interact with tubulin beta-III negative cells of adult brain tissue.

Abstract:

:Fluorescent nanodiamonds (NDs) coated with therapeutics and cell-targeting structures serve as effective tools for drug delivery. However, NDs circulating in blood can eventually interact with the blood-brain barrier, resulting in undesired pathology. Here, we aimed to detect interaction between NDs and adult brain tissue. First, we cultured neuronal tissue with ND ex vivo and studied cell prosperity, regeneration, cytokine secretion, and nanodiamond uptake. Then, we applied NDs systemically into C57BL/6 animals and assessed accumulation of nanodiamonds in brain tissue and cytokine response. We found that only non-neuronal cells internalized coated nanodiamonds and responded by excretion of interleukin-6 and interferon-γ. Cells of neuronal origin expressing tubulin beta-III did not internalize any NDs. Once we applied coated NDs intravenously, we found no presence of NDs in the adult cortex but observed transient release of interleukin-1α. We conclude that specialized adult neuronal cells do not internalize plain or coated NDs. However, coated nanodiamonds interact with non-neuronal cells present within the cortex tissue. Moreover, the coated NDs do not cross the blood-brain barrier but they interact with adjacent barrier cells and trigger a temporary cytokine response. This study represents the first report concerning interaction of NDs with adult brain tissue.

journal_name

Biointerphases

journal_title

Biointerphases

authors

Šimková V,Freislebenová H,Neuhöferová E,Petráková V,Amini A,Benson V

doi

10.1116/6.0000525

subject

Has Abstract

pub_date

2020-12-03 00:00:00

pages

061009

issue

6

eissn

1934-8630

issn

1559-4106

journal_volume

15

pub_type

杂志文章
  • Photonic biosensor based on photocorrosion of GaAs/AlGaAs quantum heterostructures for detection of Legionella pneumophila.

    abstract::Photocorrosion of semiconductors is strongly sensitive to the presence of surface states, and it could be influenced by electrically charged molecules immobilized near the semiconductor/electrolyte interface. The underlying mechanism is related to band bending of the semiconductor structure near the surface and the as...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4941983

    authors: Aziziyan MR,Hassen WM,Morris D,Frost EH,Dubowski JJ

    更新日期:2016-03-22 00:00:00

  • Membrane composition-mediated protein-protein interactions.

    abstract::The authors investigate membrane composition-mediated interactions between proteins adsorbed onto a two-component lipid bilayer close to critical demixing using coarse-grained molecular dynamics simulations and a phenomenological Ginzburg-Landau theory. The simulations consist of three-bead lipids and platelike protei...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.2977492

    authors: Reynwar BJ,Deserno M

    更新日期:2008-06-01 00:00:00

  • Gelatin methacrylamide as coating material in cell culture.

    abstract::Unmodified gelatin (uG) is widely used as a coating material in cell culture for improving surface properties. In this study, the authors investigated if gelatin methacrylamide (GM) with a medium degree of methacrylamide modification (GM1.5) and a high degree of methacrylamide modification (GM4) are equally suitable f...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4949545

    authors: Egger M,Tovar GE,Hoch E,Southan A

    更新日期:2016-06-13 00:00:00

  • Assembly and structure of alpha-helical peptide films on hydrophobic fluorocarbon surfaces.

    abstract::The structure, orientation, and formation of amphiphilic alpha-helix model peptide films on fluorocarbon surfaces has been monitored with sum frequency generation (SFG) vibrational spectroscopy, near-edge x-ray absorption fine structure (NEXAFS) spectroscopy, and x-ray photoelectron spectroscopy (XPS). The alpha-helix...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.3317116

    authors: Weidner T,Samuel NT,McCrea K,Gamble LJ,Ward RS,Castner DG

    更新日期:2010-03-01 00:00:00

  • Chemical measurements of polyethylene glycol shells on gold nanoparticles in the presence of aggregation.

    abstract::Understanding and controlling the performance of engineered nanoparticle (NP) systems is greatly assisted by quantitative characterization of their coatings. Useful measurements methods have been described for NPs in liquid environment, but NP aggregation often represents a limiting factor which impairs the accuracy o...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4968882

    authors: Minelli C,Shard AG

    更新日期:2016-11-30 00:00:00

  • Carbon nanodots: Opportunities and limitations to study their biodistribution at the human lung epithelial tissue barrier.

    abstract::Inhalation of combustion-derived ultrafine particles (≤0.1 μm) has been found to be associated with pulmonary and cardiovascular diseases. However, correlation of the physicochemical properties of carbon-based particles such as surface charge and agglomeration state with adverse health effects has not yet been establi...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.5043373

    authors: Durantie E,Barosova H,Drasler B,Rodriguez-Lorenzo L,Urban DA,Vanhecke D,Septiadi D,Hirschi-Ackermann L,Petri-Fink A,Rothen-Rutishauser B

    更新日期:2018-09-11 00:00:00

  • Morphological and chemical changes of aerosolized E. coli treated with a dielectric barrier discharge.

    abstract::This study presents the morphological and chemical modification of the cell structure of aerosolized Escherichia coli treated with a dielectric barrier discharge (DBD). Exposure to DBD results in severe oxidation of the bacteria, leading to the formation of hydroxyl groups and carbonyl groups and a significant reducti...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4941367

    authors: Romero-Mangado J,Nordlund D,Soberon F,Deane G,Maughan K,Sainio S,Singh G,Daniels S,Saunders IT,Loftus D,Meyyappan M,Koehne J,Gandhiraman RP

    更新日期:2016-03-12 00:00:00

  • In vitro observation of dynamic ordering processes in the extracellular matrix of living, adherent cells.

    abstract::Collecting information at the interface between living cells and artificial substrates is exceedingly difficult. The extracellular matrix (ECM) mediates all cell-substrate interactions, and its ordered, fibrillar constituents are organized with nanometer precision. The proceedings at this interface are highly dynamic ...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.3651142

    authors: Diesner MO,Welle A,Kazanci M,Kaiser P,Spatz J,Koelsch P

    更新日期:2011-12-01 00:00:00

  • Grafting of architecture controlled poly(styrene sodium sulfonate) onto titanium surfaces using bio-adhesive molecules: Surface characterization and biological properties.

    abstract::This contribution reports on grafting of bioactive polymers such as poly(sodium styrene sulfonate) (polyNaSS) onto titanium (Ti) surfaces. This grafting process uses a modified dopamine as an anchor molecule to link polyNaSS to the Ti surface. The grafting process combines reversible addition-fragmentation chain trans...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4985608

    authors: Chouirfa H,Evans MDM,Castner DG,Bean P,Mercier D,Galtayries A,Falentin-Daudré C,Migonney V

    更新日期:2017-06-14 00:00:00

  • Antifungal coatings by caspofungin immobilization onto biomaterials surfaces via a plasma polymer interlayer.

    abstract::Not only bacteria but also fungal pathogens, particularly Candida species, can lead to biofilm infections on biomedical devices. By covalent grafting of the antifungal drug caspofungin, which targets the fungal cell wall, onto solid biomaterials, a surface layer can be created that might be able to provide long-term p...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4933108

    authors: Griesser SS,Jasieniak M,Coad BR,Griesser HJ

    更新日期:2015-12-14 00:00:00

  • DNA-nanoparticle interactions: Formation of a DNA corona and its effects on a protein corona.

    abstract::There has been much recent interest in the protein "corona," the nonspecific adsorption of proteins on the surface of nanoparticles used in biological applications. This research investigates an analogous DNA corona. We find that particles (200 nm and 1 μm) incubated with DNA form a DNA corona, with a higher concentra...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/6.0000439

    authors: Griffith DM,Jayaram DT,Spencer DM,Pisetsky DS,Payne CK

    更新日期:2020-10-01 00:00:00

  • Synthesis and characterization of molybdenum disulfide nanoparticles in Shewanella oneidensis MR-1 biofilms.

    abstract::Shewanella oneidensis MR-1 is a dissimilatory metal-reducing bacterium capable of reducing various metal and sulfur compounds and precipitating them in nanoparticulate form. Here, we report the synthesis of molybdenum disulfide nanomaterials at the site of S. oneidensis biofilms grown in the presence of molybdenum tri...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/6.0000199

    authors: Rees JD,Gorby YA,Sawyer SM

    更新日期:2020-07-24 00:00:00

  • Time-of-flight secondary ion mass spectrometry analyses of vancomycin.

    abstract::As an antibiotic that prevents and treats infections caused by Gram-positive bacteria such as Staphylococcus aureus, vancomycin incorporated in a biodegradable polymer poly(lactide-co-glycolide) provides opportunities to construct controlled-release drug delivery systems. Developments associated with this promising sy...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.5016186

    authors: Du L,Yang X,Li W,Li H,Feng S,Zeng R,Yu B,Xiao L,Liu Y,Tu M,Nie HY

    更新日期:2018-01-10 00:00:00

  • Mixed DNA/oligo(ethylene glycol) functionalized gold surfaces improve DNA hybridization in complex media.

    abstract::Reliable, direct "sample-to-answer" capture of nucleic acid targets from complex media would greatly improve existing capabilities of DNA microarrays and biosensors. This goal has proven elusive for many current nucleic acid detection technologies attempting to produce assay results directly from complex real-world sa...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.2219110

    authors: Lee CY,Gamble LJ,Grainger DW,Castner DG

    更新日期:2006-06-01 00:00:00

  • Observation of endoplasmic reticulum tubules via TOF-SIMS tandem mass spectrometry imaging of transfected cells.

    abstract::Advances in three-dimensional secondary ion mass spectrometry (SIMS) imaging have enabled visualizing the subcellular distributions of various lipid species within individual cells. However, the difficulty of locating organelles using SIMS limits efforts to study their lipid compositions. Here, the authors have assess...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.5019736

    authors: Chini CE,Fisher GL,Johnson B,Tamkun MM,Kraft ML

    更新日期:2018-02-26 00:00:00

  • Nanotribological characterization of human head hair by friction force microscopy in dry atmosphere and aqueous environment.

    abstract::Friction force microscopy was employed for the tribological investigation of human head hair in two different environments: a dry atmosphere and de-ionized water. The fibers were immobilized by embedding them in indium. The effects of bleaching, conditioning, and immersion in methanolic KOH were quantified in terms of...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.3432462

    authors: Nikogeorgos N,Fletcher IW,Boardman C,Doyle P,Ortuoste N,Leggett GJ

    更新日期:2010-06-01 00:00:00

  • Analysis of protein coatings on gold nanoparticles by XPS and liquid-based particle sizing techniques.

    abstract::The precise use of nanoparticles in technological applications requires control over their surface properties. This implies the ability to quantitatively describe, for example, molecular coatings in terms of their thickness, areal mass, or number of molecules. Here, the authors describe two different approaches to the...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4913566

    authors: Belsey NA,Shard AG,Minelli C

    更新日期:2015-03-27 00:00:00

  • Lateral field excited quartz crystal microbalances for biosensing applications.

    abstract::The most common bulk acoustic wave device used in biosensing applications is the quartz crystal microbalance (QCM), in which a resonant pure shear acoustic wave is excited via electrodes on both major faces of a thin AT-cut quartz plate. For biosensing, the QCM is used to detect the capture of a target by a target-cap...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/6.0000144

    authors: Hartz JSR,Emanetoglu NW,Howell C,Vetelino JF

    更新日期:2020-06-02 00:00:00

  • Skin irritation testing of antimicrobial conjugated electrolytes.

    abstract::Each year, the United States spends about $20 billion to treat people who have been infected with antibiotic resistant bacteria. Even so, the development of new antibiotics has slowed considerably since the mid-20th century. As a result, researchers are looking into developing synthetic compounds and materials with an...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4979918

    authors: Wilde KN,Nguyen PAH,Whitten DG,Canavan HE

    更新日期:2017-04-20 00:00:00

  • Effect of current density on the microstructure and corrosion resistance of microarc oxidized ZK60 magnesium alloy.

    abstract::The application of magnesium alloys as biomaterials is limited by their poor corrosion behavior. Microarc oxidation (MAO) treatment was used to prepare ceramic coatings on ZK60 magnesium alloys in order to overcome the poor corrosion resistance. The process was conducted at different current densities (3.5 and 9.0 A/d...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4889734

    authors: You Q,Yu H,Wang H,Pan Y,Chen C

    更新日期:2014-09-01 00:00:00

  • Effect of micropatterned TiO2 nanotubes thin film on the deposition of endothelial extracellular matrix: For the purpose of enhancing surface biocompatibility.

    abstract::The vascular endothelial cells (EC) extracellular matrix (ECM) on the biomaterial surface can significantly improve the blood compatibility and cell compatibility of the cardiovascular materials. In the present study, two types of micropatterned TiO2 nanotubes surfaces (gronano and toponano) were fabricated on the tit...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4928304

    authors: Wu J,Li J,Wu F,He Z,Yang P,Huang N

    更新日期:2015-12-17 00:00:00

  • Native E. coli inner membrane incorporation in solid-supported lipid bilayer membranes.

    abstract::Solid-supported bilayer lipid membranes (SBLMs) containing membrane protein have been generated through a simple lipid dilution technique. SBLM formation from mixtures of native Escherichia coli bacterial inner membrane (IM) vesicles diluted with egg phosphatidylcholine (egg PC) vesicles has been explored with dissipa...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.2896113

    authors: Dodd CE,Johnson BR,Jeuken LJ,Bugg TD,Bushby RJ,Evans SD

    更新日期:2008-06-01 00:00:00

  • Alternating electric fields induce a period-dependent motion of Escherichia coli in three-dimension near a conductive surface.

    abstract::It has been demonstrated that electric fields can minimize surface adhesion of bacteria, but how they affect the near-surface bacterial dynamics has remained largely overlooked. In the present study, the three-dimensional motions of Escherichia coli (E. coli) HCB1 and HCB1414 near a conductive surface under alternatin...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.5078543

    authors: Zhou X,Qi M,Huang G,Ma C,Bao L,Gong X,Zhang G,Zeng EY

    更新日期:2019-02-20 00:00:00

  • Selective immobilization of biomolecules onto an activated polymeric adlayer.

    abstract::The authors report a facile method for the selective immobilization of biomolecules onto a gold surface that was preactivated by a polymeric adlayer. The polymeric adlayer was designed to perform triple functions: high resistance to nonspecific protein adsorption, efficient surface anchoring, and subsequent covalent a...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.2801974

    authors: Lee BS,Park S,Lee KB,Jon S,Choi IS

    更新日期:2007-12-01 00:00:00

  • Comparison of antibody immobilization strategies in detection of Vibrio cholerae by surface plasmon resonance.

    abstract::Surface plasmon resonance immunosensor for the detection of bacterial cells was first reported in 1998 with high detection limit as much as 107 cfu/ml. Since then, many efforts have been made aiming to lower the detection limit and improve the sensitivity of detection. The aim of this study was to compare the effect o...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4971270

    authors: Taheri RA,Rezayan AH,Rahimi F,Mohammadnejad J,Kamali M

    更新日期:2016-12-06 00:00:00

  • Antifouling coatings for dental implants: Polyethylene glycol-like coatings on titanium by plasma polymerization.

    abstract::Titanium dental implants are commonly used for the replacement of lost teeth, but they present a considerable number of failures due to the infection on surrounding tissues. The aim of this paper is the development of a polyethylene glycol-like (PEG-like) coating on the titanium surface by plasma polymerization to obt...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4913376

    authors: Buxadera-Palomero J,Canal C,Torrent-Camarero S,Garrido B,Javier Gil F,Rodríguez D

    更新日期:2015-06-12 00:00:00

  • Biomimetic assembly of polyelectrolyte multilayers containing phosvitin monitored with reflectometric interference spectroscopy.

    abstract::Coatings of biomaterials or implants that facilitate biomineralization possess a great potential for applications focused to the replacement, augmentation, and regeneration of bone tissue. Biomimetic approaches utilize biomolecules for either templating or supporting the crystallization process. One of these promising...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.3589176

    authors: Grohmann S,Rothe H,Eisenhuth S,Hoffmann C,Liefeith K

    更新日期:2011-06-01 00:00:00

  • Electrochemical switching of the flavoprotein dodecin at gold surfaces modified by flavin-DNA hybrid linkers.

    abstract::Dodecin from Halobacterium salinarum is a dodecameric, hollow-spherical protein, which unspecifically adopts flavin molecules. Reduction of flavin dodecin holocomplexes induces dissociation into apododecin and free flavin. Unspecific binding and dissociation upon reduction were used as key properties to construct an e...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.2965134

    authors: Grininger M,Nöll G,Trawöger S,Sinner EK,Oesterhelt D

    更新日期:2008-09-01 00:00:00

  • Effect of ionic strength on PNA-DNA hybridization on surfaces and in solution.

    abstract::Peptide nucleic acids (PNAs) are mimics of oligonucleotides containing a neutral peptidelike backbone and are able to bind complementary DNA targets with high affinity and selectivity. In order to investigate the effect of the ionic strength of the buffer solution, hybridization experiments with PNAs as (catcher) prob...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.2746871

    authors: Park H,Germini A,Sforza S,Corradini R,Marchelli R,Knoll W

    更新日期:2007-06-01 00:00:00

  • X-ray spectromicroscopy of nanoparticulate iron oxide phases.

    abstract::Soft x-ray spectromicroscopy techniques have seen great amount of development in the recent years, and with the development of new diffraction limited synchrotron source, many new nanoscale and mesoscale characterization opportunities of applied materials are foreseen. In this perspective, the authors present some exa...

    journal_title:Biointerphases

    pub_type: 杂志文章

    doi:10.1116/1.4966654

    authors: Dietrich PM,Unger WE,Swaraj S

    更新日期:2016-10-28 00:00:00