Abstract：
OBJECTIVE:To review the evidence suggesting a significant association between gout and erectile dysfunction (ED) and evaluate possible underlying pathways that may explain this relationship. METHODS:English medical literature was searched from January 1, 2010, to January 1, 2020, for randomized or quasi-randomized controlled trials, cross-sectional studies, case-cohort studies, or meta-analysis evaluating the relationship between gout and ED. RESULTS:All nine gout studies included in the study found a significant association between gout and ED. ED pathophysiology in gout involves hyperuricemia, increased reactive oxygen species, decreased nitric oxide synthesis, and low-grade inflammation. CONCLUSION:The findings of this review suggest that the effect of urate-lowering therapy on the incidence of ED in gout patients should be studied. Additionally, we propose that all gout patients should be assessed for ED.
journal_name
Urologyjournal_title
Urologyauthors
Park K,Gupta NK,Olweny EO,Schlesinger Ndoi
10.1016/j.urology.2020.12.005subject
Has Abstractpub_date
2020-12-17 00:00:00eissn
0090-4295issn
1527-9995pii
S0090-4295(20)31492-8pub_type
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