Sex Differences in Outcome After Thrombectomy for Acute Ischemic Stroke are Explained by Confounding Factors.

Abstract:

PURPOSE:The aim of this study was to analyze sex differences in outcome after thrombectomy for acute ischemic stroke in clinical practice in a large prospective multicenter registry. METHODS:Data of consecutive stroke patients treated with thrombectomy (June 2015-April 2018) derived from an industry-independent registry (German Stroke Registry-Endovascular Treatment) were prospectively analyzed. Multivariable binary logistic regression analyses were applied to determine whether sex is a predictor of functional independence outcome (defined as a modified Rankin scale [mRS] 0-2) 90 days after stroke. RESULTS:In total, 2316 patients were included in the analysis, 1170 (50.5%) were female and 1146 (49.5%) were male. Women were older (median age 78 vs. 72 years; p < 0.001) and more frequently had a prestroke functional impairment defined by mRS >1 (24.8% vs. 14.1%; p < 0.001). In unadjusted analyses, independent outcome at 90 days was less frequent in women (33.2%) than men (40.6%; p < 0.001). Likewise, mortality was higher in women than in men (30.7% vs. 26.4%; p = 0.024). In adjusted regression analyses, however, sex was not associated with outcome. Lower age, a lower baseline National Institutes of Health Stroke Scale score, a higher Alberta Stroke Program Early CT score, prestroke functional independence, successful reperfusion, and concomitant intravenous thrombolysis therapy predicted independent outcome. CONCLUSION:Women showed a worse functional outcome after thrombectomy for acute ischemic stroke in clinical practice; however, after adjustment for crucial confounders sex was not a predictor of outcome. The difference in outcome thus appears to result from differences in confounding factors such as age and prestroke functional status.

journal_name

Clin Neuroradiol

journal_title

Clinical neuroradiology

authors

Deb-Chatterji M,Schlemm E,Flottmann F,Meyer L,Alegiani A,Brekenfeld C,Fiehler J,Gerloff C,Thomalla G,GSR-ET Investigators.

doi

10.1007/s00062-020-00983-2

subject

Has Abstract

pub_date

2020-12-21 00:00:00

eissn

1869-1439

issn

1869-1447

pii

10.1007/s00062-020-00983-2

pub_type

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