Abstract:
:This study sought to (a) determine the domains of clinical balance impairments associated with Huntington's disease (HD), and (b) evaluate associations between balance test scores and other disease-related impairments. Eighteen subjects with genetically definite HD and 17 age-matched control subjects were evaluated on the Mini-BESTest for their clinical balance impairments as well as the Unified HD Rating Scale (UHDRS) motor and total functional capacity scales, Activity-Specific Balance Confidence (ABC) Scale-short form, Montreal Cognitive Assessment (MoCA), and Symbol Digit Modalities Test (SDMT). Results showed that subjects with HD exhibited significantly lower total Mini-BESTest scores than subjects without HD (mean (95% CI)=76 (64-87)% with HD, 98 (96-99)% without HD; p=0.0011). Mini-BESTest item scores were significantly lower for subjects with HD on one-leg stance, postural responses, standing with eyes closed on foam, and dual-task timed up-and-go. Mini-BESTest scores significantly correlated with UHDRS motor (r(2)=0.68; p=0.00003) and total functional capacity (r(2)=0.75; p=0.000006) scores as well as with scores on the ABC short form (r(2)=0.45; p=0.0024), SDMT (r(2)=0.42; p=0.0036), and MoCA (r(2)=0.23; p=0.046) assessments. This study, therefore, demonstrates that balance impairments associated with HD span domains of anticipatory postural adjustments, postural responses, stance in challenging sensory conditions, and gait. Although preliminary, clinical balance impairment appears to be an efficient proxy evaluation of multiple HD-related factors due to associations with functional capacity, other motor impairments, balance confidence, and cognitive abilities.
journal_name
Gait Posturejournal_title
Gait & postureauthors
Jacobs JV,Boyd JT,Hogarth P,Horak FBdoi
10.1016/j.gaitpost.2015.02.018subject
Has Abstractpub_date
2015-03-01 00:00:00pages
867-70issue
3eissn
0966-6362issn
1879-2219pii
S0966-6362(15)00066-1journal_volume
41pub_type
杂志文章相关文献
GAIT & POSTURE文献大全abstract::Tripping over obstacles is a common cause of falls in older adults, and muscle fatigue, which can alter walking patterns, may add to this risk. To date, no study has examined the effect of lower limb muscle fatigue on obstacle negotiation in older adults. 30 older adults (13 women, aged 78.3 [6.2] years) negotiated a ...
journal_title:Gait & posture
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.gaitpost.2012.09.004
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:Patellar tendinopathy is a highly prevalent overuse injury, and most treatments are only effective to some extent. This persistence of complaints could be linked to changed proprioception. One study showed diminished proprioception in athletes with lateral epicondylitis. Aim of this study was to determine diffe...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2016.02.010
更新日期:2016-03-01 00:00:00
abstract::Traditional measures of postural stability consider movement of the center of pressure (COP) or the center of mass (COM) without regard to the boundary of support (BOS). A potentially more appropriate measure is postural time-to-contact (TtC) which defines the spatio-temporal proximity of the COM or COP to the BOS. Gi...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2011.09.103
更新日期:2012-02-01 00:00:00
abstract::Active control of trunk motion is believed to enable humans to maintain stability during walking, suggesting that stability of the trunk is prioritized over other segments by the nervous system. We investigated if superior segments are more stable than inferior segments during walking and if age-related differences ar...
journal_title:Gait & posture
pub_type: 临床试验,杂志文章
doi:10.1016/j.gaitpost.2009.05.003
更新日期:2009-08-01 00:00:00
abstract::Patients undergoing a clinical gait analysis often walk slower than healthy people. However, data on how speed affects upper body movements, especially of the arms and shoulders, are scarce. Therefore, in this descriptive study, we examined how changes in walking speed affect upper-body kinematics and aspects of inter...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2017.03.025
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Differences in joint mechanics between running shoes are commonly assessed using discrete parameters, yet statistically significant differences in these parameters between shoes are often scarce with small effect sizes. Statistical parametric mapping (SPM) has been suggested as suitable method for analyzing ...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2019.01.013
更新日期:2019-03-01 00:00:00
abstract::Weight bearing asymmetry is common in patients with unilateral lower limb musculoskeletal pathologies. The Nintendo Wii Balance Board (WBB) has been suggested as a low-cost and widely-available tool to measure weight bearing asymmetry in a clinical environment; however no study has evaluated the validity of this tool ...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2015.01.023
更新日期:2015-02-01 00:00:00
abstract::In many cases knee osteoarthritis leads to total knee replacement surgery (TKR) even if the lateral compartment is not involved. More recently, a bicompartmental knee replacement system (BKR) (Journey Deuce, Smith & Nephew Inc., Memphis, TN, USA) has been developed that only replaces the medial tibiofemoral and the pa...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2012.04.008
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Altered gait mechanics are frequently reported in individuals with chronic ankle instability (CAI), and increasing information suggests proximal muscle adaptations occur in this population. Ultrasound imaging (USI) offers a visual means to evaluate muscle activity during movement, and overcomes limitations o...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2019.04.007
更新日期:2019-06-01 00:00:00
abstract::For older people balance control in standing is critical for performance of activities of daily living without falling. The aims were to investigate reliability of quantification of the usage of the two balance mechanisms M(1) 'moving the centre of pressure' and M(2) 'segment acceleration' and also to compare calculat...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2011.05.025
更新日期:2011-07-01 00:00:00
abstract::Walking in daily life places high demands on the interplay between cognitive and motor functions. A well-functioning dual-tasking ability is thus essential for walking safely. The aims were to study longitudinal changes in gait function during single- and dual-tasking over a period of two years among people with initi...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2013.12.026
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Balance responses to perturbations often involve the arms in an attempt to either restore balance or protect against impact. Although a majority of research has been dedicated to understanding age-related changes in lower limb balance responses, there is a growing body of evidence supporting age-related chan...
journal_title:Gait & posture
pub_type: 杂志文章,评审
doi:10.1016/j.gaitpost.2020.08.134
更新日期:2020-10-01 00:00:00
abstract:INTRODUCTION:Principal component analysis (PCA) has been used to reduce the volume of gait data and can also be used to identify the differences between populations. This approach has not been used on stair climbing gait data. Our objective was to use PCA to compare the gait patterns between young and older adults duri...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2009.10.005
更新日期:2010-02-01 00:00:00
abstract::Previous studies have identified two discrete strategies for the control of posture in the sagittal plane based on EMG activations, body kinematics, and ground reaction forces. The ankle strategy was characterized by body sway resembling a single-segment-inverted pendulum and was elicited on flat support surfaces. In ...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/s0966-6362(99)00032-6
更新日期:1999-10-01 00:00:00
abstract::The aims of this study were to investigate whether older adults modify their walking mechanics to compensate for the degeneration in their muscle-tendon units (MTUs), and to examine whether running has a beneficial effect on walking mechanics in younger and older adults. The investigation was conducted on 30 older and...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2006.06.015
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Stair walking contributed to 26% of self-reported falls and become the leading cause of accidental death for the elderly. The risk of fall increases while performing a cognitive task, like talking and/or reasoning. RESEARCH QUESTION:Our work aimed to found out whether body stability under physical-cognitive...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2018.08.008
更新日期:2018-10-01 00:00:00
abstract::Functional tests, such as the timed-up-and-go (TUG), are routinely used to screen for mobility issues and fall risk. While the TUG is easy to administer and evaluate, its single time-to-completion outcome may not discriminate between different mobility challenges. Wearable sensors provide an opportunity to collect a v...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2015.03.009
更新日期:2015-05-01 00:00:00
abstract::The Edinburgh Visual Gait Score (EVGS) for cerebral palsy has been validated for observer reliability and validity for observers experienced in gait analysis. This study investigated the reliability and validity of the EVGS for observers inexperienced in gait analysis. Six medical students used the score to analyse vi...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2008.01.008
更新日期:2008-08-01 00:00:00
abstract::Falls during stair descent are a serious problem and can lead to accidental death. Inappropriate foot placement on, and clearance over, steps have been identified as causes for falls on stairs. This study investigated a new method for measuring placement and clearance during stair descent in 10 healthy young subjects....
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2010.12.004
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:Walking instability is a contributor to falls and other undesired changes in walking performance. We investigated the effect of split-belt treadmill based perturbations on dynamic stability. Furthermore, we examined the relationships for dynamic stability and symmetry during unperturbed and perturbed walki...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2018.03.006
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Multiple sclerosis (MS) is a neurological disease marked by demyelination and axonal loss. Individuals with MS experience increases in clinical signs and symptoms during heat exposure. OBJECTIVE:To test the hypothesis that moderate heat exposure adversely affects postural sway in individuals with MS. METHO...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2017.01.025
更新日期:2017-03-01 00:00:00
abstract::For clinical application the quantification of the actual subject-specific kinematics is necessary. Soft tissue artefact (STA) propagation to joint kinematics can nullify the clinical interpretability of stereophotogrammetric analysis. STA was assessed to be strongly subject- and task-specific. The global optimisation...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2008.07.008
更新日期:2009-01-01 00:00:00
abstract::Physicians routinely prescribe partial weight bearing in a walking boot following fractures of the lower limbs in order to produce the needed mechanical environment to facilitate healing. Plantar pressure measurements can provide key information regarding the mechanical environment experienced by lower limb bones. The...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2012.04.015
更新日期:2012-07-01 00:00:00
abstract::The development of scoliosis in boys with Duchenne Muscular Dystrophy (DMD) is a significant, morbid event in the progression of the disease caused by progressive spinal musculature weakness. As an alternative to muscle activity, the spine can also be stabilised by locking the articular facet joints, which is achieved...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2007.10.008
更新日期:2008-07-01 00:00:00
abstract::We investigated the effect of stride frequency (SF) on metabolic costs and rating of perceived exertion (RPE) during walking in water and on dry land. Eleven male subjects walked on a treadmill on dry land and on an underwater treadmill at their preferred SF (PSF) and walked at an SF which was lower and higher than th...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2012.12.010
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To determine the accuracy of clinicians' visual observations of gait disorders following traumatic brain injury (TBI). METHODS:30 ambulant participants (sample of convenience) receiving physiotherapy for mobility limitations following TBI and 25 age, height, weight and sex matched healthy unimpaired controls...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2008.11.005
更新日期:2009-04-01 00:00:00
abstract::In the last decade, various methods for the estimation of gait events and temporal parameters from the acceleration signals of a single inertial measurement unit (IMU) mounted at waist level have been proposed. Despite the growing interest for such methodologies, a thorough comparative analysis of methods with regards...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2014.07.007
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Immature balance control is considered an important rate limiter for maturation of gait. The spatial margin of stability (MoS) is a biomechanical measure of dynamic balance control that might provide insights into balance control strategies used by children during the developmental course of gait. RESEARCH ...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2018.04.019
更新日期:2018-06-01 00:00:00
abstract::This study examined the adaptation of postural responses in transtibial amputees during both perturbed and volitional dynamic balance tasks during a five-month period following discharge from inpatient rehabilitation. Seven unilateral transtibial amputees performed the sensory organisation test (SOT) and the limits of...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2012.07.023
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Pedobarography is a commonly used testing procedure in clinical gait analysis, yet has limited roles in quantification for treatment planning, outcome assessment, and classification. Spatial registration between plantar pressure and motion capture data allows for accurate quantitative assessment and metric d...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2019.11.001
更新日期:2020-02-01 00:00:00