Worldwide Burden of Gastric Cancer Attributable to Tobacco Smoking in 2012 and Predictions for 2020.


BACKGROUND:The heterogeneous patterns and trends in tobacco consumption contribute to regional and gender differences in the burden of gastric cancer attributable to smoking. AIMS:To estimate the proportion and absolute number of gastric cancer cases that can be attributed to smoking in different countries, in 2012 and 2020. METHODS:Population attributable fractions (PAFs) were computed for 118 countries, using data of smoking prevalence in 2002 and 2011 and published estimates of the magnitude of the association between smoking and gastric cancer, assuming a time lag of ≈10 years. RESULTS:For men, the highest PAF estimates in 2012 were observed in Eastern Asia and the lowest in North America, whereas for women the highest were in Western Europe and the lowest in Africa. Very high Human Development Index (HDI) countries presented the lowest median PAF in men (very high vs. high, medium, and low HDI: 17.2 vs. 20.8 %, p = 0.014) and the highest median PAF in women (very high vs. high, medium, and low HDI: 4.3 vs. 1.8 %, p < 0.001). Estimates for 2020 show a decrease in median PAFs, but the estimated absolute number of cases attributable to smoking in the countries analyzed increased for men (≈154,000 vs. ≈160,000) and decreased for women (≈6200 vs. ≈5600). CONCLUSIONS:Smoking accounts for a larger number of gastric cancer cases among men, and gender differences are expected to increase in the next decade, despite the decrease in PAFs. Intensified efforts to control smoking are needed to further reduce the burden of gastric cancer.


Dig Dis Sci


Peleteiro B,Castro C,Morais S,Ferro A,Lunet N




Has Abstract


2015-08-01 00:00:00












  • Complications in celiac disease under gluten-free diet.

    abstract::We assessed the onset of malignant and nonmalignant complications in a cohort of celiac disease (CD) patients under gluten-free diet (GFD). Five hundred and forty-nine CD patients were retrospectively assessed. Two hundred and fifty-one (45.7%) showed classical, 262 (47.7%) subclinical, and 36 (6.6%) silent form of CD...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tursi A,Elisei W,Giorgetti GM,Brandimarte G,Aiello F

    更新日期:2009-10-01 00:00:00

  • Delayed hemorrhage following endoscopic retrograde sphincterotomy for choledocholithiasis.

    abstract::To define the clinical significance of delayed postsphincterotomy hemorrhage, we reviewed 476 consecutive ERCP procedures performed over a three-year period. Of 250 patients who underwent endoscopic sphincterotomy (ES), five (2%) developed postprocedure hemorrhage, two of whom had immediate, self-limited bleeding that...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gholson CF,Favrot D,Vickers B,Dies D,Wilder W

    更新日期:1996-05-01 00:00:00

  • Gallbladder dynamics in chronic pancreatitis. Relationship to exocrine pancreatic function, CCK, and PP release.

    abstract::Gallbladder dynamics, cholecystokinin (CCK), and pancreatic polypeptide (PP) release were studied in 14 patients with chronic pancreatitis (CP) (2 females, 12 males; age range 24-56 years) and 12 control subjects (4 females, 8 males, 21-50 years). On day 1, gallbladder contractility was investigated after ceruletide i...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Glasbrenner B,Malfertheiner P,Pieramico O,Klatt S,Riepl R,Friess H,Ditschuneit H

    更新日期:1993-03-01 00:00:00

  • Similar response to entecavir 0.5 and 1.0 mg in treatment-naïve chronic hepatitis B patients: a case-control study.

    abstract:BACKGROUND AND AIMS:The dose recommendation for entecavir (ETV) is 0.5 mg daily for treatment-naïve chronic hepatitis B (CHB) patients and 1.0 mg daily for lamivudine-refractory patients; however, few data are available for the efficacy of a 1.0-mg daily dose in treatment-naïve CHB patients. Our goal is to examine the ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ha NB,Ha NB,Chaung KT,Trinh HN,Nguyen HA,Nguyen KK,Nguyen MH

    更新日期:2014-01-01 00:00:00

  • Changes in cell proliferation and differentiation of adult rat small intestine epithelium after adrenalectomy: kinetic, biochemical, and morphological studies.

    abstract::The effects of 10-day bilateral adrenalectomy on morphometry, proliferation, and apoptosis were determined in the small intestine of 3-month-old Sprague-Dawley rats. The activities of sucrase, lactase, and its respective mRNA, aminopeptidase N, and intestinal alkaline phosphatase were also evaluated. Adrenalectomy lea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Foligne B,Aissaoui S,Senegas-Balas F,Cayuela C,Bernard P,Antoine JM,Balas D

    更新日期:2001-06-01 00:00:00

  • Bortezomib synergizes TRAIL-induced apoptosis in gastric cancer cells.

    abstract::Background/Aims Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a newly identified biological agent has shown promising antitumor effects in a wide range of cancers. However, gastric cancer cells are less sensitive than other cancer cells to TRAIL-induced apoptosis.Here, we combined TRAIL with borte...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Liu J,Qu XJ,Xu L,Zang Y,Qu JL,Hou KZ,Liu YP

    更新日期:2010-12-01 00:00:00

  • Is use of PPIs related to increased intraepithelial lymphocytes in the colon?

    abstract:BACKGROUND:The use of proton pump inhibitors (PPIs) is thought to increase the incidence of microscopic colitis (MC), although the exact mechanisms are not fully understood. Increased infiltration of intraepithelial lymphocytes (IELs) is a pathologic finding of MC (including collagenous or lymphocytic colitis). AIMS:W...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Yu YH,Han DS,Choi EY,Park HS,Jeong JY,Eun CS,Oh YH,Pyo JY

    更新日期:2012-10-01 00:00:00

  • Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess.

    abstract::The aims of our randomized, single-blind trial involving 49 patients were to study the efficacy, side effects, and tolerance of metronidazole and satranidazole in patients of amebic liver abscess. Twenty-five patients received metronidazole (800 mg TID) and 24 received satranidazole (300 mg TID with placebo at mealtim...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Muzaffar J,Madan K,Sharma MP,Kar P

    更新日期:2006-12-01 00:00:00

  • Community-based health preferences for proctocolectomy: a race comparison.

    abstract::Our objective was to determine whether there are dominating racial differences in patient preferences for surgery that may explain the disparities in proctocolectomy utilization between African Americans (AA) and whites. We used the time trade-off technique to measure health preferences for undergoing ileal pouch anal...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Nguyen GC,Tuskey A,Bayless TM,LaVeist TA,Brant SR

    更新日期:2008-03-01 00:00:00

  • Smoking and male gender rather than CagA protein are associated with increased risk for duodenal ulcer in Helicobacter pylori-infected patients in Taiwan.

    abstract::The aim of this study was to examine the seroprevalence of antibody to CagA antigen, as well as other major H. pylori antigens by Western blot in H. pylori-infected subjects with endoscopically normal mucosa (N = 54) and duodenal ulcer (N = 51). The role of the host and environmental factors was also evaluated. There ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Chen TS,Chang FY,Lee SD

    更新日期:1999-10-01 00:00:00

  • Gallbladder kinetics in obese patients. Effect of a regular meal and low-calorie meal.

    abstract::Gallbladder contractility has been studied in 21 obese patients (greater than 130% ideal weight) and 30 nonobese subjects before and at regular intervals after the administration of a regular solid-liquid meal, and after a low-calorie, low-fat meal used conventionally for weight-loss purposes (Modifast). Gallbladder v...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Marzio L,Capone F,Neri M,Mezzetti A,De Angelis C,Cuccurullo F

    更新日期:1988-01-01 00:00:00

  • Factors affecting methane production in humans. Gastrointestinal diseases and alterations of colonic flora.

    abstract::Breath methane was studied in 394 subjects. Among 152 controls, 50.0% produced methane--42.1% of males and 57.9% of females. One hundred sixteen patients with gastrointestinal diseases were studied. Among 32 with Crohn's disease, only 2 (6.1%) produced methane, as well as 16 of 51 ulcerative colitis patients (31.4%) a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Peled Y,Weinberg D,Hallak A,Gilat T

    更新日期:1987-03-01 00:00:00

  • Randomized, double-blind, placebo-controlled crossover trial of pirenzepine in patients with gastroesophageal reflux.

    abstract::A muscarinic receptor subtype 1 (M1) antagonist, pirenzepine, recently has been shown to be relatively free of the usual anticholinergic side effects on esophageal smooth muscle and thus has been implicated for the treatment of gastroesophageal reflux disease (GERD). However, the effect of pirenzepine on GERD remains ...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sato TL,Wu WC,Castell DO

    更新日期:1992-02-01 00:00:00

  • Effect of portacaval anastomosis on glutamine synthetase activities in liver, brain, and skeletal muscle.

    abstract::Glutamine synthetase is responsible for the ATP-dependent amidation of glutamate to glutamine. In liver the enzyme is highly localized in perivenous hepatocytes; in brain the enzyme is localized in astrocytes. Portacaval anastomosis resulted in liver atrophy, hyperammonemia, and up to 90% loss of glutamine synthetase ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Girard G,Butterworth RF

    更新日期:1992-07-01 00:00:00

  • Mucosal glucosamine synthetase activity in inflammatory bowel disease.

    abstract::Abnormalities in colonic glycoprotein synthesis have been implicated in the pathogenesis of ulcerative colitis and Crohn's disease. Glucosamine synthetase is the rate-limiting step in the biosynthesis of gastrointestinal glycoprotein and has been measured in control subjects (N = 23) and patients with ulcerative colit...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Winslet MC,Poxon V,Allan A,Keighley MR

    更新日期:1994-03-01 00:00:00

  • Vitamin D deficiency and corticosteroid use are risk factors for low bone mineral density in inflammatory bowel disease patients.

    abstract:BACKGROUND:As several factors can contribute to low bone mineral density (BMD), we investigated the role of vitamin D in low BMD while controlling for other risk factors in inflammatory bowel diseases (IBD) patients. METHODS:We conducted a prospective cross-sectional study between 2008 and 2012 in adult IBD patients. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Abraham BP,Prasad P,Malaty HM

    更新日期:2014-08-01 00:00:00

  • Hepatitis C virus infection--pathobiology and implications for new therapeutic options.

    abstract::Despite progress in therapeutic approaches for the elimination of hepatitis C, chronic hepatitis C virus infection remains an important cause of liver disease. Therapeutic intervention with the currently available interferon-based treatment regimens is quite successful, but treatment is difficult to tolerate and is co...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Davis GL,Krawczynski K,Szabo G

    更新日期:2007-04-01 00:00:00

  • Novel expression and regulation of gastrin gene in human ovarian cancer cell line, SW626.

    abstract::Gastrin-secreting tumors have been identified in ectopic locations including the ovary; the mechanisms regulating gastrin gene expression, its distribution, and signaling pathways in these ectopic tissues are not known. The purpose of our present study was to determine: (1) whether the gastrin gene and peptide could b...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kim HJ,Evers BM,Banker NA,Greeley GH Jr,Hellmich MR,Thompson JC,Townsend CM Jr

    更新日期:1998-07-01 00:00:00

  • Control of irritable bowel syndrome with polyamine analogs: a structure-activity study.

    abstract::The evaluation of a group of polyamine analogs as agents to ameliorate diarrhea-predominant irritable bowel syndrome is described. Each compound was assessed when administered subcutaneously in a psychological stress-induced model of irritable bowel syndrome in rodents for its ability to reduce stool output in a dose-...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bergeron RJ,Wiegand J,Fannin TL

    更新日期:2001-12-01 00:00:00

  • Prealbumin and D-dimer as Prognostic Indicators for Rebleeding in Patients with Nonvariceal Upper Gastrointestinal Bleeding.

    abstract:BACKGROUND:Determining the risk stratification of nonvariceal upper gastrointestinal bleeding (NVUGIB) plays a vital role in treating upper gastrointestinal bleeding (UGIB). Traditional scores like Glasgow-Blatchford score (GBS), Rockall score (RS), and AIMS65 score have been widely utilized in UGIB practice, however e...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Yue W,Liu Y,Jiang W,Huang J,Liu J

    更新日期:2020-06-24 00:00:00

  • The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective.

    abstract::Barrett's esophagus (BE) is intestinal metaplasia of the lower esophagus and a precursor lesion for esophageal adenocarcinoma (EAC). Both are important health issues as they have rising incidences in the Western world. Improving the management of BE relies on understanding the underlying biology of this disease, but t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: To H,Clemons NJ,Duong CP,Trainer AH,Phillips WA

    更新日期:2016-07-01 00:00:00

  • Fatal progressive hepatic necrosis associated with lamotrigine treatment: a case report and literature review.

    abstract::We present a case of fatal, progressive hepatotoxicity in a patient treated with lamotrigine. After presenting with a rash and fever, she developed elevated liver function tests and clinical sequelae of hepatic failure. The subacute course of her progressive liver damage is documented in serial liver biopsies. While h...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Overstreet K,Costanza C,Behling C,Hassanin T,Masliah E

    更新日期:2002-09-01 00:00:00

  • Involvement of alpha(2)-adrenoceptors in the gastric protective effect of nitroglycerin against acidified ethanol-induced mucosal injury.

    abstract::Clinical observations reveal that alcohol intake is associated with an increase in upper gastrointestinal hemorrhage requiring hospitalization and that nitroglycerin or long-acting nitrates lower this risk. Nitroglycerin, a gastric vasodilator that can increase gastric fluid volume, protects the rodent stomach against...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Leung FW,Chan CC

    更新日期:2007-11-01 00:00:00

  • Effects of beta-adrenoceptor stimulation on rectosigmoid motility in man.

    abstract::Effects of selective beta-adrenoceptor agonists on rectosigmoid motility during prolonged rectal distension were studied in 12 healthy volunteers in a double-blind, randomized fashion. Continuous distension was performed with a balloon in the proximal part of the rectum. Pressure was recorded by this balloon and by a ...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lyrenäs E,Abrahamsson H,Dotevall G

    更新日期:1985-06-01 00:00:00

  • Current Concepts in Diabetes Mellitus and Chronic Liver Disease: Clinical Outcomes, Hepatitis C Virus Association, and Therapy.

    abstract::Hereditary type 2 diabetes mellitus is a risk factor for chronic liver disease, and ~30 % of patients with liver cirrhosis develop diabetes. Diabetes mellitus has been associated with cirrhotic and non-cirrhotic hepatitis C virus liver infection, can aggravate the course the liver infection, and can induce a lower sus...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: García-Compeán D,González-González JA,Lavalle-González FJ,González-Moreno EI,Villarreal-Pérez JZ,Maldonado-Garza HJ

    更新日期:2016-02-01 00:00:00

  • Naturally occurring glycoalkaloids in potatoes aggravate intestinal inflammation in two mouse models of inflammatory bowel disease.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) may be initiated following disruption of the intestinal epithelial barrier. This disruption, in turn, permits luminal antigens unfettered access to the mucosal immune system and leads to an uncontrolled inflammatory response. Glycoalkaloids, which are found in potatoes, disru...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Iablokov V,Sydora BC,Foshaug R,Meddings J,Driedger D,Churchill T,Fedorak RN

    更新日期:2010-11-01 00:00:00

  • Low acid output in Pima Indians. A possible cause for the rarity of duodenal ulcer in this population.

    abstract::Duodenal ulcer has not been observed in full-heritage Pima Indians, while gastric cancer is relatively frequent. To investigate possible underlying factors for this phenomenon, we determined gastric acid output, gastric emptying rate, and plasma levels of gastrin, pepsinogen I, and pepsinogen II in apparently healthy ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sasaki H,Nagulesparan M,Samloff IM,Straus E,Sievers ML,Dubois A

    更新日期:1984-09-01 00:00:00

  • Hepatic copper content is normal in early primary biliary cirrhosis and primary sclerosing cholangitis.

    abstract::In previous studies, the majority of patients with the cholestatic liver diseases, primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), had increased hepatic copper (Cu) levels even in early stages of disease. We prospectively measured hepatic copper content by atomic absorption spectrophotometry ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kowdley KV,Knox TA,Kaplan MM

    更新日期:1994-11-01 00:00:00

  • Diagnostic Delay Is Associated with a Greater Risk of Early Surgery in a French Cohort of Crohn's Disease Patients.

    abstract:AIM:To investigate whether a diagnostic delay is associated with a poor outcome in Crohn's disease (CD). METHODS:Medical and socioeconomic characteristics as well as medications and need for surgery of consecutive CD adults patients followed in three referral centers were prospectively recorded using an electronic dat...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Nahon S,Lahmek P,Paupard T,Lesgourgues B,Chaussade S,Peyrin-Biroulet L,Abitbol V

    更新日期:2016-11-01 00:00:00

  • Interleukin-1β Mediates β-Catenin-Driven Downregulation of Claudin-3 and Barrier Dysfunction in Caco2 Cells.

    abstract:BACKGROUND:IL-1β is a cytokine involved in mediating epithelial barrier dysfunction in the gut. It is known that IL-1β mediates activation of non-muscle myosin light chain kinase in epithelial cells, but the precise mechanism by which epithelial barrier dysfunction is induced by IL-1β is not understood. METHODS AND RE...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Haines RJ,Beard RS Jr,Chen L,Eitnier RA,Wu MH

    更新日期:2016-08-01 00:00:00