Prognosis of high-risk patients with nonoperated symptomatic extracranial carotid tight stenosis.


:Forty-five patients with symptomatic (20 with transient ischemic attack, 25 with minor stroke) greater than or equal to 75% stenosis of the cervical internal carotid artery had no endarterectomy and received only medical therapy because the surgical risks (severe cardiac disease, chronic obstructive pulmonary disease, hypertension or diabetes with systemic complications, aortic aneurysm) were believed to be unacceptable. During follow-up (mean 48 months), occlusion of the internal carotid artery developed without symptoms in two patients and with symptoms in three patients. The cumulative stroke and/or death rate was 24% at 2 years and 50% at 6 years. The ipsilateral infarct rate was 10% after the first year, but decreased markedly thereafter (2.4% per year), and one third of these infarcts were probably lacunes due to hypertensive small vessel disease. Overall, stroke related to previously symptomatic internal carotid artery stenosis was not the major problem during follow-up but was largely overcome by other strokes and cardiac death.






Bogousslavsky J,Despland PA,Regli F




Has Abstract


1988-01-01 00:00:00














  • Differential changes in alpha- and beta-adrenoceptors in the cerebral cortex and hippocampus of the Mongolian gerbil after unilateral brain ischemia.

    abstract:BACKGROUND AND PURPOSE:Changes in adrenoceptors in the cerebral cortex and hippocampus of Mongolian gerbils after brain ischemia were investigated. METHODS:Twenty-four hours after unilateral occlusion of the common carotid artery, alpha 1-, alpha 2-, and beta-receptors of the membrane fraction of the cerebral cortex o...


    pub_type: 杂志文章


    authors: Mizuki T,Kobayashi H,Ueno S,Nakashima Y,Kuroiwa A,Izumi F

    更新日期:1995-12-01 00:00:00

  • A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young.

    abstract:BACKGROUND AND PURPOSE:The vitamin K-dependent protein Z (PZ) has been shown to possess anticoagulant as well as procoagulant properties. Plasma levels of PZ show a broad interindividual variation, but it is unknown to which extent this variation is under genetic control. Recent clinical studies revealed contradictory ...


    pub_type: 杂志文章


    authors: Lichy C,Kropp S,Dong-Si T,Genius J,Dolan T,Hampe T,Stoll F,Reuner K,Grond-Ginsbach C,Grau A

    更新日期:2004-01-01 00:00:00

  • Endothelial progenitor cell research in stroke: a potential shift in pathophysiological and therapeutical concepts.

    abstract:BACKGROUND AND PURPOSE:Stroke is the leading cause of disability in the Western world; however, few therapies are at hand to decrease this burden. SUMMARY OF REVIEW:Endothelial progenitor cells (EPCs) have been introduced in cardiovascular medicine as factotums. EPCs can repair damaged endothelium and attenuate the de...


    pub_type: 杂志文章


    authors: Rouhl RP,van Oostenbrugge RJ,Damoiseaux J,Tervaert JW,Lodder J

    更新日期:2008-07-01 00:00:00

  • Carotid intima-media thickness is different in large- and small-vessel ischemic stroke: the SMART study.

    abstract:BACKGROUND AND PURPOSE:The role of athersclerosis in the difference between the pathogenesis of large-vessel disease (LVD) and small-vessel disease (SVD) is a matter of debate. Common carotid artery intima-media thickness (CCA IMT) is a marker of atherosclerosis. Our aim was to compare CCA IMT between SVD and LVD patie...


    pub_type: 杂志文章


    authors: Pruissen DM,Gerritsen SA,Prinsen TJ,Dijk JM,Kappelle LJ,Algra A,SMART Study Group.

    更新日期:2007-04-01 00:00:00

  • The electrocardiogram in stroke: relationship to pathophysiological type and comparison with prior tracings.

    abstract::The author reviewed electrocardiographic records of 150 patients with acute stroke and 150 age- and sex-matched controls, to assess the relative frequencies of ECG abnormalities among the pathophysiologic categories of stroke, and to distinguish new abnormalities at the time of the stroke from those noted on prior tra...


    pub_type: 杂志文章


    authors: Goldstein DS

    更新日期:1979-05-01 00:00:00

  • Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes.

    abstract:BACKGROUND AND PURPOSE:Hemorrhagic conversion after tissue plasminogen activator (tPA) stroke therapy has been linked with elevations in matrix metalloproteinase-9 (MMP-9) at the neurovascular interface. Here, we test the idea that statins may directly ameliorate tPA-induced MMP-9 dysregulation. METHODS:Recombinant hu...


    pub_type: 杂志文章


    authors: Wang S,Lee SR,Guo SZ,Kim WJ,Montaner J,Wang X,Lo EH

    更新日期:2006-07-01 00:00:00

  • Detection of hyperacute primary intraparenchymal hemorrhage by magnetic resonance imaging.

    abstract:BACKGROUND:MRI has become increasingly used in the acute setting to manage patients with stroke. There has been concern that MRI may not be sensitive in the detection of acute intracranial hemorrhage. We assessed whether strongly susceptibility-weighted MRI would be sensitive to intraparenchymal hemorrhage in the first...


    pub_type: 杂志文章


    authors: Patel MR,Edelman RR,Warach S

    更新日期:1996-12-01 00:00:00

  • Effects of locomotion training with assistance of a robot-driven gait orthosis in hemiparetic patients after stroke: a randomized controlled pilot study.

    abstract:BACKGROUND AND PURPOSE:The success of gait rehabilitation after stroke depends on active walking exercises. However, the disabling after-effects of stroke often make such exercises impossible at the onset of therapy. To facilitate treadmill training of paraparetic patients, a robot-driven gait orthosis (Lokomat) was de...


    pub_type: 杂志文章,随机对照试验


    authors: Husemann B,Müller F,Krewer C,Heller S,Koenig E

    更新日期:2007-02-01 00:00:00

  • Stent-based thrombectomy versus intravenous tissue plasminogen activator in patients with acute middle cerebral artery occlusion.

    abstract:BACKGROUND AND PURPOSE:Our goal was to compare outcomes of patients with proximal middle cerebral artery occlusions treated with intravenous tissue plasminogen activator (tPA) with those of patients treated with stent-based thrombectomy (SBT). METHODS:Patients with proximal middle cerebral artery occlusions included i...


    pub_type: 杂志文章


    authors: Leker RR,Eichel R,Gomori JM,Ramirez de Noriega F,Ben-Hur T,Cohen JE

    更新日期:2012-12-01 00:00:00

  • Efficacy and safety of vorapaxar in patients with prior ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:Vorapaxar is an antiplatelet agent that antagonizes thrombin-mediated activation of the protease-activated receptor-1 on platelets. We tested the efficacy and safety of vorapaxar in a prespecified analysis in the stroke subcohort from a multinational, randomized, placebo-controlled trial. METHOD...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Morrow DA,Alberts MJ,Mohr JP,Ameriso SF,Bonaca MP,Goto S,Hankey GJ,Murphy SA,Scirica BM,Braunwald E,Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events–TIMI 50 Steering Committee and Investigators

    更新日期:2013-03-01 00:00:00

  • Ischemic neuroprotection with selective kappa-opioid receptor agonist is gender specific.

    abstract:BACKGROUND AND PURPOSE:We demonstrated previously that treatment with selective kappa-opioid receptor (KOR) agonist BRL 52537 hydrochloride [(+/-)-1-(3,4-dichlorophenyl) acetyl-2-(1-pyrrolidinyl) methylpiperidine] (1) has a long therapeutic window for providing ischemic neuroprotection, and (2) attenuates ischemia-evok...


    pub_type: 杂志文章


    authors: Chen CH,Toung TJ,Hurn PD,Koehler RC,Bhardwaj A

    更新日期:2005-07-01 00:00:00

  • Recommendations for the management of cerebral and cerebellar infarction with swelling: a statement for healthcare professionals from the American Heart Association/American Stroke Association.

    abstract:BACKGROUND AND PURPOSE:There are uncertainties surrounding the optimal management of patients with brain swelling after an ischemic stroke. Guidelines are needed on how to manage this major complication, how to provide the best comprehensive neurological and medical care, and how to best inform families facing complex ...


    pub_type: 杂志文章,实务指引


    authors: Wijdicks EF,Sheth KN,Carter BS,Greer DM,Kasner SE,Kimberly WT,Schwab S,Smith EE,Tamargo RJ,Wintermark M,American Heart Association Stroke Council.

    更新日期:2014-04-01 00:00:00

  • Perforating branches of the middle cerebral artery. Microanatomy and clinical significance of their intracerebral segments.

    abstract::Perforating branches of the middle cerebral arteries (MCA) were examined on the forebrain hemispheres of fourteen human brains. It was noticed that their intracerebral segments arose from the MCA main trunk, and its terminal and collateral (cortical) branches. They terminated in certain parts of the basal ganglia and ...


    pub_type: 杂志文章


    authors: Marinkovic SV,Milisavljevic MM,Kovacevic MS,Stevic ZD

    更新日期:1985-11-01 00:00:00

  • Does acupuncture improve motor recovery after stroke? A meta-analysis of randomized controlled trials.

    abstract:BACKGROUND AND PURPOSE:Acupuncture may be a promising treatment for poststroke paralysis. We conducted a meta-analysis, assessing the efficacy of acupuncture with and without stroke rehabilitation. METHODS:We identified randomized trials comparing acupuncture with no acupuncture within 6 months of stroke by searching ...


    pub_type: 杂志文章,meta分析


    authors: Sze FK,Wong E,Or KK,Lau J,Woo J

    更新日期:2002-11-01 00:00:00

  • Short-term anomia training and electrical brain stimulation.

    abstract:BACKGROUND AND PURPOSE:Language training success in chronic aphasia remains only moderate. Electric brain stimulation may be a viable way to enhance treatment efficacy. METHODS:In a randomized, double-blind, sham-controlled crossover trial, we assessed if anodal transcranial direct current stimulation compared to cath...


    pub_type: 杂志文章,随机对照试验


    authors: Flöel A,Meinzer M,Kirstein R,Nijhof S,Deppe M,Knecht S,Breitenstein C

    更新日期:2011-07-01 00:00:00

  • Repeated Intravenous Thrombolysis for Early Recurrent Stroke: Challenging the Exclusion Criterion.

    abstract:BACKGROUND AND PURPOSE:Intravenous thrombolysis (IVT) within 4.5 hours from symptom onset improves functional outcome in patients with acute ischemic stroke. Its use in patients with previous stroke within the preceding 3 months is contraindicated because of the assumed higher risk of intracranial hemorrhage. In additi...


    pub_type: 杂志文章


    authors: Kahles T,Mono ML,Heldner MR,Baumgartner RW,Sarikaya H,Luft A,Bohlhalter S,Traenka C,Engelter ST,Kurka N,Köhrmann M,Curtze S,Michel P,Tatlisumak T,Nedeltchev K

    更新日期:2016-08-01 00:00:00

  • Exaggeration of focal cerebral ischemia in transgenic mice carrying human Renin and human angiotensinogen genes.

    abstract:BACKGROUND AND PURPOSE:We examined the possibility that activation of the human brain renin-angiotensin system is involved in enhancement of ischemic brain damage using chimeric transgenic mice with human renin (hRN) and human angiotensinogen (hANG) genes. METHODS:Chimeric (hRN/hANG-Tg) mice were generated by mating o...


    pub_type: 杂志文章


    authors: Inaba S,Iwai M,Tomono Y,Senba I,Furuno M,Kanno H,Okayama H,Mogi M,Higaki J,Horiuchi M

    更新日期:2009-02-01 00:00:00

  • Soluble CD40L Is a Useful Marker to Predict Future Strokes in Patients With Minor Stroke and Transient Ischemic Attack.

    abstract:BACKGROUND AND PURPOSE:Elevated soluble CD40 ligand (sCD40L) was shown to be related to cardiovascular events, but the role of sCD40L in predicting recurrent stroke remains unclear. METHODS:Baseline sCD40L levels were measured in 3044 consecutive patients with acute minor stroke and transient ischemic attack, who had ...


    pub_type: 杂志文章,随机对照试验


    authors: Li J,Wang Y,Lin J,Wang D,Wang A,Zhao X,Liu L,Wang C,Wang Y,CHANCE Investigators.

    更新日期:2015-07-01 00:00:00

  • Microglial Calcium Waves During the Hyperacute Phase of Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Ischemic injury triggers multiple pathological responses in the brain tissue, including spreading depolarizations across the cerebral cortex (cortical spreading depolarizations [CSD]). Microglia have been recently shown to play a significant role in the propagation of CSD. However, the intracellu...


    pub_type: 杂志文章


    authors: Liu L,Kearns KN,Eli I,Sharifi KA,Soldozy S,Carlson EW,Scott KW,Sluzewski MF,Acton ST,Stauderman KA,Kalani MYS,Park M,Tvrdik P

    更新日期:2021-01-01 00:00:00

  • Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans.

    abstract:BACKGROUND AND PURPOSE:A precise definition of genetic factors responsible for common forms of stroke is still lacking. The purpose of the present study was to investigate the contributory role of the genes encoding atrial natriuretic peptide (ANP) and type A natriuretic peptide receptor (NPRA) in humans' susceptibilit...


    pub_type: 杂志文章


    authors: Rubattu S,Stanzione R,Di Angelantonio E,Zanda B,Evangelista A,Tarasi D,Gigante B,Pirisi A,Brunetti E,Volpe M

    更新日期:2004-04-01 00:00:00

  • Is white matter involved in patients entered into typical trials of neuroprotection?

    abstract:BACKGROUND AND PURPOSE:One of the reasons for the failure of trials of neuroprotection in stroke may be the lack of white matter (WM) protection. However, whether patients entered into typical neuroprotection trials have WM involved in the ischemic process is unknown. We studied patients who were enrolled in neuroprote...


    pub_type: 杂志文章


    authors: Ho PW,Reutens DC,Phan TG,Wright PM,Markus R,Indra I,Young D,Donnan GA

    更新日期:2005-12-01 00:00:00

  • Prognosis for survival after an initial stroke.

    abstract:BACKGROUND AND PURPOSE:We studied prognosis for survival after an initial stroke in 662 patients who survived at least 30 days after onset while taking into account age, sex, the number of neurological deficits from the initial stroke, stroke type, and five selected medical conditions: hypertension, myocardial infarcti...


    pub_type: 杂志文章


    authors: Lai SM,Alter M,Friday G,Sobel E

    更新日期:1995-11-01 00:00:00

  • Trial of secondary prevention with atenolol after transient ischemic attack or nondisabling ischemic stroke. The Dutch TIA Trial Study Group.

    abstract:BACKGROUND AND PURPOSE:beta-Blockers prevent vascular events in patients after myocardial infarction and lower blood pressure, the main risk factor for stroke. Hence, we assessed the effects of atenolol on the occurrence of death from vascular causes, stroke, or myocardial infarction and on blood pressure in patients a...


    pub_type: 临床试验,杂志文章,随机对照试验



    更新日期:1993-04-01 00:00:00

  • Silent cerebral infarction in a community-based autopsy series in Japan. The Hisayama Study.

    abstract:BACKGROUND AND PURPOSE:The purpose of this study was to assess the prevalence and characteristics of silent cerebral infarction in a population-based consecutive autopsy series of residents of Hisayama, Kyushu, Japan. METHODS:Autopsy records, cerebral pathological findings, and clinical charts of 966 Hisayama resident...


    pub_type: 杂志文章


    authors: Shinkawa A,Ueda K,Kiyohara Y,Kato I,Sueishi K,Tsuneyoshi M,Fujishima M

    更新日期:1995-03-01 00:00:00

  • Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group.

    abstract:BACKGROUND AND PURPOSE:In clinical trials and observational studies there is considerable inconsistency in the use of definitions to describe delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. A major cause for this inconsistency is the combining of radiographic evidence of vasospasm with clinica...


    pub_type: 杂志文章


    authors: Vergouwen MD,Vermeulen M,van Gijn J,Rinkel GJ,Wijdicks EF,Muizelaar JP,Mendelow AD,Juvela S,Yonas H,Terbrugge KG,Macdonald RL,Diringer MN,Broderick JP,Dreier JP,Roos YB

    更新日期:2010-10-01 00:00:00

  • Coronary and Basilar Artery Ectasia Are Associated: Results From an Autopsy Case-Control Study.

    abstract:BACKGROUND AND PURPOSE:Intracranial artery dolichoectasia (IADE) and coronary artery ectasia have been associated with stroke and myocardial infarction, respectively. Only rarely have cases of coexisting IADE and coronary artery ectasia been reported. We investigated this association in a large consecutive autopsy seri...


    pub_type: 杂志文章


    authors: Pico F,Labreuche J,Hauw JJ,Seilhean D,Duyckaerts C,Amarenco P

    更新日期:2016-01-01 00:00:00

  • Effect of BQ-123 and tissue plasminogen activator on vasospasm after subarachnoid hemorrhage in monkeys.

    abstract:BACKGROUND AND PURPOSE:We aimed to determine the effect of intracisternal administration of an endothelin-A receptor antagonist (BQ-123) against vasospasm in a monkey model and to determine whether this drug would have adverse interactions with intracisternal tissue plasminogen activator (TPA). METHODS:Thirty-three mo...


    pub_type: 杂志文章


    authors: Kim CJ,Bassiouny M,Macdonald RL,Weir B,Johns LM

    更新日期:1996-09-01 00:00:00

  • Regression of carotid stenoses after corticosteroid therapy in occlusive thromboaortopathy (Takayasu's disease).

    abstract::A 34-year-old, single Japanese woman with active Takayasu's disease presented with stenosed bilateral common carotid arteries, subtotal occlusion of the left subclavian artery, and complete occlusion of the ipsilateral proximal vertebral artery, as demonstrated by angiography. A right subclavian-left vertebral bypass ...


    pub_type: 杂志文章


    authors: Ishikawa K,Yonekawa Y

    更新日期:1987-05-01 00:00:00

  • Transient Ischemic Attack Results in Delayed Brain Atrophy and Cognitive Decline.

    abstract:BACKGROUND AND PURPOSE:Transient ischemic attack (TIA) initiates an ischemic cascade without resulting in frank infarction and, as such, represents a novel model to study the effects of this ischemic cascade and secondary neurodegeneration in humans. METHODS:Patients with suspected TIA underwent acute brain perfusion ...


    pub_type: 杂志文章


    authors: Bivard A,Lillicrap T,Maréchal B,Garcia-Esperon C,Holliday E,Krishnamurthy V,Levi CR,Parsons M

    更新日期:2018-02-01 00:00:00

  • Flow patterns in the human carotid artery bifurcation.

    abstract::To elucidate the connection between blood flow and the localized genesis and development of atherosclerosis and thrombosis at the human carotid artery bifurcation, detailed studies of the flow patterns and distributions of fluid velocity and wall shear rate in this region were carried out using a transparent segment o...


    pub_type: 杂志文章


    authors: Motomiya M,Karino T

    更新日期:1984-01-01 00:00:00