Prognosis of high-risk patients with nonoperated symptomatic extracranial carotid tight stenosis.

abstract：BACKGROUND AND PURPOSE:Changes in adrenoceptors in the cerebral cortex and hippocampus of Mongolian gerbils after brain ischemia were investigated. METHODS:Twenty-four hours after unilateral occlusion of the common carotid artery, alpha 1-, alpha 2-, and beta-receptors of the membrane fraction of the cerebral cortex o...

journal_title：Stroke

authors： Mizuki T,Kobayashi H,Ueno S,Nakashima Y,Kuroiwa A,Izumi F

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The vitamin K-dependent protein Z (PZ) has been shown to possess anticoagulant as well as procoagulant properties. Plasma levels of PZ show a broad interindividual variation, but it is unknown to which extent this variation is under genetic control. Recent clinical studies revealed contradictory ...

journal_title：Stroke

authors： Lichy C,Kropp S,Dong-Si T,Genius J,Dolan T,Hampe T,Stoll F,Reuner K,Grond-Ginsbach C,Grau A

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke is the leading cause of disability in the Western world; however, few therapies are at hand to decrease this burden. SUMMARY OF REVIEW:Endothelial progenitor cells (EPCs) have been introduced in cardiovascular medicine as factotums. EPCs can repair damaged endothelium and attenuate the de...

journal_title：Stroke

authors： Rouhl RP,van Oostenbrugge RJ,Damoiseaux J,Tervaert JW,Lodder J

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The role of athersclerosis in the difference between the pathogenesis of large-vessel disease (LVD) and small-vessel disease (SVD) is a matter of debate. Common carotid artery intima-media thickness (CCA IMT) is a marker of atherosclerosis. Our aim was to compare CCA IMT between SVD and LVD patie...

journal_title：Stroke

authors： Pruissen DM,Gerritsen SA,Prinsen TJ,Dijk JM,Kappelle LJ,Algra A,SMART Study Group.

更新日期：2007-04-01 00:00:00

abstract：:The author reviewed electrocardiographic records of 150 patients with acute stroke and 150 age- and sex-matched controls, to assess the relative frequencies of ECG abnormalities among the pathophysiologic categories of stroke, and to distinguish new abnormalities at the time of the stroke from those noted on prior tra...

journal_title：Stroke

authors： Goldstein DS

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hemorrhagic conversion after tissue plasminogen activator (tPA) stroke therapy has been linked with elevations in matrix metalloproteinase-9 (MMP-9) at the neurovascular interface. Here, we test the idea that statins may directly ameliorate tPA-induced MMP-9 dysregulation. METHODS:Recombinant hu...

journal_title：Stroke

authors： Wang S,Lee SR,Guo SZ,Kim WJ,Montaner J,Wang X,Lo EH

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:MRI has become increasingly used in the acute setting to manage patients with stroke. There has been concern that MRI may not be sensitive in the detection of acute intracranial hemorrhage. We assessed whether strongly susceptibility-weighted MRI would be sensitive to intraparenchymal hemorrhage in the first...

journal_title：Stroke

authors： Patel MR,Edelman RR,Warach S

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The success of gait rehabilitation after stroke depends on active walking exercises. However, the disabling after-effects of stroke often make such exercises impossible at the onset of therapy. To facilitate treadmill training of paraparetic patients, a robot-driven gait orthosis (Lokomat) was de...

journal_title：Stroke

authors： Husemann B,Müller F,Krewer C,Heller S,Koenig E

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Our goal was to compare outcomes of patients with proximal middle cerebral artery occlusions treated with intravenous tissue plasminogen activator (tPA) with those of patients treated with stent-based thrombectomy (SBT). METHODS:Patients with proximal middle cerebral artery occlusions included i...

journal_title：Stroke

authors： Leker RR,Eichel R,Gomori JM,Ramirez de Noriega F,Ben-Hur T,Cohen JE

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Vorapaxar is an antiplatelet agent that antagonizes thrombin-mediated activation of the protease-activated receptor-1 on platelets. We tested the efficacy and safety of vorapaxar in a prespecified analysis in the stroke subcohort from a multinational, randomized, placebo-controlled trial. METHOD...

journal_title：Stroke

authors： Morrow DA,Alberts MJ,Mohr JP,Ameriso SF,Bonaca MP,Goto S,Hankey GJ,Murphy SA,Scirica BM,Braunwald E,Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events–TIMI 50 Steering Committee and Investigators

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We demonstrated previously that treatment with selective kappa-opioid receptor (KOR) agonist BRL 52537 hydrochloride [(+/-)-1-(3,4-dichlorophenyl) acetyl-2-(1-pyrrolidinyl) methylpiperidine] (1) has a long therapeutic window for providing ischemic neuroprotection, and (2) attenuates ischemia-evok...

journal_title：Stroke

authors： Chen CH,Toung TJ,Hurn PD,Koehler RC,Bhardwaj A

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There are uncertainties surrounding the optimal management of patients with brain swelling after an ischemic stroke. Guidelines are needed on how to manage this major complication, how to provide the best comprehensive neurological and medical care, and how to best inform families facing complex ...

journal_title：Stroke

authors： Wijdicks EF,Sheth KN,Carter BS,Greer DM,Kasner SE,Kimberly WT,Schwab S,Smith EE,Tamargo RJ,Wintermark M,American Heart Association Stroke Council.

更新日期：2014-04-01 00:00:00

abstract：:Perforating branches of the middle cerebral arteries (MCA) were examined on the forebrain hemispheres of fourteen human brains. It was noticed that their intracerebral segments arose from the MCA main trunk, and its terminal and collateral (cortical) branches. They terminated in certain parts of the basal ganglia and ...

journal_title：Stroke

authors： Marinkovic SV,Milisavljevic MM,Kovacevic MS,Stevic ZD

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Acupuncture may be a promising treatment for poststroke paralysis. We conducted a meta-analysis, assessing the efficacy of acupuncture with and without stroke rehabilitation. METHODS:We identified randomized trials comparing acupuncture with no acupuncture within 6 months of stroke by searching ...

journal_title：Stroke

authors： Sze FK,Wong E,Or KK,Lau J,Woo J

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Language training success in chronic aphasia remains only moderate. Electric brain stimulation may be a viable way to enhance treatment efficacy. METHODS:In a randomized, double-blind, sham-controlled crossover trial, we assessed if anodal transcranial direct current stimulation compared to cath...

journal_title：Stroke

authors： Flöel A,Meinzer M,Kirstein R,Nijhof S,Deppe M,Knecht S,Breitenstein C

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intravenous thrombolysis (IVT) within 4.5 hours from symptom onset improves functional outcome in patients with acute ischemic stroke. Its use in patients with previous stroke within the preceding 3 months is contraindicated because of the assumed higher risk of intracranial hemorrhage. In additi...

journal_title：Stroke

authors： Kahles T,Mono ML,Heldner MR,Baumgartner RW,Sarikaya H,Luft A,Bohlhalter S,Traenka C,Engelter ST,Kurka N,Köhrmann M,Curtze S,Michel P,Tatlisumak T,Nedeltchev K

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We examined the possibility that activation of the human brain renin-angiotensin system is involved in enhancement of ischemic brain damage using chimeric transgenic mice with human renin (hRN) and human angiotensinogen (hANG) genes. METHODS:Chimeric (hRN/hANG-Tg) mice were generated by mating o...

journal_title：Stroke

authors： Inaba S,Iwai M,Tomono Y,Senba I,Furuno M,Kanno H,Okayama H,Mogi M,Higaki J,Horiuchi M

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Elevated soluble CD40 ligand (sCD40L) was shown to be related to cardiovascular events, but the role of sCD40L in predicting recurrent stroke remains unclear. METHODS:Baseline sCD40L levels were measured in 3044 consecutive patients with acute minor stroke and transient ischemic attack, who had ...

journal_title：Stroke

authors： Li J,Wang Y,Lin J,Wang D,Wang A,Zhao X,Liu L,Wang C,Wang Y,CHANCE Investigators.

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischemic injury triggers multiple pathological responses in the brain tissue, including spreading depolarizations across the cerebral cortex (cortical spreading depolarizations [CSD]). Microglia have been recently shown to play a significant role in the propagation of CSD. However, the intracellu...

journal_title：Stroke

authors： Liu L,Kearns KN,Eli I,Sharifi KA,Soldozy S,Carlson EW,Scott KW,Sluzewski MF,Acton ST,Stauderman KA,Kalani MYS,Park M,Tvrdik P

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A precise definition of genetic factors responsible for common forms of stroke is still lacking. The purpose of the present study was to investigate the contributory role of the genes encoding atrial natriuretic peptide (ANP) and type A natriuretic peptide receptor (NPRA) in humans' susceptibilit...

journal_title：Stroke

authors： Rubattu S,Stanzione R,Di Angelantonio E,Zanda B,Evangelista A,Tarasi D,Gigante B,Pirisi A,Brunetti E,Volpe M

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:One of the reasons for the failure of trials of neuroprotection in stroke may be the lack of white matter (WM) protection. However, whether patients entered into typical neuroprotection trials have WM involved in the ischemic process is unknown. We studied patients who were enrolled in neuroprote...

journal_title：Stroke

authors： Ho PW,Reutens DC,Phan TG,Wright PM,Markus R,Indra I,Young D,Donnan GA

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We studied prognosis for survival after an initial stroke in 662 patients who survived at least 30 days after onset while taking into account age, sex, the number of neurological deficits from the initial stroke, stroke type, and five selected medical conditions: hypertension, myocardial infarcti...

journal_title：Stroke

authors： Lai SM,Alter M,Friday G,Sobel E

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:beta-Blockers prevent vascular events in patients after myocardial infarction and lower blood pressure, the main risk factor for stroke. Hence, we assessed the effects of atenolol on the occurrence of death from vascular causes, stroke, or myocardial infarction and on blood pressure in patients a...

journal_title：Stroke

authors：

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to assess the prevalence and characteristics of silent cerebral infarction in a population-based consecutive autopsy series of residents of Hisayama, Kyushu, Japan. METHODS:Autopsy records, cerebral pathological findings, and clinical charts of 966 Hisayama resident...

journal_title：Stroke

authors： Shinkawa A,Ueda K,Kiyohara Y,Kato I,Sueishi K,Tsuneyoshi M,Fujishima M

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In clinical trials and observational studies there is considerable inconsistency in the use of definitions to describe delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. A major cause for this inconsistency is the combining of radiographic evidence of vasospasm with clinica...

journal_title：Stroke

authors： Vergouwen MD,Vermeulen M,van Gijn J,Rinkel GJ,Wijdicks EF,Muizelaar JP,Mendelow AD,Juvela S,Yonas H,Terbrugge KG,Macdonald RL,Diringer MN,Broderick JP,Dreier JP,Roos YB

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intracranial artery dolichoectasia (IADE) and coronary artery ectasia have been associated with stroke and myocardial infarction, respectively. Only rarely have cases of coexisting IADE and coronary artery ectasia been reported. We investigated this association in a large consecutive autopsy seri...

journal_title：Stroke

authors： Pico F,Labreuche J,Hauw JJ,Seilhean D,Duyckaerts C,Amarenco P

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to determine the effect of intracisternal administration of an endothelin-A receptor antagonist (BQ-123) against vasospasm in a monkey model and to determine whether this drug would have adverse interactions with intracisternal tissue plasminogen activator (TPA). METHODS:Thirty-three mo...

journal_title：Stroke

authors： Kim CJ,Bassiouny M,Macdonald RL,Weir B,Johns LM

更新日期：1996-09-01 00:00:00

abstract：:A 34-year-old, single Japanese woman with active Takayasu's disease presented with stenosed bilateral common carotid arteries, subtotal occlusion of the left subclavian artery, and complete occlusion of the ipsilateral proximal vertebral artery, as demonstrated by angiography. A right subclavian-left vertebral bypass ...

journal_title：Stroke

authors： Ishikawa K,Yonekawa Y

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transient ischemic attack (TIA) initiates an ischemic cascade without resulting in frank infarction and, as such, represents a novel model to study the effects of this ischemic cascade and secondary neurodegeneration in humans. METHODS:Patients with suspected TIA underwent acute brain perfusion ...

journal_title：Stroke

authors： Bivard A,Lillicrap T,Maréchal B,Garcia-Esperon C,Holliday E,Krishnamurthy V,Levi CR,Parsons M

更新日期：2018-02-01 00:00:00

abstract：:To elucidate the connection between blood flow and the localized genesis and development of atherosclerosis and thrombosis at the human carotid artery bifurcation, detailed studies of the flow patterns and distributions of fluid velocity and wall shear rate in this region were carried out using a transparent segment o...

journal_title：Stroke

authors： Motomiya M,Karino T

更新日期：1984-01-01 00:00:00