Contemporary Analysis of Minimal Clinically Important Difference in the Neurosurgical Literature.

Abstract:

BACKGROUND:Minimal clinically important difference (MCID) is determined when a patient or physician defines the minimal change that outweighs the costs and untoward effects of a treatment. These measurements are "anchored" to validated quality-of-life instruments or physician-rated, disease-activity indices. To capture the subjective clinical experience in a measurable way, there is an increasing use of MCID. OBJECTIVE:To review the overall concept, method of calculation, strengths, and weaknesses of MCID and its application in the neurosurgical literature. METHODS:Recent articles were reviewed based on PubMed query. To illustrate the strengths and limitations of MCID, studies regarding the measurement of pain are emphasized and their impact on subsequent publications queried. RESULTS:MCID varies by population baseline characteristics and calculation method. In the context of pain, MCID varied based on the quality of pain, chronicity, and treatment options. CONCLUSION:MCID evaluates outcomes relative to whether they provide a meaningful change to patients, incorporating the risks and benefits of a treatment. Using MCID in the process of evaluating outcomes helps to avoid the error of interpreting a small but statistically significant outcome difference as being clinically important.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Zervos TM,Asmaro K,Air EL

doi

10.1093/neuros/nyaa490

subject

Has Abstract

pub_date

2020-12-28 00:00:00

eissn

0148-396X

issn

1524-4040

pii

6053822

pub_type

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