Contemporary Analysis of Minimal Clinically Important Difference in the Neurosurgical Literature.


BACKGROUND:Minimal clinically important difference (MCID) is determined when a patient or physician defines the minimal change that outweighs the costs and untoward effects of a treatment. These measurements are "anchored" to validated quality-of-life instruments or physician-rated, disease-activity indices. To capture the subjective clinical experience in a measurable way, there is an increasing use of MCID. OBJECTIVE:To review the overall concept, method of calculation, strengths, and weaknesses of MCID and its application in the neurosurgical literature. METHODS:Recent articles were reviewed based on PubMed query. To illustrate the strengths and limitations of MCID, studies regarding the measurement of pain are emphasized and their impact on subsequent publications queried. RESULTS:MCID varies by population baseline characteristics and calculation method. In the context of pain, MCID varied based on the quality of pain, chronicity, and treatment options. CONCLUSION:MCID evaluates outcomes relative to whether they provide a meaningful change to patients, incorporating the risks and benefits of a treatment. Using MCID in the process of evaluating outcomes helps to avoid the error of interpreting a small but statistically significant outcome difference as being clinically important.






Zervos TM,Asmaro K,Air EL




Has Abstract


2020-12-28 00:00:00








  • Recurrent germinoma in the optic nerve: report of two cases.

    abstract:OBJECTIVE AND IMPORTANCE:Intracranial germinomas often disseminate via the ventricular and subarachnoid pathways, but seeding to the perioptic arachnoid space is extremely unusual. We report two cases of recurrent germinoma seeding in the optic nerve. CLINICAL PRESENTATION:Two men with pure germinoma were initially tr...


    pub_type: 杂志文章,评审


    authors: Nakajima T,Kumabe T,Jokura H,Yoshimoto T

    更新日期:2001-01-01 00:00:00

  • Postmortem Autopsy-Confirmation of Antemortem [F-18]FDDNP-PET Scans in a Football Player With Chronic Traumatic Encephalopathy.

    abstract::Currently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [...


    pub_type: 杂志文章


    authors: Omalu B,Small GW,Bailes J,Ercoli LM,Merrill DA,Wong KP,Huang SC,Satyamurthy N,Hammers JL,Lee J,Fitzsimmons RP,Barrio JR

    更新日期:2018-02-01 00:00:00

  • Isolated injection injury to the posterior femoral cutaneous nerve.

    abstract::The sciatic nerve is by far the most common nerve accidentally injured during intramuscular injection. Despite its close proximity to the sciatic nerve, however, injury to the posterior femoral cutaneous nerve is apparently quite rare. In this report, clinical features of a patient with isolated injection injury to th...


    pub_type: 杂志文章


    authors: Iyer VG,Shields CB

    更新日期:1989-11-01 00:00:00

  • Novel device and technique for minimally invasive intracerebral hematoma evacuation in the same setting of a ruptured intracranial aneurysm: combined treatment in the neurointerventional angiography suite.

    abstract:BACKGROUND:The presence of intracerebral hematoma from aneurysm rupture is an indication for craniotomy for clot evacuation and aneurysm clipping. Some centers have begun securing aneurysms with coil embolization followed by clot evacuation in the operating room. This approach requires transporting a patient from the a...


    pub_type: 杂志文章


    authors: Turner RD,Vargas J,Turk AS,Chaudry MI,Spiotta AM

    更新日期:2015-03-01 00:00:00

  • Brucellosis of the spine.

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    pub_type: 杂志文章


    authors: Tekkök IH,Berker M,Ozcan OE,Ozgen T,Akalin E

    更新日期:1993-11-01 00:00:00

  • Contralateral cerebellar hemorrhagic infarction after pterional craniotomy: report of five cases and review of the literature.

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    pub_type: 杂志文章,评审


    authors: Papanastassiou V,Kerr R,Adams C

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  • Intraoperative autologous blood transfusion in intracranial surgery.

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    pub_type: 杂志文章


    authors: Cataldi S,Bruder N,Dufour H,Lefevre P,Grisoli F,François G

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  • Localization of the placental form of glutathione S-transferase messenger ribonucleic acid in human glioma cell lines.

    abstract::Localization of the placental form of glutathione S-transferase (GST-pi) messenger ribonucleic acid (mRNA) in three human glioma cell lines (A172, T98G, and Tc77) was studied by in situ hybridization with digoxigenin-labeled GST-pi complementary DNA followed by immunocytochemistry with antidigoxigenin antibody. A172 g...


    pub_type: 杂志文章


    authors: Hara A,Sakai N,Yamada H,Niikawa S,Yoshimi N,Mori H

    更新日期:1993-07-01 00:00:00

  • The Dancing Cord: Inherent Spinal Cord Motion and Its Effect on Cord Dose in Spine Stereotactic Body Radiation Therapy.

    abstract:BACKGROUND:Spinal cord dose limits are critically important for the safe practice of spine stereotactic body radiotherapy (SBRT). However, the effect of inherent spinal cord motion on cord dose in SBRT is unknown. OBJECTIVE:To assess the effects of cord motion on spinal cord dose in SBRT. METHODS:Dynamic balanced fas...


    pub_type: 杂志文章


    authors: Oztek MA,Mayr NA,Mossa-Basha M,Nyflot M,Sponseller PA,Wu W,Hofstetter CP,Saigal R,Bowen SR,Hippe DS,Yuh WTC,Stewart RD,Lo SS

    更新日期:2020-06-04 00:00:00

  • Initial multicenter technical experience with the Apollo device for minimally invasive intracerebral hematoma evacuation.

    abstract:BACKGROUND:No conventional surgical intervention has been shown to improve outcomes for patients with spontaneous intracerebral hemorrhage (ICH) compared with medical management. OBJECTIVE:We report the initial multicenter experience with a novel technique for the minimally invasive evacuation of ICH using the Penumbr...


    pub_type: 杂志文章,多中心研究


    authors: Spiotta AM,Fiorella D,Vargas J,Khalessi A,Hoit D,Arthur A,Lena J,Turk AS,Chaudry MI,Gutman F,Davis R,Chesler DA,Turner RD

    更新日期:2015-06-01 00:00:00

  • Quality of life in patients 2 to 4 years after closed head injury.

    abstract::This study evaluated quality of life in 78 patients with closed head injury (CHI) 2 to 4 years postinjury. Using both interview data and mean data from the Sickness Impact Profile questionnaire, impaired quality of life was observed in the areas of psychosocial functioning, social role functioning, leisure activities,...


    pub_type: 杂志文章


    authors: Klonoff PS,Snow WG,Costa LD

    更新日期:1986-11-01 00:00:00

  • Pathological status of the mesial temporal lobe predicts memory outcome from left anterior temporal lobectomy.

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    pub_type: 杂志文章


    authors: Hermann BP,Wyler AR,Somes G,Berry AD 3rd,Dohan FC Jr

    更新日期:1992-10-01 00:00:00

  • A comparison of fluoroscopy and computed tomography-derived volumetric multiple exposure transmission holography for the guidance of lumbar pedicle screw insertion.

    abstract::Holographic technology has recently been modified in such a manner that it may now provide clinical use. It allows the visualization of complex structures in three dimensions and permits clinician interaction with the image, which, in turn, provides significant additional geometric and anatomic information. To objecti...


    pub_type: 杂志文章


    authors: Benzel EC,Rupp FW,McCormack BM,Baldwin NG,Anson JA,Adams MS

    更新日期:1995-10-01 00:00:00

  • Thrombectomy Technique Predicts Outcome in Posterior Circulation Stroke-Insights from the STAR Collaboration.

    abstract:BACKGROUND:Randomized controlled trials evaluating mechanical thrombectomy (MT) for acute ischemic stroke predominantly studied anterior circulation patients. Both procedural and clinical predictors of outcome in posterior circulation patients have not been evaluated in large cohort studies. OBJECTIVE:To investigate t...


    pub_type: 杂志文章


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    更新日期:2020-10-15 00:00:00

  • Long-Term Endocrine Outcomes Following Endoscopic Endonasal Transsphenoidal Surgery for Acromegaly and Associated Prognostic Factors.

    abstract:BACKGROUND:Long-term remission rates from endoscopic transsphenoidal surgery for acromegaly and their relationship to prognostic indicators of disease aggressiveness are not well documented. OBJECTIVE:To investigate long-term remission rates in patients with acromegaly after endoscopic transsphenoidal surgery, and cor...


    pub_type: 杂志文章


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  • Mini-open stabilization of a sacral fracture: technical case report.

    abstract:BACKGROUND AND IMPORTANCE:Comminuted sacral fractures present significant challenges for operative management. Open and percutaneous sacroiliac screws have been used for stabilization but carry not insignificant rates of complications, including wound infection for the former and malposition and neurological injury for...


    pub_type: 杂志文章


    authors: Hong J,Spire WJ,Simmons NE

    更新日期:2013-03-01 00:00:00

  • Delayed retraction of the pipeline embolization device and corking failure: pitfalls of pipeline embolization device placement in the setting of a ruptured aneurysm.

    abstract:BACKGROUND AND IMPORTANCE:The safety of flow-diverting stents for the treatment of ruptured intracranial aneurysms is unknown. CLINICAL PRESENTATION:A 35-year-old woman with a ruptured dissecting aneurysm of the intradural right vertebral artery and incorporating the right posterior inferior cerebellar artery was trea...


    pub_type: 杂志文章


    authors: McTaggart RA,Santarelli JG,Marcellus ML,Steinberg GK,Dodd RL,Do HM,Marks MP

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  • Prenatal diagnosis of occipital encephalocele by ultrasound scanning.

    abstract::Fetal visualization in utero can be routinely accomplished using noninvasive ultrasound techniques that do not administer ionizing radiation. Image resolution with real time sonography is sufficient to demonstrate details of possible congenital central nervous system malformations before delivery. The case reported il...


    pub_type: 杂志文章


    authors: Weinstein P,Weinstein L,Dotters D,Bedrick A,Anderson C

    更新日期:1983-06-01 00:00:00

  • Morbidity and mortality from surgical treatment of unruptured cerebral aneurysms at Research Institute for Brain and Blood Vessels-Akita.

    abstract:OBJECTIVE:Although the necessity of craniotomy for an unruptured cerebral aneurysm (UCA) is controversial, surgery is warranted if surgical risks are less than the risks of natural history. In this study, we investigated the need for craniotomy for UCAs on the basis of surgical risk. METHODS:History of cerebrovascular...


    pub_type: 杂志文章


    authors: Moroi J,Hadeishi H,Suzuki A,Yasui N

    更新日期:2005-02-01 00:00:00

  • Microscope-integrated quantitative analysis of intraoperative indocyanine green fluorescence angiography for blood flow assessment: first experience in 30 patients.

    abstract:BACKGROUND:Intraoperative measurements of cerebral blood flow are of interest during vascular neurosurgery. Near-infrared indocyanine green (ICG) fluorescence angiography was introduced for visualizing vessel patency intraoperatively. However, quantitative information has not been available. OBJECTIVE:To report our ex...


    pub_type: 杂志文章


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    更新日期:2012-03-01 00:00:00

  • Surgical results of the oblique paraspinal approach in upper lumbar disc herniation and thoracolumbar junction.

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    pub_type: 杂志文章


    authors: Kim JS,Lee SH,Moon KH,Lee HY

    更新日期:2009-07-01 00:00:00

  • Hemangioma calcificans in the fourth ventricle.

    abstract::A case of hemangioma calcificans in the 4th ventricle is reported. Skull x-ray films demonstrated a dense calcification in the posterior fossa. Computed tomography disclosed a hyperdense mass in the 4th ventricle. The clinical picture was of increased intracranial pressure due to obstructive hydrocephalus. An hemangio...


    pub_type: 杂志文章


    authors: Kobayashi H,Kawano H,Ito H,Hayashi M,Yamamoto S

    更新日期:1984-06-01 00:00:00

  • Delayed ischemic deterioration in patients with early aneurysm operation and intravenous nimodipine.

    abstract::A consecutive series of 100 individuals with aneurysmal subarachnoid hemorrhage were subjected to early aneurysm operation followed by subsequent intravenous administration of the calcium antagonist nimodipine during the critical period for symptomatic vasospasm. A total of 85 patients were in Hunt and Hess neurologic...


    pub_type: 杂志文章


    authors: Säveland H,Ljunggren B,Brandt L,Messeter K

    更新日期:1986-02-01 00:00:00

  • Gastric secretory and mucosal injury response to severe head trauma.

    abstract::The problem of gastric secretory and mucosal injury response was evaluated in 19 patients who had suffered a severe head injury. Fifteen of 19 patients had some evidence of gastrointestinal hemorrhage. In 7 cases, this was marked. The mean volume of gastric secretions ranged from 36.4 ml/hour on Day 1 to 47.6 ml/hour ...


    pub_type: 杂志文章


    authors: Gudeman SK,Wheeler CB,Miller JD,Halloran LG,Becker DP

    更新日期:1983-02-01 00:00:00

  • Boron neutron capture therapy of brain tumors: an emerging therapeutic modality.

    abstract::Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when boron-10, a stable isotope, is irradiated with low-energy thermal neutrons to yield alpha particles and recoiling lithium-7 nuclei. For BNCT to be successful, a large number of 10B atoms must be localized on or preferably within neo...


    pub_type: 杂志文章,评审


    authors: Barth RF,Soloway AH,Goodman JH,Gahbauer RA,Gupta N,Blue TE,Yang W,Tjarks W

    更新日期:1999-03-01 00:00:00

  • Meningiomas: role of vascular endothelial growth factor/vascular permeability factor in angiogenesis and peritumoral edema.

    abstract:OBJECTIVE:Vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) is a potent angiogenic growth factor implicated in the tumor angiogenesis/metastasis of a number of human cancers. Activation of receptors for VEGF/VPF is specifically mitogenic to endothelial cells and increases their permeability. ...


    pub_type: 杂志文章


    authors: Provias J,Claffey K,delAguila L,Lau N,Feldkamp M,Guha A

    更新日期:1997-05-01 00:00:00

  • Long-term tumor control and functional outcome in patients with cavernous sinus meningiomas treated by radiotherapy with or without previous surgery: is there an alternative to aggressive tumor removal?

    abstract:OBJECTIVE:We report the long-term follow-up of 31 patients with cavernous sinus meningiomas who were treated either with surgery and radiotherapy (RT) or with RT alone. This retrospective review was undertaken to compare long-term efficacy and morbidity of RT with or without previous surgery versus complete, aggressive...


    pub_type: 杂志文章


    authors: Dufour H,Muracciole X,Métellus P,Régis J,Chinot O,Grisoli F

    更新日期:2001-02-01 00:00:00

  • Neurosurgery at the University of Michigan.

    abstract::Neurosurgery at the University of Michigan was established as a specialty three-quarters of a century ago by Max Minor Peet. It developed under the successive leadership of Edgar Allan Kahn, Richard Coy Schneider, and Julian T. Hoff. Each has made unique contributions to the program, which has a strong tradition of te...


    pub_type: 传,历史文章,杂志文章


    authors: Hoff JT,Taren JA

    更新日期:1995-07-01 00:00:00

  • Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Pretreatment Ophthalmology Evaluation in Patients With Suspected Nonfunctioning Pituitary Adenomas.

    abstract:BACKGROUND:Nonfunctioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. Visual symptoms from NFPAs are common and include visual field defects, loss of central vision, and motility problems resulting in diplopia. OBJECTIVE:To create evidence-based guidelines in an attempt to formulate guidance for...


    pub_type: 杂志文章,实务指引,评审


    authors: Newman SA,Turbin RE,Bodach ME,Tumialan LM,Oyesiku NM,Litvack Z,Zada G,Patil CG,Aghi MK

    更新日期:2016-10-01 00:00:00

  • Transvascular coil hooking procedure to retrieve an unraveled Guglielmi detachable coil: technical note.

    abstract:OBJECTIVE:A patient with an anterior communicating artery aneurysm was treated by use of endovascular coiling, and a Guglielmi detachable coil (Boston Scientific/Target, Fremont, CA) fractured distal to its connection to the delivering catheter. The unraveled coil floated out from the aneurysm to extend into the bifurc...


    pub_type: 杂志文章


    authors: Raftopoulos C,Goffette P,Billa RF,Mathurin P

    更新日期:2002-04-01 00:00:00