Abstract：
:Depression is a major psychiatric disorder affecting more than 120 million people worldwide every year. Changes in monoaminergic transmitter release are suggested to take part in the pathophysiology of depression. However, more recent experimental evidence suggests that glutamatergic mechanisms might play a more central role in the development of this disorder. The importance of the glutamatergic system in depression was particularly highlighted by the discovery that N-methyl-D-aspartate (NMDA) receptor antagonists (particularly ketamine) exert relatively long-lasting antidepressant like effects with rapid onset. Importantly, the antidepressant-like effects of NMDA receptor antagonists, but also other antidepressants (both classical and novel), require activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Additionally, expression of AMPA receptors is altered in patients with depression. Moreover, preclinical evidence supports an important involvement of AMPA receptor-dependent signaling and plasticity in the pathophysiology and treatment of depression. Here we summarize work published on the involvement of AMPA receptors in depression and discuss a possible central role for AMPA receptors in the pathophysiology, course and treatment of depression.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Freudenberg F,Celikel T,Reif Adoi
10.1016/j.neubiorev.2015.03.005subject
Has Abstractpub_date
2015-05-01 00:00:00pages
193-206eissn
0149-7634issn
1873-7528pii
S0149-7634(15)00079-2journal_volume
52pub_type
杂志文章,评审abstract：:There is convincing evidence that schizophrenia is characterised by progressive brain volume changes during the course of the illness. In a large longitudinal study it was shown that different age-related trajectories of brain tissue loss are present in patients compared to healthy subjects, suggesting that brain matu...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2012.09.006
更新日期：2013-12-01 00:00:00
abstract：:Schizophrenia is a complex brain disorder associated with deficits in synaptic connectivity. The insidious onset of this illness during late adolescence and early adulthood has been reported to be dependent on several key processes of brain development including synaptic refinement, myelination and the physiological m...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2014.03.018
更新日期：2014-09-01 00:00:00
abstract：:Many psychiatric illnesses are associated with early mortality and with an increased risk of developing physical diseases that are more typically seen in the elderly. Moreover, certain psychiatric illnesses may be associated with accelerated cellular aging, evidenced by shortened leukocyte telomere length (LTL), which...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2015.05.007
更新日期：2015-08-01 00:00:00
abstract：:Cognitive dysfunction in schizophrenia is an important target for novel therapies. Effectively measuring the cognitive effects of compounds in clinical trials of schizophrenia could be a major barrier to drug development. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) programme ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/j.neubiorev.2010.01.012
更新日期：2010-07-01 00:00:00
abstract：:The effect of manipulations aimed at modifying the function of the 5-HT system has been reviewed. 5-HT uptake inhibitors are devoid of any activity in rats and induce an anti-immobility effect in mice. The so-called 5-HT1A agonists reduce the immobility time with some differences in mice and rats, mice being less sens...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/0149-7634(94)00050-b
更新日期：1995-10-01 00:00:00
abstract：:Yawning is a phylogenetically old behaviour that can be observed in most vertebrate species from foetal stages to old age. The origin and function of this conspicuous phenomenon have been subject to speculations for centuries. Here, we review the experimental evidence for each of these hypotheses. It is found that the...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2010.03.008
更新日期：2010-07-01 00:00:00
abstract：:Response inhibition has been shown to be associated with monoamine-related gene polymorphisms, although evidence is inconclusive. To comprehensively examine these genotype effects on behavioural correlates of response inhibition in non-clinical adult populations, we performed a two-step approach. A systematic review o...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.neubiorev.2017.11.009
更新日期：2018-01-01 00:00:00
abstract：:The neural systems underlying reward-related behaviors across development have recently generated a great amount of interest. Yet, the neurodevelopmental literature on reward processing is marked by inconsistencies due to the heterogeneity of the reward paradigms used, the complexity of the behaviors being studied, an...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/j.neubiorev.2013.03.004
更新日期：2013-06-01 00:00:00
abstract：:Risk assessment is the attempt to characterize the chance of obtaining an adverse effect after exposure to an agent. Traditionally, high levels of an agent have been used to estimate the likelihood a lower dose might have an effect either by using low-dose extrapolation models or by attempting to establish a dose with...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/s0149-7634(05)80108-3
更新日期：1991-04-01 00:00:00
abstract：:The role of prior stress experience on the response of the organism to a later stressor has been studied in terms of the extent of gastric ulceration induced by the second stressor. These studies have focused largely on effects of prior stress (shock, restraint, activity) on the ulceration developing under later restr...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(05)80024-7
更新日期：1991-10-01 00:00:00
abstract：:Abundant evidence suggests links between trauma exposure, altered secretion of the glucocorticoid cortisol and the development/maintenance of posttraumatic stress disorder (PTSD), albeit with some inconsistency in findings. Further insight into the complex relations underlying this process may be derived from an incre...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2016.07.015
更新日期：2016-10-01 00:00:00
abstract：:While the question whether free will exists or not has concerned philosophers for centuries, empirical research on this question is relatively young. About 35 years ago Benjamin Libet designed an experiment that challenged the common intuition of free will, namely that conscious intentions are causally efficacious. Li...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2019.04.024
更新日期：2019-07-01 00:00:00
abstract：:The effect of adding 0.125% saccharin to 3% or 32% solutions of Polycose, sucrose and glucose on the fluid intake and preference of adult female rats was examined. In Experiment 1, the rats consumed more of a 3% Polycose + 0.125% saccharin solution (P + s) than of either a 3% Polycose or 0.125% saccharin solution; sim...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/s0149-7634(87)80030-1
更新日期：1987-07-01 00:00:00
abstract：:The study of 5-hydroxytryptamine (5-HT) system has benefited from the identification, classification and cloning of multiple 5-HT receptors (5-HT1 to 5-HT7). Growing evidence suggests that 5-HT is important in learning and memory and all its receptors might be implicated in this. Actually, 5-HT pathways, 5-HT reuptake...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(99)00067-6
更新日期：1999-12-01 00:00:00
abstract：:Social and emotional problems have been implicated in the development and maintenance of eating disorders (ED). This paper reviews the facets of social processing in ED according to the NIMH Research and Domain Criteria (NIMH RDoC) 'Systems for Social Processes' framework. Embase, Medline, PsycInfo and Web of Science ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.neubiorev.2013.12.002
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Children and adolescents with conduct disorder (CD) show repetitive and persistent patterns of aggressive behaviour and the more severe forms are often associated with callous-unemotional (CU) traits. OBJECTIVES:To systematically review and, where data are adequate, conduct meta-analyses on the efficacy of ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,meta分析
doi：10.1016/j.neubiorev.2017.01.024
更新日期：2018-08-01 00:00:00
abstract：:In Parkinson's disease, together with the classic loss of dopamine neurons of the substantia nigra pars compacta, neuropathological studies and biochemical findings documented the occurrence of a concomitant significant cell death in the locus coeruleus. This review analyzes the latest data obtained from experimental ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(00)00028-2
更新日期：2000-08-01 00:00:00
abstract：:This review critically evaluates the animal and human research concerning vasopressin's putative mnemonic role. Weaknesses in the interpretations of the early animal experiments as well as the implications of the later inconsistent findings are discussed. It is concluded that both the initial enthusiasm and the subseq...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/0149-7634(85)90018-1
更新日期：1985-10-01 00:00:00
abstract：:Disruptive Behavior Disorders (DBDs) are stable and impairing disorders, heterogeneous in presentation, developmental pathways, and treatment needs. Disentangling subtypes according to psychopathological dimensions is helpful for timely diagnoses, precise prognoses and tailored interventions. Psychopathic traits are r...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2016.09.023
更新日期：2018-08-01 00:00:00
abstract：:Pathological dissociation is a severe, debilitating and transdiagnostic psychiatric symptom. This review identifies biomarkers of pathological dissociation in a transdiagnostic manner to recommend the most promising research and treatment pathways in support of the precision medicine framework. A total of 205 unique s...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2020.11.019
更新日期：2020-11-30 00:00:00
abstract：:Paradoxical sleep in rats, cats and mice is usually preceded and sometimes followed by a short-lasting (a few seconds) electroencephalogram (EEG) stage characterized by high-amplitude spindles in the anterior cortex and low-frequency theta rhythm in the dorsal hippocampus. The former is an index of advanced slow-wave ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/0149-7634(95)00055-0
更新日期：1996-10-01 00:00:00
abstract：:Tourette syndrome (TS) is a neuropsychiatric disorder involving motor and phonic tics. Inhibitory control is a key issue in TS, and many disruptive or impulsive behaviors might arise from inhibitory deficits. However, conflicting findings regarding TS patients' inhibitory performance in neuropsychological tasks have b...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.neubiorev.2017.05.006
更新日期：2017-09-01 00:00:00
abstract：:The effects of a range of antiandrogens and antiestrogens on conflict behaviors in laboratory rats and mice are reassessed in the light of recent studies applying ethophamacological analyses (recording the full spectrum of behaviors) to such investigations. It is argued that any antihostility properties of the antiand...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/s0149-7634(05)80143-5
更新日期：1991-01-01 00:00:00
abstract：:Although largely unrecognized by sleep scholars, sleeping is a pleasure. This report aims first, to fill the gap: sleep, like food, water and sex, is a primary reinforcer. The levels of extracellular mesolimbic dopamine show circadian oscillations and mark the "wanting" for pro-homeostatic stimuli. Further, the dopami...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2018.03.012
更新日期：2018-05-01 00:00:00
abstract：:The transition from adolescence to adulthood is characterized by improvements in higher-order cognitive abilities and corresponding refinements of the structure and function of the brain regions that support them. Whereas the neurobiological mechanisms that govern early development of sensory systems are well-understo...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2018.09.005
更新日期：2018-11-01 00:00:00
abstract：:The rapid rise in obesity prevalence in the modern world parallels a significant reduction in restorative sleep (Agras et al., 2004; Dixon et al., 2007, 2001; Gangwisch and Heymsfield, 2004; Gupta et al., 2002; Sekine et al., 2002; Vioque et al., 2000; Wolk et al., 2003). Reduced sleep time and quality increases the r...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2012.01.001
更新日期：2012-03-01 00:00:00
abstract：:Intermediate phenotypes may contribute to elucidate the genetic determinants of schizophrenia. A regulatory dopamine 2-receptor gene (DRD2) polymorphism (rs1076560; G>T) has been identified as a genetic risk factor for schizophrenia. Studies report conflicting results on its involvement in schizophrenia intermediate p...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.neubiorev.2017.01.006
更新日期：2017-03-01 00:00:00
abstract：:The technology toolbox by which neural elements can be selectively manipulated in vertebrate and invertebrate brains has expanded greatly in recent years, to now include sophisticated optogenetics and novel designer receptors. Application of such tools allow for ascertaining whether a particular behavioural phenotype ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2014.07.026
更新日期：2014-11-01 00:00:00
abstract：:Despite decades of research, the nature of the involvement of the motor system in action language processing is still controversial, and little is known about how processing action language relates to observing, imaging and executing motor actions. This study combines a systematic review of the literature, an ALE meta...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2020.06.025
更新日期：2020-09-01 00:00:00
abstract：:Among the most useful models for depressive disorders are those, which involve a stress induced change in behaviour. Learned helplessness is one such model and is induced through exposure to uncontrollable and unpredictable aversive events. Learned helplessness as induced in rats using foot shock is well characterized...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2005.03.019
更新日期：2005-01-01 00:00:00
