Occupational exposure to N-nitrosamines and pesticides and risk of pancreatic cancer.

Abstract:

OBJECTIVES:Animal evidence shows that N-nitrosamines and similar xenobiotic compounds are pancreatic carcinogens. We aimed to determine whether occupational exposure to N-nitrosamines or to pesticides increases risk of pancreatic cancer development. METHODS:Participants (504 cases, 643 controls) in a population-based case-control study (The Queensland Pancreatic Cancer Study) provided data on demographic, medical and lifestyle factors and lifetime job histories. Specific questions were asked regarding work in rubber and leather industries, metalworking jobs and occupational or direct use of pesticides on animals or crops. An occupational hygienist reviewed this information (blind to case status) to assess likelihood of exposure to N-nitrosamines and pesticides, and estimated level and frequency of such exposures. RESULTS:No associations were found for risk of pancreatic cancer and occupational exposure to N-nitrosamines (OR=0.85, 95% CI 0.51 to 1.42) and no associations were seen with level or frequency of exposure. No associations were observed for ever exposure to pesticides in general (OR=0.90, 95% CI 0.61 to 1.33) or to any of the pesticide subgroups. Stratification by history of cigarette smoking did not change these results. CONCLUSIONS:This comprehensive analysis of a large case-control study does not support an association between occupational exposure to N-nitrosamines or pesticide use and risk of pancreatic cancer.

journal_name

Occup Environ Med

authors

Fritschi L,Benke G,Risch HA,Schulte A,Webb PM,Whiteman DC,Fawcett J,Neale RE

doi

10.1136/oemed-2014-102522

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

678-83

issue

9

eissn

1351-0711

issn

1470-7926

pii

oemed-2014-102522

journal_volume

72

pub_type

杂志文章
  • Systematic review and meta-analysis of interventions aimed at enhancing return to work for sick-listed workers with common mental disorders, stress-related disorders, somatoform disorders and personality disorders.

    abstract:OBJECTIVES:Mental disorders are associated with significant functional impairment, sickness absence and disability. The consequences of sickness absence warrant investigation into interventions aimed at enhancing return to work (RTW) for workers with mental disorders. The present systematic review and meta-analysis aim...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,meta分析

    doi:10.1136/oemed-2018-105073

    authors: Mikkelsen MB,Rosholm M

    更新日期:2018-09-01 00:00:00

  • Hourly variation in fine particle exposure is associated with transiently increased risk of ST segment depression.

    abstract:OBJECTIVES:To evaluate whether hourly changes in fine particle (PM(2.5), diameter<2.5 microm) exposure or outdoor particle concentrations are associated with rapid ischaemic responses. METHODS:41 non-smoking elderly people with coronary heart disease were followed up with biweekly clinic visits in Helsinki, Finland. T...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2007.037531

    authors: Lanki T,Hoek G,Timonen KL,Peters A,Tiittanen P,Vanninen E,Pekkanen J

    更新日期:2008-11-01 00:00:00

  • Exposure and dose modelling in occupational epidemiology.

    abstract::Complex and dynamic physiologic processes underlie the exposure-response relations that occupational and environmental epidemiologists study. Simple summary measures of exposure such as the average, cumulative exposure, or duration of exposure, can be applied suitably in exposure-response analyses in many instances. H...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2006.030031

    authors: Kriebel D,Checkoway H,Pearce N

    更新日期:2007-07-01 00:00:00

  • Manager-oriented intervention to reduce absence among pregnant employees in the healthcare and daycare sector: a cluster randomised trial.

    abstract:OBJECTIVE:The aim was to test if targeting managers with an educational intervention reduces absence among pregnant employees. METHODS:The study was a non-blinded cluster randomised trial conducted in hospitals and daycare institutions from two administrative Danish Regions and two Danish municipalities. Clusters (wor...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2020-106794

    authors: Begtrup LM,Malmros P,Brauer C,Soegaard Toettenborg S,Flachs EM,Hammer PEC,Bonde JP

    更新日期:2021-01-12 00:00:00

  • Cancer surveillance among workers in plastics and rubber manufacturing in Ontario, Canada.

    abstract:OBJECTIVE:Occupational exposure to agents in plastics and rubber manufacturing has been associated with elevated risk of certain cancers. We sought to evaluate cancer risk among workers employed in occupations and industries with these exposures as part of an ongoing surveillance programme in Ontario, Canada. METHODS:...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2020-106581

    authors: DeBono NL,Logar-Henderson C,Warden H,Shakik S,Dakouo M,MacLeod J,Demers PA

    更新日期:2020-12-01 00:00:00

  • Gender differences in the association of age with physical workload and functioning.

    abstract:AIMS:To test whether (1) physically demanding work is less frequent for older than younger employees, and whether (2) the association of physically demanding work with decline of physical functioning is stronger for older employees than their younger counterparts. The gender differences in these associations were exami...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2004.014035

    authors: Aittomäki A,Lahelma E,Roos E,Leino-Arjas P,Martikainen P

    更新日期:2005-02-01 00:00:00

  • Respiratory symptoms and ventilatory function in confectionery workers.

    abstract::Respiratory symptoms and ventilatory capacity were studied in a group of 288 workers (259 women and 29 men) employed in a confectionery plant. A group of workers (96 women and 31 men) not exposed to confectionery manufacture were also studied as controls. The prevalence of chronic respiratory symptoms was higher in ex...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.51.7.435

    authors: Zuskin E,Mustajbegovic J,Schachter EN,Kern J

    更新日期:1994-07-01 00:00:00

  • Influenza immunisation: attitudes and beliefs of UK healthcare workers.

    abstract:AIM:To explore attitudes to influenza immunisation and rates of uptake among staff working in acute hospitals in the UK. METHOD:A cross-sectional survey of 11,670 healthcare workers in six UK hospitals was carried out using a postal questionnaire. RESULTS:Among 6302 responders (54% of those mailed), 19% had taken up ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1136/oem.2005.023564

    authors: Smedley J,Poole J,Waclawski E,Stevens A,Harrison J,Watson J,Hayward A,Coggon D

    更新日期:2007-04-01 00:00:00

  • The role of cumulative physical work load in lumbar spine disease: risk factors for lumbar osteochondrosis and spondylosis associated with chronic complaints.

    abstract:OBJECTIVES:To investigate the relation with a case-control study between symptomatic osteochondrosis or spondylosis of the lumbar spine and cumulative occupational exposure to lifting or carrying and to working postures with extreme forward bending. METHODS:From two practices and four clinics were recruited 229 male p...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.58.11.735

    authors: Seidler A,Bolm-Audorff U,Heiskel H,Henkel N,Roth-Küver B,Kaiser U,Bickeböller R,Willingstorfer WJ,Beck W,Elsner G

    更新日期:2001-11-01 00:00:00

  • Measurement of human exposure to biologically relevant fractions of inhaled aerosols.

    abstract::Aerosol sampling has evolved with changes in technology and our understanding of the importance of assessing the biologically relevant fractions of the total aerosol. During the past decade there has been international agreement on the definitions for the inhalable, thoracic, and respirable fractions and instruments h...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,评审

    doi:10.1136/oem.56.11.747

    authors: Cherrie JW,Aitken RJ

    更新日期:1999-11-01 00:00:00

  • Ineffective disability management by doctors is an obstacle for return-to-work: a cohort study on low back pain patients sicklisted for 3-4 months.

    abstract:AIMS:To determine obstacles for return-to-work in disability management of low back pain patients sicklisted for 3-4 months. METHODS:A cohort of 467 low back pain patients sicklisted for 3-4 months was recruited. A questionnaire was sent to their occupational physicians (OPs) concerning the medical management, obstacl...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.59.11.729

    authors: Anema JR,Van Der Giezen AM,Buijs PC,Van Mechelen W

    更新日期:2002-11-01 00:00:00

  • Work related and individual predictors for incident neck pain among office employees working with video display units.

    abstract:AIMS:To investigate work related and individual factors as predictors for incident neck pain among office employees working with video display units (VDUs). METHODS:Employees in three administrative units of a medium sized city in Finland (n = 515) received mailed questionnaires in the baseline survey in 1998 and in t...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.60.7.475

    authors: Korhonen T,Ketola R,Toivonen R,Luukkonen R,Häkkänen M,Viikari-Juntura E

    更新日期:2003-07-01 00:00:00

  • Return-to-work interventions integrated into cancer care: a systematic review.

    abstract:OBJECTIVES:The purpose of this study was to review the literature on the content of interventions focusing on return to work, employment status, or work retention in patients with cancer. Furthermore, the effect of the interventions on return to work was assessed in studies reporting return to work. METHODS:A literatu...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,评审

    doi:10.1136/oem.2009.050070

    authors: Tamminga SJ,de Boer AG,Verbeek JH,Frings-Dresen MH

    更新日期:2010-09-01 00:00:00

  • Sex ratio in offspring of those affected by dioxin and dioxin-like compounds: the Yusho, Seveso, and Yucheng incidents.

    abstract::Sex ratios in the offspring of those affected by dioxins or dioxin-like compounds have been reported from Seveso, Italy and Yucheng, Taiwan. The sex ratio of live births in Yusho, Japan after a similar accidental massive exposure to polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) in 1968 are...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.58.8.540

    authors: Yoshimura T,Kaneko S,Hayabuchi H

    更新日期:2001-08-01 00:00:00

  • Respiratory symptoms and diseases among workers in the soft tissue producing industry.

    abstract:AIMS:To correlate the prevalence of respiratory tract symptoms and diseases with dust and fibre exposure in the soft tissue industry in Germany. METHODS:Ambient monitoring was performed for inhalable, respirable dust and fibres in seven soft tissue producing factories. In 441 workers (72 controls, 90 moderate, 279 hig...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.59.12.830

    authors: Kraus T,Pfahlberg A,Gefeller O,Raithel HJ

    更新日期:2002-12-01 00:00:00

  • Prevalence of spirometry-defined airflow obstruction in never-smoking working US coal miners by pneumoconiosis status.

    abstract:INTRODUCTION:This study estimated the prevalence of spirometry-defined airflow obstruction and coal workers' pneumoconiosis (CWP) among never-smoking coal miners participating in the National Institute for Occupational Safety and Health (NIOSH) Coal Workers' Health Surveillance Program (CWHSP). METHODS:Data were from ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2019-106213

    authors: Kurth L,Laney AS,Blackley DJ,Halldin CN

    更新日期:2020-04-01 00:00:00

  • Occupational accidents aboard merchant ships.

    abstract:OBJECTIVES:To investigate the frequency, circumstances, and causes of occupational accidents aboard merchant ships in international trade, and to identify risk factors for the occurrence of occupational accidents as well as dangerous working situations where possible preventive measures may be initiated. METHODS:The s...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.59.2.85

    authors: Hansen HL,Nielsen D,Frydenberg M

    更新日期:2002-02-01 00:00:00

  • Cancer mortality in German carbon black workers 1976-98.

    abstract:BACKGROUND:Few studies have investigated cancer risks in carbon black workers and the findings were inconclusive. METHODS:The current study explores the mortality of a cohort of 1535 male German blue-collar workers employed at a carbon black manufacturing plant for at least one year between 1960 and 1998. Vital status...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2006.026526

    authors: Wellmann J,Weiland SK,Neiteler G,Klein G,Straif K

    更新日期:2006-08-01 00:00:00

  • Occupational noise exposure and ischaemic heart disease mortality.

    abstract:AIMS:To investigate the hypothesis that long term exposure to excessive noise can increase the risk of ischaemic heart disease. METHODS:A case-control design, nested within a cohort of nuclear power workers employed at two sites in England over the period 1950-98, was used. Cases were men who died from ischaemic heart...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1136/oem.2005.026245

    authors: McNamee R,Burgess G,Dippnall WM,Cherry N

    更新日期:2006-12-01 00:00:00

  • Dutch monitor on stress and physical load: risk factors, consequences, and preventive action.

    abstract:OBJECTIVES:Due to recent changes in legislation on occupational health and safety, a national monitor on stress and physical load was developed in The Netherlands to monitor (a) risks and consequences of stress and physical load at work, (b) preventive actions in companies to reduce these risks, and (c) organisational ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.55.2.73

    authors: Houtman IL,Goudswaard A,Dhondt S,van der Grinten MP,Hildebrandt VH,van der Poel EG

    更新日期:1998-02-01 00:00:00

  • Lung cancer risk in welders and foundry workers with a history of heavy smoking in the USA: The National Lung Screening Trial.

    abstract:OBJECTIVES:Foundry work is a risk factor for lung cancer; however, the association with welding is unclear, as smoking is common among metalworkers and may mask the relationship. We evaluated whether history of welding and foundry work, independently and jointly, and employment duration were associated with lung cancer...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/oemed-2016-104168

    authors: Wong JYY,Bassig BA,Seow WJ,Hu W,Ji BT,Blair A,Silverman DT,Lan Q

    更新日期:2017-06-01 00:00:00

  • Prevalence of workplace violence against healthcare workers: a systematic review and meta-analysis.

    abstract::We aim to quantitatively synthesise available epidemiological evidence on the prevalence rates of workplace violence (WPV) by patients and visitors against healthcare workers. We systematically searched PubMed, Embase and Web of Science from their inception to October 2018, as well as the reference lists of all includ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,meta分析

    doi:10.1136/oemed-2019-105849

    authors: Liu J,Gan Y,Jiang H,Li L,Dwyer R,Lu K,Yan S,Sampson O,Xu H,Wang C,Zhu Y,Chang Y,Yang Y,Yang T,Chen Y,Song F,Lu Z

    更新日期:2019-12-01 00:00:00

  • Domestic use of bleach and infections in children: a multicentre cross-sectional study.

    abstract:OBJECTIVE:To report the effects of bleach use at home on the frequency of infections in 9102 school-age children participating in the HITEA project. METHODS:Parents of pupils aged 6-12 years from schools in Barcelona province (Spain), Utrecht province (the Netherlands) and Eastern and Central Finland were administered...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2014-102701

    authors: Casas L,Espinosa A,Borràs-Santos A,Jacobs J,Krop E,Heederik D,Nemery B,Pekkanen J,Hyvärinen A,Täubel M,Zock JP

    更新日期:2015-08-01 00:00:00

  • The relationship between multiple myeloma and occupational exposure to six chlorinated solvents.

    abstract:OBJECTIVES:Few studies have examined whether exposure to chlorinated solvents is associated with multiple myeloma. We evaluated associations between multiple myeloma and occupational exposure to six chlorinated solvents: 1,1,1-trichloroethane, trichloroethylene (TCE), methylene chloride (DCM), perchloroethylene, carbon...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2009.054809

    authors: Gold LS,Stewart PA,Milliken K,Purdue M,Severson R,Seixas N,Blair A,Hartge P,Davis S,De Roos AJ

    更新日期:2011-06-01 00:00:00

  • Exposure to benzene and urinary concentrations of 8-hydroxydeoxyguanosine, a biological marker of oxidative damage to DNA.

    abstract:OBJECTIVES:Benzene is an established animal and human carcinogen. The mechanism of benzene toxicity, particularly its leukaemogenic effect, is not fully understood. The modified base 8-hydroxy-deoxyguanosine (8-OHdG) is a sensitive marker of the DNA damage due to hydroxyl radical attack at the C8 of guanine. This damag...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.51.11.739

    authors: Lagorio S,Tagesson C,Forastiere F,Iavarone I,Axelson O,Carere A

    更新日期:1994-11-01 00:00:00

  • Urinary neutral endopeptidase in workers exposed to cadmium: interaction with cigarette smoking.

    abstract:OBJECTIVES:Structural impairment of the renal proximal tubular epithelium induced by cadmium (Cd) was investigated by measuring the concentration of neutral endopeptidase 24.11 (NEP), an ectoenzyme of the apical brush border, in the urine of 106 male workers employed in a Cd smelter (among whom 52 were occupationally e...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.54.6.432

    authors: Nortier J,Bernard A,Roels H,Deschodt-Lanckman M,Gueuning C,Lauwerys R

    更新日期:1997-06-01 00:00:00

  • Use of molecular epidemiological techniques in a pilot study on workers exposed to chromium.

    abstract:OBJECTIVES:Molecular epidemiological techniques, capable of detecting damage to DNA, were used to see if such damage occurred in the lymphocytes of a group of workers exposed to chromium. The two aims of this pilot study were to see if these new techniques might make useful biological monitoring tools for workers expos...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.51.10.663

    authors: Gao M,Levy LS,Faux SP,Aw TC,Braithwaite RA,Brown SS

    更新日期:1994-10-01 00:00:00

  • Point-of-sale glass bottle recycling: indoor airborne exposures and symptoms among employees.

    abstract:AIMS:To assess the impact of newly introduced point-of-sale glass bottle recycling on indoor air quality and employee health. METHODS:Airborne exposures and both chronic and acute respiratory and somatic symptoms were surveyed among 226 employees at 36 randomly selected liquor stores with bottle recycling and in-house...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2003.009753

    authors: Kennedy SM,Copes R,Bartlett KH,Brauer M

    更新日期:2004-07-01 00:00:00

  • Shift work, job strain and changes in the body mass index among women: a prospective study.

    abstract:OBJECTIVES:The effects of job strain and shift work on weight gain have not been studied jointly. Cross-sectional and longitudinal studies on shift work and weight gain have reported different results. This study examines potential effect modification by job strain on the link between shift work and weight gain, and co...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2016-103747

    authors: Fujishiro K,Lividoti Hibert E,Schernhammer E,Rich-Edwards JW

    更新日期:2017-06-01 00:00:00

  • Risk of leukaemia among children living near the Solway coast of Dumfries and Galloway Health Board area, Scotland, 1975-2002.

    abstract:OBJECTIVE:To investigate allegations of an excess risk of leukaemia among children living near the Solway Firth coast of Dumfries and Galloway Health Board area in Scotland, UK. METHODS:Incident cases of childhood leukaemia (International Classification of Diseases, 10th revision, C91-C95, patients aged 0-14 years) fo...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2006.028829

    authors: Stark JM,Black RJ,Brewster DH

    更新日期:2007-01-01 00:00:00