Occupational exposure to N-nitrosamines and pesticides and risk of pancreatic cancer.


OBJECTIVES:Animal evidence shows that N-nitrosamines and similar xenobiotic compounds are pancreatic carcinogens. We aimed to determine whether occupational exposure to N-nitrosamines or to pesticides increases risk of pancreatic cancer development. METHODS:Participants (504 cases, 643 controls) in a population-based case-control study (The Queensland Pancreatic Cancer Study) provided data on demographic, medical and lifestyle factors and lifetime job histories. Specific questions were asked regarding work in rubber and leather industries, metalworking jobs and occupational or direct use of pesticides on animals or crops. An occupational hygienist reviewed this information (blind to case status) to assess likelihood of exposure to N-nitrosamines and pesticides, and estimated level and frequency of such exposures. RESULTS:No associations were found for risk of pancreatic cancer and occupational exposure to N-nitrosamines (OR=0.85, 95% CI 0.51 to 1.42) and no associations were seen with level or frequency of exposure. No associations were observed for ever exposure to pesticides in general (OR=0.90, 95% CI 0.61 to 1.33) or to any of the pesticide subgroups. Stratification by history of cigarette smoking did not change these results. CONCLUSIONS:This comprehensive analysis of a large case-control study does not support an association between occupational exposure to N-nitrosamines or pesticide use and risk of pancreatic cancer.


Occup Environ Med


Fritschi L,Benke G,Risch HA,Schulte A,Webb PM,Whiteman DC,Fawcett J,Neale RE




Has Abstract


2015-09-01 00:00:00














  • Efficacy of measures of hygiene in workers sensitised to acid anhydrides and the influence of selection bias on the results.

    abstract:OBJECTIVES:Organic acid anhydrides are potential sensitisers and cause occupational airway diseases. In an intervention study the efficacy of measures of hygiene at the workplace and possible selection bias were investigated. METHODS:A first investigation with 110 workers exposed to hexahydrophthalic acid anhydride (H...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Drexler H,Schaller KH,Nielsen J,Weber A,Weihrauch M,Welinder H,Skerfving S

    更新日期:1999-03-01 00:00:00

  • Manager-oriented intervention to reduce absence among pregnant employees in the healthcare and daycare sector: a cluster randomised trial.

    abstract:OBJECTIVE:The aim was to test if targeting managers with an educational intervention reduces absence among pregnant employees. METHODS:The study was a non-blinded cluster randomised trial conducted in hospitals and daycare institutions from two administrative Danish Regions and two Danish municipalities. Clusters (wor...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Begtrup LM,Malmros P,Brauer C,Soegaard Toettenborg S,Flachs EM,Hammer PEC,Bonde JP

    更新日期:2021-01-12 00:00:00

  • Cancer mortality in German carbon black workers 1976-98.

    abstract:BACKGROUND:Few studies have investigated cancer risks in carbon black workers and the findings were inconclusive. METHODS:The current study explores the mortality of a cohort of 1535 male German blue-collar workers employed at a carbon black manufacturing plant for at least one year between 1960 and 1998. Vital status...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Wellmann J,Weiland SK,Neiteler G,Klein G,Straif K

    更新日期:2006-08-01 00:00:00

  • Rhinitis associated with pesticide exposure among commercial pesticide applicators in the Agricultural Health Study.

    abstract:OBJECTIVES:Rhinitis is common, but the risk factors are not well described. To investigate the association between current rhinitis and pesticide use, we used data from 2245 Iowa commercial pesticide applicators in the Agricultural Health Study. METHODS:Using logistic regression models adjusted for age, education and ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Slager RE,Poole JA,LeVan TD,Sandler DP,Alavanja MC,Hoppin JA

    更新日期:2009-11-01 00:00:00

  • Breast cancer and serum organochlorine residues.

    abstract:BACKGROUND:Controversy still exists about the breast carcinogenic properties in humans of environmental xenoestrogens (organochlorines), justifying new investigations. AIMS:To compare the blood levels of total dichlorodiphenyltrichloroethane (DDT) and hexachlorobenzene (HCB) in samples collected at the time of breast ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Charlier C,Albert A,Herman P,Hamoir E,Gaspard U,Meurisse M,Plomteux G

    更新日期:2003-05-01 00:00:00

  • The effects of work-related and individual factors on the Work Ability Index: a systematic review.

    abstract::This paper systematically reviews the scientific literature on the effects of individual and work-related factors on the Work Ability Index (WAI). Studies on work ability published from 1985 to 2006 were identified through a structured search in PubMed, and Web of Science. Studies were included if the WAI was used as ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,评审


    authors: van den Berg TI,Elders LA,de Zwart BC,Burdorf A

    更新日期:2009-04-01 00:00:00

  • Fatigue as a predictor of sickness absence: results from the Maastricht cohort study on fatigue at work.

    abstract:OBJECTIVES:To investigate whether there is a relationship between fatigue and sickness absence. Two additional hypotheses were based on the theoretical distinction between involuntary, health related absence and voluntary, attitudinal absence. In the literature, the former term is usually used to describe long term sic...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究


    authors: Janssen N,Kant IJ,Swaen GM,Janssen PP,Schröer CA

    更新日期:2003-06-01 00:00:00

  • Shift work and diabetes mellitus: a meta-analysis of observational studies.

    abstract:BACKGROUND:Observational studies suggest that shift work may be associated with diabetes mellitus (DM). However, the results are inconsistent. No systematic reviews have applied quantitative techniques to compute summary risk estimates. OBJECTIVES:To conduct a meta-analysis of observational studies assessing the assoc...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Gan Y,Yang C,Tong X,Sun H,Cong Y,Yin X,Li L,Cao S,Dong X,Gong Y,Shi O,Deng J,Bi H,Lu Z

    更新日期:2015-01-01 00:00:00

  • Varicose veins in the lower extremities in relation to occupational mechanical exposures: a longitudinal study.

    abstract:OBJECTIVES:To evaluate if occupational mechanical exposures are associated with an increased risk of surgery for varicose veins (VV) in the lower extremities. METHODS:We conducted a longitudinal study of persons from the Musculoskeletal Research Database at the Danish Ramazzini Centre who were 18-65 years old when the...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Tabatabaeifar S,Frost P,Andersen JH,Jensen LD,Thomsen JF,Svendsen SW

    更新日期:2015-05-01 00:00:00

  • Sex ratio in offspring of those affected by dioxin and dioxin-like compounds: the Yusho, Seveso, and Yucheng incidents.

    abstract::Sex ratios in the offspring of those affected by dioxins or dioxin-like compounds have been reported from Seveso, Italy and Yucheng, Taiwan. The sex ratio of live births in Yusho, Japan after a similar accidental massive exposure to polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) in 1968 are...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Yoshimura T,Kaneko S,Hayabuchi H

    更新日期:2001-08-01 00:00:00

  • Iron associated with asbestos bodies is responsible for the formation of single strand breaks in phi X174 RFI DNA.

    abstract::The ability of amosite cored asbestos bodies isolated from human lungs to catalyse damage to phi X174 RFI DNA in vitro was measured and compared with that of uncoated amosite fibres with a similar distribution of length. Asbestos bodies (5000 bodies) suspended for 30 minutes in 50 mM NaCl containing 0.5 micrograms phi...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Lund LG,Williams MG,Dodson RF,Aust AE

    更新日期:1994-03-01 00:00:00

  • Respiratory symptoms and ventilatory function in confectionery workers.

    abstract::Respiratory symptoms and ventilatory capacity were studied in a group of 288 workers (259 women and 29 men) employed in a confectionery plant. A group of workers (96 women and 31 men) not exposed to confectionery manufacture were also studied as controls. The prevalence of chronic respiratory symptoms was higher in ex...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Zuskin E,Mustajbegovic J,Schachter EN,Kern J

    更新日期:1994-07-01 00:00:00

  • Cross-validation and refinement of the Stoffenmanager as a first tier exposure assessment tool for REACH.

    abstract:OBJECTIVES:For regulatory risk assessment under REACH a tiered approach is proposed in which the first tier models should provide a conservative exposure estimate that can discriminate between scenarios which are of concern and those which are not. The Stoffenmanager is mentioned as a first tier approach in the REACH g...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Schinkel J,Fransman W,Heussen H,Kromhout H,Marquart H,Tielemans E

    更新日期:2010-02-01 00:00:00

  • Systematic review of fit note use for workers in the UK.

    abstract:OBJECTIVES:The fit note, introduced in England, Wales and Scotland in 2010, was designed to change radically the sickness certification process from advising individuals on their inability to work to advising them on what they could do if work could be adapted. Our review aimed to evaluate the following: (1) Is the 'ma...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Dorrington S,Roberts E,Mykletun A,Hatch S,Madan I,Hotopf M

    更新日期:2018-07-01 00:00:00

  • Aircraft noise around a large international airport and its impact on general health and medication use.

    abstract:AIMS:To assess the prevalence of general health status, use of sleep medication, and use of medication for cardiovascular diseases, and to study their relation to aircraft noise exposure. METHODS:These health indicators were measured by a cross-sectional survey among 11 812 respondents living within a radius of 25 km ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Franssen EA,van Wiechen CM,Nagelkerke NJ,Lebret E

    更新日期:2004-05-01 00:00:00

  • Latex allergy: a follow up study of 1040 healthcare workers.

    abstract:BACKGROUND:Natural rubber latex allergy can cause skin and respiratory symptoms The aim of this study was to evaluate the prevalence and incidence of latex related symptoms and sensitisation among a large group of healthcare workers in Trieste hospitals, followed for three years before and after the introduction of pow...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究


    authors: Filon FL,Radman G

    更新日期:2006-02-01 00:00:00

  • Validating self-reported mobile phone use in adults using a newly developed smartphone application.

    abstract:OBJECTIVE:Interpretation of epidemiological studies on health effects from mobile phone use is hindered by uncertainties in the exposure assessment. We used a newly developed smartphone application (app) to validate self-reported mobile phone use and behaviour among adults. METHODS:107 participants (mean age 41.4 year...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Goedhart G,Kromhout H,Wiart J,Vermeulen R

    更新日期:2015-11-01 00:00:00

  • Cancer incidence among women flax textile manufacturing workers in Lithuania.

    abstract:OBJECTIVE:To determine site-specific cancer incidence among women spinning-weaving and dyeing-finishing workers in the largest flax textile factory in Lithuania. METHOD:The cancer incidence of a cohort of 3447 women workers from a flax textile factory was investigated for the period 1978-2002. All subjects were employ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Kuzmickiene I,Stukonis M

    更新日期:2010-07-01 00:00:00

  • Home care aides' experiences of verbal abuse: a survey of characteristics and risk factors.

    abstract:OBJECTIVE:Violence from care recipients and family members, including both verbal and physical abuse, is a serious occupational hazard for healthcare and social assistance workers. Most workplace violence studies in this sector focus on hospitals and other institutional settings. This study examined verbal abuse in a l...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Karlsson ND,Markkanen PK,Kriebel D,Gore RJ,Galligan CJ,Sama SR,Quinn MM

    更新日期:2019-07-01 00:00:00

  • Individual exposure to particulate air pollution and its relevance to thresholds for health effects: a study of traffic wardens.

    abstract:OBJECTIVE:To investigate the differences between measurements of personal exposure to particulate air pollution and static area measurements in a group of people working close to traffic and to determine whether such differences might obscure any threshold for health effects in epidemiological studies. METHODS:Persona...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Watt M,Godden D,Cherrie J,Seaton A

    更新日期:1995-12-01 00:00:00

  • Cancer and circulatory disease risks in US radiologic technologists associated with performing procedures involving radionuclides.

    abstract:OBJECTIVES:The number of nuclear medicine procedures has increased substantially over the past several decades, with uncertain health risks to the medical workers who perform them. We estimated risks of incidence and mortality from cancer and circulatory disease associated with performing procedures involving the use o...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Kitahara CM,Linet MS,Drozdovitch V,Alexander BH,Preston DL,Simon SL,Freedman DM,Brill AB,Miller JS,Little MP,Rajaraman P,Doody MM

    更新日期:2015-11-01 00:00:00

  • Occupational exposures and risk of oesophageal cancer by histological type: a case-control study in eastern Spain.

    abstract:OBJECTIVE:To explore the relationship between occupations and specific occupational exposures and oesophageal cancer (OC) by histological type. METHODS:A multicentre hospital-based case-control study was conducted in two Mediterranean provinces of Spain. Occupational, sociodemographic and lifestyle information was col...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究


    authors: Santibañez M,Vioque J,Alguacil J,Barber X,García de la Hera M,Kauppinen T,PANESOES Study Group.

    更新日期:2008-11-01 00:00:00

  • Blood lead in pregnant women in the urban slums of Lucknow, India.

    abstract:OBJECTIVES:To determine the concentrations of blood lead (PbB) in pregnant women in the slums of Lucknow, north India. METHODS:Of the 203 designated municipal slums in Lucknow, 70 were randomly selected for study and a cohort of 500 pregnant women was enrolled. Each participant was interviewed with questions on possib...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Awasthi S,Awasthi R,Pande VK,Srivastav RC,Frumkin H

    更新日期:1996-12-01 00:00:00

  • Impact of depressive symptoms on worklife expectancy: a longitudinal study on Danish employees.

    abstract:OBJECTIVE:Depressive symptoms are associated with sickness absence, work disability and unemployment, but little is known about worklife expectancy (WLE). This study investigates the impact of depressive symptoms on the WLE of a large sample of Danish employees. METHODS:We used occupational health survey data of 11 96...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Pedersen J,Thorsen SV,Andersen MF,Hanvold TN,Schlünssen V,Bültmann U

    更新日期:2019-11-01 00:00:00

  • Glycol ethers and semen quality: a cross-sectional study among male workers in the Paris Municipality.

    abstract:OBJECTIVES:Apparent increases in human male reproductive disorders, including low sperm production, may have occurred because of increased chemical exposure. Various glycol ether-based solvents have pronounced adverse effects on sperm production and male fertility in laboratory animals. The authors investigated the eff...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Multigner L,Ben Brik E,Arnaud I,Haguenoer JM,Jouannet P,Auger J,Eustache F

    更新日期:2007-07-01 00:00:00

  • Risk of fatal industrial accidents and death from other external causes among asphalt workers.

    abstract::The hypothesis that asphalt workers are at increased risk of mortality from industrial accidents and other external causes was tested. Mortality rates for external and violent causes of death in a cohort of asphalt industry employees from seven European countries and Israel were compared to that of the general populat...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究


    authors: Burstyn I,Boffetta P,Järvholm B,Partanen T,Svane O,Langård S,Kauppinen T,Stücker I,Shaham J,Heederik D,Ahrens W,Bergdahl I,Cenée S,Hooiveld M,Randem BG,Johansen C,Ferro G,Kromhout H

    更新日期:2004-01-01 00:00:00

  • Effects of direction of rotation in continuous and discontinuous 8 hour shift systems.

    abstract:OBJECTIVES:Previous research has produced conflicting evidence on the relative merits of advancing and delaying shift systems. The current study assessed the effects of the direction of shift rotation within 8 hour systems, upon a range of measures including sleep, on shift alertness, physical health, and psychological...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Tucker P,Smith L,Macdonald I,Folkard S

    更新日期:2000-10-01 00:00:00

  • Respiratory symptoms and diseases among workers in the soft tissue producing industry.

    abstract:AIMS:To correlate the prevalence of respiratory tract symptoms and diseases with dust and fibre exposure in the soft tissue industry in Germany. METHODS:Ambient monitoring was performed for inhalable, respirable dust and fibres in seven soft tissue producing factories. In 441 workers (72 controls, 90 moderate, 279 hig...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Kraus T,Pfahlberg A,Gefeller O,Raithel HJ

    更新日期:2002-12-01 00:00:00

  • Work related musculoskeletal disorders and ergonomic stressors in the South African workforce.

    abstract:OBJECTIVES:The main objective of this study was to investigate exposure-response relations between adverse musculoskeletal outcomes and ergonomic exposure variables. METHODS:A cross sectional analytical study was conducted in 11 factories from seven sectors of manufacturing industry in South Africa. Exposure to workpl...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Schierhout GH,Meyers JE,Bridger RS

    更新日期:1995-01-01 00:00:00

  • Exposure to non-arsenic pesticides is associated with lymphoma among farmers in Spain.

    abstract:OBJECTIVES:To estimate the risk of lymphoma among farmers in Spain. METHODS:This is a multicentre case control study conducted in Spain. Cases were subjects diagnosed with lymphoma according to the World Health Organization (WHO) classification in four hospitals between 1998-2002. Hospital controls were frequency matc...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究


    authors: van Balen E,Font R,Cavallé N,Font L,Garcia-Villanueva M,Benavente Y,Brennan P,de Sanjose S

    更新日期:2006-10-01 00:00:00