Post-transplantation diabetes mellitus: evaluation of treatment strategies.


BACKGROUND:Post-transplantation diabetes mellitus (PTDM) is a serious complication after kidney transplantation, but evidence regarding long-term outcomes of treatment regimens remains scarce. AIM AND METHODS:The aim of this retrospective cohort analysis was to assess the long-term efficiency and safety of antidiabetic treatments in kidney transplant recipients (KTRs), who were diagnosed with PTDM by an oral glucose tolerance test (OGTT). RESULTS:Of 561 KTRs that were screened for PTDM at our outpatient clinic, 71 (13%) had a diabetic OGTT and were included in this study. Mean follow-up was 34.2 ± 16.1 months. Thirty-six PTDM patients (51%) received antidiabetic treatment after diagnosis with either a dipeptidyl peptidase-4 (DPP-4) inhibitor, a sulfonylurea, pioglitazone, or insulin. These patients had significantly higher fasting glucose and two-h plasma glucose (2HPG) values at baseline than those who remained without therapy. In contrast to lifestyle modification alone or sulfonylureas, DPP-4 inhibitors improved glycemic control significantly. Adverse events were generally mild and occurred at similar rates in all groups. CONCLUSION:While sulfonylureas failed to improve glycemic control, DPP-4 inhibitors appeared effective and safe for the therapy of PTDM after kidney transplantation.


Clin Transplant


Clinical transplantation


Haidinger M,Antlanger M,Kopecky C,Kovarik JJ,Säemann MD,Werzowa J




Has Abstract


2015-05-01 00:00:00












  • Access to living donor transplantation for Aboriginal recipients: a study of living donor presentation and exclusion.

    abstract::Aboriginals experience high rates of end-stage renal disease (ESRD) and are less likely to receive a kidney transplant from a living donor. We hypothesized that higher rates of hypertension and diabetes in Aboriginal communities would result in fewer potential living donors coming forward and more exclusions for medic...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Dunsmore S,Karpinski M,Young A,Storsley L

    更新日期:2011-11-01 00:00:00

  • Impact of the ratio of graft kidney volume to recipient body surface area on graft function after live donor kidney transplantation.

    abstract::Functioning nephron mass is a determinant of the graft function of kidney transplant recipients. The graft kidney volume and its weight have been reported to be surrogates of the nephron mass. To investigate the impact of the ratios of the surrogates to recipient body surface area (BSA) and body weight on the graft fu...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Lee JH,Won JH,Oh CK

    更新日期:2011-11-01 00:00:00

  • Influence of anti-rejection therapy on the timing of cytomegalovirus disease and other infections in renal transplant recipients.

    abstract::Infections are an important cause of mortality and morbidity in renal transplant recipients. To study the impact of anti-rejection therapy on the timing of infections, the records of 599 consecutive renal transplants, performed prior to 31 December 1996 at the Royal Melbourne Hospital, were reviewed. Patients were gro...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Jamil B,Nicholls KM,Becker GJ,Walker RG

    更新日期:2000-02-01 00:00:00

  • Cost-benefit analysis of a clinical pharmacist-managed medication assistance program in a renal transplant clinic.

    abstract:UNLABELLED:Medicare pays for 80% of the cost of immunosuppressant agents needed within the first 3 years of solid organ transplantation; however, many patients cannot afford the remaining 20%. Furthermore, many patients who are beyond 3 years post-transplantation and have prescription coverage cannot afford the co-paym...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Chisholm MA,Vollenweider LJ,Mulloy LL,Wynn JJ,Wade WE,DiPiro JT

    更新日期:2000-08-01 00:00:00

  • Renal transplantation offers a better survival in HCV-infected ESRD patients.

    abstract::Sezer S, Ozdemir FN, Akcay A, Arat Z, Boyacioglu S, Haberal M. Renal transplantation offers a better survival in HCV-infected ESRD patients. Clin Transplant 2004 DOI: 10.1111/j.1399-0012.2004.00252. Abstract: The presence of hepatitis C virus (HCV) infection has been found to adversely affect the morbidity and mortali...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Sezer S,Ozdemir FN,Akcay A,Arat Z,Boyacioglu S,Haberal M

    更新日期:2004-10-01 00:00:00

  • Hypercoagulable state associated with kidney-pancreas transplantation. Thromboelastogram-directed anti-coagulation and implications for future therapy.

    abstract:BACKGROUND:The clinical consequences of type 1 diabetes mellitus (IDDM) include diabetic triopathy: retinopathy, nephropathy, and neuropathy, as well as microangiopathy, accelerated atherosclerotic disease, and hypercoagulability. The etiology of the hypercoagulability is multifactorial, involving various clotting fact...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Burke GW 3rd,Ciancio G,Figueiro J,Buigas R,Olson L,Roth D,Kupin W,Miller J

    更新日期:2004-08-01 00:00:00

  • Influence of dialysis on post-transplant events.

    abstract:INTRODUCTION:We examined the effect of haemodialysis (HD) or peritoneal dialysis (PD) on acute rejection, delayed graft function (DGF), graft and patient survival after cadaveric renal transplantation. MATERIALS AND METHODS:We carried out a retrospective analysis of 325 patients (cyclosporin [CyA]-based therapy) who h...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Joseph JT,Jindal RM

    更新日期:2002-02-01 00:00:00

  • Regulatory T cells and tolerance induction.

    abstract::Transplantation tolerance is the ultimate goal of organ transplantation. Natural regulatory T cells (Treg) have been expected to reach clinical applications for tolerance induction because their initial description. More than ten yr later, Treg have started moving from experimental animal models into clinical applicat...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审


    authors: Fritzsching E,Kunz P,Maurer B,Pöschl J,Fritzsching B

    更新日期:2009-12-01 00:00:00

  • Echinocandin use in lung transplant recipients.

    abstract:BACKGROUND:Invasive fungal infections (IFI) are associated with significant morbidity and mortality in lung transplant recipients (LTRs). However, data outlining use of echinocandins in prophylaxis and therapy of LTRs are limited. METHOD:A single-center retrospective cohort study on all LTRs from January-2010 to Decem...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章


    authors: Al Jishi Y,Rotstein C,Kumar D,Humar A,Singer LG,Keshavjee S,Husain S

    更新日期:2018-12-01 00:00:00

  • Parvovirus B19 infection in a liver transplant recipient: case report and review in organ transplant recipients.

    abstract::We report an adult liver transplant recipient with parvovirus B19 infection, presenting as chronic transfusion-dependent anemia ensuing 1 month post-transplantation. Both serum and bone marrow cells were positive for parvovirus B19 DNA detected by polymerase chain reaction. The bone marrow biopsy revealed erythroid hy...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审


    authors: Chang FY,Singh N,Gayowski T,Marino IR

    更新日期:1996-06-01 00:00:00

  • The impact of intraoperative fluid management during laparoscopic donor nephrectomy on donor and recipient outcomes.

    abstract:BACKGROUND:Intraoperative fluid management during laparoscopic donor nephrectomy (LDN) may have a significant effect on donor and recipient outcomes. We sought to quantify variability in fluid management and investigate its impact on donor and recipient outcomes. METHODS:A retrospective review of patients who underwen...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Williams AM,Kumar SS,Bhatti UF,Biesterveld BE,Kathawate RG,Sung RS,Woodside KJ,Englesbe MJ,Alameddine MB,Waits SA

    更新日期:2019-06-01 00:00:00

  • Bosentan in heart transplantation candidates with severe pulmonary hypertension: efficacy, safety and outcome after transplantation.

    abstract:BACKGROUND:Increased pulmonary vascular resistance (PVR) is associated with increased right ventricular failure and mortality after heart transplantation. METHODS:In this prospective study, 22 patients considered high-risk candidates for heart transplantation because of severe pulmonary hypertension (PVR = 6 ± 2 Wood ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Perez-Villa F,Farrero M,Cardona M,Castel MA,Tatjer I,Penela D,Vallejos I

    更新日期:2013-01-01 00:00:00

  • The role of tacrolimus in adult kidney transplantation: a review.

    abstract::The use of tacrolimus (FK506) in adult kidney-transplant recipients has been the subject of a number of single- and multi-center studies. This review article focuses on those studies in which tacrolimus was used either as rescue therapy in patients who developed refractory rejection on cyclosporine (CyA)-based regimen...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审


    authors: Laskow DA,Neylan JF 3rd,Shapiro RS,Pirsch JD,Vergne-Marini PJ,Tomlanovich SJ

    更新日期:1998-12-01 00:00:00

  • Psychosocial outcome of living donors after living donor liver transplantation: a pilot study.

    abstract::In view of the scarcity of organ resources available for transplantation, living donor liver transplantation (LDLT) is gaining growing importance in the treatment of chronically terminal liver diseases. In the period between December 1999 and October 2000, 47 potential living liver donors were evaluated and 24 right h...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Walter M,Bronner E,Pascher A,Steinmüller T,Neuhaus P,Klapp BF,Danzer G

    更新日期:2002-10-01 00:00:00

  • A randomized, crossover pharmacokinetic study comparing generic tacrolimus vs. the reference formulation in subpopulations of kidney transplant patients.

    abstract::An exploratory, post hoc analysis was performed using data from a prospective, multicenter, open-label, randomized, two-period (14 d per period), two-sequence, crossover, steady-state pharmacokinetic study comparing generic tacrolimus (Sandoz) vs. reference tacrolimus in stable renal transplant patients receiving thei...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Bloom RD,Trofe-Clark J,Wiland A,Alloway RR

    更新日期:2013-11-01 00:00:00

  • Methamphetamine use in deceased kidney donors impairs one-yr graft function.

    abstract:BACKGROUND:Methamphetamine (MA) has cumulative deleterious effects on multiple organ systems. A history of MA exposure in kidney donors may affect adversely graft function in recipients. METHODS:Between September 2000 and March 2004, all deceased kidney donors were identified from the local registry (97 donors). Twent...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Inouye DS,Kickertz K,Wong LL

    更新日期:2007-09-01 00:00:00

  • Blood glutathione as a marker of cardiac allograft vasculopathy in heart transplant recipients.

    abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) limits survival after heart transplantation (HTx). Between immunologic and non-immunologic factors, reactive oxygen species generation has been proposed as pathogenetic mechanism. This study was aimed at evaluating redox status in HTx recipients and verifying whether it c...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: De Chiara B,Bigi R,Campolo J,Parolini M,Turazza F,Masciocco G,Frigerio M,Fiorentini C,Parodi O

    更新日期:2005-06-01 00:00:00

  • GORD symptoms in lung transplantation: how efficient is the reflux symptom index questionnaire compared to the esophageal impedance test?

    abstract:OBJECTIVE:As Gastroesophageal reflux disease (GORD) affects long-term survival in lung transplant recipients, the aim of this observational prospective study was to analyze the efficacy of The Reflux Symptom Index Questionnaire (RSI) compared to the esophageal impedance test. METHODS:Both esophageal impedance studies ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Soresi S,Zeriouh M,Sabashnikov A,Mc Dermott G,Weymann A,Wippermann J,Wahlers T,Reed A,Carby M,Simon AR,Popov AF

    更新日期:2016-01-01 00:00:00

  • Multiple renal arteries do not pose an impediment to the routine use of laparoscopic donor nephrectomy.

    abstract:UNLABELLED:Since the first description by Ratner and collegues in 1996, laparoscopic live-donor nephrectomy is gaining wide acceptance in an attempt to minimize the donor morbidity, length of hospital stay and length of time to return to work. It is unknown whether multiple renal arteries pose additional problems with ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Johnston T,Reddy K,Mastrangelo M,Lucas B,Ranjan D

    更新日期:2001-01-01 00:00:00

  • Living-related liver transplantation in adult recipients: a hypothesis.

    abstract::Living-related liver transplantation (LRLT) in pediatric recipients has been successful with 90% 1-year survival (1, 2). LRLT in adults is yet to succeed. We hypothesize a management strategy based on the donor graft weight-to-recipient body weight ratio (GRBWR) and the Redox Tolerance Index (RTI) (3). Favorable recip...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Habib N,Tanaka K

    更新日期:1995-02-01 00:00:00

  • A call to action: Feasible strategies to reduce the discard of transplantable kidneys in the United States.

    abstract::Changes to the United States kidney allocation system targeted at reducing organ discard have failed to improve organ utilization. High Kidney Donor Profile Index kidneys continue to be discarded at high rates as a result of the regulatory and financial barriers to widespread utilization of these organs. However, ther...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Stewart ZA,Shah SA,Formica RN,Kandaswamy R,Paramesh AS,Friedman J,Squires R,Cooper M,Axelrod DA

    更新日期:2020-09-01 00:00:00

  • High-dose busulfan and the risk of pulmonary mortality after autologous stem cell transplant.

    abstract::The non-relapse mortality of autologous stem cell transplant is low enough that the procedure has been extended to older patients with non-Hodgkin's lymphoma. We treated 537 non-Hodgkin's lymphoma patients with high-dose chemotherapy consisting of busulfan, cyclophosphamide, and etoposide followed by autologous stem c...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Kalaycio M,Pohlman B,Kuczkowski E,Rybicki L,Andresen S,Sobecks R,Bolwell B

    更新日期:2006-11-01 00:00:00

  • Endothelin-1 plasma levels and hypertension in cyclosporine-treated renal transplant patients.

    abstract::Experimental models suggest that endothelin-1 (ET-1) has a significant role in the pathogenesis of cyclosporin A (CyA)-induced hypertension. However, its serum levels evaluated in different studies, including patients who received solid organ transplants, exhibited controversial results. Our study population consisted...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章


    authors: Cauduro RL,Costa C,Lhulier F,Garcia RG,Cabral RD,Gonçalves LF,Manfro RC

    更新日期:2005-08-01 00:00:00

  • Can the Timed Up & Go Test and Montreal Cognitive Assessment predict outcomes in patients waitlisted for renal transplant?

    abstract:PURPOSE:Frail patients who undergo renal transplantation (RT) have more complications; however, little is known if these patients can sustain the wait to RT. We used the Timed Up and Go Test (TUGT) and Montreal Cognitive Assessment (MoCA) to determine outcomes of RT candidates. METHODS:In this retrospective study, 526...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Bozhilov K,Vo KB,Wong LL

    更新日期:2020-11-20 00:00:00

  • Renal allograft outcomes following early corticosteroid withdrawal in Hispanic transplant recipients.

    abstract:BACKGROUND:Renal transplant outcomes in Hispanics have been conflicting regarding acute rejection (AR) and allograft survival. Additionally, the feasibility of early corticosteroid withdrawal (ECW) regimens among Hispanics has not been adequately addressed. The purpose of this study is to report outcomes following ECW ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Afaneh C,Cheng E,Aull MJ,Watkins AC,Kim J,Leeser DB,Kapur S

    更新日期:2013-11-01 00:00:00

  • Neutrophil gelatinase-associated lipocalin associated with irreversibility of pre-liver transplant kidney dysfunction.

    abstract::Kidney outcomes in early post-liver transplantation (LT) are crucial for long-term prognosis, but difficult to predict. Among 203 adult LT patients, we studied the value of plasma neutrophil gelatinase-associated lipocalin (NGAL) measured pre-LT for predicting acute kidney injury (AKI), kidney-replacement therapy with...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Aberg F,Lempinen M,Hollmén M,Nordin A,Mäkisalo H,Isoniemi H

    更新日期:2014-08-01 00:00:00

  • Current principles and practice in autologous intraportal islet transplantation: a meta-analysis of the technical considerations.

    abstract:OBJECTIVES:Autologous islet transplantation (IAT) following pancreatectomy is now a recognized, albeit highly specialized procedure carried out in a small number of centers worldwide. Current clinical principles and best practice with emphasis on examining the technical aspects of surgery in centers with significant IA...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,meta分析,评审


    authors: Kumar R,Chung WY,Dennison AR,Garcea G

    更新日期:2016-04-01 00:00:00

  • Clinical analysis of living donor liver transplantation in patients with portal vein thrombosis.

    abstract::The aim of this study was to improve outcomes in living donor liver transplantation (LDLT) patients with portal vein thrombosis (PVT). Of 246 adult patients who underwent LDLT with a right lobe graft between January 2000 and May 2007, PVT was diagnosed in 50 patients (20.3%), who were further subdivided into partial (...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Kim SJ,Kim DG,Park JH,Moon IS,Lee MD,Kim JI,Yoon YC,Yoo YK

    更新日期:2011-01-01 00:00:00

  • Higher dose of CD34+ peripheral blood stem cells is associated with better survival after haploidentical stem cell transplantation in pediatric patients.

    abstract::Haploidentical stem cell transplantation (SCT) is increasingly used to treat pediatric patients with malignant or nonmalignant hematological disorders. The CD34+ dose of bone marrow or peripheral blood stem cells (PBSCs) has been shown to be an important determinant of the transplant outcome in adults under various pr...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Chen Y,Xu LP,Liu KY,Chen H,Chen YH,Zhang XH,Wang Y,Wang FR,Han W,Wang JZ,Yan CH,Huang XJ

    更新日期:2017-02-01 00:00:00

  • Care of international living kidney donor candidates in the United States: A survey of contemporary experience, practice, and challenges.

    abstract::The evaluation and care of non-US citizen, non-US residents who wish to come to the United States to serve as international living kidney donors (ILKDs) can pose unique challenges. We surveyed US transplant programs to better understand practices related to ILKD care. We distributed the survey by email and professiona...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Lentine KL,Motter JD,Henderson ML,Hays RE,Shukhman E,Hunt J,Al Ammary F,Kumar V,LaPointe Rudow D,Van Pilsum Rasmussen SE,Nishio-Lucar AG,Schaefer HM,Cooper M,Mandelbrot DA

    更新日期:2020-11-01 00:00:00