Management of Onychomycosis in Canada in 2014.


BACKGROUND:Onychomycosis has several clinical presentations and is caused by various infectious organisms. OBJECTIVE:To provide guidance for selection of appropriate treatment. METHODS:The literature on onychomycosis management was reviewed to generate an evidence-based decision tree. RESULTS AND CONCLUSION:Several options are available: terbinafine, itraconazole, fluconazole, ciclopirox 8% nail lacquer, efinaconazole 10% nail solution, and laser therapy. Further studies on lasers are needed before use can be recommended. Nondermatophyte molds or mixed infection can be managed with terbinafine or itraconazole with or without topicals. Itraconazole, fluconazole, and efinaconazole can be used for Candida infection. For dermatophytes, topicals can be considered for mild to moderate onychomycosis. For moderate to severe cases, any oral monotherapy can be used; however, we suggest terbinafine if there is a possibility of a drug interaction. These recommendations can be applied for all ages, immune function, or metabolic status, but proper monitoring and contraindications should be taken into consideration.


J Cutan Med Surg


Gupta AK,Paquet M




Has Abstract


2015-05-01 00:00:00














  • Genital Ulcer Disease: A Review of Pathogenesis and Clinical Features.

    abstract::Genital ulcer disease can be caused by a wide variety of sources. Most commonly, genital ulcer disease is grouped into infectious and noninfectious causes. HSV, syphilis, lymphogranuloma venereum, and chancroid represent some common infectious ulcers. Noninfectious causes on the other hand can be inflammatory, noninfl...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审


    authors: Maliyar K,Mufti A,Syed M,Selk A,Dutil M,Bunce PE,Alavi A

    更新日期:2019-11-01 00:00:00

  • Canadian hand dermatitis management guidelines.

    abstract:BACKGROUND:Hand dermatitis (HD) is one of the most common skin conditions; however, it is not a homogeneous disease entity. The severity of HD may range from very mild cases to severe chronic forms, which may result in prolonged disability and, occasionally, refractory HD. Chronic hand dermatitis (CHD) is associated wi...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审


    authors: Lynde C,Guenther L,Diepgen TL,Sasseville D,Poulin Y,Gulliver W,Agner T,Barber K,Bissonnette R,Ho V,Shear NH,Toole J

    更新日期:2010-11-01 00:00:00

  • Schnitzler Syndrome Without a Monoclonal Gammopathy: A Case Report.

    abstract:BACKGROUND:Schnitzler syndrome (SS) is a rare autoinflammatory disorder characterized by a recurrent urticarial rash and a monoclonal immunoglobulin M gammopathy, as well as 2 of the following minor criteria: recurrent fever (>38°C), objective signs of abnormal bone remodeling, elevated C-reactive protein level or leuk...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Urbanski M,Holfeld K,Milne A,Abbas M

    更新日期:2016-11-01 00:00:00

  • Primary localized cutaneous amyloidosis in association with papillary thyroid carcinoma.

    abstract:BACKGROUND:Lichen amyloidosis, a type of primary localized cutaneous amyloidosis, is characterized by pruritic brown or grayish pigmented papules. OBJECTIVE:We report a case of lichen amyloidosis in which the skin lesion consisted of asymptomatic salmon-pink-colored papules on the back of the neck to the upper back. T...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Sangen Y,Kawada A,Maeda A,Aragane Y,Tezuka T

    更新日期:2002-07-01 00:00:00

  • Mosaic Neurofibromatosis Type 1 in Children: A Single-Institution Experience.

    abstract:BACKGROUND:Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder caused by loss-of-function mutation in the NF1 gene. Segmental or mosaic NF1 (MNF) is an uncommon presentation of the NF1 result of postzygotic mutations that present with subtle localised clinical findings. OBJECTIVES:Our study's objectives were t...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Lara-Corrales I,Moazzami M,García-Romero MT,Pope E,Parkin P,Shugar A,Kannu P

    更新日期:2017-09-01 00:00:00

  • Naftifine: a review.

    abstract:BACKGROUND:Naftifine is a topical allylamine that is effective and safe in the management of superficial dermatomycoses. Naftifine is fungicidal in vitro against a broad spectrum of dermatophyte fungi and provides good activity against Candida and Aspergillus species. It is also effective against gram-negative and gram...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审


    authors: Gupta AK,Ryder JE,Cooper EA

    更新日期:2008-03-01 00:00:00

  • Axillary granular parakeratosis.

    abstract:BACKGROUND:Granular parakeratosis is a hyperkeratotic eruption of unknown etiology that occurs in the axilla and other intertriginous areas. The histologic features are unique for the retention of keratohyalin granules in the stratum corneum. OBJECTIVE:The aim of the article is to review the clinical manifestations an...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审


    authors: English JC 3rd,Derdeyn AS,Wilson WM,Patterson JW

    更新日期:2003-07-01 00:00:00

  • The Real-Life Effectiveness and Safety of Omalizumab Updosing in Patients With Chronic Spontaneous Urticaria.

    abstract:BACKGROUND:Omalizumab is a third-line treatment for chronic spontaneous urticaria (CSU). Studies investigating the use of higher doses of omalizumab in patients unresponsive to regular doses are limited. OBJECTIVES:This study aims to investigate the effectiveness and safety of omalizumab 450 mg in CSU. METHODS:A retr...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Salman A,Comert E

    更新日期:2019-09-01 00:00:00

  • Diseases of abnormal sensitivity to cold in children on psychostimulant drugs.

    abstract:BACKGROUND:Oral psychostimulant (PS) drugs, the pharmacologic treatment of choice for attention-deficit/hyperactivity disorder (ADHD), have been associated with diseases of abnormal sensitivity to cold (DASC) such as Raynaud phenomenon and acrocyanosis. OBJECTIVES:In a cohort of pediatric patients with DASC, we sought...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Coulombe J,Powell J,Hatami A,McCuaig C,Renet S,Marcoux D

    更新日期:2015-03-01 00:00:00

  • Lymphangiosarcoma of the scalp.

    abstract:BACKGROUND:Lymphangiosarcoma is a rare, aggressive malignancy that originates from the endothelial cells lining lymphatic vessels and carries an extremely poor prognosis. Its clinical and histologic features are often indistinguishable from angiosarcoma. OBJECTIVE:We sought to better characterize the clinical and hist...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Mamelak AJ,Collie MR,Kroll R,Hanson ML,Harris HM

    更新日期:2014-03-01 00:00:00

  • Paraneoplastic pemphigus: a refractory autoimmune mucocutaneous disease.

    abstract:BACKGROUND AND OBJECTIVE:We report on a 42-year-old man with Stage IIA non-Hodgkin's lymphoma who developed a severe mucocutaneous blistering eruption. His diagnosis, paraneoplastic pemphigus, was based on clinical, histological, and immunofluorescence findings and confirmed by immunoprecipitation. Despite maximal ther...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Ng PP,Rencic A,Nousari HC

    更新日期:2002-09-01 00:00:00

  • Should we consider hypohidrotic ectodermal dysplasia as a possible risk factor for malignant melanoma?

    abstract:BACKGROUND:Hypohidrotic ectodermal dysplasia (HED) is a rare multisystem disorder that typically affects hair, teeth, nails, and sweat glands in combination with abnormalities of ectodermal originated tissues. OBJECTIVE:To raise the issue of whether heightened awareness is required in the follow-up of pigmented lesion...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Gregoriou S,Rigopoulos D,Vergou T,Korfitis C,Menegakis G,Kontochristopoulos G

    更新日期:2007-09-01 00:00:00

  • Antiangiogenic properties of a novel shark cartilage extract: potential role in the treatment of psoriasis.

    abstract:BACKGROUND:A number of inflammatory and immune diseases are associated with vascular changes. Psoriasis, as an example, is a common inflammatory skin disease with dilation of capillaries as an early histological change. In more developed psoriatic lesions there is proliferation of blood vessels and neovascularization. ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Dupont E,Savard PE,Jourdain C,Juneau C,Thibodeau A,Ross N,Marenus K,Maes DH,Pelletier G,Sauder DN

    更新日期:1998-01-01 00:00:00

  • Updated review of the pathogenesis and management of Merkel cell carcinoma.

    abstract:BACKGROUND:Merkel cell carcinoma is a rare, aggressive, malignant cutaneous tumor of the elderly or immunosuppressed individuals that usually appears on sun-exposed areas of the body. Its pathogenesis is still debated, and, currently, no standardized treatment exists. OBJECTIVE:To provide a current updated review of t...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审


    authors: Zampetti A,Feliciani C,Massi G,Tulli A

    更新日期:2010-03-01 00:00:00

  • Strongyloidiasis presenting as larva currens 38 years after presumed exposure.

    abstract:BACKGROUND:We present a case of strongyloidiasis presenting as larva currens 38 years after potential exposure in a country with what is typically thought of as low epidemiologic risk. CONCLUSION:This case highlights several important features of strongyloidiasis, including its varied epidemiology, long incubation per...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Showler A,Boggild AK

    更新日期:2012-11-01 00:00:00

  • Antepartum intravenous immunoglobulin therapy in refractory pemphigoid gestationis: case report and literature review.

    abstract:BACKGROUND:pemphigoid gestationis is an autoimmune blistering disease affecting pregnant women. Treatment often consists of topical corticosteroids, oral antihistamines, and oral prednisone followed by immunosuppressants. Refractory cases in antepartum patients present a particular therapeutic challenge as the majority...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审


    authors: Doiron P,Pratt M

    更新日期:2010-07-01 00:00:00

  • Effect of retinoic acid on apoptosis and DNA repair in human keratinocytes after UVB irradiation.

    abstract:BACKGROUND:Skin cancer is extremely common. Epidemiological studies indicated that ultraviolet radiation (UV) is the primary cause for skin cancers, and that retinoic acid (RA) is able to inhibit this UV-induced skin carcinogenesis; however, the molecular mechanism of the anti-UV action of RA is unclear. OBJECTIVE:The...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Li G,Bush JA,Ho VC

    更新日期:2000-01-01 00:00:00

  • Needs survey of Canadian rosacea patients.

    abstract:BACKGROUND:In 1995, a Rosacea Awareness Program (RAP) was initiated in Canada to make available educational resources for physicians and rosacea patients. Material is in French or English, and is accessible though physician offices and by toll-free telephone. Information was communicated to the public via noncommercial...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Shear NH,Levine C

    更新日期:1999-04-01 00:00:00

  • Pemphigus vegetans associated with intranasal cocaine abuse.

    abstract:BACKGROUND:Pemphigus vegetans is a rare variant of pemphigus vulgaris, comprising 1 to 2% of all pemphigus cases. Exposures to oral agents such as captopril and penicillamine and, less commonly, physical or chemical factors have been implicated in the development of pemphigus. METHODS:We report a 42-year-old white mal...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Ngo JT,Trotter MJ,Robertson LH

    更新日期:2012-09-01 00:00:00

  • Public Engagement with Dermatology Contents on Facebook.

    abstract:BACKGROUND:The gtring presence of dermatology platforms on Facebook has been acknowledged; however, little is known about the extent to which different types of content influence the level of engagement with online users. OBJECTIVE:To assess the level of public engagement with different types of content posted on Face...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Kim WB,Marinas JE,Vender RB

    更新日期:2015-05-01 00:00:00

  • Giant Juvenile Xanthogranuloma: Case Report, Literature Review, and Algorithm for Classification.

    abstract::Juvenile xanthogranuloma (JXG) is a member of the non-Langerhans cell group of proliferative disorders of mononuclear phagocytes. JXG is a benign tumour of histiocytic cells. Classic JXG is divided into 2 main clinical subtypes: dome-shaped papules (<0.5 cm) and single/multiple nodules (<2.0 cm). A rare variant is ref...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审


    authors: Ladha MA,Haber RM

    更新日期:2018-09-01 00:00:00

  • Wound healing and chronic wounds.

    abstract::A renaissance is taking place in the field of wound healing. Interest in wounds has probably never been so great, and a number of key therapeutic advances in the last 2 or 3 years are only an indication of more progress to come. In large part, we are benefitting from decades of basic research that has provided the kno...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审


    authors: Falanga V

    更新日期:1998-12-01 00:00:00

  • Erythema multiforme major associated with CMV infection in an immunocompetent patient.

    abstract:BACKGROUND:Cytomegalovirus (CMV) infection usually remains asymptomatic in immunocompetent adults, and few cases of complicated disease in nonimmunosuppressed patients have been reported. Erythema multiforme (EM), an acute and self-limiting skin eruption characterized by a typical targetoid lesion that may also affect ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Vitiello M,Echeverria B,Elgart G,Kerdel F

    更新日期:2011-03-01 00:00:00

  • Clinical Pearls: Leprosy Reactions.

    abstract::Leprosy reactions are acute inflammatory episodes that occur in the setting of Mycobacterium leprae infection. Precipitants of reactions can be pharmacologic and nonpharmacologic. Both type 1 and type 2 reactions typically occur before and during leprosy treatment but may also occur after treatment has been completed....

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Wu J,Boggild AK

    更新日期:2016-09-01 00:00:00

  • Treatment of Linear Scleroderma (en Coup de Sabre) With Dermal Fat Grafting.

    abstract:BACKGROUND:Linear scleroderma, also known as "en coup de sabre," is a subtype of localized scleroderma that warrants aesthetic correction because it appears on the forehead region in children. OBJECTIVE:To report dermal fat grafting as a novel and effective surgical treatment option in linear scleroderma. METHODS:Und...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Barin EZ,Cinal H,Cakmak MA,Tan O

    更新日期:2016-05-01 00:00:00

  • What's in a name? Comments on the dermatological dictionary by Ledier, Rosenblum, and Carter.

    abstract:BACKGROUND:Any scientific discipline needs a sharply defined set of words for exact and reproducible communication. Surprisingly this has never been a strong point in dermatological science, especially as regards the living gross pathology of skin disease. OBJECTIVE:This article briefly reviews the four editions of a ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Jackson R

    更新日期:2001-11-01 00:00:00

  • Effective treatment of chronic hand dermatitis with 36 continuous months of alitretinoin administration: report of three cases.

    abstract:BACKGROUND:Moderate to severe chronic hand dermatitis (CHD) is not well controlled by current medical strategies; however, recent studies have shown significant improvement in patients treated with up to 6 months of oral alitretinoin (9-cis-retinoic acid). The results of longer-term continuous treatment are lacking. O...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Gulliver WP,Baker KA

    更新日期:2012-07-01 00:00:00

  • The remittive effects of alefacept.

    abstract::The duration of response to treatment with alefacept has been assessed in patients with moderate to severe chronic plaque psoriasis who responded to alefacept therapy in phase 2 and phase 3 clinical studies. In a phase 2 trial, duration of response was based on time to retreatment with alefacept. In two phase 3 studie...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审


    authors: Krueger GG

    更新日期:2004-12-01 00:00:00

  • Mycobacterium marinum with associated bursitis.

    abstract:BACKGROUND:Mycobacterium marinum infections have been reported for over 50 years, mostly in association with trauma in the setting of water exposure. OBJECTIVE:The differential diagnosis for nodules in a sporotrichoid distribution with simultaneous bursitis is discussed. Mycobacterium marinum treatment regimens for sk...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Saadatmand B,Poulton JK,Kauffman CL

    更新日期:1999-04-01 00:00:00

  • Dermatologic manifestations of Sjögren syndrome.

    abstract:BACKGROUND:Sjögren syndrome (SS) is a chronic autoimmune inflammatory disease that involves primarily the exocrine glands, resulting in their functional impairment. SS typically presents as dry eyes (xerophthalmia) and dry mouth (xerostomia). This process can manifest either as the independent phenomenon of primary SS ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审


    authors: Kittridge A,Routhouska SB,Korman NJ

    更新日期:2011-01-01 00:00:00