DNA flow cytometry and morphometry as prognostic indicators in advanced ovarian cancer: a step forward in predicting the clinical outcome.


:In 74 patients with advanced ovarian cancer, the value of DNA flow cytometry and morphometry was evaluated and compared with histological grading and clinical outcome. By means of both DNA flow cytometry and morphometry a clear distinction was found between a favorable group of 15 patients, with a median survival of more than 60 months, and the remaining patients, of whom the majority died during the same follow-up period. The levels of significance for DNA flow cytometry (P = 0.0002) and morphometry (P = 0.0001) with respect to survival of the favorable and unfavorable groups of patients were higher than for histological grading (P = 0.02). In a multivariate analysis it was demonstrated that morphometry proved to be the factor of most relevance for survival, although the effect of DNA flow cytometry was almost as good. Data such as presence of ascites, the size of the residual tumor mass, choice of chemotherapy, FIGO stage, and histological grade were not of additional prognostic relevance in this analysis. It is concluded that both morphometry and DNA flow cytometry are a step forward in identifying favorable and unfavorable groups of patients with advanced ovarian cancer. For the daily practice of management of ovarian cancer patients, morphometry may be an attractive support of visual grading.


Gynecol Oncol


Gynecologic oncology


Rodenburg CJ,Cornelisse CJ,Hermans J,Fleuren GJ




Has Abstract


1988-02-01 00:00:00












  • Usefulness of combining testing for p16 protein and human papillomavirus (HPV) in cervical carcinoma screening.

    abstract:OBJECTIVE:To evaluate the value of the combination of p16 and HPV detection in the screening for cervical cancer. METHODS:186 patients with previous abnormal cervical lesion were studied. After colposcopic examination, two conventional Pap slides were prepared: the first was Papanicolaou-stained and examined by cytolo...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ekalaksananan T,Pientong C,Sriamporn S,Kongyingyoes B,Pengsa P,Kleebkaow P,Kritpetcharat O,Parkin DM

    更新日期:2006-10-01 00:00:00

  • Risk factors for prolonged hospitalization after gynecologic laparoscopic surgery.

    abstract:OBJECTIVE:To determine perioperative risk factors for prolonged hospitalization after gynecologic laparoscopic surgery. METHODS:Data on patients who underwent gynecologic laparoscopic surgery at a single academic institution from January 2000 to January 2009 were evaluated. Patient demographics, clinical history, intr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zand B,Frumovitz M,Jofre MF,Nick AM,Dos Reis R,Munsell MF,Sangi-Haghpeykar H,Levenback C,Soliman PT,Schmeler KM,Ramirez PT

    更新日期:2012-09-01 00:00:00

  • Single-dose actinomycin D in the treatment of postmolar trophoblastic disease.

    abstract::From 1973 to 1982 single-dose (0.04 mg/kg or 1.25 mg/m2), biweekly actinomycin D was used to treat 28 women with postmolar, good-prognosis trophoblastic disease. Among the 17 patients fully evaluable for response to treatment 12 were nonmetastatic (NMTD) and 5 had lung metastases (MTD). Nine NMTD patients and 5 MTD pa...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Schlaerth JB,Morrow CP,Nalick RH,Gaddis O Jr

    更新日期:1984-09-01 00:00:00

  • Paget's disease of the vulva: Diagnosis and follow-up key to management; a retrospective study of 50 cases from Queensland.

    abstract:OBJECTIVE:To review the clinical features, diagnosis, management, and outcomes for the 50 cases of Paget's disease (PD) of the vulva referred to Queensland Centre for Gynaecological Cancer between 1986 and 2009. METHODS:Vulvar PD cases from QCGC were reviewed and analyzed using the computer software Statistical Packag...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Jones IS,Crandon A,Sanday K

    更新日期:2011-07-01 00:00:00

  • Impact of p53 immunostaining in predicting advanced or recurrent placental site trophoblastic tumors: a study of 12 cases.

    abstract:OBJECTIVES:To identify an indicator that can predict tumor cell spread beyond the uterine corpus. METHODS:We studied clinicopathology and immunohistochemistry of 12 cases of PSTT. Two cases of epithelioid trophoblastic tumor (ETT) were included as reference cases. For immunohistochemistry, antibodies against Ki-67, p5...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Nagai Y,Kamoi S,Matsuoka T,Hata A,Jobo T,Ogasawara T,Aoki Y,Ohira S,Okamoto T,Nakamoto T,Kanda K,Matsui H

    更新日期:2007-09-01 00:00:00

  • Phase II trial of doxorubicin, 5-fluorouracil, etoposide, and cisplatin in advanced or recurrent endometrial carcinoma.

    abstract::We have previously reported an overall response rate of 41% and a median survival duration of 14 months in a series of 49 patients with metastatic or recurrent endometrial carcinoma treated by a combination of etoposide, 5-fluorouracil, and cisplatin. In order to increase response rate and survival duration, doxorubic...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Pierga JY,Diéras V,Beuzeboc P,Dorval T,Palangié T,Jouve M,Scholl SM,Garcia-Giralt E,Pouillart P

    更新日期:1997-08-01 00:00:00

  • Metastasis from a stage IB cervical adenocarcinoma in a transposed ovary: a case report and review of the literature.

    abstract::Adenocarcinoma originating in the endocervix may remain occult for many years. This may result in an extension to the uterine isthmus and corpus, with subsequent dissemination along the pathways of spread of uterine carcinoma, including metastasis to the ovaries. The patient described in this report had a bulky stage ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Parham G,Heppard MC,DiSaia PJ

    更新日期:1994-12-01 00:00:00

  • A phase II trial of docetaxel and bevacizumab in recurrent ovarian cancer within 12 months of prior platinum-based chemotherapy.

    abstract:OBJECTIVES:The efficacy and safety of bevacizumab and docetaxel were evaluated in women who developed recurrent epithelial ovarian, fallopian, or peritoneal cancer within 12 months of platinum-based therapy. METHODS:Patients received docetaxel (40 mg/m(2)) on days 1 and 8 and bevacizumab (15 mg/kg) on day 1 of a 21-da...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Wenham RM,Lapolla J,Lin HY,Apte SM,Lancaster JM,Judson PL,Gonzalez-Bosquet J,Herschberger A,Havrilesky LJ,Secord AA

    更新日期:2013-07-01 00:00:00

  • The prognostic significance of preoperative leukocytosis in epithelial ovarian carcinoma: a retrospective cohort study.

    abstract:OBJECTIVE:Preoperative leukocytosis is known to be a negative prognostic factor for several gynecologic malignancies, but its relationship with epithelial ovarian carcinoma (EOC) is unknown. We sought to evaluate the prognostic implications of preoperative leukocytosis for women with EOC. METHODS:We retrospectively re...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: So KA,Hong JH,Jin HM,Kim JW,Song JY,Lee JK,Lee NW

    更新日期:2014-03-01 00:00:00

  • Correlation between LRIG1 and LRIG2 expressions and expression of 11 tumor markers, with special reference to tumor suppressors, in CIN and normal cervical epithelium.

    abstract:OBJECTIVE:Novel biological markers LRIG1 and LRIG2 have been associated with favorable as well as poor prognosis, respectively, in different cancer types, including cervical cancer. The aim of this study was to investigate possible interactions between these proteins and other tumor markers, and as diagnostic adjuncts ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lindström AK,Asplund A,Hellberg D

    更新日期:2011-08-01 00:00:00

  • Prognostic significance of hysteroscopic imaging in endometrioid endometrial adenocarcinoma.

    abstract:OBJECTIVE:The aim of this study was to relate hysteroscopic features of endometrioid endometrial adenocarcinoma to stage, grade and overall survival. METHODS:Sixty women with endometrioid adenocarcinoma underwent laparotomy and staging according to current FIGO classification. Before surgery hysteroscopy was performed...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Garuti G,De Giorgi O,Sambruni I,Cellani F,Luerti M

    更新日期:2001-06-01 00:00:00

  • HLA-DQB1 and cervical cancer in Venezuelan women.

    abstract:BACKGROUND:Cervical cancer represents a major health problem in Venezuela as well as in other Latin American countries. High-risk human papillomavirus (HR-HPV) infection is known as the major risk factor of cervical cancer. However, whether or not a HR-HPV-infected woman progresses to cervical cancer may depend on the ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Dao DD,Sierra-Torres CH,Robazetti SC,de Gomez MN,König R,Lema C,Lester LJ,Au WW,Tyring SK

    更新日期:2005-02-01 00:00:00

  • Early invasive carcinoma of the cervix.

    abstract::Ninety-two patients with early invasive carcinoma of the cervix (5 mm or less) treated between July 1977 and June 1990 are reviewed. Eighty patients had squamous cell carcinomas and 12 had adenocarcinomas. The diagnosis was established by conization in 77 of 92 (83.6%) patients. Thirty-six patients (39%) had a depth o...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Jones WB,Mercer GO,Lewis JL Jr,Rubin SC,Hoskins WJ

    更新日期:1993-10-01 00:00:00

  • Laparoscopic hand-assisted Miami Pouch after pelvic exenteration in 10 steps.

    abstract:BACKGROUND:Improvements in surgical technique of pelvic exenteration have mainly occurred in the reconstructive phase of the procedure. Quality of life seems to be improved when performing continent rather than non-continent urinary diversion [1]. Unfortunately, Miami continent urinary pouch is a surgical technique not...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Angeles MA,Martínez-Gómez C,Martinez A,Ferron G

    更新日期:2018-08-01 00:00:00

  • Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted?

    abstract:OBJECTIVE:Given the paucity of data regarding the patterns of metastasis from ovarian sex cord-stromal tumors (SCSTs), we sought to determine the risk of lymph node metastasis in patients with SCSTs. METHODS:A retrospective chart review was performed after clinical and pathology databases were queried for ovarian SCST...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Brown J,Sood AK,Deavers MT,Milojevic L,Gershenson DM

    更新日期:2009-04-01 00:00:00

  • 10-Gy single-fraction pelvic irradiation for palliation and life prolongation in patients with cancer of the cervix and corpus uteri.

    abstract:OBJECTIVE:The goal of this study was to evaluate the effects of single fractions of 10 Gy pelvic irradiation for palliation and life prolongation in patients with cancer of the uterine cervix or corpus. METHODS:A retrospective analysis was performed on 37 cervical cancer and 27 corpus cancer patients treated in the pe...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Onsrud M,Hagen B,Strickert T

    更新日期:2001-07-01 00:00:00

  • Assessment of inhibin and p53 in granulosa cell tumors of the ovary.

    abstract:OBJECTIVE:The goal of this work was to determine the cellular content of inhibin and p53 in granulosa cell tumors (GCTs). METHODS:Clinical records of 47 patients (mean age, 54 years; range, 20-85 years) presenting with GCT surgically managed at our institution were abstracted. International Federation of Gynecology st...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Gebhart JB,Roche PC,Keeney GL,Lesnick TG,Podratz KC

    更新日期:2000-05-01 00:00:00

  • The morbidity and utility of periaortic radiotherapy in cervical carcinoma.

    abstract::From 1971 through 1981, 81 women received 4350 to 5075 rad to the periaortic lymph nodes as part of their primary management for carcinoma of the uterine cervix. While two patients developed chronic small bowel damage, only one required surgical intervention. Five-year disease-free survival was 40%. Approximately one-...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Potish R,Adcock L,Jones T Jr,Levitt S,Prem K,Savage J,Twiggs L

    更新日期:1983-02-01 00:00:00

  • Methylation in host and viral genes as marker of aggressiveness in cervical lesions: Analysis in 543 unscreened women.

    abstract:OBJECTIVE:The present study aimed to evaluate the association between altered methylation and histologically confirmed high grade cervical intraepithelial neoplasia (hgCIN). METHODS:Methylation levels in selected host (CADM1, MAL, DAPK1) and HPV (L1_I, L1_II, L2) genes were measured by pyrosequencing in DNA samples ob...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fiano V,Trevisan M,Fasanelli F,Grasso C,Marabese F,da Graça Bicalho M,de Carvalho NS,Maestri CA,Merletti F,Sacerdote C,De Marco L,Gillio-Tos A

    更新日期:2018-11-01 00:00:00

  • Metastatic cervical carcinoma to the breast.

    abstract::Metastatic disease to the breast is often an unexpected diagnosis in a female who presents with a breast mass. The most important factor suggesting the appropriate diagnosis is a history of cancer. Correlation of mammographic and ultrasonographic findings may also raise the possibility of a metastatic mass. A well-def...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Younathan CM,Steinbach BG,DeBose CD

    更新日期:1992-05-01 00:00:00

  • Improved therapeutic index of lower dose topotecan chemotherapy in recurrent ovarian cancer.

    abstract:OBJECTIVE:Topotecan (1.5 mg/m(2)) administered daily for 5 consecutive days of a 21-day cycle is an established chemotherapeutic regimen in recurrent ovarian cancer. However, noncumulative myelosuppression has limited its use by many clinicians. We sought to determine whether a lower dose of topotecan could provide com...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rodriguez M,Rose PG

    更新日期:2001-11-01 00:00:00

  • Invasive adenocarcinoma of the cervix following LLETZ (large loop excision of the transformation zone) for adenocarcinoma in situ.

    abstract::Adenocarcinoma in situ (AIS) of the cervix is a controversial entity which is being encountered with increasing frequency. Current critical issues in its management are the safety of uterine preservation in younger patients and the use of LLETZ conization. A 28-year-old patient was diagnosed with AIS and managed with ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kennedy AW,elTabbakh GH,Biscotti CV,Wirth S

    更新日期:1995-08-01 00:00:00

  • A population-based case-control study of genetic variation in cytokine genes associated with risk of cervical and vulvar cancers.

    abstract:OBJECTIVE:Persistent infection with oncogenic human papillomavirus (HPV) is known to be the necessary cause of cervical cancer and a majority of vulvar cancers. Persistent HPV infections must evade host immune responses, including cytokines released by activated T-helper (Th) cells. In this study, we investigated the r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hardikar S,Johnson LG,Malkki M,Petersdorf EW,Galloway DA,Schwartz SM,Madeleine MM

    更新日期:2015-10-01 00:00:00

  • The Wertheim hysterectomy: Development, modifications, and impact in the present day.

    abstract::Ernst Wertheim was a pioneer in the history of the surgical treatment of cervical cancer. His English-language manuscript "The extended abdominal operation for carcinoma uteri (based on 500 operative cases)," which was published in 1912, detailed his standardization of the radical hysterectomy and formed the basis of ...

    journal_title:Gynecologic oncology

    pub_type: 历史文章,杂志文章


    authors: Swailes AL,Gockley A,Phaëton R,Kesterson JP

    更新日期:2017-04-01 00:00:00

  • Glutathione S-transferase polymorphisms and ovarian cancer treatment and survival.

    abstract:OBJECTIVE:Members of the glutathione S-transferase (GST) family have been shown to have functional polymorphisms that may affect drug metabolism and influence the effects of chemotherapy and survival from cancer. GSTM1, GSTT1, and GSTP1 genotypes were evaluated for their role in ovarian cancer treatment and survival. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Beeghly A,Katsaros D,Chen H,Fracchioli S,Zhang Y,Massobrio M,Risch H,Jones B,Yu H

    更新日期:2006-02-01 00:00:00

  • Advanced cervical carcinoma presenting with toxic shock syndrome.

    abstract::Toxic shock syndrome is a multisystem disease which presents with a high fever, rash, gastrointestinal symptoms, and hypotension. A 58-year-old woman presented to the emergency room with these symptoms, hypotension and tachycardia. Because of vaginal spotting a pelvic examination was performed which demonstrated vulvo...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rose PG,Wilson G

    更新日期:1994-02-01 00:00:00

  • Increased frequency of complete hydatidiform mole in women with repeated abortion.

    abstract::The association between spontaneous abortion and gestational trophoblastic disease (GTD) has been investigated in a study based on 93 women with 2 consecutive (repeated) spontaneous abortions and 82 control subjects who delivered normal babies. Nine molar pregnancies were observed among 7 of the 93 cases of repeated a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Acaia B,Parazzini F,La Vecchia C,Ricciardiello O,Fedele L,Battista Candiani G

    更新日期:1988-10-01 00:00:00

  • The implementation of critical pathways in gynecologic oncology in a managed care setting: a cost analysis.

    abstract:OBJECTIVES:The aim of the study is to determine whether critical pathways can be implemented at an academic institution to limit cost, without compromising patient satisfaction and quality of care. PATIENTS AND METHODS:Patients undergoing a hysterectomy with either cervical or endometrial cancer were placed on specifi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ghosh K,Downs LS,Padilla LA,Murray KP,Twiggs LB,Letourneau CM,Carson LF

    更新日期:2001-11-01 00:00:00

  • Recurrent and persistent squamous cell cervical carcinoma in women under age 35.

    abstract::Forty-five patients with invasive cervical squamous cell carcinoma were registered in the Tom Baker Cancer Centre from 1980 to 1985. The natural history of 22 patients (48.9%) who developed persistent or recurrent disease including 11 Stage IB, 8 Stage IIB, and 3 Stage IIIB is reported. Only one patient who had the un...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Stuart GC,Robertson DI,Fedorkow DM,Duggan MA,Nation JG

    更新日期:1988-06-01 00:00:00

  • Long-term survival with advanced ovarian cancer: an analysis of 5-year survivors in the Australian trial comparing combination versus sequential chlorambucil and cisplatin therapy.

    abstract::Of 369 patients with apparent advanced ovarian cancer entered on a randomized trial between September 1979 and June 1983, 56 survived more than 5 years. Central pathology review confirmed the diagnosis in 318 cases (15 cases not ovarian primary, 36 slides did not reach central review). Two hundred ninety-eight were in...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tattersall MH,Swanson CE,Solomon HJ

    更新日期:1992-12-01 00:00:00