Distribution, industrial applications, and enzymatic synthesis of D-amino acids.

Abstract:

:D-Amino acids exist widely in microbes, plants, animals, and food and can be applied in pharmaceutical, food, and cosmetics. Because of their widespread applications in industry, D-amino acids have recently received more and more attention. Enzymes including D-hydantoinase, N-acyl-D-amino acid amidohydrolase, D-amino acid amidase, D-aminopeptidase, D-peptidase, L-amino acid oxidase, D-amino acid aminotransferase, and D-amino acid dehydrogenase can be used for D-amino acids synthesis by kinetic resolution or asymmetric amination. In this review, the distribution, industrial applications, and enzymatic synthesis methods are summarized. And, among all the current enzymatic methods, D-amino acid dehydrogenase method not only produces D-amino acid by a one-step reaction but also takes environment and atom economics into consideration; therefore, it is deserved to be paid more attention.

authors

Gao X,Ma Q,Zhu H

doi

10.1007/s00253-015-6507-3

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

3341-9

issue

8

eissn

0175-7598

issn

1432-0614

journal_volume

99

pub_type

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