The role of trichloracetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat.

Abstract:

:Fischer 344 rats and B6C3F1 mice of both sexes were exposed to 400 ppm perchloroethylene (PER) by inhalation, 6 hr/day for 14, 21, or 28 days or to 200 ppm for 28 days. Increased numbers of peroxisomes were seen under the electron microscope and increased peroxisomal cyanide-insensitive palmitoyl CoA oxidation was measured (3.6-fold increase in males and 2.1-fold increase in females) in the livers of mice exposed to PER. Hepatic catalase was not increased. Peroxisome proliferation was not observed in rat liver or in the kidneys of either species. Trichloracetic acid (TCA), a known carcinogen and hepatic peroxisome proliferating agent, was found to be a major metabolite of PER. Blood levels of this metabolite measured in mice and rats during and for 48 hr after a single 6-hr exposure to 400 ppm PER showed that peak blood levels in mice were 13 times higher than those seen in rats. Comparison of areas under the curves over the time course of the experiment showed that mice were exposed to 6.7 times more TCA than rats. The difference in metabolism of PER to TCA in mice and rats leads to the species difference in hepatic peroxisome proliferation which is believed to be the basis of the species difference in hepatocarcinogenicity. Peroxisome proliferation does not appear to play a role in the apparent carcinogenicity of PER in the rat kidney.

journal_name

Toxicol Appl Pharmacol

authors

Odum J,Green T,Foster JR,Hext PM

doi

10.1016/0041-008x(88)90232-3

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

103-12

issue

1

eissn

0041-008X

issn

1096-0333

journal_volume

92

pub_type

杂志文章
  • Gene polymorphisms and the risk of warfarin-induced bleeding complications at therapeutic international normalized ratio (INR).

    abstract:BACKGROUND:Bleeding episodes commonly occur in patients on warfarin treatment even in those within therapeutic range of international normalized ratio (INR). The objective of this study was to investigate the effects of the 8 examined polymorphisms on the risk of bleeding complications in a sample of Iranian patients. ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2016.08.026

    authors: Pourgholi L,Goodarzynejad H,Mandegary A,Ziaee S,Talasaz AH,Jalali A,Boroumand M

    更新日期:2016-10-15 00:00:00

  • Mdr1a plays a crucial role in regulating the analgesic effect and toxicity of aconitine by altering its pharmacokinetic characteristics.

    abstract::Aconitine (AC) is the primary bioactive/toxic alkaloid in plants of the Aconitum species. Our previous study demonstrated that Mdr1 was involved in efflux of AC. However, the mechanism by which Mdr1 regulates the efficacy/toxicity of AC in vivo remains unclear. The present study aimed to determine the effects of Mdr1a...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2017.02.008

    authors: Zhu L,Wu J,Zhao M,Song W,Qi X,Wang Y,Lu L,Liu Z

    更新日期:2017-04-01 00:00:00

  • Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression.

    abstract::Puerarin is a natural product isolated from Puerarin lobata and has various pharmacological effects, including anti-hyperglycemic and anti-allergic properties. In the present study, we investigated the effect of puerarin against advanced glycation end products (AGEs)-induced inflammation in mouse mesangial cells. Puer...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2009.12.023

    authors: Kim KM,Jung DH,Jang DS,Kim YS,Kim JM,Kim HN,Surh YJ,Kim JS

    更新日期:2010-04-15 00:00:00

  • Hepatic UDP-glucuronyltransferase(s) activity toward thyroid hormones in rats: induction and effects on serum thyroid hormone levels following treatment with various enzyme inducers.

    abstract::Induction of hepatic UDP-glucuronyltransferase(s) (hUDP-GT(s] activity toward thyroid hormones and the relationship between the activity and the serum thyroid hormones or the thyroid stimulating hormone (TSH) level were examined in male Sprague-Dawley rats after four consecutive ip doses of various hepatic enzyme indu...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/0041-008x(91)90138-5

    authors: Saito K,Kaneko H,Sato K,Yoshitake A,Yamada H

    更新日期:1991-10-01 00:00:00

  • Pancreatic cancer: pathogenesis, prevention and treatment.

    abstract::Pancreatic cancer is the fourth leading cause of cancer death in the United States with a very low survival rate of 5 years. To better design new preventive and/or therapeutic strategies for the fight against pancreatic cancer, the knowledge of the pathogenesis of pancreatic cancer at the molecular level is very impor...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.taap.2006.11.007

    authors: Sarkar FH,Banerjee S,Li Y

    更新日期:2007-11-01 00:00:00

  • Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism.

    abstract::There is a subpopulation of the CF-1 mouse strain that is very sensitive to the neurotoxicity induced by the avermectins, a class of natural products widely used in veterinary and human medicine as anti-parasitic agents. This sensitivity results from a lack of P-glycoprotein in the intestine and brain of sensitive ani...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1006/taap.1997.8225

    authors: Umbenhauer DR,Lankas GR,Pippert TR,Wise LD,Cartwright ME,Hall SJ,Beare CM

    更新日期:1997-09-01 00:00:00

  • Effects of the UV filter benzophenone-3 (oxybenzone) at low concentrations in zebrafish (Danio rerio).

    abstract::Organic UV filters including benzophenone-3 (BP-3) are widely used to protect humans and materials from damage by UV irradiation. Despite the environmental occurrence of BP-3 in the aquatic environment, little is known about its effects and modes of action. In the present study we assess molecular and physiological ef...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2012.06.008

    authors: Blüthgen N,Zucchi S,Fent K

    更新日期:2012-09-01 00:00:00

  • Pesticides and human chronic diseases: evidences, mechanisms, and perspectives.

    abstract::Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson,...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.taap.2013.01.025

    authors: Mostafalou S,Abdollahi M

    更新日期:2013-04-15 00:00:00

  • In vitro ozone exposure increases release of arachidonic acid products from a human bronchial epithelial cell line.

    abstract::Eicosanoids released after ozone exposure of a human bronchial epithelial cell line, BEAS-S6, were analyzed by high-pressure liquid chromatography (HPLC) of supernatants from exposed cells prelabeled with [3H]arachidonic acid. BEAS cells released thromboxane B2 (TxB2), prostaglandin E2 (PGE2), leukotriene C4 (LTC4), L...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1006/taap.1993.1027

    authors: McKinnon KP,Madden MC,Noah TL,Devlin RB

    更新日期:1993-02-01 00:00:00

  • Malignant human cell transformation of Marcellus Shale gas drilling flow back water.

    abstract::The rapid development of high-volume horizontal hydraulic fracturing for mining natural gas from shale has posed potential impacts on human health and biodiversity. The produced flow back waters after hydraulic stimulation are known to carry high levels of saline and total dissolved solids. To understand the toxicity ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2015.07.011

    authors: Yao Y,Chen T,Shen SS,Niu Y,DesMarais TL,Linn R,Saunders E,Fan Z,Lioy P,Kluz T,Chen LC,Wu Z,Costa M,Zelikoff J

    更新日期:2015-10-01 00:00:00

  • The effect of interferon-α on the expression of cytochrome P450 3A4 in human hepatoma cells.

    abstract::Interferon α (IFNα) is used to treat malignancies and chronic viral infections. It has been found to decrease the rate of drug metabolism by acting on cytochrome P450 enzymes, but no studies have investigated the consequences of IFNα treatment on the CYP3A4 isoform, responsible for the metabolism of a majority of drug...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2011.03.019

    authors: Flaman AS,Gravel C,Hashem AM,Tocchi M,Li X

    更新日期:2011-06-01 00:00:00

  • Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux.

    abstract::There is concern that P-glycoprotein mediated efflux contributes to steroid resistance. Therefore, this study examined bidirectional corticosteroid transport and induction capabilities for P-glycoprotein (P-gp) to understand which of the systemic and inhaled corticosteroids interacted with P-gp to the greatest extent....

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2012.03.008

    authors: Crowe A,Tan AM

    更新日期:2012-05-01 00:00:00

  • Polyamines and nonmelanoma skin cancer.

    abstract::Elevated levels of polyamines have long been associated with skin tumorigenesis. Tightly regulated metabolism of polyamines is critical for cell survival and normal skin homeostasis, and these controls are dysregulated in skin tumorigenesis. A key enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC) is upre...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.taap.2006.11.023

    authors: Gilmour SK

    更新日期:2007-11-01 00:00:00

  • Upregulation of ubiquitinated proteins and their degradation pathway in muscle atrophy induced by cisplatin in mice.

    abstract::We previously demonstrated that cisplatin administration in mice induces muscle atrophy and an increase in the expression of two muscle-specific ubiquitin E3 ligase genes, muscle ring finger protein 1 (MuRF1), and atrophy gene-1 (atrogin-1), in skeletal muscle. Ubiquitination serves as a degradation signal in both the...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2020.115165

    authors: Sakai H,Ikeno Y,Tsukimura Y,Inomata M,Suzuki Y,Kon R,Ikarashi N,Chiba Y,Yamada T,Kamei J

    更新日期:2020-09-15 00:00:00

  • Circadian toxicology of cyclosporin.

    abstract::Cyclosporin (Cs), a cyclic nonpolar undecapeptide of fungal origin, has potent immunosuppressive and antiparasitic activities, and renal and hepatic toxicities, the mechanisms of which are not worked out. Many nephrotoxins and hepatotoxins are predictably more or less harmful, depending upon the circadian stage at whi...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/0041-008x(85)90279-0

    authors: Magnus G,Cavallini M,Halberg F,Cornelissen G,Sutherland DE,Najarian JA,Hrushesky WJ

    更新日期:1985-01-01 00:00:00

  • Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitors.

    abstract::Nucleoside analog reverse transcriptase inhibitors (NRTIs) are known to directly inhibit mitochondrial complex I activity as well as various mitochondrial kinases. Recent observations that complex I activity and superoxide production are modulated through cAMP-dependent phosphorylation suggests a mechanism through whi...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2007.08.015

    authors: Lund KC,Wallace KB

    更新日期:2008-01-01 00:00:00

  • Alteration of programmed cell death and gene expression by 5-bromodeoxyuridine during limb development in mice.

    abstract::Some chemicals are known to induce limb malformations in mice. The occurrence of limb abnormality induced by chemical reagents is due to changes in the programmed cell death (PCD). 5-Bromodeoxyuridine (BrdU) is known as a potent teratogen and has been reported to induce polydactyly and other limb malformations in rode...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1006/taap.2000.8989

    authors: Nakamura N,Fujioka M,Mori C

    更新日期:2000-09-01 00:00:00

  • The fate of isoprene inhaled by rats: comparison to butadiene.

    abstract::Isoprene (2-methyl-1,3-butadiene), a volatile monomer occurring in the natural environment and used in the manufacture of elastomers, is a close chemical relative of the animal carcinogen 1,3-butadiene. To obtain toxicokinetic data for inhaled isoprene, male F344 rats were exposed in groups of 30 to 14C-labeled isopre...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/0041-008x(87)90044-5

    authors: Dahl AR,Birnbaum LS,Bond JA,Gervasi PG,Henderson RF

    更新日期:1987-06-30 00:00:00

  • Analysis of the safety and pharmacodynamics of human fibrinogen concentrate in animals.

    abstract::Fibrinogen, a soluble 340kDa plasma glycoprotein, is critical in achieving and maintaining hemostasis. Reduced fibrinogen levels are associated with an increased risk of bleeding and recent research has investigated the efficacy of fibrinogen concentrate for controlling perioperative bleeding. European guidelines on t...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2014.07.019

    authors: Beyerle A,Nolte MW,Solomon C,Herzog E,Dickneite G

    更新日期:2014-10-01 00:00:00

  • Hyperglucagonemia following cisplatin treatment.

    abstract::These studies were initiated to determine (1) if cisplatin (cis-DDP)-induced hyperglucagonemia is related to decreased hormone degradation, (2) the relationship between impaired kidney function associated with cis-DDP nephrotoxicity and hyperglucagonemia, and (3) the contribution of cis-DDP-induced hyperglucagonemia t...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/0041-008x(83)90009-1

    authors: Goldstein RS,Mayor GH,Gingerich RL,Hook JB,Robinson B,Bond JT

    更新日期:1983-04-01 00:00:00

  • Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-β1/ROCK1 pathway in silicosis in rat.

    abstract::The epithelial-mesenchymal transition (EMT) is a critical stage during the development of silicosis fibrosis. In the current study, we hypothesized that the anti-fibrotic tetrapeptide, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) may exert its anti-fibrotic effects via activation of the TGF-β1/ROCK1 pathway, leadin...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2016.01.010

    authors: Deng H,Xu H,Zhang X,Sun Y,Wang R,Brann D,Yang F

    更新日期:2016-03-01 00:00:00

  • Acute airway effects of airborne formaldehyde in sensitized and non-sensitized mice housed in a dry or humid environment.

    abstract::We investigated the role of air humidity and allergic sensitization on the acute airway response to inhaled formaldehyde (FA) vapor. Mice were sensitized to the immunogen ovalbumin (OVA) by three intraperitoneal injections followed by two aerosol challenges, giving rise to allergic airway inflammation. Control mice we...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2013.02.006

    authors: Larsen ST,Wolkoff P,Hammer M,Kofoed-Sørensen V,Clausen PA,Nielsen GD

    更新日期:2013-05-01 00:00:00

  • EPR studies of in vivo radical production by 3,3',5,5'-tetrabromobisphenol A (TBBPA) in the Sprague-Dawley rat.

    abstract::Brominated flame retardants (BFRs) are present in many consumer products ranging from fabrics to plastics and electronics. Wide use of flame retardants can pose an environmental hazard and it is of interest to determine the mechanism of their toxicity. Of all the BFRs, 3,3',5,5'-tetrabromobisphenol A (TBBPA) is produc...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2008.01.035

    authors: Chignell CF,Han SK,Mouithys-Mickalad A,Sik RH,Stadler K,Kadiiska MB

    更新日期:2008-07-01 00:00:00

  • Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard.

    abstract::Nitrogen mustard is a vesicant that causes damage to the respiratory tract. In these studies, we characterized the acute effects of nitrogen mustard on lung structure, inflammatory mediator expression, and pulmonary function, with the goal of identifying mediators potentially involved in toxicity. Treatment of rats (m...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2010.09.016

    authors: Sunil VR,Patel KJ,Shen J,Reimer D,Gow AJ,Laskin JD,Laskin DL

    更新日期:2011-01-01 00:00:00

  • Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring rats exposed throughout pregnancy and lactation.

    abstract::The effects of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the reproductive system of male offspring rats were examined. The dams were treated subcutaneously 2 weeks prior to mating and throughout mating, pregnancy, and lactation. They received an initial loading dose of 25, 60, or 300 ng TCDD/kg body w...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1006/taap.1998.8433

    authors: Faqi AS,Dalsenter PR,Merker HJ,Chahoud I

    更新日期:1998-06-01 00:00:00

  • Axonal atrophy is a specific component of 2,5-hexanedione peripheral neuropathy.

    abstract::To assess the relevance of previously identified axonal atrophy to hexanedione neuropathy, the present study quantitated fiber size in peripheral nerve of rats intoxicated with 2,5-hexanedione (HD) by either oral ingestion (0.4% in drinking water) or ip injection (0.4 g/kg/day). Prior to the appearance of neurobehavio...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1006/taap.1995.1208

    authors: Lehning EJ,Dyer KS,Jortner BS,LoPachin RM

    更新日期:1995-11-01 00:00:00

  • Female-specific activation of pregnane X receptor mediates sex difference in fetal hepatotoxicity by prenatal monocrotaline exposure.

    abstract::Pyrrolizidine alkaloids (PAs) are a group of hepatic toxicant widely present in plants. Cytochrome P450 (CYP) 3A plays a key role in metabolic activation of PAs to generate electrophilic metabolites, which is the main cause of hepatotoxicity. We have previously demonstrated the sex difference in developmental toxicity...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2020.115137

    authors: Xiang E,Guo Q,Dai YG,Sun XX,Liu J,Fan CP,Wang YQ,Qiu SK,Wang H,Guo Y

    更新日期:2020-11-01 00:00:00

  • Development of morphologic, hemodynamic, and biochemical changes in lungs of rats given monocrotaline pyrrole.

    abstract::A single, intravenous administration of a low dose of monocrotaline pyrrole (MCTP), a derivative of the pyrrolizidine alkaloid monocrotaline (MCT), induces progressive pulmonary hypertension and right ventricular hypertrophy (RVH) in rats. The temporal relationship between morphologic alterations, biochemical markers ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/0041-008x(90)90239-q

    authors: Reindel JF,Ganey PE,Wagner JG,Slocombe RF,Roth RA

    更新日期:1990-11-01 00:00:00

  • Alleviating anastrozole induced bone toxicity by selenium nanoparticles in SD rats.

    abstract::Aromatase inhibitors like anastrozole play an undisputed key role in the treatment of breast cancer, but on the other hand, various side effects like osteoporosis and increased risk of bone fracture accompany the chronic administration of these drugs. Here we show for the first time that selenium nanoparticles, when g...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.taap.2013.01.028

    authors: Vekariya KK,Kaur J,Tikoo K

    更新日期:2013-04-15 00:00:00

  • Effects of benzo[a]pyrene on concanavalin A-stimulated human peripheral blood mononuclear cells in vitro: inhibition of proliferation but no effect on parameters related to the G1 phase of the cell cycle.

    abstract::The immunotoxic effects of the environmental carcinogen benzo[a]pyrene (BaP) have been evaluated using mouse, but not human, lymphocytes. Since susceptibility to immunomodulation by BaP may be species-related, the effects of BaP on human peripheral blood mononuclear cells (HPBMC) from several individuals were investig...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章

    doi:10.1006/taap.1993.1057

    authors: Mudzinski SP

    更新日期:1993-04-01 00:00:00