Abstract:
:The loci DNF15S1 and DNF15S2 are members of a small repetitive sequence family at discrete chromosomal locations, namely, 1p36 and 3p21, respectively. Studies of the structure, arrangement, and interrelations of the family suggest that the single copy on chromosome 3 is the original member and that this gave rise to the several members on chromosome 1 by transposition, partial duplication, and amplification. Several restriction fragment length polymorphisms have been discovered at the DNF15S1 locus and these have been assigned to the different subfamilies of the repeat at this locus. The existence of these RFLPs, and the nonallelic restriction site variation also found in this sequence family, suggests that transposition and amplification occurred as discrete events. We sequenced across the ancient junction between chromosomes 1 and 3 and noted features which might explain the mechanics of the transposition and amplification events.
journal_name
Genomicsjournal_title
Genomicsauthors
Welch HM,Darby JK,Pilz AJ,Ko CM,Carritt Bdoi
10.1016/0888-7543(89)90005-0subject
Has Abstractpub_date
1989-10-01 00:00:00pages
423-30issue
3eissn
0888-7543issn
1089-8646pii
0888-7543(89)90005-0journal_volume
5pub_type
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