Physical linkage of a GABAA receptor subunit gene to the DXS374 locus in human Xq28.

Abstract:

:We report the physical linkage of the gene encoding one of the subunits of the GABAA receptor (GABRA3) to the polymorphic locus DXS374 on the human X chromosome at Xq28. X-linked manic depression and other psychiatric disorders have been mapped to this region, and thus GABRA3 is a potential candidate gene for these disorders. DXS374--and therefore GABRA3--lies distal to the fragile X locus at a recombination fraction of approximately .15.

journal_name

Am J Hum Genet

authors

Bell MV,Bloomfield J,McKinley M,Patterson MN,Darlison MG,Barnard EA,Davies KE

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

883-8

issue

6

eissn

0002-9297

issn

1537-6605

journal_volume

45

pub_type

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