Abstract：
:Eight patients with arthritis (seven with rheumatoid, one with psoriatic arthritis) were treated for 7 d with a daily injection of 10 mg of mouse monoclonal anti-CD4 antibodies (three with VIT4, five with MT151). With the exception of a short-lasting low-grade fever in one patient, no side effects were observed. Clinical symptoms (morning stiffness, number of swollen joints, pain assessment and Ritchie articular index) improved in all patients within 7 d of treatment. Improvement lasted from 3 weeks to greater than or equal to 5 months (mean approximately 11 weeks). Rheumatoid factors, immune complexes and other laboratory parameters did not change during or after treatment. Skin reactivity to recall antigens was suppressed in four out of six patients during treatment but returned to pretreatment levels within 6 weeks. Immunofluorescent analysis revealed a short-lasting drop of T cells, mainly of the CD4+ CDw29+ subset, but monocytes were also affected. The injected antibody was detectable on circulating cells for about 10 h. Within 20-24 h, the cell distribution returned to pretreatment levels. In six out of eight patients an anti-mouse-Ig response was seen. We conclude that mouse anti-CD4 monoclonal antibody (MoAb) treatment is well tolerated and that the cellular immunological changes observed are short-lasting. The low incidence of side effects may justify further clinical studies to evaluate the clinical efficacy of such treatment.
journal_name
J Autoimmunjournal_title
Journal of autoimmunityauthors
Herzog C,Walker C,Müller W,Rieber P,Reiter C,Riethmüller G,Wassmer P,Stockinger H,Madic O,Pichler WJdoi
10.1016/s0896-8411(89)80002-2subject
Has Abstractpub_date
1989-10-01 00:00:00pages
627-42issue
5eissn
0896-8411issn
1095-9157journal_volume
2pub_type
杂志文章abstract：:Natural autoantibodies (autoNAb) recognize self antigens and are an important component of the immune system, as species ranging from invertebrates to vertebrates have polyreactive IgM NAbs. In higher vertebrates, different polyreactive autoNAbs isotypes are also frequently encountered and autopolyreactive IgG NAbs ar...
journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/j.jaut.2013.01.006
更新日期：2013-03-01 00:00:00
abstract：:Oxidative stress makes an important contribution to the development of autoimmune diabetes. We therefore tested the possible therapeutic value of two anti-oxidants, butylated hydroxyanisole (BHA) and pyrrolidine dithiocarbamate (PDTC), in the animal model of diabetes induced in susceptible DA rats by multiple low dose...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2004.01.005
更新日期：2004-06-01 00:00:00
abstract：:Malathion administration at non-cholinergical doses was shown to elevate macrophage, proliferative and humoral immune responses. This study examined the effects of malathion on autoimmunity, autoantibody formation, macrophage function and mitogenic responses in MRL-lpr mice (genetically predisposed to autoimmune disea...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.1997.0145
更新日期：1997-08-01 00:00:00
abstract：OBJECTIVE:Gut dysbiosis has been reported implicated in ankylosing spondylitis (AS), a common chronic inflammatory disease mainly affects sacroiliac joints and spine. Utilizing deep sequencing on the feces of untreated AS patients, our study aimed at providing an in-depth understanding of AS gut microbiota. METHODS:We...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2019.102360
更新日期：2020-02-01 00:00:00
abstract：:Class II antigens of the major histocompatibility complex (MHC) have a well-defined role in restricting cellular interactions and presenting processed antigen to T cells. In addition, a fundamental role for Class II antigens in cellular activation has been suggested, following studies demonstrating that Class II antig...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/0896-8411(89)90133-9
更新日期：1989-06-01 00:00:00
abstract：:Immunoblotting was optimized to detect autoantibodies to TSH receptors from human and porcine thyroid tissue and to determine their epitope specificity. Autoantibodies to putative TSH receptor proteins in thyroid particulate membranes were detected in approximately 35% of sera from patients with Graves' disease. Howev...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/0896-8411(91)90164-8
更新日期：1991-06-01 00:00:00
abstract：:Vitiligo is an acquired dermatological disorder characterized by a loss of epidermal melanocytes resulting in depigmentation of the skin. Mechanisms underlying the destruction of melanocytes in vitiligo remain unclear. An animal model to study spontaneously occurring autoimmune vitiligo is the mutant Smyth line (SL) o...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2003.09.006
更新日期：2004-02-01 00:00:00
abstract：:Interventional approaches that have been successful in delaying insulin-dependent diabetes mellitus (IDDM) using antigen-based immunotherapies include parenteral immunization. It has potential for clinical application provided that effective adjuvants suitable for human use can be found. We have previously shown that ...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.1996.0047
更新日期：1996-06-01 00:00:00
abstract：:CD8(+) cytotoxic T lymphocytes (CTL) can rapidly kill beta-cells and therefore contribute to the development of type 1 diabetes (T1D). CTL-mediated beta-cell killing can occur via perforin-mediated lysis, Fas-Fas-L interaction, and the secretion of TNF-alpha or IFN-gamma. The secretion of IFN-gamma can contribute to b...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2006.08.002
更新日期：2006-11-01 00:00:00
abstract：:Interferon regulatory factor-1 (IRF-1), a transcriptional factor, regulates type I interferon and interferon-induced genes. It was reported that IRF-1 regulates important molecules required for inflammation and immune reactions. To investigate the role of IRF-1 in the development of autoimmune diabetes, we established...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.2001.0531
更新日期：2001-09-01 00:00:00
abstract：:Most of our current understanding of the genetic predisposition to autoimmune disease can be traced to experiments performed in the decade from 1971 to 1981. Chella David was a key contributor to this research. Many of these early steps came from studies of experimental autoimmune thyroiditis. This model has been espe...
journal_title：Journal of autoimmunity
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.jaut.2011.04.002
更新日期：2011-09-01 00:00:00
abstract：:Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome. Numerous inflammatory cells infiltrate the upper dermis in BP. IgG autoantibodies in BP fix complement and ...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2008.08.009
更新日期：2008-12-01 00:00:00
abstract：:Allogeneic hematopoietic cell transplantation (HCT) is an increasingly widely used treatment modality in hematological malignancies. Alloreactivity mediated by donor T cells (and, in some settings, by donor natural killer cells) can produce durable immunologic control or eradication of residual malignancy after alloge...
journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/j.jaut.2007.12.002
更新日期：2008-05-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology. The major hallmark of this disease is the presence of antibodies against nuclear components, including double-stranded (ds)DNA and histones. The disease affects different organs, particularly the skin, kidneys and the nervous system. ...
journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/s0896-8411(02)00110-5
更新日期：2003-03-01 00:00:00
abstract：:The presence or absence of autoimmune disease is a qualitative outcome resulting from the combined influences of genetic, environmental and stochastic factors that interact in complex ways. Because of the nature of these interactions, the effects of risk factors that contribute to the aetiology of disease cannot be ad...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.2000.0479
更新日期：2001-05-01 00:00:00
abstract：:The obstetric management of women with antiphospholipid (aPL) syndrome remains controversial. Despite recent advances, the controversies have been fueled by our limited understanding of the multi-factorial causes of aPL-associated pregnancy loss and the lack of data from randomized studies. We have escaped from the na...
journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1006/jaut.2000.0417
更新日期：2000-09-01 00:00:00
abstract：:Several polymorphisms of the insulin gene and its flanking regions (INS region) are in linkage disequilibrium and confer susceptibility to insulin-dependent diabetes (IDDM). We have analysed INS AA and AB-BB genotypes at the 1,428 FokI site (3' of the insulin gene) in 217 patients with IDDM, 402 non-diabetic first deg...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.1994.1053
更新日期：1994-10-01 00:00:00
abstract：:Our aim was to investigate presence of tumour necrosis factor (TNF) and interleukin (IL)-10 in serum and their relation to different genotypes as well as to clinical and laboratory phenotypes in patients with polymyositis and dermatomyositis. In 65 patients with poly- or dermatomyositis the inflammatory cytokine balan...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2006.06.003
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:CD6 is emerging as a new target for treating many pathological conditions in which T cells are integrally involved, but even the latest data from studies of CD6 gene engineered mice were still contradictory. To address this issue, we studied experimental autoimmune uveitis (EAU), a model of autoimmune uveitis...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2018.02.004
更新日期：2018-06-01 00:00:00
abstract：:Beta(2)-glycoprotein I (beta(2)GPI) is known as a major autoantigen for antiphospholipid antibodies. Our recent data show that binding of beta(2)GPI to oxidized low-density lipoprotein (oxLDL) or to liposomes containing anionic phospholipid(s) may facilitate the presentation of beta(2)GPI's epitope by macrophages/dend...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2007.07.003
更新日期：2007-09-01 00:00:00
abstract：:The pathogenetic mechanisms of organ-specific autoimmune diseases remain obscured by the complexity of the genetic and environmental factors participating in the breakdown of tolerance. A unique opportunity to study the pathogenesis of human autoimmunity is provided by autoimmune polyendocrinopathy-candidiasis-ectoder...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2010.07.008
更新日期：2010-12-01 00:00:00
abstract：:Autoimmunity is a field that has only been around for a little over a century. Initially, it was thought that autoimmunity could not happen, that the body would never turn on itself (i.e. "horror autotoxicus"). It was only around the First World War that autoimmunity was recognized as the pathogenesis of various disea...
journal_title：Journal of autoimmunity
pub_type： 社论,历史文章
doi：10.1016/j.jaut.2013.12.019
更新日期：2014-02-01 00:00:00
abstract：:Many years of work, multiplex family collection and endless genotyping finally give fruit. The original aim cannot be lost. The aim is not only to identify mutations involved in susceptibility for systemic lupus erythematosus (SLE) but to elucidate the disease pathogenesis as well. After genetics comes the biology. We...
journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/s0896-8411(03)00093-3
更新日期：2003-09-01 00:00:00
abstract：:The antigenic specificity of anti-phospholipid antibodies (APA) is a matter of intensive investigation. To further characterize these antibodies, we attempted to isolate human monoclonal APA. B-cells of patients with at least one positive test for antibodies against cardiolipin, phosphatidylserine, beta2-glycoprotein ...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.1999.0316
更新日期：1999-09-01 00:00:00
abstract：:The incidence of the autoimmune thyroid disease Hashimoto thyroiditis (HT) has increased in recent years, and increasing evidence supports the contribution of excess iodine intake to thyroid disease. In this study, we examined the status of autophagy and apoptosis in thyroid tissues obtained from patients with HT, and...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2016.07.008
更新日期：2016-12-01 00:00:00
abstract：:Dysregulation of autophagy has been implicated in the development of various disease indications including autoimmune diseases. Here we identified hitherto unsuspected molecular alterations of autophagy occurring at an early stage of the macroautophagy pathway in the salivary glands and spleen of NOD.H-2h4 mice that d...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2020.102418
更新日期：2020-03-01 00:00:00
abstract：:Spontaneous idiotype shift of anti-DNA antibodies in systemic lupus erythematosus was shown to be associated with changes in the clinical manifestations of the disease. Characterization of two anti-DNA antibody preparations from the same lupus patient showed that lupus nephritis was associated with antibodies showing ...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/0896-8411(89)90271-0
更新日期：1989-06-01 00:00:00
abstract：:The present study was undertaken to determine whether germline encoded and polyreactive antibodies might be pathogenic and whether the breach of early tolerance checkpoints in systemic lupus erythematosus (SLE) might lead to a population of B cells expressing germline encoded antibodies that become pathogenic merely b...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2009.03.011
更新日期：2009-11-01 00:00:00
abstract：:There is now convincing evidence for the imposition of self-tolerance by means of the clonal deletion of self-reactive T cells operating within the thymus. Since not all self components may be encountered there, the question must be asked whether tolerance can occur post-thymically. To test this, we have used transgen...
journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/0896-8411(92)90016-j
更新日期：1992-04-01 00:00:00
abstract：:NZB mice demonstrate common and consistent abnormalities in B-cell activation and signalling. One of the hallmark characteristics of lupus disease is the prevalent hypergammaglobulinaemia, composed primarily of anti-nuclear antibodies. In addition to the hyperproliferation seen in mice exhibiting disease, the B cells ...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.2002.0607
更新日期：2002-11-01 00:00:00
