当前位置： SCI文献检索 > CLINICAL THERAPEUTICS期刊下所有文献 > Cost-effectiveness of routine varicella vaccination using the measles, mumps, rubella and varicella vaccine in France: an economic analysis based on a dynamic transmission model for varicella and herpes zoster.

Cost-effectiveness of routine varicella vaccination using the measles, mumps, rubella and varicella vaccine in France: an economic analysis based on a dynamic transmission model for varicella and herpes zoster.

Abstract：

PURPOSE:Each year in France, varicella and zoster affect large numbers of children and adults, resulting in medical visits, hospitalizations for varicella- and zoster-related complications, and societal costs. Disease prevention by varicella vaccination is feasible, wherein a plausible option involves replacing the combined measles, mumps, and rubella (MMR) vaccine with the combined MMR and varicella (MMRV) vaccine. This study aimed to: (1) assess the cost-effectiveness of adding routine varicella vaccination through MMRV, using different vaccination strategies in France; and (2) address key uncertainties, such as the economic consequences of breakthrough varicella cases, the waning of vaccine-conferred protection, vaccination coverage, and indirect costs. METHODS:Based on the outputs of a dynamic transmission model that used data on epidemiology and costs from France, a cost-effectiveness model was built. A conservative approach was taken regarding the impact of varicella vaccination on zoster incidence by assuming the validity of the hypothesis of an age-specific boosting of immunity against varicella. FINDINGS:The model determined that routine MMRV vaccination is expected to be a cost-effective option, considering a cost-effectiveness threshold of €20,000 per quality-adjusted life-year saved; routine vaccination was cost-saving from the societal perspective. Results were driven by a large decrease in varicella incidence despite a temporary initial increase in the number of zoster cases due to the assumption of exogenous boosting. In the scenario analyses, despite moderate changes in assumptions about incidence and costs, varicella vaccination remained a cost-effective option for France. IMPLICATIONS:Routine vaccination with MMRV was associated with high gains in quality-adjusted life-years, substantial reduction in the occurrences of varicella- and zoster-related complications, and few deaths due to varicella. Routine MMRV vaccination is also expected to provide reductions in costs related to hospitalizations, medication use, and general-practitioner visits, as well as indirect costs, and it is expected to be a cost-effective intervention in France (GSK study identifier: HO-12-6924).

journal_name

Clin Ther

journal_title

Clinical therapeutics

authors

Littlewood KJ,Ouwens MJ,Sauboin C,Tehard B,Alain S,Denis F

doi

10.1016/j.clinthera.2015.01.006

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

830-841.e7

issue

4

eissn

0149-2918

issn

1879-114X

pii

S0149-2918(15)00015-6

journal_volume

37

pub_type

杂志文章

相关文献

CLINICAL THERAPEUTICS文献大全
  • Pathogen Prevalence and Antimicrobial Susceptibility Among Enterobacteriaceae Causing Hospital-associated Intra-abdominal Infections in Adults in the United States (2012-2013).

    abstract：PURPOSE:Selection and prompt initiation of the appropriate empiric antimicrobial therapy are critical to decrease morbidity and mortality and shorten the length of hospitalization among patients with hospital-associated intra-abdominal infections (HA-IAIs). Therapeutic choices for the treatment of patients with HA-IAI ...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2016.04.035

    authors： Zalacain M,Biedenbach DJ,Badal RE,Young K,Motyl M,Sahm DF

    更新日期：2016-06-01 00:00:00

  • Pharmacokinetic interactions between eperisone hydrochloride and aceclofenac: a randomized, open-label, crossover study of healthy Korean men.

    abstract：BACKGROUND:Eperisone hydrochloride, a centrally acting muscle relaxant, is a calcium antagonist that causes vasodilation and antispastic actions. Aceclofenac, an anti-inflammatory analgesic and antipyretic drug, has similar efficacy and improved gastrointestinal tolerance compared with other nonsteroidal anti-inflammat...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.clinthera.2013.08.012

    authors： Kim MJ,Lim HS,Noh YH,Kim YH,Choi HY,Park KM,Kim SE,Bae KS

    更新日期：2013-10-01 00:00:00

  • Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: a double-blind, randomized, placebo-controlled study in healthy male volunteers.

    abstract：BACKGROUND:Dipeptidyl peptidase-IV (DPP-IV) inhibitors represent a new class of oral antihyperglycemic agents. Sitagliptin is an orally active and selective DPP-IV inhibitor currently in Phase III development for the treatment of type 2 diabetes mellitus. OBJECTIVE:The aim of this study was to assess the pharmacokinet...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.clinthera.2006.01.015

    authors： Bergman AJ,Stevens C,Zhou Y,Yi B,Laethem M,De Smet M,Snyder K,Hilliard D,Tanaka W,Zeng W,Tanen M,Wang AQ,Chen L,Winchell G,Davies MJ,Ramael S,Wagner JA,Herman GA

    更新日期：2006-01-01 00:00:00

  • Adefovir and lamivudine in combination compared with adefovir monotherapy in HBeAg-negative adults with chronic hepatitis B virus infection and clinical or virologic resistance to lamivudine: a retrospective, multicenter, nonrandomized, open-label study.

    abstract：OBJECTIVES:The aim of this study was to assess the therapeutic effectiveness of adefovir dipivoxil (ADV), administered in combination with lamivudine (LAM) or as monotherapy, and the rate of resistance to ADV, in hepatitis B e antigen (HBeAg)-negative adult patients with chronic hepatitis B virus (HBV) infection and cl...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2008.02.012

    authors： Pellicelli AM,Barbaro G,Francavilla R,Romano M,Barbarini G,Mazzoni E,Mecenate F,Paffetti A,Barlattani A,Struglia C,Villani R,Nauri L,Nosotti L,Armignacco O,Ferri F,Camporiondo MP,Soccorsi F,Club Epatologi Ospedalieri (C

    更新日期：2008-02-01 00:00:00

  • Antidepressant pharmacotherapy: economic outcomes in a health maintenance organization.

    abstract：:Recent pharmacotherapeutic advances in the treatment of depression have included the development of selective serotonin re-uptake inhibitors (SSRIs). The present study was designed to contrast direct health service expenditures for the treatment of depression among patients enrolled in a health maintenance organizatio...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/s0011-393x(05)80275-9

    authors： Sclar DA,Robison LM,Skaer TL,Legg RF,Nemec NL,Galin RS,Hughes TE,Buesching DP

    更新日期：1994-07-01 00:00:00

  • Relationship between compliance and persistence with osteoporosis medications and fracture risk in primary health care in France: a retrospective case-control analysis.

    abstract：BACKGROUND:Nonadherence to treatment is an important determinant of long-term outcomes in women with osteoporosis. OBJECTIVES:This study was conducted to investigate the association between adherence and osteoporotic fracture risk and to identify optimal thresholds for good compliance and persistence. A secondary obje...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2008.12.019

    authors： Cotté FE,Mercier F,De Pouvourville G

    更新日期：2008-12-01 00:00:00

  • Integrins: Integrating the Biology and Therapy of Cell-cell Interactions.

    abstract：PURPOSE:Although the role of integrins has been described in a variety of diseases, these roles seem to be distinct. To date, no study has attempted to provide links to the various pathways by which such integrins can be involved in these diverse disease settings. The purpose of this review was to address this gap in o...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinthera.2017.11.002

    authors： Pandolfi F,Franza L,Altamura S,Mandolini C,Cianci R,Ansari A,Kurnick JT

    更新日期：2017-12-01 00:00:00

  • Biosimilars: impact of biologic product life cycle and European experience on the regulatory trajectory in the United States.

    abstract：BACKGROUND:Biosimilars are defined as biologic products that are highly similar to reference products, notwithstanding minor differences in clinically inactive components, with no clinically meaningful differences between the biologic product and the reference product in terms of safety profile, purity, and potency. Du...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinthera.2011.12.005

    authors： Ahmed I,Kaspar B,Sharma U

    更新日期：2012-02-01 00:00:00

  • Effects of felodipine on natriuresis, atrial natriuretic factor, the renin-angiotensin-aldosterone system, and blood pressure in essential hypertension.

    abstract：:The aim of this study was to evaluate the short-term and long-term effects of felodipine, a new dihydropiridine calcium antagonist, on arterial blood pressure (BP), the renin-angiotensin-aldosterone system, diuresis, natriuresis, and the atrial natriuretic factor (ANF). In 15 essential hypertensives (WHO class II) BP,...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Cerasola G,Cottone S,Mangano MT,D'Ignoto G,Pinto A,Carone MB

    更新日期：1988-01-01 00:00:00

  • Safety of bronchodilator therapy in pediatric asthma patients.

    abstract：:This article reviews the drugs used in the treatment of childhood asthma (bronchodilators and anti-inflammatory agents) from the perspective of their safety and clinical tolerability. Adverse events observed in adults are likely to be seen to a greater degree in children and adolescents for many types of antiasthma dr...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：

    authors： Selcow JE

    更新日期：1994-07-01 00:00:00

  • Comparative effectiveness of a prenatal medical food to prenatal vitamins on hemoglobin levels and adverse outcomes: a retrospective analysis.

    abstract：BACKGROUND:The role of folate in pregnancy is well established, with most prenatal vitamins (PNVs) on the market containing at least 800 μg of folic acid. Folic acid must be converted in the body to L-methylfolate, the natural and biologically active form of folate. The role of vitamin B(12) in pregnancy is less charac...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.clinthera.2011.02.010

    authors： Bentley S,Hermes A,Phillips D,Daoud YA,Hanna S

    更新日期：2011-02-01 00:00:00

  • Dosing considerations in the pediatric patient.

    abstract：:Pediatric patients experience unique differences from the adult population in pharmacokinetic parameters and, consequently, require individualized dosing. Medications useful in pediatric medicine often lack a therapeutic indication and dosing guideline for this population. In addition, the absence of an available pedi...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：

    authors： Skaer TL

    更新日期：1991-09-01 00:00:00

  • Trends in off-label beta-blocker use: a secondary data analysis.

    abstract：BACKGROUND:The off-label use of beta-blockers might be prevalent, but no studies have provided empiric data on the off-label use based on utilization data. OBJECTIVE:This secondary data analysis was conducted to describe the trends of off-label use of beta-blockers among ambulatory visits made to office-based physicia...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2006.10.015

    authors： Lin HW,Phan K,Lin SJ

    更新日期：2006-10-01 00:00:00

  • Cost-analysis of imipenem-cilastatin monotherapy compared with clindamycin+aminoglycoside combination therapy for treatment of serious lower respiratory, intra-abdominal, gynecologic, and urinary tract infections.

    abstract：:To determine the cost relative to efficacy and tolerability of two antimicrobial regimens, a prospective, multicenter study compared imipenem-cilastatin (I-C) monotherapy with clindamycin+aminoglycoside (C+A) in the treatment of serious lower respiratory, intra-abdominal, gynecologic, and urinary tract infections. The...

    journal_title：Clinical therapeutics

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Kreter B

    更新日期：1992-01-01 00:00:00

  • Utilization patterns of antihypertensive drugs among the chronic kidney disease population in the United States: a cross-sectional analysis of the national health and nutrition examination survey.

    abstract：PURPOSE:Antihypertensive drugs are prescribed to patients with chronic kidney disease (CKD) for their cardioprotective and renoprotective effects. Nationally representative information on the use of antihypertensive drugs among CKD patients is limited. The purpose of this study was to assess the utilization patterns of...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2014.11.011

    authors： Sonawane KB,Qian J,Hansen RA

    更新日期：2015-01-01 00:00:00

  • Comparisons of rosiglitazone versus pioglitazone monotherapy introduction and associated health care utilization in medicaid-enrolled patients with type 2 diabetes mellitus.

    abstract：BACKGROUND:Outcomes in patients with type 2 diabetes mellitus (DM) can differ based on the antidiabetic medication that is used. Thiazolidinediones (TZDs) are a newer class of agents used for the treatment of type 2 DM. No previous study has compared health care utilization associated with the 2 TZDs on the market. OB...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Balkrishnan R,Arondekar BV,Camacho FT,Shenolikar RA,Horblyuk R,Anderson RT

    更新日期：2007-01-01 00:00:00

  • Economic impact of introducing propentofylline for the treatment of dementia in Sweden.

    abstract：:The purpose of this study was to estimate the impact of the introduction of propentofylline, a glial-cell modulator with neuroprotective properties, on the costs of dementia care in Sweden. To estimate the clinical effects of propentofylline treatment on dementia, we conducted a meta-analysis of four double-masked, pl...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,meta分析

    doi：10.1016/s0149-2918(98)80065-9

    authors： Wimo A,Witthaus E,Rother M,Winblad B

    更新日期：1998-05-01 00:00:00

  • Nonadherence to oral linezolid after hospitalization: a retrospective claims analysis of the incidence and consequence of claim reversals.

    abstract：BACKGROUND:Linezolid is available in an oral as well as an intravenous formulation. It is an oxazolidinone antibiotic and is effective in treating resistant gram-positive organisms such as methicillin-resistant Staphylococcus aureus and multidrug-resistant Streptococcus pneumoniae. OBJECTIVES:The goals of this study w...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/S0149-2918(10)80027-X

    authors： Ball AT,Xu Y,Sanchez RJ,Shelbaya A,Deminski MC,Nau DP

    更新日期：2010-12-01 00:00:00

  • In vitro activity of clarithromycin, cefprozil, and other common oral antimicrobial agents against gram-positive and gram-negative pathogens.

    abstract：:Macrolide and beta-lactam antimicrobial agents are frequently used for the treatment of upper and lower respiratory tract infections and skin or skin structure infections. To evaluate the relative in vitro activity of these antimicrobial drugs against organisms commonly involved in these infections, we tested clarithr...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Ritchie DJ,Hopefl AW,Milligan TW,Byrne JE,Maddux MS

    更新日期：1993-01-01 00:00:00

  • Efficacy and safety profile of glimepiride in Mexican American Patients with type 2 diabetes mellitus: a randomized, placebo-controlled study.

    abstract：BACKGROUND:Mexican Americans, the fastest growing ethnic group in the United States, have a 2- to 3-fold higher prevalence of type 2 diabetes mellitus relative to the non-Hispanic white population. It is estimated that 10% of Mexican Americans >or=20 years of age have diabetes. OBJECTIVE:The goal of this study was to ...

    journal_title：Clinical therapeutics

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0149-2918(03)90025-7

    authors： Luis Bautista J,Bugos C,Dirnberger G,Atherton T

    更新日期：2003-01-01 00:00:00

  • Effects of Mycotoxins on Neuropsychiatric Symptoms and Immune Processes.

    abstract：PURPOSE:The effects of air pollutants have been receiving increased attention both clinically and in the media. One such pollutant is mold, fungal growth in the form of multicellular filaments known as hyphae. The growth of molds is omnipresent not only in outdoor settings but also in indoor environments containing exc...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinthera.2018.05.004

    authors： Ratnaseelan AM,Tsilioni I,Theoharides TC

    更新日期：2018-06-01 00:00:00

  • Cefpodoxime for antimicrobial prophylaxis in neutropenia: a retrospective case series.

    abstract：BACKGROUND:Antimicrobial prophylaxis in select neutropenic patients has reduced fever, infection rates, hospital length of stay, and hospitalization rates. Guidelines from the Infectious Diseases Society of America recommend the consideration of prophylaxis with a fluoroquinolone in patients at high risk for infection ...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2014.04.013

    authors： Wojenski DJ,Barreto JN,Wolf RC,Tosh PK

    更新日期：2014-06-01 00:00:00

  • New techniques for augmenting saliva collection: bacon rules and lozenge drools.

    abstract：PURPOSE:Saliva is a reliable, noninvasive, and cost-effective alternative to biomarkers measured in other biological fluids. Within certain populations, saliva sampling may be difficult because of insufficient saliva flow, which may compromise disease diagnosis or research integrity. Methods to improve flow rates (eg, ...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2015.02.015

    authors： Peres JC,Rouquette JL,Miočević O,Warner MC,Slowey PD,Shirtcliff EA

    更新日期：2015-03-01 00:00:00

  • Effect on body weight of bupropion sustained-release in patients with major depression treated for 52 weeks.

    abstract：BACKGROUND:Short-term studies have demonstrated a modest weight-reducing to weight-neutral effect among patients receiving bupropion sustained-release (SR) for the treatment of depression. OBJECTIVE:This study was conducted to evaluate the long-term effects of bupropion SR on body weight in patients with depression. ...

    journal_title：Clinical therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0149-2918(02)85141-4

    authors： Croft H,Houser TL,Jamerson BD,Leadbetter R,Bolden-Watson C,Donahue R,Metz A

    更新日期：2002-04-01 00:00:00

  • A pharmacokinetic evaluation of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis.

    abstract：BACKGROUND:Systemic absorption of topical fluorouracil, although usually low, may vary as a result of the specific skin disease, product formulation, and other factors. OBJECTIVE:The present study was conducted to determine the pharmacokinetic profile and tolerability of a new topical 0.5% fluorouracil cream formulati...

    journal_title：Clinical therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0149-2918(01)80078-3

    authors： Levy S,Furst K,Chern W

    更新日期：2001-06-01 00:00:00

  • Comparative clinical efficacy and safety of netilmicin and tobramycin in children with serious gram-negative infections.

    abstract：:Thirty children with serious gram-negative infections were treated with either netilmicin, 2 mg/kg, or tobramycin, 1 mg/kg, every eight hours for a minimum of 72 hours. Because of the administration of different doses, a "blind" investigator evaluated treatment response while another investigator adjusted the doses on...

    journal_title：Clinical therapeutics

    pub_type： 临床试验,杂志文章

    doi：

    authors： Weippl G

    更新日期：1983-01-01 00:00:00

  • Retrospective review of sex differences in the management of dyslipidemia in coronary heart disease: an analysis of patient data from a Maryland-based health maintenance organization.

    abstract：BACKGROUND:Coronary heart disease (CHD) is the leading cause of death in men and women in the United States, with a higher mortality in women, despite a lower prevalence. Statins effectively treat dyslipidemia and reduce the risk of CHD mortality. OBJECTIVE:The objective of this study was to evaluate the treatment of ...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2006.04.012

    authors： Cooke CE,Hammerash WJ Jr

    更新日期：2006-04-01 00:00:00

  • Use of Adult Sensory Panel to Study Individual Differences in the Palatability of a Pediatric HIV Treatment Drug.

    abstract：PURPOSE:The recommended first-line treatment for young children infected with HIV includes the liquid formulation of the co-formulated protease inhibitors lopinavir/ritonavir (Kaletra® [Abbott Laboratories, Chicago, Illinois]). Clinical reports indicate that some children readily accept the taste of Kaletra, whereas ot...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2017.08.012

    authors： Mennella JA,Mathew PS,Lowenthal ED

    更新日期：2017-10-01 00:00:00

  • A clinical and mycological assessment of tioconazole solution in the treatment of superficial dermatomycoses.

    abstract：:The efficacy, acceptability, and tolerability of tioconazole solution (1%) in a pump spray were evaluated in an open-label trial in 26 patients with dermatophytosis, superficial candidiasis, and tinea versicolor. Medication was applied twice daily for 30 consecutive days. Eighteen patients had dermatophyte lesions: fo...

    journal_title：Clinical therapeutics

    pub_type： 临床试验,杂志文章

    doi：

    authors： del Palacio Hernanz A,Lopez Gomez S,Iglesias Diez L

    更新日期：1987-01-01 00:00:00

  • Plasma concentrations of flecainide acetate, a new antiarrhythmic agent, in humans.

    abstract：:Flecainide, a new antiarrhythmic agent, was given to eight healthy men to ascertain plasma drug levels and to assess tolerance for the drug. Each subject received a single intravenous (IV) dose (0.5, 1, 1.5, or 2 mg/kg) of flecainide, and plasma levels of unchanged flecainide were measured by gas-liquid chromatography...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Conard GJ,Carlson GL,Frost JW,Ober RE,Leon AS,Hunninghake DB

    更新日期：1984-01-01 00:00:00