Abstract:
:The analysis of genetic diversity in SARS-CoV-2 is the focus of several studies, providing insights into how the virus emerged and evolves. Most common changes in SARS CoV-2 are single or point nucleotide substitutions, meanwhile insertions and deletions (indels) have been identified as a less frequent source of viral genetic variability. Here, we report the emergence of a 12-nucleotide deletion in ORF7a, resulting in a 4-amino-acid in-frame deletion. The Δ12 variant was identified in viruses from patients of a single outbreak and represents the first report of this deletion in South American isolates. Phylogenetic analysis revealed that Δ12 strains belong to the lineage B.1.1 and clustered separated from the remaining Uruguayan strains. The ∆12 variant was detected in 14 patients of this outbreak by NGS sequencing and/or two rapid and economic methodologies: Sanger amplicon sequencing and capillary electrophoresis. The presence of strong molecular markers as the deletion described here are useful for tracking outbreaks and reveal a significant aspect of the SARS-CoV-2 evolution on the robustness of the virus to keep its functionality regardless loss of genetic material.
journal_name
Transbound Emerg Disjournal_title
Transboundary and emerging diseasesauthors
Panzera Y,Ramos N,Frabasile S,Calleros L,Marandino A,Tomás G,Techera C,Grecco S,Fuques E,Goñi N,Ramas V,Coppola L,Chiparelli H,Sorhouet C,Mogdasy C,Arbiza J,Delfraro A,Perez Rdoi
10.1111/tbed.14002subject
Has Abstractpub_date
2021-01-27 00:00:00eissn
1865-1674issn
1865-1682pub_type
杂志文章abstract::Sloths are genetically and physiologically divergent mammals. Phleboviruses are major arthropod-borne viruses (arboviruses) causing disease in humans and other animals globally. Sloths host arboviruses, but virus detections are scarce. A phlebovirus termed Anhanga virus (ANHV) was isolated from a Brazilian Linnaeus's ...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.13333
更新日期:2020-01-01 00:00:00
abstract::Q fever, caused by the zoonotic bacterium Coxiella burnetii, is a globally distributed emerging infectious disease. Livestock are the most important zoonotic transmission sources, yet infection in people without livestock exposure is common. Identifying potential exposure pathways is necessary to design effective inte...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.13565
更新日期:2020-04-07 00:00:00
abstract::African swine fever (ASF) is emerging in Vietnam and poses a continuing severe threat to the swine industry. A histopathological study of clinical samples collected during the May to July 2019 outbreak of ASF was performed to determine the characteristic lesions. We analysed samples from eight ASFV-infected farms. His...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.13851
更新日期:2020-09-26 00:00:00
abstract::Newcastle disease (ND), caused by virulent strains of avian paramyxovirus type 1 (APMV-1), is considered throughout the world as one of the most important animal diseases. For over three decades now, there has been a continuing panzootic caused by a variant virulent APMV-1 strain, so-called pigeon paramyxovirus type 1...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.12006
更新日期:2014-04-01 00:00:00
abstract::A cross-sectional survey was conducted in the Belgian cattle population after the first period of infection of the emerging Schmallenberg virus. A total number of 11 635 cattle from 422 herds sampled between 2 January and 7 March 2012 were tested for the presence of Schmallenberg-specific antibodies using an ELISA kit...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.12042
更新日期:2013-02-01 00:00:00
abstract::One of the constraints to controlling foot-and-mouth disease (FMD) in East Africa is the incomplete knowledge of the specific FMD virus (FMDV) strains circulating and the way in which these viruses move across countries in the region. This retrospective study focuses on Ethiopia, which has one of the largest FMD-susce...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.13675
更新日期:2020-11-01 00:00:00
abstract::Swine influenza viruses (SIVs) are important not only for pig farming, but also for public health. In fact, pandemic A(H1N1) 2009 viruses [A(H1N1)pdm09] were derived from SIVs. Therefore, timely characterization of locally circulating SIVs is necessary for understanding the global status of SIVs. To genetically charac...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.12887
更新日期:2018-12-01 00:00:00
abstract::Porcine circovirus 3 (PCV-3) prevalence has been minimally investigated in wild boar; dynamics of infection and viral tissue distribution are currently unknown. In this study, serum samples from 518 wild boar (from years 2004 to 2018) were used to study frequency of infection. Also, serum samples from 19 boar captured...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.12988
更新日期:2019-01-01 00:00:00
abstract::The aim of this study was to better understand the molecular epidemiology of Campylobacter coli isolated from multiple sources in Belgium, by studying the genotypic diversity and antimicrobial resistance phenotypes and resistance mechanisms of 59 C. coli isolates. Isolates from broiler carcasses and human cases were g...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.13046
更新日期:2019-01-01 00:00:00
abstract::Beginning in 2006, point infection control operations and aerial distribution of oral rabies vaccines along the US border were performed in Quebec, Canada, to control the potential spread of raccoon rabies. A benefit-cost analysis assessed the economic efficiency of this rabies control programme into the future. In th...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/j.1865-1682.2012.01351.x
更新日期:2013-08-01 00:00:00
abstract::Twenty-four specific pathogen free pigs were inoculated intradermally at the front-right heel bulb with 0.5 ml of viral suspension containing 10(6.0)tissue culture infectious dose (TCID(50)) with the porcinophillic strain (O/Taiwan/97) of foot-and-mouth disease virus (FMDV) isolated from the epizootic of FMD in Taiwan...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/j.1865-1682.2009.01079.x
更新日期:2009-06-01 00:00:00
abstract::Quality and safe meat production and livestock husbandry are important foci for addressing the wider underlying economic and political challenges. In the last few years, an intense focus of the scientific community has been placed on breakouts of livestock diseases especially in Asia, which have spread into neighbouri...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1865-1682.2008.01038.x
更新日期:2008-08-01 00:00:00
abstract::The paper explains the concept of 'One world-one health', which aims at new paradigms to significantly reduce the risks to human and animal health due to globalization, to climate change, to the intensification of producing food with and from animals, and to changing human-animal interfaces. In Europe, the two major '...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1865-1682.2011.01310.x
更新日期:2012-03-01 00:00:00
abstract::We investigated episodes of suspected highly pathogenic avian influenza (HPAI)-like illness among 12 meat duck flocks in two districts in Tien Giang province (Mekong Delta, Vietnam) in November 2013. In total, duck samples from 8 of 12 farms tested positive for HPAI virus subtype A/haemagglutinin 5 and neuraminidase 1...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.12470
更新日期:2016-04-01 00:00:00
abstract::Outbreaks of abortions and lambs born with nervous clinical signs and/or congenital malformations affected different sheep farms in Spain. Initial diagnosis of 'border disease-like' was established, based on clinical signs, serology and/or RNA detection by a pan-pestivirus RT-PCR. However, further investigation using ...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.12599
更新日期:2017-02-01 00:00:00
abstract::Duck Tembusu virus (DTMUV) infected cases have increasingly been observed in several duck farms in Thailand since its first report in 2013. However, information on the genetic characteristic of DTMUVs recently circulating in ducks in Thailand is limited. In this study, we investigated the geographic distribution and g...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.13230
更新日期:2019-09-01 00:00:00
abstract::Historical evidence of tuberculosis (TB) affecting primarily captive rhinoceroses dates back almost two centuries. Although the causative Mycobacterium tuberculosis complex (MTC) species has not been determined in many cases, especially for those that occurred before bacterial culture techniques were available, the sp...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章,评审
doi:10.1111/tbed.12489
更新日期:2017-08-01 00:00:00
abstract::Since 2013, there have been an increasing number of cases of arthritis in broilers caused by avian orthoreovirus (ARV) in China, and the virus remains highly virulent in chicks with high-level maternal antibodies. However, little information is available about the complete gene analysis and pathogenicity of the epidem...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.13961
更新日期:2020-12-20 00:00:00
abstract::Leptospirosis is a neglected zoonosis of global importance with a complex epidemiology that affects humans, domestic and wild mammals. However, due to the diversity of clinical signs and difficulties of establishing a confirmatory laboratory diagnosis, the disease remains poorly investigated, particularly in the devel...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.12252
更新日期:2016-04-01 00:00:00
abstract::Anaplasma and Ehrlichia are important emerging tick-borne pathogens in both humans and animals. Here, we conducted a molecular surveillance study in Gansu, China to assess the prevalence of Anaplasma and Ehrlichia spp. in red deer and sika deer based on polymerase chain reaction (PCR) analysis and sequencing of 16S rR...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.12335
更新日期:2016-12-01 00:00:00
abstract::Mycobacterium bovis is the causal agent of bovine tuberculosis (BTB), with a diverse host range, extending from livestock to domestic and captive wild animals as well as free-ranging wildlife species. In South Africa, BTB is endemic in the Kruger National Park (KNP) and the Hluluwe iMfolozi National Park (HiP), where ...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.12132
更新日期:2013-11-01 00:00:00
abstract::Canine parvovirus type 2 (CPV-2) is an aetiological agent that causes acute haemorrhagic enteritis and fatal myocarditis in dogs. Since CPV-2 first emerged in the late 1970s, its rapid evolution has resulted in three antigenic variants: CPV-2a, CPV-2b and CPV-2c. Here, we report, for the first time in Korea, two cases...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.13501
更新日期:2020-07-01 00:00:00
abstract::Foot-and-mouth disease (FMD) is a highly contagious and economically important viral disease with high morbidity and reduced productivity of affected animals. We studied the heat intolerance (HI) (panting) syndrome and the effect of FMD virus (FMDV) infection on thyroid gland function in Indian cattle (Bos indicus). E...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/j.1865-1682.2011.01203.x
更新日期:2011-06-01 00:00:00
abstract::Since African swine fever virus (ASFV) introduction into Vietnam in 2019, most ASFV strains detected in this country belong to the p72 genotype II and intergenic region (IGR) II variant. Further investigation of the intergenic region of ASFVs isolated in the Capital Hanoi region showed two different variants, IGR I an...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.13996
更新日期:2021-01-20 00:00:00
abstract::Adult milking cow movements occurring in monthly periods in 2004-2006 were analysed to compare three network analysis measures to determine the lower and upper bounds of potential maximal epidemic size in an unrestrained epidemic: the out-degree, the infection chain or output domain of a farm, and the size of the stro...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/j.1865-1682.2008.01053.x
更新日期:2008-12-01 00:00:00
abstract::Prevalence, distribution and antibiotic resistance of Arcobacter spp. were investigated in cattle, goats, floor and treated water samples in this study. The prevalence of Arcobacter in adult and young was recorded as 8/110 (7.27%) and 4/83 (4.81%), respectively, which showed insignificant difference (P = 0.3503) in de...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/j.1865-1682.2012.01311.x
更新日期:2013-02-01 00:00:00
abstract::Foot-and-mouth disease (FMD) vaccines are routinely used as effective control tools in large regions worldwide and to limit outbreaks during epidemics. Vaccine-induced protection in cattle has been largely correlated with the FMD virus (FMDV)-specific antibodies. Genetic control of cattle immune adaptive responses has...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.12130
更新日期:2015-06-01 00:00:00
abstract::Soon after the emergence of 2009 pandemic H1N1, the first outbreaks in breeder turkey operations were reported that implicated human-to-turkey transmission. In the spring of 2016, the reoccurrence of 2009 pandemic H1N1 lineage viruses infecting breeder turkey flocks in Ontario and Manitoba, Canada, also implicated hum...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.12566
更新日期:2016-12-01 00:00:00
abstract::Hydranencephaly, the almost complete absence of the cerebral parenchyma, induced by infection with modified live bluetongue virus (BTV) crossing the placenta has previously been reported in sheep and rarely in cattle in the USA and in South Africa. The current study describes 29 cases of hydranencephaly in bovine foet...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/j.1865-1682.2008.01034.x
更新日期:2008-09-01 00:00:00
abstract::Newcastle disease virus (NDV), the pathogen of Newcastle disease, has caused significant losses to the poultry industry worldwide. However, owing to its avirulence, class I NDVs have not been studied as much as class II NDVs. We aimed to epidemiologically monitor the spread of class I NDVs in China. We isolated 104 cl...
journal_title:Transboundary and emerging diseases
pub_type: 杂志文章
doi:10.1111/tbed.13785
更新日期:2020-08-12 00:00:00