Obesity and extent of emphysema depicted at CT.

Abstract:

AIM:To investigate the underlying relationship between obesity and the extent of emphysema depicted at CT. METHODS AND MATERIALS:A dataset of 477 CT examinations was retrospectively collected from a study of chronic obstructive pulmonary disease (COPD). The low attenuation areas (LAAs; ≤950 HU) of the lungs were identified. The extent of emphysema (denoted as %LAA) was defined as the percentage of LAA divided by the lung volume. The association between log-transformed %LAA and body mass index (BMI) adjusted for age, sex, the forced expiratory volume in one second as percent predicted value (FEV1% predicted), and smoking history (pack years) was assessed using multiple linear regression analysis. RESULTS:After adjusting for age, gender, smoking history, and FEV1% predicted, BMI was negatively associated with severe emphysema in patients with COPD. Specifically, one unit increase in BMI is associated with a 0.93-fold change (95% CI: 0.91-0.96, p<0.001) in %LAA; the estimated %LAA for males was 1.75 (95% CI: 1.36-2.26, p<0.001) times that of females; per 10% increase in FEV1% predicated is associated with a 0.72-fold change (95% CI: 0.69-0.76, p<0.001) in %LAA. CONCLUSION:Increasing obesity is negatively associated with severity of emphysema independent of gender, age, and smoking history.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Gu S,Li R,Leader JK,Zheng B,Bon J,Gur D,Sciurba F,Jin C,Pu J

doi

10.1016/j.crad.2015.01.007

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

e14-9

issue

5

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(15)00035-5

journal_volume

70

pub_type

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