A role for actin polymerization in persistent pulmonary hypertension of the newborn.

abstract：:Hedysarum polybotrys polysaccharide (HPS) is the principal active fraction responsible for the antidiabetic properties of this species. The aim of this study was to determine the antidiabetic properties of 4 purified fractions of different molecular weight range HPSs (HPS1, HPS2, HPS3, HPS4). HPS3 was selected for exa...

journal_title：Canadian journal of physiology and pharmacology

authors： Hu F,Li X,Zhao L,Feng S,Wang C

更新日期：2010-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver conditions that are characterized by steatosis, inflammation, fibrosis, and liver injury. The global prevalence of NAFLD is rapidly increasing in proportion to the rising incidence of obesity and type 2 diabetes. Because NAFLD is a multifaceted di...

journal_title：Canadian journal of physiology and pharmacology

authors： Sid V,Siow YL,O K

更新日期：2017-10-01 00:00:00

abstract：:The mesangial cell is a contractile secreting cell found in a key position in the renal glomerulus. Several kidney and systemic diseases are associated with dysfunctions of the mesangial cells. We compared the effect of bradykinin (BK; B2 agonist) and des-Arg9-bradykinin (DBK; B1 agonist) on intracellular calcium mobi...

journal_title：Canadian journal of physiology and pharmacology

authors： Girolami JP,Ouardani M,Bascands JL,Pécher C,Bompart G,Leung-Tack J

更新日期：1995-07-01 00:00:00

abstract：:The long noncoding RNA (lncRNA) GAS5 has been found to act as a decoy for the glucocorticoid receptor (GR), thus implicating GAS5 as a potential regulator of glucocorticoid sensitivity and resistance. Airway smooth muscle (ASM) cells and airway epithelial cells (AEC) play an important role in the pathogenesis and pers...

journal_title：Canadian journal of physiology and pharmacology

authors： Keenan CR,Schuliga MJ,Stewart AG

更新日期：2015-03-01 00:00:00

abstract：:The role that thromboxane A2 plays in contractions induced by leukotriene D4 in guinea-pig isolated lung parenchyma was investigated under equilibrium conditions. Lung tissue generated thromboxane A2 and prostacyclin spontaneously as evidenced by the slow accumulation of their biologically inactive metabolites, thromb...

journal_title：Canadian journal of physiology and pharmacology

authors： Giembycz MA,Rodger IW

更新日期：1987-07-01 00:00:00

abstract：:The objective of this study was to investigate under controlled conditions the effects of fentanyl on the rat locus coeruleus catechol oxidation current. Using differential normal pulse voltammetry combined with electrochemically treated carbon fiber electrodes to measure the catechol oxidation current, catecholamine ...

journal_title：Canadian journal of physiology and pharmacology

authors： Milne B,Quintin L,Gillon JY,Pujol JF

更新日期：1989-05-01 00:00:00

abstract：:Recent evidence suggests that some Ca2+ channels are regulated by a tyrosine kinase pathway. The possibility that Ca2+ entry is regulated by tyrosine kinase was investigated in canine vascular muscles. Functional studies were carried out in the dog mesenteric arteries and saphenous veins. Nicardipine-insensitive refil...

journal_title：Canadian journal of physiology and pharmacology

authors： Low AM

更新日期：1996-03-01 00:00:00

abstract：:In male Sprague--Dawley rats, hypertensive development was diminished for 10 weeks when parathyroidectomy (PTX) was performed 1 week before deoxycorticosterone plus saline (DOCA + NaCl) treatment. In young spontaneously hypertensive male rats (SHR, Okamoto strain) parathyroidectomy performed after weaning lessened hyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Gairard A,Berthelot A,Schleiffer R,Pernot F

更新日期：1982-02-01 00:00:00

abstract：:Transmural nerve stimulation following sympathetic (guanethidine 10(-4) mol/L, phenoxybenzamine 2 X 10(-5) mol/L, propanolol 2 X 10(-6) mol/L) and muscarinic blockade (atropine 5 X 10(-5) mol/L) produces a relaxatory response in canine saphenous veins contracted with prostaglandin F2 alpha. This relaxatory response wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Senaratne MP,Kappagoda T

更新日期：1986-10-01 00:00:00

abstract：:The objective of this work was to evaluate whether changes in respiratory status of isolated brown-fat mitochondria influence synthesis and degradation of proteins within the organelles. Mitochondrial protein synthesis is subject to regulation, as a 24-h fast in mice reduced [35S]methionine incorporation without affec...

journal_title：Canadian journal of physiology and pharmacology

authors： Desautels M,Dulos RA

更新日期：1993-01-01 00:00:00

abstract：:Dissociated neuronal cultures have become a popular tool to address a number of questions in neurobiology. These culture systems may provide useful paradigms to approach problems related to in vivo neurotoxicity of xenobiotics. The clinical spectra of vinca neurotoxicity and alcohol teratogenesis is reviewed, and some...

journal_title：Canadian journal of physiology and pharmacology

authors： Riopelle RJ,Dow KE,Eisenhauer E

更新日期：1984-08-01 00:00:00

abstract：:Many functions of the brain and the sympathetic adrenal system are influenced by those amino acids that exert precursor control over neurotransmitter synthesis. One of the functions affected is regulation of blood pressure. Therefore, the purpose of this review is to describe how food proteins and amino acids affect t...

journal_title：Canadian journal of physiology and pharmacology

authors： Anderson GH

更新日期：1986-06-01 00:00:00

abstract：:It is accepted that nutrition is important in the development and function of the immune system. However, the study of nutritional immunology is a relatively new discipline. In part this may be due to difficulties in defining the effect of nutrition on immunity, as an immune response is the result of an orchestrated c...

journal_title：Canadian journal of physiology and pharmacology

authors： Field CJ

更新日期：1996-06-01 00:00:00

abstract：:The effect of one bout of acute exercise on impaired glucose metabolism was studied in obese (480 +/- 20 g), untrained rats, at rest (n = 10) and after 60 min of swimming (n = 5). Using the euglycemic, hyperinsulinemic (10 mU.kg-1 x min-1) clamp, glucose clearance rate increased from 7.6 +/- 0.9 at rest to 9.7 +/- 0.5...

journal_title：Canadian journal of physiology and pharmacology

authors： Burstein R,Zissholtz A,Zick-Bachar Y,Epstein Y,Shapiro Y,Karnieli E

更新日期：1992-11-01 00:00:00

abstract：:In recent experiments in conscious lambs, we showed that in addition to its well-known natriuretic and diuretic effects, i.v. injection of 2 mg/kg of furosemide resulted in a sustained increase in heart rate and an age-dependent increase in plasma renin activity. To determine whether these responses were dose dependen...

journal_title：Canadian journal of physiology and pharmacology

authors： Patel A,Smith FG

更新日期：1997-09-01 00:00:00

abstract：:Most physiological and pathophysiological responses to bradykinin are mediated by G-protein-coupled receptors designated B2 receptors. Discovery of antagonists for these receptors has brought about a revolution in research in the kinin field. The chemistry and development of antagonists for B2 kinin receptors are disc...

journal_title：Canadian journal of physiology and pharmacology

authors： Stewart JM

更新日期：1995-07-01 00:00:00

abstract：:Diazinon (DZN) is a common organophosphorus insecticide extensively used for agriculture and veterinary purposes. DZN toxicity is not limited to insects; it also induces harmful effects in mammals and birds. Our experiment evaluated the protective and antioxidant potential of sesame oil (SO) and (or) alpha-lipoic acid...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdel-Daim MM,Taha R,Ghazy EW,El-Sayed YS

更新日期：2016-01-01 00:00:00

abstract：:A systematic study has been performed in various segments of the intestine and in the urinary bladder of the mouse to identify tissues that respond to kinins and possess B1 and (or) B2 receptors. The stomach was found to contain B1 and B2 functional sites that show pharmacological profiles compatible with B1 and B2 re...

journal_title：Canadian journal of physiology and pharmacology

authors： Allogho SN,Gobeil F,Pheng LH,Nguyen-Le XK,Neugebauer W,Regoli D

更新日期：1995-12-01 00:00:00

abstract：:In open-chest pentothal-chloralose anesthetized dogs, plasma catecholamine and cyclic AMP levels were evaluated in the aortic and coronary sinus blood, during stimulations of the left ansa subclavia (1, 2, and 4 Hz). Basal aortic and coronary sinus catecholamine levels were respectively 0.373 +/- 0.090 and 0.259 +/- 0...

journal_title：Canadian journal of physiology and pharmacology

authors： Lavallée M,Laurencin C,de Champlain J,Nadeau RA

更新日期：1981-06-01 00:00:00

abstract：:The effect of chemical sympathectomy with 6-hydroxydopamine (6-OHDA) on blood volume was studied in unanesthetized splenectomized and nonsplenectomized dogs. A significant increase in total blood volume essentially accounted for by a marked plasma volume expansion was found in both groups after 6-OHDA treatment (50 mg...

journal_title：Canadian journal of physiology and pharmacology

authors： Porlier GA,Nadeau RA,de Champlain J

更新日期：1977-06-01 00:00:00

abstract：:Epinephrine caused hyperglycemia in part by increasing gluconeogenesis. However, the mechanism of its gluconeogenic effects has not been studied in ruminants. This study was undertaken to examine the effect of epinephrine on the net hepatic uptake of selected glucose precursors in sheep. The major abdominal blood vess...

journal_title：Canadian journal of physiology and pharmacology

authors： Brockman RP

更新日期：1991-04-01 00:00:00

abstract：:Cardiac injury and loss of cardiomyocytes is a causative as well as a resultant condition of cardiovascular disorders, which are the leading cause of death throughout the world. This loss of cardiomyocytes cannot be completely addressed through the currently available drugs being administered, which mainly function on...

journal_title：Canadian journal of physiology and pharmacology

authors： Padda J,Sequiera GL,Sareen N,Dhingra S

更新日期：2015-10-01 00:00:00

abstract：:At a critical premature interval, atrial premature beats encounter sinus node refractoriness and are blocked on entering and fail to reset the sinus node, resulting in interpolation of the premature beat. The transition from reset to interpolated response has been used to define the effective refractory period of the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Kerr CR

更新日期：1989-10-01 00:00:00

abstract：:The effect of high potassium depolarization on the release of exogenously supplied [3H]glutamate and endogenous glutamate from tissue slices of the cestode Hymenolepis diminuta was examined. Increasing concentrations of potassium stimulated the release of radiolabel from tissues preloaded with [3H]glutamate. This rele...

journal_title：Canadian journal of physiology and pharmacology

authors： Webb RA

更新日期：1988-07-01 00:00:00

abstract：:The electrical activity of the duodenum and proximal jejunum was studied in conscious healthy dogs implanted with unipolar silver electrodes. A computerized method was used for the calculation of the mean frequency of the slow wave for each consecutive minute of the electromyographic signal. A "slow wave frequency com...

journal_title：Canadian journal of physiology and pharmacology

authors： Pousse A,Mendel C,Aprahamian M,Kachelhoffer J,Balboni G,Plas A

更新日期：1987-06-01 00:00:00

abstract：:H2S is an important gasotransmitter with a vasorelaxant property. The modulation of endogenous H2S generation from different tissues and the functional consequence of this modulation are not clear. In the present study, the production of H2S from vascular tissues as well as the liver and ileum of rats was measured. Th...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhao W,Ndisang JF,Wang R

更新日期：2003-09-01 00:00:00

abstract：:Bacterial toxins are widespread in the environment as well as in the digestive system of humans and animals. Toxin from Gram-negative bacteria (endotoxin or lipopolysaccharide; LPS) has a life-long programming effect on reproduction in rats, but the mediators have not been well-documented, so we investigated the effec...

journal_title：Canadian journal of physiology and pharmacology

authors： Ozgocer T,Yildiz S,Elbe H,Vardi N

更新日期：2015-08-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent vasoactive peptide that exerts hypertrophic, migratory, and mitogenic effects in vascular smooth muscle cells. ET-1-induced activation of several signaling events has been shown to mediate the cellular effects of ET-1. In the past several years, transactivation of growth factor receptor...

journal_title：Canadian journal of physiology and pharmacology

authors： Bouallegue A,Vardatsikos G,Srivastava AK

更新日期：2010-05-01 00:00:00

abstract：:Amiodarone is a new antiarrhythmic drug, commonly coadministered with digoxin in various cardiac disorders. Amiodarone caused a 10-fold increase of serum digoxin in rats, when the two drugs were simultaneously administered. Amiodarone significantly reduced digoxin uptake by renal cortical slices in the rat, and failed...

journal_title：Canadian journal of physiology and pharmacology

authors： Koren G,Soldin S,Macleod SM

更新日期：1983-12-01 00:00:00

abstract：:Selected topics on the roles of sarcoplasmic reticulum (SR) in the control of vascular smooth muscle (VSM) tone are briefly reviewed with particular reference to the regulation of cytosolic concentration of free calcium ions, [Ca2+]i. Although morphological evidence and subcellular membrane studies indicate a relative...

journal_title：Canadian journal of physiology and pharmacology

authors： Daniel EE,van Breemen C,Schilling WP,Kwan CY

更新日期：1995-05-01 00:00:00