Long-term carcinogenicity bioassays on three chlorofluorocarbons (trichlorofluoromethane, FC11; dichlorodifluoromethane, FC12; chlorodifluoromethane, FC22) administered by inhalation to Sprague-Dawley rats and Swiss mice.

abstract：:Henry Kandrup wrote prolifically on the problem of relaxation of stellar systems. His picture of relaxation was significantly more refined than the standard description in terms of phase mixing and violent relaxation. In this article, I summarize Henry's work in this and related areas. ...

journal_title：Annals of the New York Academy of Sciences

authors： Merritt D

更新日期：2005-06-01 00:00:00

abstract：:Pheochromocytoma is a rare, surgically correctable cause of hypertension. Modern medical blockade has significantly improved patient survival and morbidity. The last decade has seen the identification of the genes responsible for several hereditary causes of pheochromocytoma. Evaluation of these patients has demonstra...

journal_title：Annals of the New York Academy of Sciences

authors： Walther MM

更新日期：2002-09-01 00:00:00

abstract：:Autoimmune disease affects a significant proportion of the population. The etiology of most autoimmune diseases is largely unknown, but it is thought to be multifactorial with both environmental and genetic influences. Rare monogenic autoimmune diseases, however, offer an invaluable window into potential disease mecha...

journal_title：Annals of the New York Academy of Sciences

authors： Waterfield M,Anderson MS

更新日期：2010-12-01 00:00:00

abstract：:Antisense oligonucleotides (AON) are being developed for a wide array of therapeutic applications. Significant improvements in their serum stability, target affinity, and safety profile have been achieved with the development of chemically modified oligonucleotides. Here, we compared 2'-deoxy-2'-fluoro-beta-D-arabinon...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari N,Bergeron D,Tedeschi AL,Mangos MM,Paquet L,Renzi PM,Damha MJ

更新日期：2006-10-01 00:00:00

abstract：:We reevaluated the exchange stoichiometry of the Na(+)/Ca(2+) exchange current by measuring its reversal potential. The exchange current was measured from the inside-out macropatch excised from intact sarcolemma of guinea pig ventricular myocytes. This method provides more accurate control of extracellular and cytopla...

journal_title：Annals of the New York Academy of Sciences

authors： Matsuoka S

更新日期：2002-11-01 00:00:00

abstract：:Rhythm is fundamental to every motor activity. Neural and physiological mechanisms that underlie rhythmic cognition, in general, and rhythmic pattern generation, in particular, are evolutionarily ancient. As speech production is a kind of motor activity, investigating speech rhythm can provide insight into how general...

journal_title：Annals of the New York Academy of Sciences

authors： Ordin M

更新日期：2019-10-01 00:00:00

abstract：:Two kinds of active protein fraction, TP1 and TP2, were isolated from bovine thymus extracts. Both these fractions showed a single band in polyacrylamide gel disc electrophoresis. Though these two fractions showed a difference in potency, they both lowered serum calcium in rabbits and increased lymphocytes in mice. Mo...

journal_title：Annals of the New York Academy of Sciences

authors： Mizutani Shimizu M,Suzuki I,Mizutani T,Hayase S,Mizutani A

更新日期：1975-02-28 00:00:00

abstract：:CXC chemokines have been found to be important in the regulation of angiogenesis and tumor-related immunity, and in promoting organ-specific metastases. This review highlights the importance of CXC chemokine ligands and receptors in mediating non-small cell lung cancer tumor-associated angiogenesis, "immunoangiostasis...

journal_title：Annals of the New York Academy of Sciences

authors： Strieter RM,Belperio JA,Burdick MD,Sharma S,Dubinett SM,Keane MP

更新日期：2004-12-01 00:00:00

abstract：:Policy and program implementers require evidence on whether integrated psychosocial stimulation and nutrition interventions can be effectively delivered at-scale, how, and at what cost? To address some of these issues, a comprehensive evaluation of implementation was designed for a trial in Pakistan that integrated ps...

journal_title：Annals of the New York Academy of Sciences

authors： Yousafzai AK,Rasheed MA,Siyal S

更新日期：2018-05-01 00:00:00

abstract：:It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of agin...

journal_title：Annals of the New York Academy of Sciences

authors： Hodes RJ,Sierra F,Austad SN,Epel E,Neigh GN,Erlandson KM,Schafer MJ,LeBrasseur NK,Wiley C,Campisi J,Sehl ME,Scalia R,Eguchi S,Kasinath BS,Halter JB,Cohen HJ,Demark-Wahnefried W,Ahles TA,Barzilai N,Hurria A,Hunt PW

更新日期：2016-12-01 00:00:00

abstract：:The gene encoding thermostable alanine recemase from Bacillus stearothermophilus was cloned and expressed in E. coli. The enzyme was purified to homogeneity from cell extracts of E. coli carrying a plasmid designated pICR4. The alanine racemase gene sequenced was found to contain an open reading frame of 1158 nucleoti...

journal_title：Annals of the New York Academy of Sciences

authors： Soda K,Tanizawa K

更新日期：1990-01-01 00:00:00

abstract：:Natural systems cannot be closed to the environment. At the same time there is a necessity for closure in order to build the system. It is this quint-essential tension between openness and closure that drives systems to unfold into further stages or levels of growth and development. In other words, the emergence of or...

journal_title：Annals of the New York Academy of Sciences

authors： Alvarez De Lorenzana JM

更新日期：2000-01-01 00:00:00

abstract：:The ability to recognize and discriminate conspecific faces and facial expressions has played a critical role in the evolution of social communication. Darwin was one of the first to speculate that human and nonhuman primate facial expressions share similar mechanisms for production and functions in expressing emotion...

journal_title：Annals of the New York Academy of Sciences

authors： Parr LA

更新日期：2003-12-01 00:00:00

abstract：:For more than 10 years umbilical cord blood (UCB) has been used as an alternative source of hematopoietic stem cells for allogeneic transplantation. Although the clinical results are encouraging, UCB is associated with delayed engraftment. To address these issues we have used the NOD/SCID mouse model to study the engr...

journal_title：Annals of the New York Academy of Sciences

authors： Fibbe WE,Noort WA,Schipper F,Willemze R

更新日期：2001-06-01 00:00:00

abstract：:In two experiments, musically trained and untrained adults were tested on their ability to match spoken utterances with their tonal analogues (tone sequences that retained the pitch and temporal patterns of the utterances). In both cases, musical training was associated with superior performance, indicating an enhance...

journal_title：Annals of the New York Academy of Sciences

authors： Thompson WF,Schellenberg EG,Husain G

更新日期：2003-11-01 00:00:00

abstract：:We have established that a preferential export of pyruvate-generated citrate occurs from cholesterol-rich tumor mitochondria, with both isolated mitochondrial systems as well as with viable tumor tissue slices (i.e., with whole tumors cells). Furthermore, we have demonstrated that the more rapid citrate efflux kinetic...

journal_title：Annals of the New York Academy of Sciences

authors： Coleman PS

更新日期：1986-01-01 00:00:00

abstract：:Disorientation may draw attention from other activities and its impact on cognition may cause pilot error and problems of concentration in dizzy patients. Tasks used to study the impact of disorientation include number processing, intelligence scales and Brookes matrices (reproduction of 2xD patterns of numbers vs. no...

journal_title：Annals of the New York Academy of Sciences

authors： Gresty MA,Golding JF

更新日期：2009-05-01 00:00:00

abstract：:Results obtained from projects in which self-organizing musical structures spontaneously arise through electrical interface between the brain and generative musical systems are surveyed. This provides a springboard for examining important paradigm shifts taking place in our thinking about what musical forms can be and...

journal_title：Annals of the New York Academy of Sciences

authors： Rosenboom D

更新日期：2003-11-01 00:00:00

abstract：:Externally guided sensory-motor processes deteriorate with increasing age. Internally guided, for example, predictive, behavior usually helps to overcome sensory-motor delays. We studied whether predictive components of visuomotor transformation decline with age. We investigated smooth pursuit eye movements (SPEM) of ...

journal_title：Annals of the New York Academy of Sciences

authors： Sprenger A,Trillenberg P,Pohlmann J,Herold K,Lencer R,Helmchen C

更新日期：2011-09-01 00:00:00

abstract：:We have previously demonstrated that wild-type herpes simplex virus type 1 (HSV-1), as well as nonreplicating UV-inactivated HSV-1, promptly activates the nuclear factor-kappaB (NF-kappaB) in U937 monocytoid cells and that glycoprotein D (gD) of HSV-1 is sufficient by itself to exert a similar effect. We then investig...

journal_title：Annals of the New York Academy of Sciences

authors： Teresa Sciortino M,Medici MA,Marino-Merlo F,Zaccaria D,Giuffrè M,Venuti A,Grelli S,Mastino A

更新日期：2007-01-01 00:00:00

abstract：:Cytokine-based therapies have the potential to provide novel treatments for cancer, autoimmune diseases, and many types of infectious disease. However, to date, the full clinical potential of cytokines as drugs has been limited by a number of factors. To discuss these limitations and explore ways to overcome them, the...

journal_title：Annals of the New York Academy of Sciences

authors： Donnelly RP,Young HA,Rosenberg AS

更新日期：2009-12-01 00:00:00

abstract：:One of the most striking changes in the primary lymphoid organs during human aging is the progressive involution of the thymus. As a consequence, the rate of naïve T cell output dramatically declines with age and the peripheral T cell pool shrinks. These changes lead to increased incidence of severe infections and dec...

journal_title：Annals of the New York Academy of Sciences

authors： Pfister G,Weiskopf D,Lazuardi L,Kovaiou RD,Cioca DP,Keller M,Lorbeg B,Parson W,Grubeck-Loebenstein B

更新日期：2006-05-01 00:00:00

abstract：:Heparins represent an efficient treatment of acute thrombosis and obstetric complications in antiphospholipid syndrome (APS). Enhanced microvesiculation of cell membranes, as detected by reduced membrane adhesion, can contribute to hypercoagulability in APS. Healthy donor IgG antibodies significantly increased beta2-g...

journal_title：Annals of the New York Academy of Sciences

authors： Frank M,Sodin-Semrl S,Rozman B,Potocnik M,Kralj-Iglic V

更新日期：2009-09-01 00:00:00

abstract：:The trailblazing research on sleep mechanisms and petit mal epilepsy, conducted during the period from 1940 through 1970, illuminated the brain substrate for normal consciousness and attention, as well as their disorders. This research helped inform and structure our neuropsychologically based model of the "elements" ...

journal_title：Annals of the New York Academy of Sciences

authors： Mirsky AF,Duncan CC

更新日期：2001-06-01 00:00:00

abstract：:Anticardiolipin antibodies (aCLAs) and antibodies to oxidized-low density lipoproteins (oxLDL) are associated with two distinct diseases: the antiphospholipid syndrome and atherosclerosis. Because both diseases may be apparent in patients with systemic lupus erythematosus (SLE), it is important to establish the relati...

journal_title：Annals of the New York Academy of Sciences

authors： Damoiseaux J,Jeyasekharan AD,Theunissen R,Tervaert JW

更新日期：2005-06-01 00:00:00

abstract：:Shigella, a Gram-negative bacterial species of the family Enterobacteriaceae, causes bacillary dysentery in humans, an acute rectocolitis that reflects the capacity of the microorganism to disrupt, invade, and cause the inflammatory destruction of the intestinal epithelium. Here, the pathogenesis of Shigella infection...

journal_title：Annals of the New York Academy of Sciences

authors： Sansonetti PJ

更新日期：2006-08-01 00:00:00

abstract：:Although fetal nigral transplants have been shown to survive grafting into the striatum, increased [(18)F]6-fluroro-L-3,4-dihydroxyphenylalanine ((18)F-DOPA) uptake and improved motor function in open-label assessments have failed to establish any clinical benefits in double-blind, sham-controlled studies. To understa...

journal_title：Annals of the New York Academy of Sciences

authors： Chu Y,Kordower JH

更新日期：2010-01-01 00:00:00

abstract：:Phospholemman (PLM) is the first sequenced member of the FXYD family of regulators of ion transport. The mature protein has 72 amino acids and consists of an extracellular N terminus containing the signature FXYD motif, a single transmembrane (TM) domain, and a cytoplasmic C-terminal domain containing four potential s...

journal_title：Annals of the New York Academy of Sciences

authors： Cheung JY,Rothblum LI,Moorman JR,Tucker AL,Song J,Ahlers BA,Carl LL,Wang J,Zhang XQ

更新日期：2007-03-01 00:00:00

abstract：:People discover rather than choose their sexual interests. The process of discovery typically begins before the onset of puberty and is associated with an increase in the secretion of sex hormones from the adrenal glands. However, the determinants of the direction of sexual interest, in the sense of preferences for th...

journal_title：Annals of the New York Academy of Sciences

authors： Quinsey VL

更新日期：2003-06-01 00:00:00

abstract：:Cardiac development is characterized by a complex interplay of chemical, mechanical, and electrical forces, which together contribute to the proper formation of the heart muscle. In adult myocardium, cardiomyocytes are elongated, well-coupled by gap junctions, and organized in spatially well-defined muscle fibers. Thi...

journal_title：Annals of the New York Academy of Sciences

authors： Pijnappels DA,Gregoire S,Wu SM

更新日期：2010-02-01 00:00:00