Hyperbaric effects on sensorimotor reactivity studied with acoustic startle in the rat.

Abstract:

:In three experiments, startle responses to brief intense tone-bursts (30 msec, 110 dB, 6000 Hz) and single pulse (0.1 msec) stimulation of the cochlear nucleus and the nucleus reticularis pontis caudalis are studied under high pressures of heliox (from 0 bar to 50 bars) in the rat. For each rat (N = 12), mean amplitude and latency changes in startle responses (nuchal electromyography and whole-body accelerometry) are compared at normobaric pressure and during compression, at a speed of 100 bar/H. The results indicate that high pressures decrease (50% of control size) tone evoked startle by acting on the peripheral auditory organ, probably through middle and/or inner ear barotrauma. The large increases in electrically-elicited startle (250% of control size) from the cochlear and reticular nuclei, under hyperbaric conditions, suggest that high pressures affect sensorimotor reactivity by excitatory action on synaptic transmission in the relays of the acoustic startle reflex arc at the lower brainstem and spinal levels. Startle latencies remain unaffected by the heliox high pressures studied here.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

David JM,Risso JJ,Weiss M,Brue F,Pellet J

doi

10.1016/0031-9384(88)90076-5

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

237-44

issue

3

eissn

0031-9384

issn

1873-507X

pii

0031-9384(88)90076-5

journal_volume

42

pub_type

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