Abstract:
:The empirical use of amphotericin B in febrile leukemic patients not responding to antimicrobial agents has previously led to a significant decrease in fatal fungal infections and a significant increase in complete remissions. In this series of 66 patients receiving induction therapy for acute myelogenous leukemia (AML), 49 (74%) received amphotericin B. The median interval between institution of antibiotics and amphotericin B was ten days. Fifteen patients had clinical evidence of fungal infection, but only two (3%) died of fungal infection during induction therapy for AML. We discontinued amphotericin B upon granulocyte recovery (greater than 500/cu mm) unless a pulmonary infiltrate was present. Even though only five of 15 patients with probable fungal infection received more than 1,000 mg of amphotericin B, no patient had recurrent fungal disease while in remission. The incidence of clinically suspected fungal pneumonia during consolidation therapy and reinduction therapy also suggested that our therapy was adequate. An increased incidence of late fungal pneumonia in patients receiving reinduction was associated with prolonged neutropenia (greater than 50 days). This study supports the empirical use of amphotericin B during induction therapy for AML, and suggests that doses can be smaller than those generally recommended for fungal infection.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Stein RS,Greer JP,Ferrin W,Lenox R,Baer MR,Flexner JMdoi
10.1097/00007611-198607000-00020subject
Has Abstractpub_date
1986-07-01 00:00:00pages
863-70issue
7eissn
0038-4348issn
1541-8243journal_volume
79pub_type
杂志文章abstract::We present a case believed to be the first reported North American presentation of Ascaris lumbricoides within the urogenital tract. A young man came to the emergency department because of painless hematuria and having observed a 6-inch worm exit his urethra while urinating. The most common site for A lumbricoides inf...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::Thirteen male patients consecutively admitted to an inpatient drug and alcohol rehabilitation hospital with the primary diagnosis of crack cocaine dependence were shown a 30-minute videotape that included salient environmental cues intended to elicit cocaine craving. The subjects were tested before and after the video...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199411000-00016
更新日期:1994-11-01 00:00:00
abstract::We have presented a case of chronic pancreatitis with pseudocyst involvement of the spleen complicated by splenic rupture. This complication is uncommon, only 19 cases having been reported. As illustrated by our case, there is a high risk of hemorrhage from a pseudocyst involving the spleen and pancreas. Immediate sur...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198807000-00025
更新日期:1988-07-01 00:00:00
abstract::Pregnancy is a state of many hormonal changes that can make interpretation of thyroid function tests difficult. Measuring trimester-specific reference values of thyrotropin and free thyroxine is recommended. Because overt maternal hypothyroidism negatively affects the fetus, timely recognition and treatment are import...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/SMJ.0b013e3182a66610
更新日期:2013-09-01 00:00:00
abstract::Bullosis diabeticorum, or diabetic bullae, is a non-inflammatory blistering condition that is virtually diagnostic of diabetes. Diabetic bullae most often present as painless, tense, superficial bullae that occur in an acral distribution and commonly heal in 2-6 weeks without scarring, but complications such as second...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181a506d6
更新日期:2009-06-01 00:00:00
abstract::Aminoglycosides have been reported to cause tetany by inducing renal wasting of magnesium and secondary hypocalcemia. A 9-year-old girl with AIDS was brought to the emergency department because of tetany. She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobra...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199611000-00019
更新日期:1996-11-01 00:00:00
abstract::Six patients characterized by psychopathic behavior were treated with lesions placed in the center median nucleus of the thalamus. There was marked improvement of the psychopathic behavior in five patients. One patient with unilateral thalamotomy was parqially improved. Four of the six patients have been productive an...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197504000-00013
更新日期:1975-04-01 00:00:00
abstract:BACKGROUND:In patients with FIGO (International Federation of Gynecology and Obstetrics) stage I ovarian carcinoma given care with or without subspecialists, we compared completeness of initial staging and disease-free survival. METHODS:Two groups of patients with stage I ovarian carcinoma were compared. Patients were...
journal_title:Southern medical journal
pub_type: 杂志文章,多中心研究
doi:10.1097/00007611-199711000-00008
更新日期:1997-11-01 00:00:00
abstract::Pregnancy is an unusual occurrence in women with ESRD. We report a successful pregnancy in a patient with ESRD who was receiving hemodialysis; she gave birth to a healthy female infant at 34 weeks' gestational age. We discuss possible physiologic causes of gonadal dysfunction in patients with ESRD. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199102000-00033
更新日期:1991-02-01 00:00:00
abstract::Vitamin B12 deficiency can cause profound alterations in the bone marrow. These alterations can mimic the more serious diagnosis of acute leukemia. The two patients described in this report were originally suspected of having acute leukemia or myelodysplasia on the basis of the bone marrow smear, and induction chemoth...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000082003.98003.88
更新日期:2004-03-01 00:00:00
abstract::We have reported the case of a 26-year-old man who had had intermittent but severe gastrointestinal bleeding over a 30-month period from a Meckel's diverticulum. Meckel's diverticulum should be searched for angiographically, even in the face of normal isotopic scans, in cases of chronic or intermittent gastrointestina...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198601000-00019
更新日期:1986-01-01 00:00:00
abstract::Sixteen patients with spinal epidural compression by metastatic small-cell lung cancer were given radiotherapy for palliation. Lower limb motor deficit was the most prominent clinical manifestation. Neurologic dysfunction was commonly present for more than 48 hours before the diagnosis of compression. Median interval ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199203000-00008
更新日期:1992-03-01 00:00:00
abstract::Lactulose is a poorly absorbed synthetic disaccharide frequently used in the treatment of portasystemic encephalopathy. Because lactulose syrup contains small amounts of absorbable sugars, it may cause hyperglycemia in diabetic individuals, but is usually well tolerated. We report the case of a patient with diet-contr...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199504000-00025
更新日期:1995-04-01 00:00:00
abstract::Diabetic peripheral neuropathy affects 5 to 50% of people with diabetes in the United States. It is a progressive disorder that results in a gradual decrease in peripheral sensation and eventually complete loss of sensation. Patients with diabetic peripheral neuropathy are challenging to treat because of intolerable a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000060886.57804.2E
更新日期:2003-06-01 00:00:00
abstract::Anaerobic bacteria outnumber aerobic bacteria in normal flora in the oropharynx and gastrointestinal tract. They are important and frequent causes of infection, although they often go unrecognized except in the classic and very distincitve clostridial infections and intoxications-gas gangrene, botulism, and tetanus. A...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197609000-00025
更新日期:1976-09-01 00:00:00
abstract::Medical care in resource-limited environments (austere settings) can occur in the context of a disaster, wilderness, or a tactical field operation. Regardless of the type of environment, there are common organizational themes in most successful humanitarian missions that occur in harsh natural or manmade environmental...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31827c5a2e
更新日期:2013-01-01 00:00:00
abstract::Sodium fluoride has clearly been shown to have pronounced effects on the skeleton, probably more than any other currently available therapeutic agent. Unfortunately, these effects appear to be both beneficial and potentially toxic at the same time. A more clear understanding is needed of the basic mechanisms whereby t...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199208001-00007
更新日期:1992-08-01 00:00:00
abstract::The Chronic Illness Problem Inventory (CIPI) was used to assess level of psychosocial functioning in 89 patients with sickle cell disease. The results indicated that sickle cell patients have significant psychosocial distress in the areas of employment and finances, sleeping and eating, and performance of normal daily...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198806000-00015
更新日期:1988-06-01 00:00:00
abstract::The ultimate evolution of our case and its atypical features of unilateral blindness, bilateral involvement, and extensive involvement of the trigeminal nerve revealed the pathogenesis of this case of alternating painful ophthalmoplegia resembling the Tolosa-Hunt syndrome to be that of a parasellar pituitary adenoma. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198010000-00033
更新日期:1980-10-01 00:00:00
abstract::We reviewed the first 100 consecutive patients treated with extracorporeal shock wave lithotripsy (ESWL) at one institution. A total of 115 treatments were delivered to 58 men and 42 women. Patients with calculi of various sizes were treated and compared for (1) length of hospitalization, (2) ancillary procedures, (3)...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198801000-00010
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:A small but significant number of patients make frequent emergency department (ED) visits to multiple EDs within a region. We have a unique health information exchange (HIE) that includes every ED encounter in all hospital systems in our region. Using our HIE we were able to characterize all frequent ED user...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000488
更新日期:2016-07-01 00:00:00
abstract::A septic course suggestive of intra-abdominal abscess followed surgery in a small child with a perforated appendix. Usual diagnostic studies, fluoroscopy, and rectal and wound exploration failed to localized an abscess. The use of gallium 67 scanning accurately localized multiple abscesses which were successfully drai...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197610000-00038
更新日期:1976-10-01 00:00:00
abstract:BACKGROUND:Oxybutynin is a tertiary amine and has chemical similarities like protamine sulfate. Protamine sulfate's effect on bacterial viability has been shown in some studies; however, there is scanty data regarding the effect of oxybutynin on bacterial viability. Accordingly, the aim of the present study was to inve...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000305885.23903.71
更新日期:2008-03-01 00:00:00
abstract::A case of Rocky Mountain spotted fever in a 10-year-old boy accompanied by an unusually high degree of myalgia and muscle weakness was presented. On admission to the hospital, his creatine phosphokinase, SGOT, SGPT, and aldolase values were all abnormally high. Rash did not appear until the fourth hospital day. On the...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197812000-00037
更新日期:1978-12-01 00:00:00
abstract::Retrograde gastrointestinal intussusception is a rare entity, most commonly reported after gastric resection and gastrojejunostomy. Its occurrence in the absence of previous gastric resection is extremely unusual, with only four cases reported. All cases were associated with previously placed gastrostomy tubes and imp...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract::A hallmark of the clinical syndrome of thrombotic thrombocytopenic purpura (TTP) is evidence of microangiopathic hemolytic anemia. The presence of schistocytes on the peripheral blood smear, elevated plasma lactic dehydrogenase, and decreased haptoglobin concentration are used as evidence of microangiopathic hemolytic...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000136231.83564.F6
更新日期:2005-03-01 00:00:00
abstract::Computed tomography is widely used to diagnose acute pancreatitis. Iodinated contrast medium lengthens the duration of pancreatitis and may increase the incidence of local or systemic complications. Total parenteral nutrition including IV lipid emulsion plays an important role in the management of patients with pancre...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000047667.00302.CD
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Several previous studies of invasive Group A streptococcal (GAS) disease have been hindered by small sample sizes (< or = 100 patients) and limited generalizability. METHODS:We conducted a population-based study of invasive GAS disease. The objectives of the study were to describe the clinical features of i...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000051060.95210.9A
更新日期:2003-10-01 00:00:00
abstract::Endobronchial tuberculosis (EBTB) is an infection of the tracheobronchial tree. A 17-year-old male patient with tuberculosis who developed middle lobe syndrome on antituberculous treatment is presented. The patient was admitted with complaints of fever, cough and weight loss. Right paracardiac and perihilar heterogene...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181b66e7a
更新日期:2009-10-01 00:00:00
abstract::Most congenital heart anomalies now can be surgically corrected in a neonate or very young infant. Because their hearts are so small, it is advantageous to work in a bloodless and motionless operative field. Deep hypothermia with circulatory arrest provides this setting. Physiologic problems associated with hypothermi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197605000-00038
更新日期:1976-05-01 00:00:00