Skin flap necrosis in guinea pigs: limitation of glucose supply and accumulation of lactate.

Abstract:

:The distribution of glucose and lactate within skin flaps was determined in full-thickness guinea pig skin (excluding the panniculus carnosus). The distal end of the flaps had a low glucose content (less than 50 percent of normal) but high lactate level (2 to 3 times normal) during the 3 days after flap elevation. Progressively decreasing gradients of glucose content, and increasing gradients of lactate content, were demonstrated from the mid-region to the distal end of the flaps at 3 hours postoperatively. The decrease in glucose and the accumulation of lactate may play a significant role in skin necrosis.

journal_name

Plast Reconstr Surg

authors

Hoopes JE,Im MJ

doi

10.1097/00006534-197805000-00015

subject

Has Abstract

pub_date

1978-05-01 00:00:00

pages

748-52

issue

5

eissn

0032-1052

issn

1529-4242

journal_volume

61

pub_type

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