Abstract:
:In this study, the biological properties of natural abietane-type diterpenoids with an aromatic C ring are reviewed. An overview of the synthetic studies of this group of abietanes, including dehydroabietic acid, callitrisic acid and ferruginol, is presented. The review contains about 160 references.
journal_name
Nat Prod Repjournal_title
Natural product reportsauthors
González MAdoi
10.1039/c4np00110asubject
Has Abstractpub_date
2015-05-01 00:00:00pages
684-704issue
5eissn
0265-0568issn
1460-4752journal_volume
32pub_type
杂志文章,评审abstract::Microorganisms and in particular actinomycetes and microfungi are known to produce a vast number of bioactive secondary metabolites. For industrially important fungal genera such as Penicillium and Aspergillus the production of these compounds has been demonstrated to be very consistent at the species level. This mean...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b404943h
更新日期:2005-12-01 00:00:00
abstract::Covering: up to the end of 2018 Piperazic acid is a cyclic hydrazine and a non-proteinogenic amino acid found in diverse non-ribosomal peptide (NRP) and hybrid NRP-polyketide (PK) structures. Piperazic acid was first identified as a residue in the monamycins in 1959. Since then, the piperazic acid residue has been fou...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00076j
更新日期:2019-12-11 00:00:00
abstract::This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review discusses more than...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c0np00027b
更新日期:2011-01-01 00:00:00
abstract::Bracken (Pteridium spp.) is a ubiquitous fern which has been described as one of the five most common plants on the earth. The toxic effects of bracken on livestock have been recorded since the end of the 19th century, and extensive and intensive investigations for the bracken toxin(s) led to the isolation of ptaquilo...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b614160a
更新日期:2007-08-01 00:00:00
abstract::This review will detail progress made in the previous decade on the chemistry and bioactivity of birch bark extractive products. Current and future applications of birch bark natural products in pharmaceuticals, cosmetics, and dietary supplements for the prevention and treatment of cancer, HIV,and other human pathogen...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b606816b
更新日期:2006-12-01 00:00:00
abstract::Novel organic reactions drive the advance of chemical synthesis in the same way that enabling technologies drive new scientific discoveries. One area of organic methodology that has undergone significant growth during the last decade is that of homogeneous gold-catalyzed transformations. This trend has been further en...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70075e
更新日期:2014-04-01 00:00:00
abstract::Covering: up to early 2018 Polyketides and nonribosomal peptides are two major families of natural product with a broad range of biological activities. Polyketide synthases (PKSs) assemble small acetic acid-type acyl building blocks into polyketides through C-C bonds, and nonribosomal peptide synthetases (NRPSs) assem...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00022k
更新日期:2018-11-14 00:00:00
abstract::The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review w...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b202149h
更新日期:2003-04-01 00:00:00
abstract::Although natural products have been marginalized by major pharmaceutical companies over the last 20-30 years, the changing landscape of drug discovery now favors a greatly enhanced role for Nature's privileged structures. Screening for drug leads in phenotypic screens provides the best opportunity to realize the value...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c1np00033k
更新日期:2011-10-01 00:00:00
abstract::This review deals with the isolation and structure elucidation of meroterpenoids (natural products of mixed biosynthetic origin which are partially derived from terpenoids) from higher and lower fungi, and discusses biosynthetic studies and biological activities as appropriate. It describes 333 fungal meroterpenoids a...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b820413f
更新日期:2009-08-01 00:00:00
abstract::Covering: July 2012 to December 2019Over the last seven years, expanding research efforts focused on sesterterpenoids has led to the isolation, identification, and characterization of numerous structurally novel and biologically active sesterterpenoids. These newly reported sesterterpenoids provide diverse structures ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/d0np00070a
更新日期:2020-12-22 00:00:00
abstract::Covering: up to 2018 The Haemodoraceae family is a monocotyledonous family in the order Commelinales consisting of 14 genera. Many species from the family are endemic to Australia and their use by the Aboriginal People of Australia as both pigments or remedies has been ethnobotanically documented. Phenylphenalenones a...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00067k
更新日期:2019-05-22 00:00:00
abstract::Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superf...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70054b
更新日期:2014-01-01 00:00:00
abstract::This Highlight describes some of the recent synthetic work on imidazole-containing alkaloids isolated from marine sponges. Target molecules have been chosen which demonstrate synthetic strategies leading towards metabolites containing intact imidazole moieties as well as systems bearing modified imidazole rings. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b700206h
更新日期:2007-10-01 00:00:00
abstract::Contact chemosensation, or tasting, is a complex process governed by nonvolatile phytochemicals that tell host-seeking insects whether they should accept or reject a plant. During this process, insect gustatory receptors (GRs) contribute to deciphering a host plant's metabolic code. GRs recognise many different classe...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00002b
更新日期:2017-05-10 00:00:00
abstract::Phytotoxic compounds produced by plant pathogens are often crucial determinants of plant disease. Knowledge of them provides insights into disease syndromes and may be exploited by conventional breeding and biotechnology to obtain resistant crops. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b513232k
更新日期:2007-02-01 00:00:00
abstract::Heterologous expression of biosynthetic pathways is an indispensable tool in the discovery, production, engineering, and characterization of bacterial polyketides and the complex enzymology involved in their biosynthesis. Ensuring transcription of polyketide biosynthetic gene clusters in heterologous hosts is a pressi...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70060g
更新日期:2013-10-11 00:00:00
abstract::Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteria and archaea. This suggests that the pathway is a strong candidate for the discovery of novel antibiotic and herbicidal compounds. The enzymology of this short pathway in both bacteria ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b316419p
更新日期:2004-12-01 00:00:00
abstract::Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a n...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70122k
更新日期:2014-09-01 00:00:00
abstract::Antibiotics are a therapeutic class that, once deployed, select for resistant bacterial pathogens and so shorten their useful life cycles. As a consequence new versions of antibiotics are constantly needed. Among the antibiotic natural products, morphed peptide scaffolds, converting conformationally mobile, short-live...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00011a
更新日期:2017-07-01 00:00:00
abstract::Natural products have evolved, at least in part, to bind to biological macromolecules, particularly proteins. As a result, natural products are able to interact with many specific targets within the cell. Indeed for many years this has been central in the drug development process. Today, however, natural products are ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b616808f
更新日期:2007-12-01 00:00:00
abstract::Covering: 2000 up to 2020 Few classes of natural products have inspired as many chemists and biologists as have the iboga alkaloids. This family of monoterpenoid indole alkaloids includes the anti-addictive compound ibogaine as well as catharanthine, a precursor to the chemotherapeutic vinblastine. Despite being known...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/d0np00033g
更新日期:2020-08-14 00:00:00
abstract::This review covers the literature on simple indole alkaloids and those with a nonrearranged monoterpenoid unit from the beginning of 2012 up to the end of 2013, which includes newly isolated alkaloids, structure determinations, total syntheses and biological activities. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00032g
更新日期:2015-09-23 00:00:00
abstract::A detailed overview is presented of recent total synthesis approaches to four different diterpenoids--the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemist...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b705652b
更新日期:2008-04-01 00:00:00
abstract::In the recent past, macromolecular crystallography has gone through substantial methodological and technological development. The purpose of this review is to provide a general overview of structural biology and its impact on enzyme structure/function analysis and illustrate how it is modifying the focus of research r...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np20057k
更新日期:2012-10-01 00:00:00
abstract::The aim of the present review is to summarise the knowledge about newly isolated acetogenins (ACGs) in the last six years. It will also report the total syntheses that have allowed either the confirmation or the revision of some structures, together with the biological activities and mechanism of action of such intere...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b500186m
更新日期:2005-04-01 00:00:00
abstract::We compiled a data set of the compounds that terrestrial vertebrates (amniotes) use to send chemical signals, and searched for relationships between signal compound properties and signal function. Overall, relationships were scarce and formed only small-scale patterns. Terrestrial vertebrate signalling compounds are i...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00029g
更新日期:2015-07-01 00:00:00
abstract::Discovering molecular components and their functionality is key to the development of hypotheses concerning the organization and regulation of metabolic networks. The iterative experimental testing of such hypotheses is the trajectory that can ultimately enable accurate computational modelling and prediction of metabo...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np20111b
更新日期:2013-04-01 00:00:00
abstract::This review covers the biosynthesis of aliphatic and aromatic polyketides as well as mixed polyketide/NRPS metabolites, and discusses the molecular genetics and enzymology of the proteins responsible for their formation. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b301028g
更新日期:2006-04-01 00:00:00
abstract::Oligo-, polysaccharides, and glycoconjugates are a relevant part of the bioactive components of the natural products exploited in therapeutics, diagnostics, food additives, and biomaterials. Glycans are directly involved in important biological processes, such as immunostimulation, anti-inflammatory, antioxidant, and ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np20032e
更新日期:2012-06-01 00:00:00