Immune surveillance and tumors of the nervous system.

Abstract:

:The theory of immune surveillance postulates that one function of the immune system is to eliminate small numbers of malignant cells that arise spontaneously within the organism. Although there has been a great deal of both clinical and experimental evidence in favor of thistheory as it applies to general oncology, the question of whether or not such a surveillance system would be effective for tumors arising within the nervous system has never been studied. The young of pregnant rats which had been exposed to the neurocarcinogen ethylnitrosourea (ENU) were divided into control, immunosuppressed, and immunoenhanced groups. These lifetime alterations of the immune system had no effect on the course of nervous system tumor fromation. We believe that the most likely explanation for our results is that the "immunological privilege" of the brain prevents the usual interaction of the neoplasm and the immune system from occurring.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Morantz RA,Shain W,Cravioto H

doi

10.3171/jns.1978.49.1.0084

subject

Has Abstract

pub_date

1978-07-01 00:00:00

pages

84-92

issue

1

eissn

0022-3085

issn

1933-0693

journal_volume

49

pub_type

杂志文章
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    doi:10.3171/jns.1979.51.4.0429

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  • Poststroke fixed dystonia of the foot relieved by chronic stimulation of the posterior limb of the internal capsule.

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  • Transcranial electrical stimulation through screw electrodes for intraoperative monitoring of motor evoked potentials. Technical note.

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  • Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker.

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  • Spontaneous cerebrospinal fluid rhinorrhea associated with dysplastic optic discs and a basal encephalocele: case report.

    abstract::A 24-year-old man presented with a history of recurrent meningitis secondary to cerebrospinal fluid (CSF) rhinorrhea. The patient had bilateral optic disc dysplasia in association with a basal encephalocele, but had no midline facial anomalies. The syndrome is rare, and this is the first report of a patient with this ...

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    doi:10.3171/jns.1981.54.6.0807

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  • Neuronavigated percutaneous approach to the sphenopalatine ganglion.

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  • Computerized tomography of peripheral nerve lesions.

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    pub_type: 杂志文章

    doi:10.3171/jns.1983.59.1.0131

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  • Hand prehension recovery after brachial plexus avulsion injury by performing a full-length phrenic nerve transfer via endoscopic thoracic surgery.

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    pub_type: 杂志文章

    doi:10.3171/JNS/2008/108/6/1215

    authors: Xu WD,Lu JZ,Qiu YQ,Jiang S,Xu L,Xu JG,Gu YD

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  • Delayed cyst formation after stereotactic radiosurgery for brain arteriovenous malformations.

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    更新日期:2018-10-01 00:00:00

  • Long-term catheter angiography after aneurysm coil therapy: results of 209 patients and predictors of delayed recurrence and retreatment.

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  • Multiple giant hydatid cysts of the brain. Case report.

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    pub_type: 杂志文章

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  • Factor X deficiency presenting as a pseudotumor. Case report.

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  • Cervical myeloradiculopathy caused by arthrotic hypertrophy of the posterior facets and laminae.

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    pub_type: 杂志文章

    doi:10.3171/jns.1978.49.3.0387

    authors: Epstein JA,Epstein BS,Lavine LS,Carras R,Rosenthal AD

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  • Sudden hemorrhage in an acoustic neuroma. Case report.

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  • Results of nerve grafting in radial nerve injuries occurring proximal to the humerus, including those within the posterior cord.

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    pub_type: 历史文章,杂志文章

    doi:10.3171/jns.1994.81.1.0147

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  • Compound anterior cranial base fractures: classification using computerized tomography scanning as a basis for selection of patients for dural repair.

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