Neuroleptic malignant syndrome.

Abstract:

:The neuroleptic malignant syndrome (NMS) is a rare but potentially lethal disorder associated with the administration of neuroleptic agents. This syndrome may be underdiagnosed because it is poorly understood and often unrecognized. It affects all age groups and has a 20% mortality. Presenting features include extrapyramidal symptoms, altered mental consciousness, autonomic dysfunction, and hyperthermia. The underlying explanation for these manifestations is a disturbance of the dopaminergic system within the basal ganglia and hypothalamus. Dantrolene (Dantrium), amantadine (Symmetrel), and bromocriptine mesylate (Parlodel) have been efficacious in conjunction with supportive therapy. I report three cases successfully treated with bromocriptine and supportive therapy.

journal_name

South Med J

journal_title

Southern medical journal

authors

Rampertaap MP

doi

10.1097/00007611-198603000-00018

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

331-6

issue

3

eissn

0038-4348

issn

1541-8243

journal_volume

79

pub_type

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