Abstract：
:Proarrhythmia is a potentially lethal adverse effect of antiarrhythmic drugs. Underlying mechanisms and the approaches to identification are discussed. The applicability of electrophysiologic testing is considered, with particular reference to the validity of the different responses to programmed stimulation considered to be manifestations of proarrhythmia. The incidence of proarrhythmia in relation to individual antiarrhythmic agents is also reviewed.
journal_name
Cardiol Clinjournal_title
Cardiology clinicsauthors
Rae APsubject
Has Abstractpub_date
1986-08-01 00:00:00pages
487-96issue
3eissn
0733-8651issn
1558-2264journal_volume
4pub_type
杂志文章,评审abstract：:The Swan-Ganz catheter was developed 35 to 40 years ago for intensive and cardiac care units to allow bedside placement and continuous monitoring and recording of right-sided heart, pulmonary artery, and wedge pressures and reasonably accurate determinations of cardiac output. Considerations for the clinical applicati...
journal_title：Cardiology clinics
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.ccl.2007.08.005
更新日期：2007-11-01 00:00:00
abstract：:The advent of immunotherapy, particularly immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy, has ushered in a promising new era of treatment of patients with a variety of malignancies who historically had a poor prognosis. However, these therapies are associated with potentially life-threatenin...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2019.07.008
更新日期：2019-11-01 00:00:00
abstract：:This article describes the background and methodology of the published studies assessing the effects of cholesterol-lowering therapy and of treatment of multiple risk factors on the progression of coronary atherosclerosis. The results are then presented, followed by a discussion of the lessons that can be learned from...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8651(05)70259-9
更新日期：1996-02-01 00:00:00
abstract：:Patients who have chest pain following the use of cocaine have become more common in emergency departments throughout the United States,with approximately 6% of these patients sustaining an acute MI. The authors have described the rationale for recommending aspirin, benzodiaze-pines, and nitroglycerin as first-line tr...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2005.09.003
更新日期：2006-02-01 00:00:00
abstract：:The initial evaluation of patients with transient loss of consciousness (LOC) comprises a detailed medical history, physical examination, and 12-lead electrocardiogram. Because there are many causes of syncopal and nonsyncopal LOC, an adequate method of taking the clinical history, which is the cornerstone of diagnosi...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2015.04.002
更新日期：2015-08-01 00:00:00
abstract：:Transesophageal echocardiography (TEE) provides excellent delineation of ventricular function in the ambulatory and critical settings. Major indications include the acutely ill patient with suboptimal images with other techniques and the intraoperative assessment of patients undergoing cardiac surgery and of cardiac p...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8651(05)70174-0
更新日期：2000-11-01 00:00:00
abstract：:The chronotropic response is the most important means by which cardiac output is increased and oxygen delivery is maintained in response to increased oxygen consumption during exercise or stress. When the chronotropic response is suboptimal or absent, exercise intolerance results. This condition, called chronotropic i...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8651(05)70132-6
更新日期：2000-02-01 00:00:00
abstract：:Diseases of the thoracic aorta are serious conditions that require close observations. Impressive advances in imaging modalities such as magnetic resonance imaging, computed tomography sacs, and transesophageal echocardiography have aided diagnosis and provided insights into the pathogenesis and natural history of tho...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8651(05)70109-0
更新日期：1999-11-01 00:00:00
abstract：:Mechanical circulatory support using left ventricular assist devices (LVAD) has become an accepted mode of therapy for both bridging patients with end-stage heart failure to transplant and as a destination therapy. Right ventricular (RV) dysfunction is common after LVAD insertion and is a significant source of morbidi...
journal_title：Cardiology clinics
pub_type： 杂志文章
doi：10.1016/j.ccl.2011.08.011
更新日期：2011-11-01 00:00:00
abstract：:This is an extensive review of thrombolysis in myocardial infarction with discussions of the pathophysiology of occlusion, clinical occlusion and rationale for thrombolysis, thrombolytic agents, results of thrombolysis (incidence of reperfusion, left ventricular function, and mortality), complications of thrombolytic ...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：
更新日期：1988-02-01 00:00:00
abstract：:Catheter ablation for atrial fibrillation in patients with heart failure with reduced ejection fraction is associated with improvement in patient-centered outcomes, such as mortality, heart failure readmission, and atrial fibrillation recurrence, compared with standard medical therapy with or without device therapy. T...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2019.01.004
更新日期：2019-05-01 00:00:00
abstract：:Despite tremendous progress made in the management of CHD, a significant number of fatal and nonfatal CHD events still occur, which leads researchers to target other modifiable risk factors for CHD including low HDL-c (high density lipoprotein cholesterol). Although the torcetrapib experience was a major blow to CETP ...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2008.06.005
更新日期：2008-11-01 00:00:00
abstract：:Initially, transcatheter aortic valve replacement (TAVR) was only used in patients with severe symptomatic aortic stenosis and prohibitive risk for surgical aortic valve replacement. Subsequently, TAVR was extended to patients with high and intermediate surgical risk. Recently, the results of randomized trials in low-...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2019.09.007
更新日期：2020-02-01 00:00:00
abstract：:The physiology and hemodynamic functions of the right ventricle in normal and disease states differ considerably from those of the left ventricle. To illuminate these differences, the right ventricle's essential functions in the normal circulation are reviewed, its functional anatomy and blood supply are described, pr...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：
更新日期：1992-02-01 00:00:00
abstract：:The Fontan operation is a unique approach to create a circulation in series without 2 distinct pumping chambers. Although the approach has enabled many patients to live well into adulthood, the unique physiology results in many complications, cardiac and extracardiac. This review focuses on the pathophysiology of the ...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2015.07.010
更新日期：2015-11-01 00:00:00
abstract：:Hypertensive heart disease (HHD), a result of long-standing hypertension, is characterized by changes in the myocardial structure and function in the absence of other primary cardiovascular abnormalities. Although increased blood pressure is the initiating stimulus, neurohormonal factors, particularly the renin-angiot...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2010.07.005
更新日期：2010-11-01 00:00:00
abstract：:The cardiologist and internist can make a major contribution to the care of patients with neurologic disease, both in terms of treating patients with symptomatic cardiac involvement and reducing mortality. This article highlights the need to recognize ECG abnormalities that may represent purely neurologic disease as w...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：
更新日期：1995-05-01 00:00:00
abstract：:Incident heart failure and the burden of hospitalization may be demonstrating a decline. However, as the population ages, the prevalence of heart failure continues to increase. Mortality among heart failure patients is increasingly due to non-cardiovascular causes. Current evidence-based therapy for heart failure has ...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2016.12.008
更新日期：2017-05-01 00:00:00
abstract：:ACC Stage C heart failure includes those patients with prior or current symptoms of heart failure in the context of an underlying structural heart problem who are primarily managed with medical therapy. Although there is guideline-based medical therapy for those with heart failure with reduced ejection fraction (HFrEF...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2013.09.012
更新日期：2014-02-01 00:00:00
abstract：:Cardiovascular drugs are often used in pregnancy for the treatment of maternal and fetal conditions. The complex physiologic changes occurring during pregnancy may significantly affect the pharmacokinetics of many drugs and, consequently, the toxicity and therapeutic response. Of special concern are the effects of mat...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：
更新日期：1987-11-01 00:00:00
abstract：:Because of constraints on the costs of providing medical care, cardiologists in the future will find themselves challenged to provide care for their patients in the most cost-effective manner possible. Although stress-echocardiography has been shown to compare favorably with other tests in diagnostic accuracy, data on...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8651(05)70098-9
更新日期：1999-08-01 00:00:00
abstract：:This article briefly reviews the background and rationale for the development of polymer paving. The process of endoluminal paving is described both in its generic form as well as in three experimental embodiments. Several experimental studies with two forms of paving, solid paving and gel paving, are reviewed. Finall...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：
更新日期：1994-11-01 00:00:00
abstract：:Venous thromboembolism (VTE) is a potentially fatal condition and includes deep vein thrombosis and pulmonary embolism. The novel oral anticoagulants, which include the direct thrombin and factor Xa inhibitors, have been shown to be safe and effective for the treatment of VTE. Additional interventions include thrombol...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2014.09.007
更新日期：2015-02-01 00:00:00
abstract：:Congenital abnormalities of the pericardium are a rare group of disorders that include congenital absence of the pericardium, pericardial cysts, and diverticula. These congenital defects result from alterations in the embryologic formation and structure of the pericardium. Although many cases are incidentally found, t...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2017.07.012
更新日期：2017-11-01 00:00:00
abstract：:The medical management of patients with CHF and ventricular arrhythmias is one of the most challenging clinical situations frequently encountered by physicians on a daily basis. Reviewed and examined in this article are available data regarding the clinical relevance and prevalence of ventricular arrhythmias, their pr...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：
更新日期：1994-02-01 00:00:00
abstract：:This article presents an approach to real-time three-dimensional imaging of the tricuspid valve from three different views. This is followed by some representative cases that illustrate these views and some unique tricuspid valve abnormalities, including one case of corrected transposition. ...
journal_title：Cardiology clinics
pub_type： 杂志文章
doi：10.1016/j.ccl.2007.06.001
更新日期：2007-05-01 00:00:00
abstract：:Although the growing use of continuous-flow left ventricular assist devices (LVADs) has improved the survival and quality of life of patients with stage D heart failure, ischemic and hemorrhagic cerebrovascular accidents remain one of the most-feared complications of this therapy and a significant source of disability...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2018.06.007
更新日期：2018-11-01 00:00:00
abstract：:Atrial fibrillation (AF), an escalating dysrhythmia, is accountable for extensive population morbidity and mortality. In the United States, approximately 2.3 million people are presently diagnosed with AF and it is estimated that this prevalence may increase to 5.6 million by 2050. Foremost predisposing risk factors f...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2008.09.015
更新日期：2009-02-01 00:00:00
abstract：:Under normal baseline conditions the unique anatomy, myocardial ultrastructure, and coronary physiology of the right ventricle (RV) reflect a high-volume low-pressure pump. Early work described the RV as a passive conduit with minimal pumping capability. It is now appreciated that through a mechanism of ventricular in...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ccl.2012.03.009
更新日期：2012-05-01 00:00:00
abstract：:Percutaneous transluminal coronary angioplasty remains the standard interventional catheterization approach for the treatment of coronary artery disease. Three broad groups of new therapeutic devices, including atherectomy or devices for mechanical debridement, lasers, and endoprostheses, and diagnostic devices such a...
journal_title：Cardiology clinics
pub_type： 杂志文章,评审
doi：
更新日期：1991-02-01 00:00:00
