Abstract:
OBJECTIVE:To describe the establishment and organization of the Danish Fetal Medicine Database and to report national results of first-trimester combined screening for trisomy 21 in the 5-year period 2008-2012. DESIGN:National register study using prospectively collected first-trimester screening data from the Danish Fetal Medicine Database. POPULATION:Pregnant women in Denmark undergoing first-trimester screening for trisomy 21. METHODS:Data on maternal characteristics, biochemical and ultrasonic markers are continuously sent electronically from local fetal medicine databases (Astraia Gmbh software) to a central national database. Data are linked to outcome data from the National Birth Register, the National Patient Register and the National Cytogenetic Register via the mother's unique personal registration number. First-trimester screening data from 2008 to 2012 were retrieved. MAIN OUTCOME MEASURES:Screening performance was assessed for the years 2008-2012 by calculating detection rates and screen-positive rates. RESULTS:A total of 268 342 first-trimester risk assessments for trisomy 21 were performed in singleton pregnancies. Participation rate in first-trimester screening was >90%. The national screen-positive rate increased from 3.6% in 2008 to 4.7% in 2012. The national detection rate of trisomy 21 was reported to be between 82 and 90% in the 5-year period. CONCLUSION:A national fetal medicine database has been successfully established in Denmark. Results from the database have shown that at a national level first-trimester screening performance for trisomy 21 is high with a low screen-positive rate and a high detection rate.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Ekelund CK,Petersen OB,Jørgensen FS,Kjaergaard S,Larsen T,Olesen AW,Skibsted L,Skovbo P,Sommer S,Sperling L,Stavnstrup B,Størup B,Zingenberg H,Uldbjerg N,Miltoft CB,Noergaard L,Wulff CB,Tabor A,Danish Fetal Medicine Rdoi
10.1111/aogs.12581subject
Has Abstractpub_date
2015-06-01 00:00:00pages
577-83issue
6eissn
0001-6349issn
1600-0412journal_volume
94pub_type
杂志文章abstract::Osteoporosis and subsequent fractures is a rapidly growing major health problem in many parts of the world. Even if prevalence and incidence are high in Europe, rate of increase is even higher in Asia. The majority of fractures occur in women underlining the importance of ovarian deficiency. Genetic factors and lifest...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:As the patterns and frequency of maternal and clinical conditions and outcomes and gross and histological placental features and lesions vary with gestational age at delivery, we aimed to study the impact of these changes on the placental diagnosis, hoping to uncover potential novel clusters of gestational ag...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12350
更新日期:2014-04-01 00:00:00
abstract:INTRODUCTION:Shoulder dystocia has remained an unpredictable and feared emergency in obstetrics. Some risk factors have been identified but nevertheless there is a lack of risk evaluation tools in clinical practice. The aim of this study was to evaluate the incidence and risk factors of shoulder dystocia in the Finnish...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.14022
更新日期:2020-10-09 00:00:00
abstract:OBJECTIVE:To study stillbirths and neonatal mortality in the postterm period. DESIGN:Register study of information obtained from the Swedish Medical Birth Registry (MBR), National Board of Health and Welfare, Stockholm. METHODS:Singleton pregnancies with deliveries occurring between 1982 and 1991 were selected involv...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.3109/00016349709024606
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:To study pregnant women's knowledge, attitudes and behaviors towards tobacco use and secondhand smoke (SHS) exposure, and exposure to advertising for and against tobacco products in Zambia and the Democratic Republic of the Congo (DRC). DESIGN:Prospective cross-sectional survey between November 2004 and Sept...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016341003605693
更新日期:2010-01-01 00:00:00
abstract::Strips of ovarian hilar tissue taken from 11 post-menopausal women were examined histologically and found to contain clusters of hilus cells in contiguity with non-myelinated nerve fibers. No other steroidogenically active structures were found. Specimens from these strips were incubated for 30 and 240 minutes in Kreb...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348209156582
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVE:To determine if oxidative stress and endothelial dysfunction exist at the same time in a young, non-obese group of patients with polycystic ovary syndrome (PCOS). DESIGN:Cross-sectional study. SETTING:Celal Bayar University, School of Medicine, Manisa, Turkey. SAMPLE:Thirty-one young, non-obese patients wi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340902859315
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:There has been a rise in the prevalence of large newborns over a few decades in many parts of the world. There is ample evidence that fetal macrosomia is associated with increased risk of complications both for the mother and the newborn. In current obstetrics, the macrosomic fetus represents a frequent clin...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.1080/00016340801899289
更新日期:2008-01-01 00:00:00
abstract::Pregnancy outcomes in 22 consecutively operated women with Müllerian anomalies are described. In 16 women the indication for metroplasty was two or more spontaneous abortions and/or premature deliveries. The frequency of successful pregnancies increased from 5% before to 76% after operation. In 6 women metroplasty was...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348809004205
更新日期:1988-01-01 00:00:00
abstract::Current methodologies to assess the process of labor, such as tocodynamometry or intrauterine pressure catheters, fetal fibronectin, cervical length measurement and digital cervical examination, have several major drawbacks. They only measure the onset of labor indirectly and do not detect cellular changes characteris...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0412.2010.01031.x
更新日期:2011-02-01 00:00:00
abstract::Does a thorough vaginal cleansing with bactericidal solutions prior to induced first-trimester vacuum aspiration abortion reduce the frequency of postabortal pelvic inflammatory disease (PID)? To answer this question we compared the frequency of PID in 372 women where a thorough preoperative vaginal cleansing with a b...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348309155808
更新日期:1983-01-01 00:00:00
abstract::International guidelines recommend that health-care providers initiate discussions about the impact of treatment on fertility with cancer patients of reproductive age, or with parents/legal guardians of children, as early as possible in the treatment process. Still, both physicians and patients confirm that this is no...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/aogs.13551
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:To investigate the role of interleukin-1 related substances in amniotic fluid in normal term labor without intrauterine infection. METHODS:Amniotic fluid samples were collected from forty-one patients with various backgrounds. A novel pre-assay treatment using Frigen II was introduced to improve the recover...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract:INTRODUCTION:Abnormally invasive placenta is a major cause of maternal morbidity and mortality. The aim of this study was to assess the effectiveness of a standardized operative approach performed by gynecological oncologists in the surgical management of abnormally invasive placenta. MATERIALS AND METHODS:We performe...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12768
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To determine whether plasma levels of fibrinogen and the placental tissue distributions of fibrinogen and histidine-rich glycoprotein (HRG) differ between early- and late-onset preeclampsia. DESIGN:The study comprised 18 women with early-onset (gestational weeks 24-32) and 19 women with late-onset (gestation...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016340903295618
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the distribution of circulating adiponectin isoforms in pregnant women with gestational diabetes mellitus (GDM) and compare isoform distribution changes 12 months after delivery. DESIGN CROSS-SECTIONAL STUDY SETTING:University Hospital. POPULATION:Sixty-four consecutive pregnant women who underw...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12137
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Fetal heart rate short term variation (STV) decreases with severe chronic hypoxia in the antenatal period. However, only limited research has been done on STV during labor. We have tested a novel algorithm for a valid baseline estimation and calculated STV. To explore the value of STV during labor, we comp...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13390
更新日期:2018-10-01 00:00:00
abstract::A case report of a quadruplet pregnancy that followed the induction of ovulation by human chorionic gonadotropin and human menopausal gonadotropin is presented. Examination revealed 4 separate placentas, indicating development from 4 different ova. The infants all did well at term, with no signs of respiratory distr...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347409157759
更新日期:1974-01-01 00:00:00
abstract::In a prospective, randomized study the duration and effectiveness of four different regimens of PCB were studied: Bupivacaine both with and without adrenaline, and chloroprocaine with and without adrenaline. The pain relief was immediate and almost complete in most patients in all four treatment groups. The duration o...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016348309155804
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:To assess the role of the placental arterial Doppler examination at 23-24 gestational weeks for predicting adverse perinatal outcome in high-risk pregnancies. DESIGN:Retrospective register study. SETTING:Skåne University Hospital in Malmö. POPULATION:Six hundred and forty-five women with high-risk pregnanc...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12488
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To produce normograms of Doppler indices of major fetal arteries and their ratios relative to the ascending aorta in a cohort of appropriately grown for gestational age fetuses. METHODS:Prospective longitudinal study of 70 women with appropriately grown for gestational age fetuses between 24 and 38 weeks' ge...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2005.00549.x
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:In a previous prospective randomised trial on pregnancies complicated by small-for-gestational-age fetuses fewer operative deliveries for fetal distress were found after antenatal surveillance with umbilical artery Doppler velocimetry (Doppler group) than after surveillance with cardiotocography (CTG group)....
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349509024383
更新日期:1995-08-01 00:00:00
abstract::Prolactin (PRL) levels in maternal serum, amniotic fluid and mixed cord blood from 11 women with post-term pregnancies and 64 women with normal term pregnancies were measured by immunoenzymetric assay in order to investigate their possible role in the onset of labor. No differences were found between term and post-ter...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349309013376
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Description of incidence, clinical signs, symptoms, and consequences of eclampsia in Scandinavia, and assessment of substandard care and potential preventability. METHODS:A descriptive cohort study including all women giving birth in a 2-year period (mid-1998-mid-2000) in Scandinavia. Notifications of eclam...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340600607149
更新日期:2006-01-01 00:00:00
abstract::Singleton pregnancies following in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased risks of abnormal placentation, pre-eclampsia and preterm birth. These risks might partly be a consequence of the number of transferred embryos. In this commentary we summarize the res...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340802307787
更新日期:2008-01-01 00:00:00
abstract::302 samples from 22 normal pregnancies were frozen and kept for the analysis of free calcium ion concentration [Ca2+](7.4) at 37 degrees C and pH 7.40, after equilibration with CO2. Individual regressions were performed, and the concentration was found to increase slightly but significantly (5%, p less than 0.005) wit...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348109158137
更新日期:1981-01-01 00:00:00
abstract::Intramuscular 15(S)15 methyl PGF2α (Prostin 15M, Upjohn) was used for induction of labour in cases of missed abortion and intra-uterine fetal death. The patients received premedication to control the gastrointestinal side effects. Prostin 15M was given at a dose of 250 µg every three hours and escalated whenever requi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.1988.67.s145.45
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:Antenatal anemia is a major public health problem in the UK, yet there is limited high quality evidence for associated poor clinical outcomes. The objectives of this study were to estimate the incidence and clinical outcomes of antenatal anemia in a Scottish population. MATERIAL AND METHODS:A retrospectiv...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12862
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To determine the performance of trained midwives in second trimester ultrasound screening for fetal structural abnormalities in a low-risk population. DESIGN:Retrospective study. SETTING:University Department of Obstetrics and Gynecology. POPULATION:About 13,882 women with singleton pregnancies. METHODS:T...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340902934688
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Accurate estimates and reliable classification of maternal deaths are imperative steps in the chain of actions targeted at reducing avoidable maternal mortality. The aims of this study were to estimate the maternal mortality ratio (MMR) in 10 Italian regions covering 77% of total national births and to ide...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13415
更新日期:2018-11-01 00:00:00