Abstract：
:Review of the literature of the past 40 years on tyrosine and its toxicity shows that no direct link between this aromatic amino acid and carcinogenesis has been well established. Ten years ago, studies of tyrosine toxicity in mice suggested the formation of an epoxide adduction product presumably derived from tyrosine by way of the liver microsomal detoxification system. Another study showed an increased frequency of hepatomas following long-term treatment with para-hydroxyphenyllactic acid, a tyrosine derivative occurring in the absence of p-hydroxyphenylpyruvate oxydase activity. Recently, studies on hereditary tyrosinemias (Type I) have indicated that the primary enzyme defect in these diseases is a deficiency of liver and renal fumarylacetoacetase. This results in an accumulation of natural alkylating derivatives of homogentisic acid such as maleyl- and fumarylacetoacetate in liver. Adduction of these compounds by glutathione is demonstrated by the presence of the mercapturic acid S-2-fumaryl-acetone-N-acetylcysteine in urine of patients. This adduct is also present in the urine of a number of heterozygote carriers after oral loads consisting of small quantities of homogentisic acid. In this report, we present the results of preliminary animal studies on the biochemical nature of the toxic effects of these tyrosine derivatives in these diseases along with preliminary data on the influence of fumarylacetone on protein synthesis in cultured eucaryotic cells. Fumarylacetone reacts as a natural alkylating agent and may, along with maleylacetoacetate, be responsible for the high incidence of late-onset hepatoma in the clinical chronic forms of hereditary tyrosinemias.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Laberge C,Lescault A,Tanguay RMdoi
10.1007/978-1-4613-1835-4_17subject
Has Abstractpub_date
1986-01-01 00:00:00pages
209-21eissn
0065-2598issn
2214-8019journal_volume
206pub_type
杂志文章abstract：:Dimethyl sulfoxide (DMSO) is one of the most commonly used solvents for hydrophobic substances in biological experiments. In addition, the compound exhibits a plethora of bioactivities, which makes it of potential pharmacological use of its own. The influence on respiration, and thus on arterial blood oxygenation, of ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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更新日期：1995-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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doi：
更新日期：2004-01-01 00:00:00
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doi：
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更新日期：1977-01-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
doi：10.1007/978-1-4615-3426-6_17
更新日期：1992-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4757-0022-0_4
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2003-01-01 00:00:00
