Abstract:
:Intracellular pH provides an important measure of the adequacy of local tissue perfusion. The purpose of this study was to measure regional intracellular myocardial pH (impH) in the ischemic zone in vivo during experimental canine coronary occlusion, with and without coronary reperfusion. Twenty adult dogs were studied. Ten dogs underwent permanent ligation of the proximal anterior left descending coronary artery (group L), five dogs had coronary reperfusion after 1 hour of total coronary occlusion (group R), and five dogs did not undergo ligation and served as controls (group C). Intracellular myocardial pH was measured by 31phosphorus nuclear magnetic resonance spectroscopy at baseline and then at 15-minute intervals for 6 hours after coronary occlusion (or after sham occlusion in group C). Baseline impH did not differ among groups (group C, 7.22 +/- 0.12 mean +/- standard error of mean; group L, 7.17 +/- 0.07; group R, 7.22 +/- 0.09). During hour 1 of total occlusion, the impH of both groups L (6.58 +/- 0.05) and R (6.55 +/- 0.08) was significantly reduced as compared with the impH of group C (7.3 +/- 0.12; p less than 0.05). At 0 to 1, 1 to 3, and 3 to 5 hours of reperfusion, the impH of group R (7.34 +/- 0.08, 7.27 +/- 0.07, and 7.29 +/- 0.06, respectively for these times) did not differ from group C (7.26 +/- 0.11, 7.21 +/- 0.07, and 7.25 +/- 0.10). At these same times, the impH of group L (6.47 +/- 0.05, 6.57 +/- 0.04, and 6.75 +/- 0.04) was significantly reduced as compared with both groups R and C (p less than 0.05). Thus a severe, persistent regional intracellular myocardial acidosis occurs in the ischemic zone with coronary occlusion but is rapidly corrected by reperfusion within 1 hour.
journal_name
Surgeryjournal_title
Surgeryauthors
Rehr RB,Clarke G,Tatum J,Hirsch J,Fatouros P,Lower R,Wetstein Lsubject
Has Abstractpub_date
1987-08-01 00:00:00pages
178-85issue
2eissn
0039-6060issn
1532-7361pii
0039-6060(87)90232-7journal_volume
102pub_type
杂志文章相关文献
SURGERY文献大全abstract:BACKGROUND:Liver cell proliferation after partial hepatectomy in rats has been thoroughly investigated. Although DNA synthesis and morphologic restoration have been studied in this rat model, the functional capacity of the remnant liver during regeneration has not been elucidated. METHODS:We measured the indocyanine g...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(97)90058-1
更新日期:1997-06-01 00:00:00
abstract::An abdominal operation combines a somatic abdominal wall wound with a second autonomic wound to the peritoneal cavity and viscera and little attention has been paid the autonomic/peritoneal wound that communicates directly to the brain by the vagus nerve. Moreover, vagal input originating from the peritoneum modulates...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.10.020
更新日期:2011-03-01 00:00:00
abstract::Ten patients who had a cricopharyngeal myotomy and diverticulum suspension for pharyngoesophageal diverticulum have been studied clinically, radiologically, and manometrically. There were no deaths or morbidity and all patients have achieved marked improvement of their symptoms. Before operation all patients but one h...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract::This report describes an experimental study in which dogs with prosthetic graft replacement of the infrarenal abdominal aorta were challenged at progressive time intervals following graft placement with a single intravenous infusion of Staphylococcus aureus in order to determine the duration of susceptibility to graft...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-08-01 00:00:00
abstract::Endorectal ileoanal anastomosis with proximal interposition of an ileal reservoir was evaluated experimentally in dogs as an approach to retain sphincteric control of defecation after proctocolectomy. Two months after the operative procedure, eight animals with a reservoir had four to eight semisolid stools per day an...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:Routine and radical lymph node dissection is a clinical concern for improving the surgical outcome in patients with intrahepatic cholangiocarcinoma (ICC). The therapeutic value of the procedure during hepatectomy has, however, not been evaluated. METHODS:Between January 1990 and December 2004, 104 patients ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2008.11.010
更新日期:2009-04-01 00:00:00
abstract::Dogs treated with 15 cm H2O positive end-expiratory pressure (PEEP) invariably show a decrease in cardiac output (CO). Plasma that is obtained from PEEP-treated dogs and applied to an isometrically contracting rat papillary muscle results in a significant depression of the peak developed tension. The present study eva...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:Hepatectomy for colorectal liver metastases (CRLM) may offer good long-term survival. The impact of the tumor-free surgical margin on long-term results remains controversial, and we have assessed this component in 185 patients. METHODS:Between 1992 and 2005, 185 patients underwent primary hepatectomy with c...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2007.09.038
更新日期:2008-03-01 00:00:00
abstract::John Syng Dorsey is one of the unsung heroes of American surgery. In 1811 he performed this country's first successful ligation of the external iliac artery, for a massive aneurysm in the right groin. Two years later he wrote America's first systematic textbook of surgery. In addition, he held the professorial chairs ...
journal_title:Surgery
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Managed care organizations use a variety of payment strategies to contract for high-end tertiary services with academic healthcare centers. We assessed the financial outcome of these strategies and attempted to identify those that maintain a balance between cost and reimbursement. METHODS:Patients admitted ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(03)00329-5
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:In clinically node-negative papillary thyroid microcarcinoma (PTMC), the frequency of subclinical lymph node metastasis (LNM) in the central cervical compartment (subclinical central LNM) has been reported to be as great as 65%. Routine prophylactic central compartment lymph node dissection (CLND) has been d...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.01.003
更新日期:2010-09-01 00:00:00
abstract::To reevaluate the validity of our policy of mandatory surgical exploration of penetrating zone II neck injuries, the charts of 110 patients who underwent surgical exploration for such injuries were reviewed. Fifty-three percent of the patients had normal findings at exploration, whereas 33% had injuries involving vasc...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:Barriers to trauma care for rural populations are well documented, but little is known about the magnitude of urban-rural disparities in injury mortality. This study sought to quantify differences in injury mortality comparing rural and nonrural residents with traumatic injuries. METHODS:Using data from the...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.06.020
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The electronic medical record (EMR) of a large, tertiary referral center was examined to study the prevalence of undiagnosed and unrecognized primary hyperparathyroidism (PHPT). METHODS:The EMR was queried for outpatient serum calcium >10.5 mg/dL over a 2-year period. RESULTS:Of 2.7 million patients, 54,19...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2013.06.051
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Approximately 10% of patients taking lithium for manic-depressive disorders become hypercalcemic. It remains unclear whether lithium initiates disease or promotes underlying hyperparathyroidism. We have previously demonstrated that at therapeutic concentrations lithium stimulates in vitro incorporation of bo...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(05)80258-2
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Detailed knowledge of the dimensions and shape of the main arteries of the body and how they change with age and disease is important for understanding arterial pathophysiology and improving minimally invasive devices to treat arterial diseases. Our goal was to describe and compare geometric remodeling of th...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.05.013
更新日期:2015-12-01 00:00:00
abstract::Hemolytic uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and acute renal failure, usually in children under 10 years of age. Gastrointestinal symptoms, including abdominal pain and bloody diarrhea, frequently precede the onset of renal failure. It has not been generally appreciated that ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Expendable autologous nerve available for repair of nerve injuries is limited. Cadaveric allografts could provide adequate nerve for grafting but are susceptible to rejection and currently require chronic systemic immunosuppression. METHODS:Age-matched Buffalo (RT1B) rats randomly assigned to 7 experimental...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Studies of sexual dimorphism in trauma outcomes suggest that women have a survival advantage compared to equivalently injured men. It is unknown if this gender disparity is mediated by potentially life-threatening complications. OBJECTIVE:To determine (1) if there is a sex-based differences in the odds of d...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.05.006
更新日期:2009-08-01 00:00:00
abstract::The relationship between the cyclosporine A (CSA) dose and rejection of varying lengths of small-bowel grafts was studied in a rat heterotopic microsurgical small-bowel transplantation model involving a haploidentical strain combination. When Lewis X Brown Norway F1 hybrid (LBN) small-bowel grafts were transplanted in...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Somatostatin analogues inhibit peptide release and cell growth through multiple postreceptor signal transduction mechanisms (PRSTM), including G proteins (GP), cyclic adenosine monophosphate (cAMP), calcium, protein kinase C (PKC), and tyrosine phosphatase (TP). Octreotide acetate (OA), a somatostatin analog...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::Social media is a necessary component of the practice of surgery. Each surgeon must embrace the power and potential of social media and serve as a guide or content expert for patients and other health care providers to facilitate and share responsible use of the various media available. Social media facilitates rapid ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.06.002
更新日期:2015-09-01 00:00:00
abstract:INTRODUCTION:Tertiary hyperparathyroidism (3HPTH) patients who undergo parathyroidectomy (PTX) are often managed with calcium lowering medications such as cinacalcet (Sensipar) before surgery. Here, we assess how cinacalcet treatment influences intraoperative parathyroid hormone (IOPTH) kinetics and surgical findings i...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2014.08.003
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Resection of T4 colon cancer remains challenging compared to lower T stages. Data on the effect of neoadjuvant radiation to improve resectability and survival are lacking. The purpose of this study is to describe the use and outcomes of neoadjuvant radiation therapy in clinical T4 colon cancer. METHODS:Adul...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.06.015
更新日期:2019-02-01 00:00:00
abstract::Tony is a practicing frontline National Health Service surgeon and director of medical innovation at Anglia Ruskin University and has founded 4 medical-technology start-ups. He has also cofounded the £500 million Anglia Ruskin MedTech Campus, which will become one of the world's largest health innovation spaces. In 20...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.07.039
更新日期:2017-05-01 00:00:00
abstract::The aims of this study were to determine whether ectopic pacemakers are present after meals in the Roux limbs of dogs after vagotomy and Roux gastrectomy, whether these pacemakers slow gastric emptying of liquids or solids, and whether abolishing the pacemakers with electric pacing might speed any slow emptying that o...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract::Segmental bilioenteric anastomosis procedures were performed on 22 patients with malignant hilar biliary obstructions. The majority of the bypasses were done to the segment 3 duct and a single anastomosis was performed in each patient. The operative mortality rate was 13.6% and morbidity, 27.3%. The biliary obstructio...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:The surgical success rate of parathyroidectomy is 95%. However, in rare patients, ectopic hyperfunctioning parathyroid glands may be located in the thyroid but missed on imaging studies or during surgery. The aim of the present study was to evaluate the perioperative findings in 6 patients with intrathyroid ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.11.009
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:The Hedgehog (Hh) gene family is known to regulate development of stem cells. In addition, activation is responsible for the induction of GLI1 proto-oncogene and subsequent cellular proliferation. Sonic Hedgehog (SHh), one of the Hh family members promotes carcinogenesis in airway and pancreatic epithelia, i...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.10.012
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Our purpose was to determine whether the combination of total liver vascular inflow occlusion (Pringle maneuver) and rapid hepatic transection with a clamp-crush technique results in significant reduction of blood loss and transfusion requirements during major hepatic resections. METHODS:A series of 49 adul...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00