Abstract:
:Antibiotic resistance is a problem of deep scientific concern both in hospital and community settings. Rapid detection in clinical laboratories is essential for the judicious recognition of antimicrobial resistant organisms. Production of extended-spectrum β-lactamases (ESBLs) is a significant resistance-mechanism that impedes the antimicrobial treatment of infections caused by Enterobacteriaceae and is a serious threat to the currently available antibiotic armory. ESBLs are classified into several groups according to their amino acid sequence homology. Proper infection control practices and barriers are essential to prevent spread and outbreaks of ESBL producing bacteria. As bacteria have developed different strategies to counter the effects of antibiotics, the identification of the resistance mechanism may help in the discovery and design of new antimicrobial agents. The carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by ESBL-producing Enterobacteriaceae, although comparative clinical trials are scarce. Hence, more expeditious diagnostic testing of ESBL-producing bacteria and the feasible modification of guidelines for community-onset bacteremia associated with different infections are prescribed.
journal_name
Saudi J Biol Scijournal_title
Saudi journal of biological sciencesauthors
Shaikh S,Fatima J,Shakil S,Rizvi SM,Kamal MAdoi
10.1016/j.sjbs.2014.08.002subject
Has Abstractpub_date
2015-01-01 00:00:00pages
90-101issue
1eissn
1319-562Xissn
2213-7106pii
S1319-562X(14)00094-1journal_volume
22pub_type
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章,评审
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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pub_type: 杂志文章
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2013.11.003
更新日期:2014-07-01 00:00:00
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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