Abstract：
BACKGROUND:Training intensity may play a key role in magnifying the protective effect of physical exercise against nonalcoholic fatty liver disease (NAFLD). PURPOSE:This study aimed to test the hypothesis that vigorous-intensity and interval training is as effective as moderate-intensity and continuous exercise training on NAFLD in high-fat diet (HFD)-induced obese mice. METHODS:C57BL/6 mice (N = 40) were fed a standard-chow diet (n = 10) or HFD (n = 30) for 16 wk. After the initial 8-wk dietary treatments, HFD mice were further divided into HFD only (n = 10), HFD plus vigorous-intensity and interval treadmill running (VIT) (n = 10), and HFD plus moderate-intensity and continuous treadmill running (MIT) (n = 10) for the remaining 8-wk period. RESULTS:Chronic exposure to HFD resulted in hepatic steatosis in conjunction with an obese and impaired glucose tolerance condition characterized by dyslipidemia, hyperinsulinemia elevated markers for the liver damage, and hypoadiponectinemia. Although VIT and MIT alleviated the NAFLD conditions, the former was more effective at alleviating hepatic steatosis than the latter. The intensity-dependent benefit of exercise training against hepatic steatosis was associated with greater activation of VIT on hepatic AMP-mediated protein kinase in conjunction with greater suppressive effect of VIT on hypoadiponectinemia, downregulation of the Adiponectin receptor 2 signaling pathway, and upregulation of the NF-κB signaling pathway in the liver. CONCLUSIONS:The current findings suggest that VIT is an alternative way of exercise training to combat hepatic steatosis associated with an obese and impaired glucose tolerance phenotype.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Cho J,Kim S,Lee S,Kang Hdoi
10.1249/MSS.0000000000000595subject
Has Abstractpub_date
2015-08-01 00:00:00pages
1624-34issue
8eissn
0195-9131issn
1530-0315journal_volume
47pub_type
杂志文章abstract：PURPOSE:This study, theoretically based on the Exercise Self-Esteem Model, EXSEM, examined effects of exercise modality on physical and global self-esteem (PSE, GSE) in breast cancer survivors. The EXSEM posits GSE at the apex with PSE feeding into GSE. PSE has three subdomains: physical condition (PC), attractive body...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0b013e31822cb5f2
更新日期：2012-02-01 00:00:00
abstract：:The association between increasing age and decreasing vagal modulation is well known. However, the importance of fitness as a determinant of the decline in vagal modulation with age is not established. To test the hypothesis that decreasing vagal modulation is largely a function of declining fitness rather than increa...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199706000-00012
更新日期：1997-06-01 00:00:00
abstract：PURPOSE:The objective of this study is to determine the effect of body mass index (BMI) on level of agreement between six previously established prediction equations for three commonly used accelerometers to predict summary measures of energy expenditure (EE) in youth. METHODS:One hundred and thirty-one youth between ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e318267b8f1
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION/PURPOSE:Aging modifies neuromuscular activation of agonist and antagonist muscles during walking. Power training can evoke adaptations in neuromuscular activation that underlie gains in muscle strength and power but it is unknown if these adaptations transfer to dynamic tasks such as walking. We examined t...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001345
更新日期：2017-11-01 00:00:00
abstract：:This study characterizes exercise-induced lipid peroxidation during graded aerobic exercise in seven healthy men and women (36.4 +/- 3 yr). Levels of ethane and pentane in expired breath during cardiopulmonary exercise stress testing were measured at rest, lactic acidosis threshold (LAT), maximal exercise (VO2max), an...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199708000-00008
更新日期：1997-08-01 00:00:00
abstract：INTRODUCTION:Loud sounds can decrease reaction time (RT) and increase force generated during voluntary contractions. Accordingly, we hypothesized that the loud starter's pistol at the Olympic Games allows runners closer to the starter to react sooner and stronger than runners farther away. METHODS:RT for the 100/110 m...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e31816770e1
更新日期：2008-06-01 00:00:00
abstract：:To inform the development of bone-specific physical activity (PA) assessment methods and contribute to bone-specific PA guidelines, accelerometer outcomes that provide the most valid estimates of skeletal loading in adults must be identified. PURPOSE:The aims of this project were two-fold. First, to assess the concur...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000002562
更新日期：2020-11-07 00:00:00
abstract：:The effects of aerobic fitness on resistance to psychosocial stressors are reviewed. To unravel the inconsistent results in studies examining the relationship between aerobic fitness and psychosocial stress response, a meta-analysis was conducted. The results of 34 studies having 92 effect size estimates from 1,449 su...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,评审
doi：
更新日期：1987-10-01 00:00:00
abstract：PURPOSE:Pedometers may provide valuable information regarding the ambulatory patterns of adolescents, but the effects of body mass index (BMI) on pedometer accuracy in this population are unknown.The purpose of this study was twofold: 1) to determine whether the New Lifestyles NL-2000 (NL) and the Digi-Walker SW-200 (D...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3182746aa5
更新日期：2013-03-01 00:00:00
abstract：:To determine the effect of large and sudden increases in training volume on performance characteristics and the feasibility of using overtraining syndrome symptoms to monitor performance changes, 15 elite judo athletes were examined through 10 wk of training. Athletes performed their regular regimens of resistance (3 ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/00005768-199012000-00014
更新日期：1990-12-01 00:00:00
abstract：PURPOSE:We investigated technical and physiological responses along with their relationships during an incremental field test to exhaustion specific to tennis (TEST) in elite players. METHODS:Twenty male elite tennis players completed TEST, which consisted of hitting alternatively forehand and backhand strokes at incr...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001303
更新日期：2017-09-01 00:00:00
abstract：PURPOSES:To validate the energy expenditure estimated from The Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ) with total energy expenditure (TEE) measured by doubly labeled water (DLW), and to present and examine the validity of an extended version of the MLTPAQ with additional questions about inactivi...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.MSS.0000093608.95629.85
更新日期：2003-11-01 00:00:00
abstract：PURPOSE:Heart rate (HR) is widely used to adjust exercise intensity in aerobic training. Training HR recommendations are calculated often from simple equations. Because at lactate steady state (LASS) may be an intensity of exercise eliciting similar objective measures of intensity and similar subjective measures of met...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200205000-00024
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Skeletal muscle from lean and obese subjects elicit differential adaptations in response to exercise/muscle contractions. In order to determine whether obesity alters the adaptations in mitochondrial dynamics in response to exercise/muscle contractions and whether any of these distinct adaptations are linked...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000002580
更新日期：2020-12-11 00:00:00
abstract：PURPOSE:Hyperventilation increases the clearance of carbon monoxide (CO) from blood; thus, we hypothesized that CO elimination would be enhanced with exercise. Accordingly, this study examined the effect of exercise on the half-life of carboxyhemolobin elimination. METHODS:Six healthy subjects (three males and three f...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0b013e3182602a00
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:This study aimed to quantify the repeated oxygen deficits attained during intermittent endurance exercise by measuring oxygen consumption (V˙O2) and oxygen demand (V˙O2) throughout a simulated roller ski race. METHODS:Eight male elite cross-country skiers (V˙O2peak, 77.4 ± 4.4 mL·kg⋅min) raced a 13.5-km roller...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000002209
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:The fluctuations in force during a steady contraction can be influenced by age, vision, and level of physiological arousal. The aim of this study was to determine the effects of a stressor on the force fluctuations and information transmission exhibited by young, middle-aged, and older adults when a pinch-grip ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000178103.72988.cd
更新日期：2005-12-01 00:00:00
abstract：INTRODUCTION:Strenuous exercise induces significant increases in cardiac biomarkers. However, it is still unclear whether this is caused by cardiomyocyte necrosis or secondary mechanisms such as ischemia, cardiac energy deficiency, increased inflammation, or renal dysfunction. METHODS:Therefore, we investigated cardia...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1249/MSS.0b013e31821b12eb
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:This study tested the hypothesis that exercise training improves myocardial blood flow and regional myocardial contractile function in a lateral border zone located adjacent to the ischemic zone during coronary artery occlusion. METHODS:Fourteen dogs were subjected to either 12 wk of dynamic exercise training ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200104000-00008
更新日期：2001-04-01 00:00:00
abstract：PURPOSE:To test the hypothesis that the initial O2 uptake kinetics during exercise where the rise in blood flow (and, by implication, O2 delivery) to the working muscles during an abrupt increase in exercise intensity is reduced (i.e., arm exercise performed above the level of the heart) would be faster when preceded b...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000159013.20244.f8
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Recent work has identified deficits in dual-task gait balance control for up to 2 months after adolescent concussion; however, how resumption of preinjury physical activities affects recovery is unknown. PURPOSE:The objective of this study is to examine how return to activity (RTA) affects recovery from con...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000000462
更新日期：2015-04-01 00:00:00
abstract：PURPOSE:The effect of quantified resistance and high impact exercise training on bone mass as modified by age and oral contraceptive (OCont) use in young women was studied. METHODS:Women were categorized by age (18-23 vs 24-31 yr) and OCont use, and were then randomized into either three sessions of resistance exercis...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00005768-200106000-00004
更新日期：2001-06-01 00:00:00
abstract：PURPOSE:Recovery of ambulatory function after stroke is routinely assessed using standardized subject- or observer-rated instruments that do not directly measure ambulatory activities in the home-community setting. Accuracy of conventional pedometers in stroke patients is not established, limiting their application in ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200203000-00002
更新日期：2002-03-01 00:00:00
abstract：PURPOSE:To determine the effect of dietary antioxidant restriction on oxidative stress, antioxidant defenses, and exercise performance in athletes. Oxidative stress has been shown to increase during exercise. To alleviate oxidative stress, a high intake of antioxidant rich foods or supplements may be required in traine...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1249/01.mss.0000150016.46508.a1
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:Walking is likely to contribute substantially to nonexercise activity thermogenesis. The Tracmor triaxial accelerometer system (Maastricht, The Netherlands) is the most widely validated system for detecting body movement in free-living subjects. The aim of this study was to validate the Tracmor triaxial acceler...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200109000-00024
更新日期：2001-09-01 00:00:00
abstract：PURPOSE:This study was conducted to test whether a low-frequency vibration-like stimulus (rapid variable resistance) applied during a single session of knee extension exercise would alter muscle performance. METHODS:Torque, knee joint angle, EMG activity of rectus femoris (RF) and vastus lateralis (VL) muscles, and VL...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000227318.39094.b6
更新日期：2006-07-01 00:00:00
abstract：PURPOSE:To study the effect of genetic factors, birth weight, early childhood growth, sport, hours of training, and pubertal status on the stature and body mass index (BMI) of children aged 9-13 participating in sports at a competitive level. METHODS:A total of 184 children (96 girls, 88 boys), competing in swimming, ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200010000-00006
更新日期：2000-10-01 00:00:00
abstract：:Changes in body composition, fat distribution and lipoprotein lipids in response to weight loss elicited by a 10-month program of hypocaloric diet (HD) therapy alone or combined with aerobic exercise training (AEX+HD) were examined in sedentary obese older males. Body composition was assessed by hydrodensitometry and ...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：UNLABELLED:Clinical treatment in physical rehabilitation routinely uses perceived relative forces. PURPOSE:This study used psychophysical methods to quantify subjects' errors during submaximal muscular force production. METHODS:A sample of young adult (aged 23 +/- 3 yr) females (N = 60, 62 +/- 14 kg) and males (N = 5...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200002000-00028
更新日期：2000-02-01 00:00:00
abstract：:The purpose of the present investigation was to examine the wet suit effect on 8 swimmers and 8 triathletes. For swimmers, the performances of a 400-m swim with and without wet suit were not statistically different (4 min 12.5 +/- 8 s vs 4 min 13.9 +/- 4 s) while for triathletes the swim times were reduced by 19 s (4 ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
