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Molecular diagnostic tests to predict the risk of progressive multifocal leukoencephalopathy in natalizumab-treated multiple sclerosis patients.

Abstract：

:Natalizumab is a humanized monoclonal antibody against the alpha4 chain of the alpha4beta1 and alpha4beta7 integrin heterodimers used with high effectiveness in the treatment of multiple sclerosis. The use of this drug can unfortunately be associated with the onset of progressive multifocal leukoencephalopathy, a possibly fatal infection of the central nervous system, caused by polyomavirus JC. To understand and quantify the risk of developing PML is important for patients who are about to start therapy with natalizumab and for patients who already are under treatment with this drug. In this review we describe and critique molecular diagnostic tests proposed in the last years to assess the risk of PML.

journal_name

Mol Cell Probes

journal_title

Molecular and cellular probes

authors

Rossi F,Newsome SD,Viscidi R

doi

10.1016/j.mcp.2014.11.007

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

54-62

issue

1

eissn

0890-8508

issn

1096-1194

pii

S0890-8508(14)00065-6

journal_volume

29

pub_type

杂志文章,评审

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