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Selective staining of a subset of Purkinje cells in the human cerebellum with monoclonal antibody mabQ113.

Abstract：

:MabQ113 is a monoclonal antibody raised against rat cerebellum which selectively strains Purkinje cells. Likewise, in mabQ113-immunoperoxidase stained sections of human cerebellum, deposits of reaction product are found only in the Purkinje cells. The dendritic arborizations, cell body, and axonal processes are immunoreactive. In rat, mabQ113 reveals a series of parasagittal antigenic bands which run throughout the cerebellar cortex. The staining distribution in human cerebellar cortex likewise reveals heterogenous staining but the pattern is a complex one and seems to be unlike the parasagittal banding found in the rat. In a number of human diseases Purkinje cell degeneration is not uniform throughout the vermis and cerebellar hemispheres. It is possible that mabQ113+ and mabQ113- subsets of Purkinje cells may respond differentially to various pathological conditions.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Plioplys AV,Thibault J,Hawkes R

doi

10.1016/0022-510x(85)90166-2

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

245-56

issue

3

eissn

0022-510X

issn

1878-5883

pii

0022-510X(85)90166-2

journal_volume

70

pub_type

杂志文章

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