Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study.

Abstract:

:A multi-center double-blind randomized clinical trial was conducted by the National Acute Spinal Cord Injury Study Group to examine the efficacy of high-dose methylprednisolone (1000-mg bolus and 1000 mg daily thereafter for 10 days) compared with that of a standard dose (100-mg bolus and 100 mg daily for 10 days). No significant difference was observed in neurological recovery of motor function, pinprick response, or touch sensation 1 year after injury between the two treatment groups, after adjustment for other potentially confounding factors. Analyses that specifically took into account the patients' total steroid dose and relative weight confirmed the lack of a steroid treatment effect. The case fatality rate was 10.7% during the 1st year after injury, and this was not associated with the steroid treatment protocol or the patient's gender. Deaths did occur significantly more frequently among patients who were completely (15.3%) and partially (8.6%) plegic than among those who were paretic (2.5%, p = 0.0005), and among patients aged 50 years or older (38.6%, p = 0.0001).

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Bracken MB,Shepard MJ,Hellenbrand KG,Collins WF,Leo LS,Freeman DF,Wagner FC,Flamm ES,Eisenberg HM,Goodman JH

doi

10.3171/jns.1985.63.5.0704

subject

Has Abstract,Author List Incomplete

pub_date

1985-11-01 00:00:00

pages

704-13

issue

5

eissn

0022-3085

issn

1933-0693

journal_volume

63

pub_type

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